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XBP1 splicing contributes to endoplasmic reticulum stress-induced human islet amyloid polypeptide up-regulation

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Genes & Diseases 2024年第5期11卷 350-359页

作者： Yun Zhang Susan Lin Jing Yao Wantong Cai Huaqiu chen Ailikemu Aierken zhe Wang Weihong Song National Clinical Research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijing 100053China Townsend Family Laboratories Department of PsychiatryThe University of British Columbia2255 Wesbrook MallVancouverBC V6T 1Z3Canada Institute of Aging Key Laboratory of Alzheimer’s Disease of Zhejiang ProvinceSchool of Mental Health and the Affiliated Kangning HospitalWenzhou Medical UniversityWenzhouZhejiang 325000China Oujiang Laboratory(zhejiang Lab for Regenerative Medicine Vision and Brain Health)WenzhouZhejiang 325001China

As a pathological hallmark of type 2 diabetes mellitus(T2DM),islet amyloid is formed by the aggregation of islet amyloid polypeptide(IAPP).Endoplasmic reticulum(ER)stress interacts with IAPP aggregates and has been implicated in the pathogenesis of *** examine the role of ER stress in T2DM,we cloned the hIAPP promoter and analyzed its promoter activity in human *** found that ER stress significantly enhanced hIAPP promoter activity and expression in human b-cells via triggering X-box binding protein 1(XBP1)*** identified a binding site of XBP1 in the hIAPP *** of this binding site by substitution or deletion mutagenesis significantly diminished the effects of ER stress on hIAPP promoter *** of XBP splicing by MKC3946 treatment inhibited ER stress-induced hIAPP up-regulation and improved human b-cell survival and *** study uncovers a link between ER stress and IAPP at the transcriptional level and may provide novel insights into the role of ER stress in IAPP cytotoxicity and the pathogenesis of T2DM.

关键词： b-cell function Endoplasmic reticulum stress Islet amyloid polypeptide Type 2 diabetes mellitus XBP1

Large-disturbance Stability Analysis of Power Systems with Synchronous Generator and Converter-interfaced Generation

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 997-1002页

作者： Lei chen yong Min Liangshuai Hao Guangzheng Xing Yalou Li Shiyun Xu Department of Electrical Engineering Tsinghua UniversityBeijing 100084China China Electric Power Research Institute Beijing 100192China

This letter studies large-disturbance stability of the power system with a synchronous generator(SG)and a converter-interfaced generation(CIG)connected to infinite *** power system is multi-timescale and first *** is shown that the boundary of region of attraction(ROA)of the simplified model is composed of stable manifolds of unstable equilibrium point(UEP)or semi-singular point(SSP),named anchor points,and singular surface *** type of anchor point determines the dominant instability pattern of the power *** the anchor point is UEP or SSP,the dominant instability pattern is the instability of rotor angle of SG or the instability of phase-locked loop and outer control loop(OCL)of CIG,*** of dominant instability pattern can be analyzed with the relative position relationship between UEP and *** effect of OCL is *** the OCL is activated,the ROA becomes smaller and the system is more prone to instability of *** is necessary to consider the OCL when studying the large-disturbance stability of the power system.

关键词： Converter-interfaced generation large-disturbance stability outer control loop phase-locked loop synchronous generator voltage source converter

Clinical features and possible pathogenesis of multiple evanescent white dot syndrome with different retinal diseases and events:a narrative review

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 583-595页

作者： Chun-Li chen Yi-zhe cheng Zhi-Han Zhang Ge Wang Xiao-Yan Peng Department of Ophthalmology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Beijing Ophthalmology and Visual Science Key Laboratory Beijing 100730China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510600Guangdong ProvinceChina

●Multiple evanescent white dot syndrome(MEWDS)is a rare fundus disease,characterized by acute vision loss and visual field *** previous studies have explained the possible pathogenesis and clinical features of primary ***,as the number of reported cases increases,secondary MEWDS occurs in other related retinal diseases and injuries,exhibiting some special *** associated retinal diseases include multifocal choroiditis/punctate inner choroidopathy(MFC/PIC),acute zonal occult outer retinopathy,best vitelliform macular dystrophy,pseudoxanthoma elasticum,and ocular *** related retinal injury is laser photocoagulation,surgery,and *** primary MEWDS often have a self-limiting course,secondary MEWDS may require treatment in some cases,according to the severity of concomitant diseases and ***,MEWDS secondary to MFC/PIC that is prone to forming choroidal neovascularization and focal choroidal excavation,needs positive treatment with *** possible underlying pathogenesis of secondary MEWDS is the exposure of choroidal antigen after the disruption of Bruch’s *** MEWDS-related features in secondary MEWDS are still evanescent under most *** prognosis and treatment depend on the severity of *** studies propose that the etiology is associated with immune factors,including viral infection,inflammation in choroid and Bruch’s membrane,and antigen exposure caused by retinal and/or choroidal *** pathogenic studies should be conducted in the *** diagnosis for secondary MEWDS could benefit patients in aspects of management and prognosis.

关键词： multiple evanescent white dot syndrome punctate inner choroidopathy multifocal choroiditis secondary multiple evanescent white dot syndrome

In-situ measurement via the flow-through method and numerical simulations for radon exhalation during measurements of the radon exhalation rate

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Nuclear Science and Techniques 2024年第7期35卷 192-207页

作者： Ming Xia yong-Jun Ye Shan-Wei Shang Ting Yu Dai-Jia chen School of Resources Environment and Safety Engineering University of South ChinaHengyang421001China Key Discipline Laboratory for National Defense for Biotechnology in Uranium Mining and Hydrometallurgy University of South ChinaHengyang421001China

Small-scale measurements of the radon exhalation rate using the flow-through and closed-loop methods were conducted on the surface of a uranium tailing pond to better understand the differences between the two *** abnormal radon exhalation behavior was observed,leading to computational fluid dynamics(CFD)-based simulations in which dynamic radon migration in a porous medium and accumulation chamber was *** on the in-situ experimental and numerical simulation results,variations in the radon exhalation rate subject to permeability,flow rate,and insertion depth were quantified and *** in-situ radon exhalation rates measured using the flow-through method were higher than those measured using the closed-loop method,which could be explained by the negative pressure difference between the inside and outside of the chamber during the *** consistency of the variations in the radon exhalation rate between the experiments and simulations suggests the reliability of CFD-based techniques in obtaining the dynamic evolution of transient radon exhalation rates for diffusion and convection at the porous medium-air *** synergistic effects of the three factors(insertion depth,flow rate,and permeability)on the negative pressure difference and measured exhalation rate were quantified,and multivariate regression models were established,with positive correlations in most cases;the exhalation rate decreased with increasing insertion depth at a permeability of 1×10^(−11) m^(2).CFD-based simulations can provide theoretical guidance for improving the flow-through method and thus achieve accurate measurements.

关键词： Radon exhalation Flow-through Numerical simulation Accumulation chamber Multivariate regression

Special Unipotent Representations of Simple Linear Lie Groups of Type A

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Acta Mathematica Sinica,English Series 2024年第3期40卷 707-716页

作者： Dan BARBASCH Jia Jun MA Bin yong SUN chen Bo ZHU Department of Mathematics Cornell UniversityIthacaNY 14853USA School of Mathematical Sciences Xiamen UniversityXiamen 361005P.R.China Department of Mathematics Xiamen University Malaysia CampusSepangSelangor Darul Ehsan43900Malaysia Institute for Advanced Study in Mathematics&New Cornerstone Science Laboratory Zhejiang UniversityHangzhou 310058P.R.China Department of Mathematics National University of Singapore10 Lower Kent Ridge RoadSingapore 119076

Let G be a special linear group over the real,the complex or the quaternion,or a special unitary *** this note,we determine all special unipotent representations of G in the sense of Arthur and Barbasch-Vogan,and show... 详细信息

关键词： Special unipotent representations unitary representations coherent continuation Weyl group representations

Understanding the Novel Approach of Nanoferroptosis for Cancer Therapy

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Nano-Micro Letters 2024年第9期16卷 501-556页

作者： Afsana Sheikh Prashant Kesharwani Waleed H.Almalki Salem Salman Almujri Linxin Dai zhe‑Sheng chen Amirhossein Sahebkar Fei Gao Department of Pharmaceutics School of Pharmaceutical Education and ResearchJamia HamdardNew Delhi 110062India Department of Pharmacology and Toxicology Faculty of PharmacyUmm Al-Qura UniversityMakkahSaudi Arabia Department of Pharmacology College of PharmacyKing Khalid University61421 Asir‑AbhaSaudi Arabia State Key Laboratory of Southwestern Chinese Medicine Resources Pharmacy SchoolChengdu University of Traditional Chinese MedicineChengdu 611130People’s Republic of China Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityNew York 11439USA Biotechnology Research Center Pharmaceutical Technology InstituteMashhad University of Medical SciencesMashhadIran Applied Biomedical Research Center Mashhad University of Medical SciencesMashhadIran

As a new form of regulated cell death,ferroptosis has unraveled the unsolicited theory of intrinsic apoptosis resistance by cancer *** molecular mechanism of ferroptosis depends on the induction of oxidative stress through excessive reactive oxygen species accumulation and glutathione depletion to damage the structural integrity of *** to their high loading and structural tunability,nanocarriers can escort the delivery of ferro-therapeutics to the desired site through enhanced permeation or retention effect or by active *** review shed light on the necessity of iron in cancer cell growth and the fascinating features of ferroptosis in regulating the cell cycle and ***,we discussed the effect of ferroptosis-mediated therapy using nanoplatforms and their chemical basis in overcoming the barriers to cancer therapy.

关键词： Ferroptosis Nanoparticles Ferrotherapy Cancer Genes Nanotechnology Toxicity Reactive oxygen species

Coordinatively unsaturated cobalt single-atom nanozymes for visual pesticides detection by smartphone-based platform

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Nano Research 2024年第4期17卷 2298-2307页

作者： Fangning Liu zhe Li Hengya Wei Peng Xu Ge Kang Shicheng Zhu Tingting Wang Ruxue He Chuanxia chen Yizhong Lu School of Materials Science and Engineering University of JinanJinan 250022China

By adjusting the coordination environment of single-atom catalysts,the enzyme-like activity can be finely tuned for highly sensitive ***,we demonstrated that coordinatively unsaturated cobalt-nitrogen sites doped within porous carbon(SA-CoN_(3))could serve as highly efficient oxidase *** with the typical planar four-coordination structure(SA-CoN_(4)),the as-obtained single-atom Co nanozymes anchored by three nitrogen atoms are found to display much higher oxidase-like catalytic *** theoretical and experimental analysis revealed that the coordinatively unsaturated Co sites could facilitate adsorption and activation of O_(2) molecule and thus improve their oxidase-like *** on the enhanced oxidase-like activity of SA-CoN_(3),a paper/smartphone sensor for organophosphorus pesticides(OPs)was successfully constructed and used to quantify glyphosate in environmental and food samples with a low detection limit of 0.66μ*** work not only highlights the important role of coordination unsaturation of SA nanozymes for promoting oxidase-like activity,but also provides an easy and cost-effective way to conduct effective quantification of OPs in the field.

关键词： single-atom nanozymes asymmetric organophosphorus pesticides oxygen adsorption smartphone

Beam based alignment using a neural network

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Nuclear Science and Techniques 2024年第4期35卷 108-118页

作者： Guan-Liang Wang Ke-Min chen Si-Wei Wang zhe Wang Tao He Masahito Hosaka Guang-Yao Feng Wei Xu National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029China Diamond Light Source Oxfordshire OX110DEUK

Beams typically do not travel through the magnet centers because of errors in storage *** beam deviating from the quadrupole centers is affected by additional dipole fields due to magnetic field ***-based alignment(BBA)is often performed to determine a golden orbit where the beam circulates around the quadrupole center *** storage rings with many quadrupoles,the conventional BBA procedure is time-consuming,particularly in the commissioning phase,because of the necessary iterative *** addition,the conventional BBA method can be affected by strong coupling and the nonlinearity of the storage ring *** this study,a novel method based on a neural network was proposed to determine the golden orbit in a much shorter time with reasonable *** golden orbit can be used directly for operation or adopted as a starting point for conventional *** method was demonstrated in the HLS-II storage ring for the first time through simulations and online *** results of the experiments showed that the golden orbit obtained using this new method was consistent with that obtained using the conventional *** development of this new method and the corresponding experiments are reported in this paper.

关键词： Golden orbit Beam-based alignment Neural network Storage ring

Joint Optimization for on-Demand Deployment of UAVs and Spectrum Allocation in UAVs-Assisted Communication

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China Communications 2024年第7期21卷 278-290页

作者： chen yong Liao Naiwen WangWei Zhang Xianyu Zhang Yu College of Communication Engineering Army Engineering University of PLANanjing 210007China The Sixty-Third Research Institute National University of Defense TechnologyNanjing 210007China

To improve the efficiency and fairness of the spectrum allocation for ground communication assisted by unmanned aerial vehicles(UAVs),a joint optimization method for on-demand deployment and spectrum allocation of UAVs is proposed,which is modeled as a mixed-integer non-convex optimization problem(MINCOP).An algorithm to estimate the minimum number of required UAVs is firstly proposed based on the pre-estimation and simulated *** MINCOP is then decomposed into three sub-problems based on the block coordinate descent method,including the spectrum allocation of UAVs,the association between UAVs and ground users,and the deployment of ***,the optimal spectrum allocation is derived based on the interference mitigation and channel *** association between UAVs and ground users is optimized based on local iterated optimization.A particle-based optimization algorithm is proposed to resolve the subproblem of the UAVs *** results show that the proposed method could effectively improve the minimum transmission rate of UAVs as well as user fairness of spectrum allocation.

关键词： block coordinate descent method on-demand deployment spectrum allocation UAVs-assisted Communication