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Clinical features and possible pathogenesis of multiple evanescent white dot syndrome with different retinal diseases and events:a narrative review

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 583-595页

作者： Chun-Li Chen yi-zhe Cheng Zhi-han Zhang Ge Wang Xiao-Yan Peng Department of Ophthalmology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Beijing Ophthalmology and Visual Science Key Laboratory Beijing 100730China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510600Guangdong ProvinceChina

●Multiple evanescent white dot syndrome(MEWDS)is a rare fundus disease,characterized by acute vision loss and visual field *** previous studies have explained the possible pathogenesis and clinical features of primary ***,as the number of reported cases increases,secondary MEWDS occurs in other related retinal diseases and injuries,exhibiting some special *** associated retinal diseases include multifocal choroiditis/punctate inner choroidopathy(MFC/PIC),acute zonal occult outer retinopathy,best vitelliform macular dystrophy,pseudoxanthoma elasticum,and ocular *** related retinal injury is laser photocoagulation,surgery,and *** primary MEWDS often have a self-limiting course,secondary MEWDS may require treatment in some cases,according to the severity of concomitant diseases and ***,MEWDS secondary to MFC/PIC that is prone to forming choroidal neovascularization and focal choroidal excavation,needs positive treatment with *** possible underlying pathogenesis of secondary MEWDS is the exposure of choroidal antigen after the disruption of Bruch’s *** MEWDS-related features in secondary MEWDS are still evanescent under most *** prognosis and treatment depend on the severity of *** studies propose that the etiology is associated with immune factors,including viral infection,inflammation in choroid and Bruch’s membrane,and antigen exposure caused by retinal and/or choroidal *** pathogenic studies should be conducted in the *** diagnosis for secondary MEWDS could benefit patients in aspects of management and prognosis.

关键词： multiple evanescent white dot syndrome punctate inner choroidopathy multifocal choroiditis secondary multiple evanescent white dot syndrome

Atmospheric responses over Asia to sea ice loss in the Barents and Kara seas in mid late winter and early spring:a perspective revealed from CMIP5 data

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Advances in Polar Science 2020年第1期31卷 55-63页

作者： han zhe LI Shuanglin CAS Key Laboratory of Regional Climate-Environment for Temperate East Asia Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Nansen-Zhu International Research Center(NZC) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China China Univercity of Geosciences Wuhan 430074China

This study investigated atmospheric responses in mid late winter and early spring to sea ice loss in the Barents and Kara seas using regressions of the January March mean atmosphere on Barents and Kara sea ice area in November and *** atmospheric circulation responses were obtained from reanalysis data and multimodel ensemble results from the Coupled Model Intercomparison Project Phase 5,i.e.,sea ice anomalies are the dominant factor driving the overlying *** results showed that an Arctic Asia dipole structure,with opposite anomalies over the mid-latitudes of Asia and over the adjoining Arctic,appears to be the key atmospheric circulation anomaly influencing the East Asian climate in mid late winter and early spring.

关键词： winter atmospheric circulation Arctic Asia dipole sea ice loss Barents and Kara seas

Efficacy,safety and treatment satisfaction of transition to a regimen of insulin degludec/aspart:A pilot study

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World Journal of Diabetes 2025年第1期16卷 65-73页

作者： Na Yang Lu Lv Shu-Meng han Li-Yun He Zi-yi Li Yu-Cheng Yang Fan Ping Ling-Ling Xu Wei Li Hua-Bing Zhang Yu-Xiu Li Department of Endocrinology Key Laboratory of Endocrinology of National Health CommissionPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Allergy Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic DiseasesNational Clinical Research Center for Dermatologic and Immunologic DiseasesPeking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China

BACKGROUND There is a lack of clinical evidence on the efficacy and safety of transitioning from a thrice-daily pre-mixed insulin or basal-prandial regimen to insulin degludec/aspart(IDegAsp)therapy,with insufficient data from the Chinese *** To demonstrate the efficacy,safety,and treatment satisfaction associated with the transition to IDegAsp in type 2 diabetes mellitus(T2DM).METHODS In this 12-week open-label,non-randomized,single-center,pilot study,patients with T2DM receiving thrice-daily insulin or intensive insulin treatment were transitioned to twice-daily injections of insulin *** doses,hemoglobin A1c(HbA1c)levels,fasting blood glucose(FBG),hypoglycemic events,a Diabetes Treatment Satisfaction Questionnaire,and other parameters were assessed at baseline and *** This study included 21 participants.A marked enhancement was observed in the FBG level(P=0.02),daily total insulin dose(P=0.03),and overall diabetes treatment satisfaction(Phances clinical outcomes,particularly FBG levels,daily cumulative insulin dose,and overall satisfaction with diabetes treatment.

关键词： Insulin degludec/aspart Type 2 diabetes management Basal-bolus insulin therapy Pre-mixed insulin Diabetes treatment satisfaction questionnaire

ONLINE MODEL AND ACTUATOR FAULT TOLERANT CONTROL FOR AUTONOMOUS MOBILE ROBOT

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Chinese Journal of Mechanical Engineering 2007年第3期20卷 29-33页

作者： SONG Qi JIANG zhe han Jianda Robotics Laboratory Shenyang Institute of Automation Chinese Academy of Sciences Shenyang 110016 China Department of Auto-Control Shenyang Institute of Aeronautical Engineering Shenyang 110136 China

A novel fault-tolerant adaptive control methodology against the actuator faults is proposed. The actuator effectiveness factors （AEFs） are introduced to denote the healthy of actuator, and the unscented Kalman filter （UKF） is employed for online estimation of both the motion states and the AEFs of mobile robot. A square root version of the UKF is introduced to improve efficiency and numerical stability. Using the information from the UKF, the reconfigurable controller is designed automatically based on an enhancement inverse dynamic control （IDC） methodology. The experiment on a 3-DOF omni-directional mobile robot is performed, and the effectiveness of the proposed method is demonstrated.

关键词： Unscented Kalman filter Active model Fault tolerance Inverse dynamic control

Association of LDLR rs1433099 with the Risk of NAFLD and CVD in Chinese han Population

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Journal of Clinical and Translational Hepatology 2021年第2期9卷 203-209页

作者： yi han Yongshuo Zhang Shousheng Liu Guangxia Chen Linlin Cao Yongning Xin Department of Infectious Disease Qingdao Municipal HospitalQingdaoShandongChina Department of Gastroenterology The First People’s Hospital of XuzhouXuzhou Municipal Hospital Affiliated to Xuzhou Medical UniversityXuzhouJiangsuChina Administrative Management Office The Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsuChina Clinical Research Center Qingdao Municipal HospitalQingdaoShandongChina

Background and Aims:Recent genome-wide association studies have shown that low-density lipoprotein receptor(LDLR)rs1433099 polymorphism is associated with cardiovascular disease(CVD)risk in many ***,the association of LDLR rs1433099 with CVD in China has not been reported *** are no studies on LDLR rs1433099 and non-alcoholic fatty liver disease(NAFLD)as *** purpose of this study was to investigate whether LDLR rs1433099 is related to CVD or NAFLD in the Chinese ***:LDLR rs1433099 polymorphism was genotyped in 507 individuals,including 140 healthy controls,79 NAFLD patients,185 CVD patients,and 103 patients with NAFLD combined with *** expression of LDLR was tested by the sequence detection system,and clinical parameters were assessed by biochemical tests and physical ***:The genotype distribution of LDLR rs1433099 was not statistically different among the NAFLD group,the CVD group,the combined group,and the healthy control group(p>0.05).There was no significant correlation of LDLR rs1433099 genotypic distribution or allele frequency and the risk of NAFLD,CVD or NAFLD combined with CVD(p>0.05).In the CVD group,T allele carriers had higher alkaline phosphatase and gamma-glutamyl transpeptidase than non-carriers(phanism involving alkaline phosphatase and gamma-glutamyl transpeptidase.

关键词： LDLR rs1433099 C44857T CVD NAFLD Gene polymorphism

Microstructure,Texture Evolution,and Mechanical Properties of ECAP-Processed ZAT522 Magnesium Alloy

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Acta Metallurgica Sinica(English Letters) 2020年第2期33卷 233-242页

作者： ying Ma Fu-yin han Cheng Liu Ming-zhe Li School of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China Shanxi Key Laboratory of Advanced Magnesium-Based Materials Taiyuan University of TechnologyTaiyuan 030024China

In this work,the high-strength Mg-5Zn-2Al-2Sn(ZAT522,in wt%) Mg alloys was obtained at 220℃ and 130℃ by a two-step equal channel angular pressing(ECAP).For each stage,two passes were *** results showed a remarkable grain refinement after the first stage of ECAP(A2 samples),leading to a fine-grained structure with average size of 1.40 μ*** additional stage(A4 samples) caused further grain refinement to 1.18 μm,and an ultra-fine grain structure(700 nm)appeared in the precipitate-rich *** grain refinement mechanism for both samples was discussed in *** this end,the original extrusion fiber texture evolved into a new strong texture characterized by the base planes tilted toward the ECAP shear plane,with a higher Schmid factor value of *** with the as-extruded alloy,the yield strength of the A2 samples increased from 180 to 245 MPa,which was mainly attributed to the combined effects of grain boundary strengthening and precipitation *** the case of A4 samples,the dislocation strengthening resulted in a net increase in yield strength to 335 MPa,while the ductility was significantly reduced.

关键词： Mg–5Zn–2Al–2Sn Mg alloy ECAP Microstructure Texture Tension properties

Transforming growth factor -β neutralizing antibodies inhibit subretinal fibrosis in a mouse model

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International Journal of Ophthalmology(English edition) 2012年第3期5卷 307-311页

作者： han Zhang zhe-Li Liu Department of Ophthalmology the First Hospital of China Medical University Shenyang 110001 Liaoning Province China

AIM:To determine the involvement of the transforming growth factor(TGF)-β with the development of experimental subretinal fibrosis in a mouse model.· METHODS:Subretinal fibrosis was induced by subretinal injection of macrophage-rich peritoneal exudate cells(PECs) and the local expression of TGF-β isoforms was assessed by quantitative real-time reverse transcription-polymerase chain reaction(RT-PCR) and enzyme-linked immunosorbent assay(ELISA) at various time *** addition,we investigated the effect of TFG-β-neutralizing antibodies(TGF-β NAb) on subretinal fibrosis development.· RESULTS:TGF-β1 and TGF-β2 mRNA level was significantly elevated at day 2 after subretinal fibrosis induction and increased further to 5 and 6.5-fold respectively at day 5,reaching the ***-β3 mRNA was not detected in the present *** result of ELSIA showed that active TGF-β1 and TGF-β2 levels were upregulated to 10-fold approximately,while total TGF-β1 and TGF-β2 levels were even upregulated more than 10-fold and more than 20-fold respectively in subretinal fibrosis mice in comparison with na?觙ve mice at day ***-β NAb resulted in a reduced subretinal fibrosis areas by 65% compared to animals from control group at day 7.· CONCLUSION:Our results indicate that TGF-β signaling may contribute to the pathogenesis of subretinal fibrogenesis and TGF-β inhibition may provide an effective,novel treatment of advanced and late-stage neovascular age-related macular degeneration.·

关键词： transforming growth factor-β subretinal fibrosis transforming growth factor-β neutralizing antibody

Deep eutectic solvents for separation and purification applications in critical metal metallurgy:Recent advances and perspectives

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 1-19页

作者： Shuo Chen Shengpeng Su Yanfang Huang Bingbing Liu Hu Sun Shuzhen Yang Guihong han School of Chemical Engineering Zhengzhou UniversityZhengzhou 450001China Zhongyuan Critical Metals Laboratory Henan ProvinceZhengzhou 450001China

Solvent extraction,a separation and purification technology,is crucial in critical metal *** solvents commonly used in solvent extraction exhibit disadvantages,such as high volatility,high toxicity,and flammability,causing a spectrum of hazards to human health and environmental *** solvents have been recognized as potential alternatives to these harmful organic *** the past two decades,several neoteric solvents have been proposed,including ionic liquids(ILs)and deep eutectic solvents(DESs).DESs have gradually become the focus of green solvents owing to several advantages,namely,low toxicity,degradability,and low *** this critical review,their classification,formation mechanisms,preparation methods,characterization technologies,and special physicochemical properties based on the most recent advancements in research have been systematically ***,the major separation and purification applications of DESs in critical metal metallurgy were comprehensively ***,future opportunities and challenges of DESs were explored in the current research *** conclusion,this review provides valuable insights for improving our overall understanding of DESs,and it holds important potential for expanding separation and purification applications in critical metal metallurgy.

关键词： deep eutectic solvents preparations properties separation and purification critical metal metallurgy

Freeze-drying synthesis of O,N-CeF_(3) with enhanced photocatalytic oxygen evolution

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Journal of Rare Earths 2023年第11期41卷 1714-1720,I0003页

作者： Bing han Renke Bi Chutong Zhou zhe Liu Zhiyu Wang State Key Laboratory of Silicon Materials Department of Materials Science and EngineeringZhejiang UniversityHangzhou310027China

Drying methods have been verified to have a considerable impact on photocatalytic efficiency via altering surface *** this study,the preparations of O,N-CeF_(3) under identical conditions using the vacuum freezing method and the oven method are *** hydroxyl,as opposed to adsorbed oxygen in CeF_(3)-O,is the main component of O faults on the surface of CeF_(3)-*** particle size and the doping atom defects of CeF_(3)-V allow for more efficient separation and faster migration of photogenerated charge ***_(3)-V has an oxygen evolution rate of up to 1.4138 mmol/(g·h)and an apparent quantum yield of 90.90%at 550 *** tails are produced as a result of the doping O and N changing the intrinsic band ***_(3)-V shows a secondary conduction band potential that is sufficient for satisfying the minimal water oxidation potential *** elucidate that defects in the states of doping O and N significantly influence CeF_(3) energy *** on how the drying process affects the band structure and encourages carriers'separation via defects is valuable,which affects how well the photocatalysis works.

关键词： Photocatalysis Oxygen evolution Band structure Defect Freeze-drying Rare earths