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Functional crosstalk and regulation of natural killer cells in tumor microenvironment: Significance and potential therapeutic strategies

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Genes & Diseases 2023年第3期10卷 990-1004页

作者： Liping Wang zhe chen Guohong Liu Yunbao Pan Department of Laboratory Medicine Zhongnan Hospital of Wuhan UniversityWuhan UniversityWuhanHubei 430071China Department of Otolaryngology Head and Neck Surgery Zhongnan Hospital of Wuhan UniversityWuhan UniversityWuhanHubei 430071China Department of Radiology Zhongnan Hospital of Wuhan UniversityWuhan UniversityWuhanHubei 430071China

Natural killer (NK) cells eliminate a large variety of tumor cells and abnormal cells. However, NK cells in the tumor microenvironment (TME) are often functionally depleted. A few subsets of NK cells even promote tumor growth. This study reviewed the biological properties of NK cells, the dynamic phenotypic changes of NK cells in the TME, and the communication between NK cells and other immune and nonimmune cells.

关键词： Cellular communication Immune checkpoints Immunotherapy Natural killer cells Tumor microenvir onment

Interleukin-13 and age-related macular degeneration

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International Journal of Ophthalmology(English edition) 2017年第4期10卷 535-540页

作者： bo Fu zhe-Li Liu Han Zhang Feng Gu China Medical University Shenyang 110001 Liaoning ProvinceChina Department of Ophthalmology the First Hospital of China Medical University Shenyang 110001 Liaoning ProvinceChina

AIM：To identify the effects of interleukin（IL）-13 on retinal pigment epithelial（RPE） cells and the IL-13 level in aqueous humor of age-related macular degeneration（AMD） ***：IL-13 levels in aqueous humor specimens from AMD patients were detected with enzyme-linked immunosorbent assay（ELISA）.ARPE-19 cells were treated with 10 ng/m L IL-13 for 12,24,and 48 *** cell proliferaton was evaluated by the MTS *** m RNA and protein levels of α-SMA and ZO-1 were evaluated with quantitative real-time polymerase chain reaction（q RT-PCR） and Western blot *** expression of tumor necrosis factor-α（TNF-α）,transforming growth factor-β（TGF-β） and vascular endothelial growth factor（VEGF） were assessed by *** LTS：IL-13 levels in the aqueous humor of patients with AMD were significantly higher than those in the control（167.33±17.64 vs 27.12±5.65 pg/m L;P〈0.01）.In vit ro,IL-13 of high concentrations（10,15,and 20 ng/m L） inhibited ARPE-19 cell proliferation.α-SMA m RNA in ARPE-19 cell were increased（1.017±0.112 vs 1.476±0.168;P〈0.001） and ZO-1 decreased（1.051±0.136 vs 0.702±0.069;P〈0.001） after treated with 10 ng/m L IL-13 for 48 *** protein expression of α-SMA and ZO-1 also showed the same tendency（α-SMA：P=0.038;ZO-1：P=0.008）.IL-13 significantly reduced the level of TNF-α（44.70±1.67 vs 31.79±3.53 pg/m L;P=0.005） at 48 h,but the le vel of TGF-β2 was significantly increased from 34.44±2.92 to 57.61±6.31 pg/m L at 24h（P=0.004） and from 61.26±1.11 to 86.91±3.59 pg/m L at 48h（P〈0.001）.While expressions of VEGF didn＇t change after IL-13 ***：IL-13 in vitr o inhibit ARPE-19 cell proliferation and expression in the aqueous may be associated with AMD.

关键词： interleukin-13 age-related macular degeneration retinal pigment epithelial cell

Gravitational Collapse of a Spherical Star with Heat Flow as a Possible Energy Mechanism of Gamma-Ray Bursts

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Communications in Theoretical Physics 2008年第7期50卷 271-274页

作者： CHANG zhe GUAN cheng-bo HUANG Chao-Guang LI Xin Institute of High Energy Physics the Chinese Academy of Sciences Beijing 100049 China Department of Physics Weihai Branch of Shandong University Weihai 264209 China

We investigate the gravitational collapse of a spherically symmetric, inhomogeneous star, which is described by a perfect fluid with heat flow and satisfies the equation of state p = p/3 at its center. In the process of the gravitational collapse, the energy of the whole star is emitted into space. And the remaining spacetime is a Minkowski one without a remnant at the end of the process. For a star with a solar mass and solar radius, the total energy emitted is at the order of 10^54 erg, and the time-scale of the process is about 8 s. These are in the typical values for a gamma-ray burst. Thus, we suggest the gravitational collapse of a spherical star with heat flow as a possible energy mechanism of gamma-ray bursts.

关键词： gravitational collapse gamma-ray burst

Reactive Power Multi-objective Optimization for Multi-terminal AC/DC Interconnected Power Systems Under Wind Power Fluctuation

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CSEE Journal of Power and Energy Systems 2020年第3期6卷 630-637页

作者： Qian Hui Yun Teng Hao Zuo zhe chen Shenyang University of Technology Shenyang 110870China Aalborg University Aalborg 9220Denmark

In view of the reactive power coordination difficulties caused by reactive power strong coupling,the provincial power grids in the interconnected system are formed by the multi-AC/DC *** power channels are under the conditions of large-scale long-distance transmission of wind power and other forms of renewable power *** AC-DC hybrid power flow equation of the interconnected system,including the AC-DC tie lines,is presented in this paper,along with the robust dynamic evolutionary optimization of the reactive power system in interconnected systems under fluctuating and uncertain wind power ***,the rapid collaborative optimization of reactive power flow and the exchange of reactive power between tie lines between provincial power grids are *** analysis was made by taking four interconnected large-scale provincial power grids of Eastern Mongolia,Jilin,Liaoning and Shandong as an *** simulation results demonstrate the effectiveness and superiority of the proposed reactive power dynamic multi-objective optimization method for interconnected power grids.

关键词： Multi-objective robust evolution multi terminal AC/DC interconnection reactive power optimization wind power transmission

Investigating the role of Ca^(2+)/calmodulin-dependent protein kinaseⅡin the survival of retinal ganglion cells

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Neural Regeneration Research 2022年第5期17卷 1001-1002页

作者： Xinzheng Guo bo chen Departments of Ophthalmology and Neuroscience Icahn School of Medicine at Mount SinaiNew YorkNYUSA

Retinal ganglion cells(RGCs)are the sole output neurons of the retina that project long axons and transmit visual information to the *** degeneration of RGCs leads to irreversible vision loss in a variety of pathologi... 详细信息

关键词： degeneration glaucoma irreversible

Data mining algorithm and framework for identifying HVAC control strategies in large commercial buildings

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Building Simulation 2021年第1期14卷 63-74页

作者： zhe chen Peng Xu Fan Feng Yifan Qiao Wei Luo Department of Mechanical and Energy Engineering Tongji UniversityShanghai201804China Department of Mechanical Engineering The University of AlabamaTuscaloosaAL35487USA

Heating,Ventilation,and Air-Conditioning(HVAC)control strategies are set arbitrarily in many commercial buildings by operators,who sometimes lack relevant skills and professional *** is acknowledged that improving the control strategy of HVAC is feasible and valid,which as a consequence can improve the overall HVAC performance of existing ***,it is quite difficult for an outsiders or a commissioning agent to tell what the HVAC control strategies are and whether they are implemented appropriately in existing *** paper is intended to carry out analysis on the data about Building Automation System(BAS),as well as the data about building energy,for the purpose of identifying the control strategies of HVAC in a given building by using data mining *** the results can be adopted by us to determine whether the building is under faulty operation or is running under suboptimal *** this paper,what are proposed are algorithms of data mining identification for some specific HVAC control strategies,including DR on/off strategy,DR reset strategy and temperature reset strategy of chilled *** the basis of data mining algorithms,a framework is then developed so as to identify these strategies,and the main scenario of this identification framework is known as analyzing many commercial buildings on an energy monitoring platform of a public *** framework takes the sensor data obtained from HVAC,including temperature,flowrate,and electricity usage,as input,which is followed by the application of Image Segmentation and PCA algorithm for ***,based on these input variables,XGboost algorithm is employed to determine whether these strategies have been implemented in buildings or *** order to get the data for training and testing the framework,EnergyPlus Runtime Language is adopted for the application of different strategies.t is finally shown by the result that the identification algorithm can achieve the a

关键词： HVAC control strategy identification data mining

Building the toolbox for in vivo glia-to-neuron reprogramming

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Neural Regeneration Research 2024年第6期19卷 1171-1172页

作者： Ye Xie bo chen Departments of Ophthalmology and Neuroscience Icahn School of Medicine at Mount SinaiNew YorkNYUSA

Unlike regenerative-competent species that possess a remarkable intrinsic capacity to replenish lost neurons and restore neurocircuits spontaneously,the central nervous system in adult mammals lacks the ability to compensate for the neuronal loss caused by neurodegenerative diseases or traumatic injuries resulting in permanent loss of *** by earlier discoveries that radial glia or astrocytes isolated from the postnatal cortex can generate neurons.

关键词： injuries cortex diseases

Numerical simulation and experimental validation of multiphysics field coupling mechanisms for a high power ICP wind tunnel

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Chinese Physics B 2021年第6期30卷 390-400页

作者： Ming-Hao Yu zhe Wang Ze-Yang Qiu bo Lv bo-Rui zheng Faculty of Mechanical and Precision Instrument Engineering Xi'an University of TechnologyXi'an 710048China School of Automation and Information Engineering Xi'an University of TechnologyXi'an 710048China

We take the established inductively coupled plasma(ICP) wind tunnel as a research object to investigate the thermal protection system of re-entry vehicles. A 1.2-MW high power ICP wind tunnel is studied through numerical simulation and experimental validation. The distribution characteristics and interaction mechanism of the flow field and electromagnetic field of the ICP wind tunnel are investigated using the multi-field coupling method of flow, electromagnetic, chemical, and thermodynamic field. The accuracy of the numerical simulation is validated by comparing the experimental results with the simulation results. Thereafter, the wind tunnel pressure, air velocity, electron density, Joule heating rate, Lorentz force, and electric field intensity obtained using the simulation are analyzed and discussed. The results indicate that for the 1.2-MW ICP wind tunnel, the maximum values of temperature, pressure, electron number density, and other parameters are observed during coil heating. The influence of the radial Lorentz force on the momentum transfer is stronger than that of the axial Lorentz force. The electron number density at the central axis and the amplitude and position of the Joule heating rate are affected by the radial Lorentz force. Moreover, the plasma in the wind tunnel is constantly in the subsonic flow state, and a strong eddy flow is easily generated at the inlet of the wind tunnel.

关键词： inductively coupled plasma multiphysics field coupling mechanism simulation and experiment

Generation of Febrile Seizures and Subsequent Epileptogenesis

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Neuroscience Bulletin 2016年第5期32卷 481-492页

作者： bo Feng Zhong chen Department of Pharmacology Key Laboratory of Medical Neurobiology of the Ministry of Health of China School of Medicine Zhejiang University

Febrile seizures（FSs） occur commonly in children aged from 6 months to 5 years. Complex（repetitive or prolonged） FSs, but not simple FSs, can lead to permanent brain modification. Human infants and immature rodents that have experienced complex FSs have a high risk of subsequent temporal lobe epilepsy. However, the causes of FSs and the mechanisms underlying the subsequent epileptogenesis remain unknown. Here, we mainly focus on two major questions concerning FSs： how fever triggers seizures, and how epileptogenesis occurs after FSs. The risk factors responsible for the occurrence of FSs and the epileptogenesis after prolonged FSs are thoroughly summarized and discussed. An understanding of these factors can provide potential therapeutic targets for the prevention of FSs and also yield biomarkers for identifying patients at risk of epileptogenesis following FSs.

关键词： Febrile seizures Epilepsy Epileptogenesis