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Constructing a nomogram to predict overall survival of colon cancer based on computed tomography characteristics and clinicopathological factors

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4104-4114页

作者： zhe-Xing Hu Yin Li Xuan Yang Yu-Xia Li Yao-Yao He Xiao-Hui Niu Ting-Ting Nie Xiao-fang Guo Zi-Long Yuan Department of Radiology Hubei Cancer HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430079Hubei ProvinceChina Department of Radiology Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014Hubei ProvinceChina College of Informatics Huazhong Agriculture UniversityWuhan 430070Hubei ProvinceChina

BACKGROUND The colon cancer prognosis is influenced by multiple factors,including clinical,pathological,and non-biological ***,only a few studies have focused on computed tomography(CT)imaging ***,this study aims to predict the prognosis of patients with colon cancer by combining CT imaging features with clinical and pathological characteristics,and establishes a nomogram to provide critical guidance for the individualized *** To establish and validate a nomogram to predict the overall survival(OS)of patients with colon *** A retrospective analysis was conducted on the survival data of 249 patients with colon cancer confirmed by surgical pathology between January 2017 and December *** patients were randomly divided into training and testing groups at a 1:1 *** and multivariate logistic regression analyses were performed to identify the independent risk factors associated with OS,and a nomogram model was constructed for the training *** curves were calculated using the Kaplan–Meier *** concordance index(C-index)and calibration curve were used to evaluate the nomogram model in the training and testing *** Multivariate logistic regression analysis revealed that lymph node metastasis on CT,perineural invasion,and tumor classification were independent prognostic factors.A nomogram incorporating these variables was constructed,and the C-index of the training and testing groups was 0.804 and 0.692,*** calibration curves demonstrated good consistency between the actual values and predicted probabilities of *** A nomogram combining CT imaging characteristics and clinicopathological factors exhibited good discrimination and *** can aid clinicians in risk stratification and postoperative monitoring and provide important guidance for the individualized treatment of patients with colon cancer.

关键词： Colon cancer Nomogram Prognosis Overall survival Computed tomography Clinicopathology

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Disulfiram ameliorates STING/MITA-dependent inflammation and autoimmunity by targeting RNF115

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Cellular & Molecular Immunology 2024年第3期21卷 275-291页

作者： Zhi-Dong Zhang Chang-Rui Shi fang-Xu Li Hu Gan Yanhong Wei Qianhui Zhang Xin Shuai Min Chen Yu-Lin Lin Tian-Chen Xiong Xiaoqi Chen Bo zhong Dandan Lin Department of Gastrointestinal Surgery Medical Research InstituteFrontier Science Center of Immunology and MetabolismZhongnan Hospital of Wuhan UniversityWuhan UniversityWuhan430071China Department of Virology College of Life SciencesWuhan UniversityWuhan430072China TaiKang Center for Life and Medical Sciences Wuhan UniversityWuhan430071China Wuhan Research Center for Infectious Diseases and Cancer Chinese Academy of Medical SciencesWuhan430071China Department of Rheumatology and Immunology Zhongnan Hospital of Wuhan UniversityWuhan430071China Cancer Center Renmin Hospital of Wuhan UniversityWuhan430060China

STING(also known as MITA)is an adaptor protein that mediates cytoplasmic DNA-triggered signaling,and aberrant activation of STING/MITA by cytosolic self-DNA or gain-of-function mutations causes severe ***,we show that STING-mediated inflammation and autoimmunity are promoted by RNF115 and alleviated by the RNF115 inhibitor disulfiram(DSF).Knockout of RNF115 or treatment with DSF significantly inhibit systemic inflammation and autoimmune lethality and restore immune cell development in Trex1^(–/–)mice and STING^(N153S/WT) bone marrow chimeric *** addition,knockdown or pharmacological inhibition of RNF115 substantially downregulate the expression of IFN-α,IFN-γand proinflammatory cytokines in PBMCs from patients with systemic lupus erythematosus(SLE)who exhibit high concentrations of dsDNA in peripheral ***,knockout or inhibition of RNF115 impair the oligomerization and Golgi localization of STING in various types of cells transfected with cGAMP and in organs and cells from Trex1^(–/–)***,knockout of RNF115 inhibits the activation and Golgi localization of STINGN153S as well as the expression of proinflammatory cytokines in myeloid cells but not in endothelial cells or *** together,these findings highlight the RNF115-mediated cell type-specific regulation of STING and STINGN153S and provide potential targeted intervention strategies for STING-related autoimmune diseases.

关键词： STING/MITA Disulfiram RNF115 SLE Autoimmunity

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Proteomic profiling of cerebrospinal fluid in pediatric myelin oligodendrocyte glycoprotein antibody-associated disease

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World Journal of Pediatrics 2024年第3期20卷 259-271页

作者： Yi-Long Wang Meng-Ying Zhu zhe-Feng Yuan Xiao-Yan Ren Xiao-Tong Guo Yi Hua Lu Xu Cong-Ying Zhao Li-Hua Jiang Xin Zhang Guo-Xia Sheng Pei-fang Jiang zheng-Yan Zhao Feng Gao Department of Neurology Children's HospitalZhejiang University School of MedicineHangzhou 310052China Children's Hospital Zhejiang University School of MedicineHangzhou 310052China Children's Hospital National Clinical Research Center for Child HealthZhejiang University School of MedicineHangzhou 310052China

Background Myelin oligodendrocyte glycoprotein(MOG)antibody-associated disease(MOGAD)is an autoimmune demy-elinating disorder of the central nervous *** Extracted proteins from 34 cerebrospinal fluid(CSF)samples[patients with MOGAD(MOG group,n=12);healthy controls(HC group,n=12);patients with MOG seronegative and metagenomics next-generation sequencing-negative inflammatory neurological diseases(IND group,n=10)]were processed and subjected to label-free quantitative *** partial least squares-discriminant analysis(PLS-DA)and orthogonal PLS-DA(O-PLS-DA)models were also performed based on proteomics *** analysis of differentially expressed proteins(DEPs)was performed using Gene Ontology,InterPro,and Kyoto Encyclopedia Genes and *** enzyme-linked immunosorbent assay was used to determine the complement levels in serum from patients with *** Four hundred and twenty-nine DEPs(149 upregulated and 280 downregulated proteins)were identified in the MOG group compared to the HC group according to the P value and fold change(FC).Using the O-PLS-DA model,872 differentially abundant proteins were identified with variable importance projection(VIP)scores>*** proteins(gamma-glutamyl hydrolase,cathepsin F,interalpha-trypsin inhibitor heavy chain 5,latent transforming growth factor beta-binding protein 4 and leukocyte-associated immunoglobulin-like receptor 1)overlapping between the top 30 DEPs with top-ranked P value and FC and top 30 proteins in PLS-DA VIP lists were *** analysis revealed that the dysregulated proteins in the MOG group were primarily involved in complement and coagulation cascades,cell adhesion,axon guidance,and glycosphingolipid biosynthesis compared to the HC *** The proteomic alterations in CSF samples from children with MOGAD identified in the current study might provide opportunities for developing novel biomarker candidates.

关键词： Acute disseminated encephalomyelitis Cerebrospinal fluid Complement cascades Myelin oligodendrocyte glycoprotein-associated disease Proteomics

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Aspartoacylase suppresses prostate cancer progression by blocking LYN activation

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Military Medical Research 2024年第2期11卷 180-205页

作者： Hong Weng Kang-Ping Xiong Wang Wang Kai-Yu Qian Shuai Yuan Gang Wang fang Yu Jun Luo Meng‑Xin Lu zhong‑Hua Yang Tao Liu Xing Huang Hang zheng Xing-Huan Wang Department of Urology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Center for Evidence‑Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Biological Repositories Zhongnan Hospital of Wuhan UniversityWuhan 430071China Hubei Key Laboratory of Tumor Biological Behaviors Wuhan 430071China Department of Pathology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Center for Pathology and Molecular Diagnostics Wuhan UniversityWuhan 430071China Wuhan Research Center for Infectious Diseases and Cancer Chinese Academy of Medical SciencesWuhan 430071China

Background:Globally,despite prostate cancer(PCa)representing second most prevalent malignancy in male,the precise molecular mechanisms implicated in its pathogenesis remain ***,elucidating the key molecular regulators that govern disease progression could substantially contribute to the establishment of novel therapeutic strategies,ultimately advancing the management of ***:A total of 49 PCa tissues and 43 adjacent normal tissues were collected from January 2017 to December 2021 at zhongnan Hospital of Wuhan *** advanced transcriptomic methodologies were employed to identify differentially expressed mRNAs in *** expression of aspartoacylase(ASPA)in PCa was thoroughly evaluated using quantitative real-time PCR and Western blotting *** elucidate the inhibitory role of ASPA in PCa cell proliferation and metastasis,a comprehensive set of in vitro and in vivo assays were conducted,including orthotopic and tumor-bearing mouse models(n=8 for each group).A combination of experimental approaches,such as Western blotting,luciferase assays,immunoprecipitation assays,mass spectrometry,glutathione S-transferase pulldown experiments,and rescue studies,were employed to investigate the underlying molecular mechanisms of ASPA's action in *** Student‘s t-test was employed to assess the statistical significance between two distinct groups,while one-way analysis of variance was utilized for comparisons involving more than two groups.A two-sided P<0.05 was deemed to indicate statistical ***:ASPA was identified as a novel inhibitor of PCa *** expression of ASPA was found to be significantly down-regulated in PCa tissue samples,and its decreased expression was independently associated with patients’prognosis(HR=0.60,95%CI 0.40–0.92,P=0.018).Our experiments demonstrated that modulation of ASPA activity,either through gain-or loss-of-function,led to the suppression or enhancement of PCa cell proliferation,mig

关键词： Prostate cancer Aspartoacylase LYN JNK AP-1 C-Jun Phosphorylation

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Construction of 2D/2D Ti_(3)C_(2)T_(x)MXene/CdS heterojunction with photothermal effect for efficient photocatalytic hydrogen production

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Journal of Materials Science & Technology 2024年第4期171卷 1-9页

作者： T.Y.Huang Z.Yang S.Y.Yang Z.H.Dai Y.J.Liu J.H.Liao G.Y.zhong Z.J.Xie Y.P.fang S.S.Zhang Key Laboratory for Biobased Materials and Energy of Ministry of Education Guangdong Laboratory for Lingnan Modern AgricultureCollege of Materials and EnergySouth China Agricultural UniversityGuangzhou 510643China School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China School of Chemical Engineering and Energy Technology Guangdong Provincial Key Laboratory of Distributed Energy SystemsDongguan University of TechnologyDongguan 523808China

The insensitivity of semiconductors to visible and infrared light is a key constraint on the utilization of light energy in photocatalytic *** photocatalysts with full-spectrum absorption through surface engineering is an effective approach to fully harnessing light energy in semiconductor ***,a novel stable Ti_(3)C_(2)T_(x)MXene/CdS heterojunction catalyst is obtained by in-situ epitaxial growth of two-dimensional(2D)CdS nanosheets on 2D MXene interface via a solvothermal *** exceptional light absorption properties of MXene confer outstanding full-spectrum driven photocat-alytic hydrogen evolution capability upon the heterogeneous *** unique 2D/2D structure effectively mitigated the recombination of photogenerated carriers,enhancing the photocatalytic performance of the ***,the composite catalyst exhibits a significantly higher surface temperature of 80.4℃under visible light irradiation at an intensity of 0.1 W/cm^(2),which is 1.84 times higher than that of *** irradiation of visible and near infrared light,the composite catalyst with photothermal ef-fect demonstrates a remarkable hydrogen evolution rate of 65.4 mmol g^(-1)h^(-1),which is 7.2 times higher than that of CdS *** study introduces a novel approach for constructing full-spectrum absorption catalysts and expands the application of the photothermal effect in photocatalytic hydrogen evolution research.

关键词： Two-dimensional structure Heterostructure Photothermal effect Photocatalyst Hydrogen evolution

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中国台湾眷村文学的三度空间书写

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南通大学学报（社会科学版） 2024年第3期40卷 66-75页

作者：方忠石琦山东师范大学文学院江苏师范大学文学院江苏师范大学科文学院

中国台湾眷村文学以鲜活的笔触保存了眷村移民的历史记忆,书写他们的流离与迁移、落地与重建,展现出地理空间、文化空间和精神空间三个层面的书写向度,弹唱出一曲哀怨婉转的“去国、怀乡、失根”的遗民悲调,营造出一个逐渐消逝在历史长... 详细信息

中国台湾眷村文学以鲜活的笔触保存了眷村移民的历史记忆,书写他们的流离与迁移、落地与重建,展现出地理空间、文化空间和精神空间三个层面的书写向度,弹唱出一曲哀怨婉转的“去国、怀乡、失根”的遗民悲调,营造出一个逐渐消逝在历史长河中的鲜活生动、富有诗意的眷村世界。眷村文学是多元化的中国台湾当代文坛不可或缺的组成部分,对于台湾地区文学史的形塑产生了重要影响。

关键词：中国台湾文学眷村地理空间文化空间精神空间

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Naoxueshu Oral Liquid Accelerates Post-Craniotomy Hematoma Absorption in Patients:An Open-Label,Multicenter,and Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第8期30卷 675-683页

作者： HE Qiu LIN Fu-xin SU Jin-ye ZHUO Ling-yunn ZHU Qing SUN Xiao-chuan JIANG Rong-cai YAO Zhi-gang WANG Lei DANG Yan-wei LIU De-zhong LIU Yang fang Wen-hua WANG fang-yu LIN Yuan-xiang WANG An-xin WANG Deng-liang KANG De-zhi Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China Department of Neurosurgery Binhai Branch of National Regional Medical CenterThe First Affiliated HospitalFujian Medical UniversityFuzhou350209China Clinical Research and Translation Center The First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China Fujian Clinical Research Center for Neurological Diseases The First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China Fujian Provincial Institutes of Brain Disorders and Brain Sciences The First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China Department of Neurosurgery The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu Province215000China Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing400000China Department of Neurosurgery Tianjin Medical University General HospitalTianjin300000China Department of Neurosurgery The Third Hospital of ShijiazhuangShijiazhuang050000China Department of Neurosurgery The First College of Clinical Medical ScienceChina Three Gorges UniversityYichangHubei Province443000China Department of Neurosurgery Yichang Central People’s HospitalYichangHubei Province443000China Department of Neurosurgery Xiangyang No.1 People’s Hospital Affiliated to Hubei University of MedicineXiangfanHubei Province441100China Department of Neurosurgery Zhoukou Central HospitalZhoukouHenan Province466000China Department of Neurosurgery The Third Hospital of MianyangMianyangSichuan Province621000China Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijing100000China China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijing100000China Department of Clinical Epidemiology and Clinical Trial Capital Medical UniversityBeijing100000China Beijing Municipal Key Laboratory of Clinical

Objective To investigate whether Naoxueshu Oral Liquid(NXS)could promote hematoma absorption in post-craniotomy hematoma(PCH)*** This is an open-label,multicenter,and randomized controlled trial conducted at 9 hospitals in *** aged 18–80 years with post-craniotomy supratentorial hematoma volume ranging from 10 to 30 mL or post-craniotomy infratentorial hematoma volume less than 10 mL,or intraventricular hemorrhage following cranial surgery were *** were randomly assigned at a 1:1 ratio to the NXS(10 mL thrice daily for 15 days)or control groups using a randomization code *** medical care was administered in both *** primary outcome was the percentage reduction in hematoma volume from day 1 to day *** secondary outcomes included the percentage reduction in hematoma volume from day 1 to day 7,the absolute reduction in hematoma volume from day 1 to day 7 and 15,and the change in neurological function from day 1 to day 7 and *** safety was closely monitored throughout the ***,subgroup analysis was performed based on age,gender,history of diabetes,and etiology of intracerebral hemorrhage(ICH).Results A total of 120 patients were enrolled and randomly assigned between March 30,2018 and April 15,*** patient was lost to follow-up in the control ***,there were 119 patients(60 in the NXS group and 59 in the control group)included in the *** the full analysis set(FAS)analysis,the NXS group had a greater percentage reduction in hematoma volume from day 1 to day 15 than the control group[median(Q1,Q3):85%(71%,97%)vs.76%(53%,93%),P0.05).Furthermore,no adverse events were reported during the *** the FAS analysis,the NXS group exhibited a higher percentage reduction in hematoma volume on day 15 in the following subgroups:male patients,patients younger than 65 yea

关键词： post-craniotomy hematoma Naoxueshu Oral Liquid hematoma absorption randomized controlled trial Chinese medicine

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Embracing digital mindsets to ensure a sustainable future

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Frontiers of Environmental Science & Engineering 2024年第3期18卷 177-179页

作者： Chengjun Li Riqing Yu Wenjing Ning Huan zhong Christian Sonne Institute of Environmental Research at Greater Bay Area Guangzhou UniversityGuangzhou 510000China Department of Biology Center for EnvironmentBiodiversity and ConservationThe University of Texas at TylerTylerTX 75701USA School of Environment Nanjing UniversityNanjing 210000China Environmental and Life Science Program Trent UniversityPeterboroughOntarioK9H 0A1Canada Faculty of Science and Technology Aarhus UniversityRoskildeDenmark 4000The Kingdom of Denmark Sustainability Cluster School of EngineeringUniversity of Petroleum&Energy StudiesDehradunUttarakhand 248001India

The 19th Asian Games astounded global audiences with an opening spectacle that showcased stunning digital fireworks(International Olympic Committee,2021;zhe,2023).The groundbreaking display was brought to life through virtual reality(VR)and augmented reality(AR)*** sets a pioneering example to replace conventional fireworks in major international events as well as in other large-scale entertainment activities,marking a historic milestone in the pursuit of a sustainable and healthy future.

关键词： Wildlife Climate Change Heavy metals Noise LAN Light pollution

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Tacrolimus combined with arsenic trioxide provides a three-in-one drug-eluting coronary stent integrating anti-restenosis,pro-endothelialization and anti-inflammation

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Medicine in Novel Technology and Devices 2024年第1期21卷 110-119页

作者： Yaojia Zhang Hongchi Yu Li Deng zhe Hou Jie Yang Fei fang Michael ZMiao Wenjun Li Xin Shen Dongyun Hao Xiaoyi Ma Lifeng Zhou Fugui He Xiaoheng Liu a1Institute of Biomedical Engineering West China School of Basic Medical Sciences&Forensic MedicineSichuan UniversityChengdu610041China Division of Oral&Craniofacial Health Sciences Adams School of DentistryUniversity of North Carolina at Chapel HillNC27599USA Beijing Key Laboratory of Cardiac Drug Device Technology and Evidence Based Medicine Beijing100021China

The limitations of current drug-eluting stent technologies in selectively inhibiting vascular smooth muscle cell proliferation,which often leads to inflammation,call for innovative approaches in coronary artery disease *** the present work,we propose a revolutionary solution:a three-in-one platform for vascular stents,combining arsenic trioxide(ATO)and tacrolimus(TAC)to address anti-proliferation,pro-endothelialization,and anti-inflammation *** findings demonstrate that the synergistic action of ATO and TAC effectively suppresses aberrant vascular smooth muscle cell proliferation and mitigates endothelial cell ***,the combination treatment of TAC/ATO enhances endothelial cell migration and adhesion ***,our TAC/ATO-eluting stent exhibits superior re-endothelialization and anti-restenosis effects in a rabbit and porcine stent implantation *** in vitro and in vivo results solidify the notion that the TAC/ATO-eluting stent ensures rapid re-endothelialization and significantly reduces the incidence of in-stent ***,this study represents a promising and novel multifunctional platform with immense potential in the therapy of coronary artery disease.

关键词： Tacrolimus Arsenic trioxide Drug-eluting stent

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Review of 2D Bi_(2)X_(3)(X=S,Se,Te):from preparation to photodetector

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Rare Metals 2024年第6期43卷 2349-2370页

作者： Zhi Zeng Dong-Bo Wang Xuan fang Jia-Mu Cao Bing-Ke Zhang Jing-Wen Pan Dong-Hao Liu Si-Hang Liu Shu-Jie Jiao Tian-Yuan Chen Gang Liu Lian-Cheng Zhao Jin-zhong Wang Department of Optoelectronic Information Science School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin 150001China Changchun University Science and Technology School of PhysicsThe State Key Laboratory of High Power Semiconductor LasersChangchun 130022China School of Astronautics Harbin Institute of TechnologyHarbin 150001China Center for High Pressure Science and Technology Advanced Research Shanghai 201203China

Detector has become an indispensable part of human *** increasing demand for photodetectors with high performance has promoted the research of novel *** the same time,with the development of rising material system,two-dimensional(2D)materials attract a lot of attention,while the suitable option for fabricating photodetector is still *** prospering of bismuth chalcogenides injected new vitality for material field,thereinto,the unique topological insulator characteristics make the research on bismuth selenide(Bi_(2)X_(3))and bismuth telluride(Bi_(2)X_(3)) intriguing.2D Bi_(2)X_(3) also exhibits unique features among various 2D materials,of which,the adjustable narrow energy band gap and polarization-sensitive photocurrent contribute to the promising application of high performance and broadband *** this review,from a bottom-up perspective,we summarize fundamental properties,synthesis method,photodetector performance of 2D Bi_(2)X_(3) based on the previous study,which provide an overall perspective of 2D Bi_(2)X_(3).Wherein,the section of the photodetector is specifically discu ssed with regard to pure Bi_(2)X_(3) photodetector and heterojunction photodetector.A brief summary and outlook were also explored in the end.

关键词： Bi_(2)X_(3) Preparation 2D Photodetector

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