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QoE oriented intelligent online learning evaluation technology in B5G scenario

Digital Communications and Networks 2024年第1期10卷 7-15页

作者： Mingzi chen Xin Wei Peizhong Xie zhe Zhang School of Communications and Information Engineering Nanjing University of Posts and TelecommunicationsNanjing210003China Key Lab of Broadband Wireless Communication and Sensor Network Technology(Nanjing University of Posts and Telecommunications) Ministry of EducationNanjing210003China Institute of Higher Education Nanjing University of Posts and TelecommunicationsNanjing210003China

Students'demand for online learning has exploded during the post-COvID-19 pandemic ***,due to their poor learning experience,students'dropout rate and learning performance of online learning are not always *** technical advantages of Beyond Fifth Generation(B5G)can guarantee a good multimedia Quality of Experience(QoE).As a special case of multimedia services,online learning takes into account both the usability of the service and the cognitive development of the *** that affect the Quality of Online Learning Experience(OL-QoE)become more *** get over this dilemma,we propose a systematic scheme by integrating big data,Machine Learning(ML)technologies,and educational psychology ***,we first formulate a general definition of OL-QoE by data analysis and experimental *** formula considers both the subjective and objective factors(i.e.,video watching ratio and test scores)that most affect ***,we induce an extended layer to the classic Broad Learning System(BLS)to construct an Extended Broad Learning System(EBLS)for the students'OL-QoE *** the extended layer can increase the width of the BLS model and reduce the redundant nodes of BLS,the proposed EBLS can achieve a trade-off between the prediction accuracy and computation ***,we provide a series of early intervention suggestions for different types of students according to their predicted OL-QoE *** timely interventions,their OL-QoE and learning performance can be *** results verify the effectiveness oftheproposed scheme.

关键词： B5G Online learning Quality of experience

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Redox signaling-governed drug-tolerant persister cancer cell:a key spark of treatment failure

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Signal Transduction and Targeted Therapy 2022年第4期7卷 955-957页

作者： Liwu Fu zhe-Sheng chen State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangdong Esophageal Cancer InstituteCancer CenterSun Yat-Sen UniversityGuangzhou 510060China Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNY 11439USA Institute for Biotechnology St.John’s UniversityQueensNY 11439USA

In a recent study published in EMbo Molecular medicine,Zhang et *** a novel insight regarding better knowledge of the drug resistant contribution of drug-tolerant persister(DTP)state in tumor evolution,especially in terms of mechanistic insights into redox regulation involved,unambiguously establishing a novel therapeutic strategy of treating multi-drug-resistant(MDR)cancer cells and preventing tumor recurrence by disequilibrating Niemann–Pick C1-like 1(NPC1L1)-mediated redox homeostasis.

关键词： cancer homeostasis insight

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A review on the hydraulic performance and erosion wear characteristic of the centrifugal slurry pump

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Particuology 2024年第12期95卷 370-392页

作者： Aoqiang Duan zhe Lin Desheng chen Yi Li zhejiang Key Laboratory of Multiflow and Fluid Machinery Zhejiang Sci-Tech UniversityHangzhou310018China

The centrifugal slurry pump is widely applied for the transportation of liquid medium containing solid *** introduction of solid particles will lead to a decrease in efficiency and wear of the slurry *** solve this problem,it is imperative to review the hydraulic performance and erosion characteristic of slurry pumps under solid-liquid two-phase flow in recent *** this review,firstly,the general structure and engineering application are ***,the experimental and simulation research methods of particle movement and erosion wear are ***,the influence of solid particles on the hydraulic performance and particle distribution is ***,the variation laws of erosion wear under different flow-passing components and particle properties are ***,according to the current research status and conclusions,the design optimization measures and future investigate direction are proposed,aiming to promote the resolution of wear damage and extend the service life of the slurry pump.

关键词： Centrifugal slurry pump Solid-liquid two-phase flow Hydraulic performance Particle distribution Erosion wear damage

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Stress-induced trend:the clustering feature of coal mine disasters and earthquakes in China

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International Journal of Coal Science & Technology 2020年第4期7卷 676-692页

作者： bo chen International Logging Company Great Wall Drilling CompanyBeijing 100101China School of Earth and Space Sciences Peking UniversityBeijing 100871China

Nearly half of coal mine disasters in China have been found to occur in clusters or to be accompanied by earthquakes nearby,in which all the disaster types are *** disturbances seem to exist among mining areas and to be responsible for the observed *** earthquakes accompanied by coal mine disasters may be the vital geophysical evidence for tectonic stress disturbances around mining *** paper analyzes all the possible causative factors to demonstrate the authenticity and reliability of the observed phenomena.A quantitative study was performed on the degree of clustering,and space-time distribution curves are *** the threshold of 100 km,47%of disasters are involved in cluster series and 372 coal mine disasters accompanied by *** majority cluster series lasting for 1-2 days correspond well earthquakes nearby,which are speculated to be related to local stress *** the minority lasting longer than 4 days correspond well with fatal earthquakes,which are speculated to be related to regional stress *** cluster series possess multiple properties,such as the area,the distance,the related disasters,etc.,and compared with the energy and the magnitude of earthquakes,good correspondences are *** indicates that the cluster series of coal mine disasters and earthquakes are linked with fatal earthquakes and may serve as footprints of regional stress *** relating to the geological model are made,and five disaster-causing models are *** earthquake research and disaster prevention,widely scientific significance is suggested.

关键词： Earthquake Coal mine disaster Cluster feature Stress disturbance

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A hierarchical updating method for finite element model of airbag buffer system under landing impact

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Chinese Journal of Aeronautics 2015年第6期28卷 1629-1639页

作者： He Huan chen zhe He cheng Ni Lei chen Guoping State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and Astronautics Institute of Vibration Engineering Research Nanjing University of Aeronautics and Astronautics Research Institute of Pilotless Aircraft Nanjing University of Aeronautics and Astronautics China Aviation Industry General Aircraft Co.Ltd.

In this paper, we propose an impact finite element （FE） model for an airbag landing buf- fer system. First, an impact FE model has been formulated for a typical airbag landing buffer system. We use the independence of the structure FE model from the full impact FE model to develop a hierarchical updating scheme for the recovery module FE model and the airbag system FE model. Second, we define impact responses at key points to compare the computational and experimental results to resolve the inconsistency between the experimental data sampling frequency and experi- mental triggering. To determine the typical characteristics of the impact dynamics response of the airbag landing buffer system, we present the impact response confidence factors （IRCFs） to evalu- ate how consistent the computational and experiment results are. An error function is defined between the experimental and computational results at key points of the impact response （KPIR） to serve as a modified objective function. A radial basis function （RBF） is introduced to construct updating variables for a surrogate model for updating the objective function, thereby converting the FE model updating problem to a soluble optimization problem. Finally, the developed method has been validated using an experimental and computational study on the impact dynamics of a classic airbag landing buffer system.

关键词： Airbag Hierarchical model Impact Model updating Radial basis function

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Human mitochondrial DNA diseases and Drosophila models

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Journal of Genetics and Genomics 2019年第4期46卷 201-212页

作者： zhe chen Fan Zhang Hong Xu National Heart Lung and Blood InstituteNational Institute of Health

Mutations that disrupt the mitochondrial genome cause a number of human diseases whose phenotypic presentation varies widely among tissues and individuals. This variability owes in part to the unconventional genetics of mitochondrial DNA(mtDNA), which includes polyploidy, maternal inheritance and dependence on nuclear-encoded factors. The recent development of genetic tools for manipulating mitochondrial genome in Drosophila melanogaster renders this powerful model organism an attractive alternative to mammalian systems for understanding mtDNA-related diseases. In this review, we summarize mtDNA genetics and human mtDNA-related diseases. We highlight existing Drosophila models of mtDNA mutations and discuss their potential use in advancing our knowledge of mitochondrial biology and in modeling human mitochondrial disorders. We also discuss the potential and present challenges of gene therapy for the future treatment of mtDNA diseases.

关键词： Mitochondrial DNA mtDNA disease mtDNA genetics Drosophila model

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A Comparison of the Effects of Interannual Arctic Sea Ice Loss and ENSO on Winter Haze Days: Observational Analyses and AGCM Simulations

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Journal of Meteorological Research 2017年第5期31卷 820-833页

作者： Shuanglin LI zhe HAN Huopo chen Department of Atmospheric Science China University of Geoscience Institute of Atmospheric Physics/Climate Change Research Center Chinese Academy of Sciences

This study compares the impacts of interarmual Arctic sea ice loss and ENSO events on winter haze days m mare- land China through observational analyses and AGCM sensitivity experiments. The results suggest that （1） Arctic sea ice loss favors an increase in haze days in central-eastern China; （2） the impact of ENSO is overall contained within southern China, with increased （reduced） haze days during La Nifia （El Nifio） winters; and （3） the impacts from sea ice loss and ENSO are linearly additive. Mechanistically, Arctic sea ice loss causes quasi-barotropic positive height anomalies over the region from northem Europe to the Ural Mountains （Urals in brief） and weak and negative height anomalies over the region from central Asia to northeastem Asia. The former favors intensified frequency of the blocking over the regions from northern Europe to the Urals, whereas the latter favors an even air pressure distribu- tion over Siberia, Mongolia, and East Asia. This large-scale circulation pattern favors more frequent occurrence of calm and steady weather in northern China and, as a consequence, increased occurrence of haze days. In comparison, La Nifia （El Nifio） exerts its influence along a tropical pathway by inducing a cyclonic （anticyclonic） lower-tropo- spheric atmospheric circulation response over the subtropical northwestern Pacific. The northeasterly （southwesterly） anomaly at the northwestern rear of the cyclone （anticyclone） causes reduced （intensified） rainfall over southeastern China, which favors increased （reduced） occurrence of haze days through the rain-washing effect.

关键词： winter haze days Arctic sea ice loss ENSO AGCM experiments

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Modeling of 3-D Air Traffic Complexity Based on Route Structure Constraints

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Transactions of Nanjing University of Aeronautics and Astronautics 2019年第2期36卷 352-360页

作者： XIE Hua WU zhe chen Feifei chen Haiyan College of Civil Aviation Nanjing University of Aeronautics and AstronauticsNanjing 211106P.R.China State Key Laboratory of Air Traffic Management System and Technology Nanjing 210007P.R.China College of Computer Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106P.R.China

It is an important issue to assess traffic situation complexity for air traffic *** is a lack of systematic review of the existing air traffic complexity assessment methods,and there is no consideration of the role of airspace and traffic coordination mechanism.A new 3-D airspace complexity measurement method is proposed based on route structure constraints to evaluate the air traffic complexity ***,the model of the impact on horizontal and vertical direction for“aircraft pair”is established based on the route *** that,the coupled complexity model for 3-D airspace is given according to the modification on the model in terms of flight ***,the global model of the airspace traffic complexity is *** is proved by the experimental data from the actual operation in airspace that the proposed model can reflect the space coupling situation and complexity of *** the same time,it can precisely describe the actual operation of civil aviation in China.

关键词： air traffic management traffic complexity flight standardization aircraft pair 3-D airspace

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Progress in the studies on the molecular mechanisms associated with multidrug resistance in cancers

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Acta Pharmaceutica Sinica B 2023年第3期13卷 982-997页

作者： Lei Zhang Biwei Ye Zhuo chen zhe-Sheng chen State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China University of Chinese Academy of Sciences Beijing 100049China Fujian Agriculture and Forestry University Fuzhou 350002China Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John's UniversityNew YorkNY 11439USA

Chemotherapy is one of the important methods to treat cancer,and the emergence of multidrug resistance(MDR)is one major cause for the failure of cancer *** all anti-tumor drugs develop drug resistance over a period of time of application in cancer patients,reducing their effects on killing cancer *** can lead to a rapid recurrence of cancers and ultimately patient *** may be induced by multiple mechanisms,which are associated with a complex process of multiple genes,factors,pathways,and multiple steps,and today the MDR-associated mechanisms are largely *** this paper,from the aspects of protein–protein interactions,alternative splicing(AS)in pre-mRNA,non-coding RNA(ncRNA)mediation,genome mutations,variance in cell functions,and influence from the tumor microenvironment,we summarize the molecular mechanisms associated with MDR in *** the end,prospects for the exploration of antitumor drugs that can reverse MDR are briefly discussed from the angle of drug systems with improved targeting properties,biocompatibility,availability,and other advantages.

关键词： Multidrug resistance(MDR) ABC transporter family Signaling pathway Alternative splicing(AS) Gene mutation None-coding RNA(ncRNA) Tumor microenvironment

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ERROR ESTIMATES FOR SPARSE OPTIMAL CONTROL PROBLEMS BY PIECEWISE LINEAR FINITE ELEMENT APPROXIMATION

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Journal of Computational Mathematics 2021年第3期39卷 471-492页

作者： Xiaoliang Song bo chen bo Yu Dalian University of Technology Dalian 116024China Department of Mathematics National University of Singapore10 Lower Kent Ridge RoadSingapore School of Mathematical Sciences Dalian University of TechnologyDalian 116024China

Optimization problems with L^(1)-control cost functional subject to an elliptic partial differential equation(PDE)are ***,different from the finite dimensiona l^(1)-regularization optimization,the resulting discretized L^(1)norm does not have a decoupled form when the standard piecewise linear finite element is employed to discretize the continuous problem.A common approach to overcome this difficulty is employing a nodal quadrature formula to approximately discretize the L^(1)-*** this paper,a new discretized scheme for the L^(1)-norm is *** to the new discretized scheme for L^(1)-norm with the nodal quadrature formula,the advantages of our new discretized scheme can be demonstrated in terms of the order of ***,finite element error estimates results for the primal problem with the new discretized scheme for the L^(1)-norm are provided,which confirms that this approximation scheme will not change the order of error *** solve the new discretized problem,a symmetric Gauss-Seidel based majorized accelerated block coordinate descent(sGS-mABCD)method is introduced to solve it via its *** proposed sGS-mABCD algorithm is illustrated at two numerical *** results not only confirm the finite element error estimates,but also show that our proposed algorithm is efficient.

关键词： Finite element method ABCD method.Approximate discretization Error estimates

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