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Rare Metals 2022年第11期41卷 3815-3822页

作者： Ting-Ting Liu Yi-Fei Hu Yang Liu zhe-jun-yu jin zheng-Hua Tang Ming-Hui Qin Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum Materials and Institute for Advanced Materials South China Academy of Advanced OptoelectronicsSouth China Normal UniversityGuangzhou510006China School of Physics and Electronic and Electrical Engineering Xiangnan UniversityChenzhou423000China

In this work,we study the domain wall motion in ferrimagnet driven by a circularly polarized magnetic field using the collective coordinate theory and atomistic micromagnetic simulations,and we pay particular attention to the effect of Dzyaloshinskii-Moriya interaction(DMI).Similar to the case of antiferromagnetic domain wall,ferrimagnetic wall moves at a speed which is linearly dependent on the DMI magnitude.In addition,it is revealed that the DMI plays a role in modulating the domain wall dynamics similar to that of the net spin density,which suggests another internal parameter for controlling domain wall in ferrimagnets.Moreover,the results show that the domain wall dynamics in ferrimagnets is much faster than that in ferromagnets,which confirms again the great potential of ferrimagnets in future spintronic applications.

关键词： Domain wall dynamics Spintronics Circularly polarized magnetic field Ferrimagnets

KLF4 Inhibits the Activation of Human Hepatic Stellate Cell In Vitro

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Current Medical Science 2024年第3期44卷 512-518页

作者： Xing-yu YANG zhe CHEN jun TAN Yin-kai XUE Hai zheNG Department of Emergency Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Department of Thoracic Surgery The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an710061China Department of Thoracic Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

Objective Hepatic stellate cells(HSCs)play a crucial role in liver fibrosis.Early-stage liver fibrosis is reversible and intimately associated with the state of HSCs.Kruppel-like factor 4(KLF4)plays a pivotal role in a wide array of physiological and pathological processes.This study aimed to investigate the effect of KLF4 on the proliferation,apoptosis and phenotype of quiescent HSCs Methods We designed a KLF4 lentiviral vector and a KLF4 siRNA lentiviral vector,to upregulate and silence KLF4 expression in human HSC LX-2 cells via transfection.Cell proliferation was assessed using the CCK-8 assay.Flow cytometry was used to detect the cell cycle distribution and apoptosis rate.Western blotting was used to determine the levels of some quiescence and activation markers of HSCs Results Overexpression of KLF4 significantly increased the levels of E-cadherin and ZO-1,which are quiescent HSC markers,while significantly decreased the levels of N-cadherin and a-SMA,known activated HSC markers.In contrast,cell proliferation and apoptosis rates were elevated in LX-2 cells in which KLF4 expression was silenced Conclusion KLF4 inhibits the proliferation and activation of human LX-2 HSCs.It might be a key regulatory protein in the maintenance of HSC quiescence and may serve as a target for the inhibition of hepatic fibrosis.

关键词： Kruppel-like factor 4 hepatic stellate cells LX-2 cells liver fibrosis

Investigation on the influence of vortex generator on particle resuspension

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Particuology 2024年第3期86卷 126-136页

作者： Dongchi yu jun-Li Lin jin-Han Xie ASML 80W Tasman DrSan Jose95134CaliforniaUSA Department of Mechanics and Engineering Science at College of Engineering and State Key Laboratory for Turbulence and Complex Systems Peking UniversityBeijing100081China

The vortex generator(VG)and its well-known effect in flow optimization are widely studied and employed across different engineering sectors.However,while the same working principles of VG may be well suited for the applications on surface-cleaning technologies,such promising potential is hardly,if any,explored in the published literature.Therefore,in the present study,the influence on flow-induced particle resuspension brought by a rectangular vG in a channel flow is investigated with the help of highfidelity computational fluid dynamics simulations.Substantial increases of particle removal forces and resuspension rates are discovered in long,strip-like regions with reduced boundary-layer thickness resulted from the vG-induced vortices,and the enhancement effect is especially significant for configurations with the VG installed at a greater angle of attack.It is also shown that while the resuspension enhancements on the lower and the upper surfaces of the channel exhibit distinct statistical characteristics,having a VG in the channel improves the overall particle-removing capability of the channel flow by introducing higher surface-averaged removal forces and particle resuspension rates.Last but not least,the increase of resuspension rate is especially significant for the smaller,micron-scale particles which are otherwise hardly disturbed by a VG-less channel flow,and such resuspension-enhancement effectgenerally subsides with increasing particle size.

关键词： Particle resuspension Vortexgenerator CFD Surface cleaning

Organic interfacial engineering of gold nanowires for selective glycerol electrooxidation

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Chinese Chemical Letters 2024年第3期35卷 502-507页

作者： zhe Wang Qingling Hong Boqiang Miao Tianjiao Wang yu Ding Pujun jin Pei Chen yu Chen Key Laboratory of Macromolecular Science of Shaanxi Province Key Laboratory of Applied Surface and Colloid Chemistry(Ministry of Education)Shaanxi Key Laboratory for Advanced Energy DevicesSchool of Materials Science and EngineeringShaanxi Normal UniversityXi'an 710062China

The selective electrochemical conversion of glycerol into value-added products is a green and sustainable strategy for the biomass utilization.In this work,Au nanowires(Au-NW)modified with polyethyleneimine(PEI)molecule(Au-NW@PEI)is obtained by an up-bottom post-modification approach.Physical characterization,molecular dynamics simulation and density functional theory demonstrate that the loose-packed PEI monolayer firmly and uniformly distribute on the Au-NW surface due to the strong Au-N interaction.Electrochemical experiments and product analysis display that PEI modification significantly enhance the electro-activity of Au-NW for the glycerol electro-oxidation reaction(GEOR)due to the electronic effect.Meanwhile,the steric hindrance and electrostatic effect of PEI layer make the optimizing adsorption of intermediates possible.Therefore,the selectivity of C3 product glyceric acid over Au-NW@PEI is increased by nearly 20%.The work thus indicates that the rational design of metal-organic interface can effectively elevate the electro-activity and selectivity of Au nanostructures,which may have wide application in biomass development.

关键词： Glycerol electrooxidation reaction Organic interface engineering Gold-based nanomaterials Electrocatalysis Selectivity

Disease and Economic Burden of Kashin-Beck Disease—China,2021

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China CDC weekly 2024年第2期6卷 40-44页

作者： Silu Cui Wenjun Que zhe Jiao Qing Deng Xufeng Zhang Yanhong Cao Ning Liu Ailin Li Alphonse Sowanou zhe Li Tuo Wang Yang Li jun yu junrui Pei NHC Key Laboratory of Etiology and Epidemiology(Harbin Medical University) Key Laboratory of Etiology and EpidemiologyEducation Bureau of Heilongjiang ProvinceInstitute of Kashin-Beck Disease ControlCenter for Endemic Disease ControlChinese Center for Disease Control and PreventionHarbin Medical UniversityHarbin CityHeilongjiang ProvinceChina NHC Key Laboratory of Etiology and Epidemiology(Harbin Medical University) Heilongjiang Provincial Key Laboratory of Trace Elements and Human HealthKey Laboratory of Etiology and EpidemiologyEducation Bureau of Heilongjiang ProvinceInstitute of Endemic Fluorosis ControlCenter for Endemic Disease ControlChinese Center for Disease Control and PreventionHarbin Medical UniversityHarbin CityHeilongjiang ProvinceChina

What is already known about this topic?Kashin-Beck disease(KBD)is a chronic and degenerative osteoarthropathy characterized by cartilage degeneration.It is an endemic disease that is highly prevalent among the Chinese population and poses a significant health risk.What is added by this report?This is the first national report on the economic burden of KBD in China.According to the data from 2021,KBD has caused significant disease and economic burdens.The most substantial reduction in healthy life expectancy was observed among patients with degree II severity and those aged 60 years and older,resulting in a total indirect economic burden of 112.74 million Chinese yuan(CNY).What are the implications for public health practice?The results of this study will contribute to informing the development of tailored prevention and control strategies by the government.These strategies will include targeted policies and recommendations for appropriate healthcare and financial subsidies,which will be based on the demographic characteristics of the endemic areas.

关键词： prevention degeneration burden

Single Fe atom-anchored manganese dioxide for efficient removal of volatile organic compounds in refrigerator

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Nano Research 2024年第5期17卷 3927-3933页

作者： Yiwen Wang jun Zhang Yongfei Zhang yu Zhang zhe Wang jing Wang yuen Wu Department of Endocrinology the First Affiliated Hospital of USTCDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefei 230001China School of Chemistry and Materials Science University of Science and Technology of ChinaHefei 230026China Hefei Hualing Co. LtdHefei 230088China Linkway Technology Co. LtdResearch Institute of Single Atom Catalysts Industry TechnologyNanning 530000China

The efficient and rapid removal of volatile organic compounds(VOCs)holds significant importance for ensuring food quality and human health,particularly within the low-temperature confined spaces in refrigerators.However,achieving effective VOCs degradation under such conditions poses challenges in terms of activating inert bonds and facilitating mass transfer.In this study,we propose a novel solution by designing a cleaner module that incorporates 1.07%single Fe atom-anchored manganese dioxide catalysts(FeSAs-MnO_(2)).The combination of single Fe atoms and defect-rich MnO_(2) substrate efficiently activates molecular oxygen,leading to enhanced generation of highly reactive oxygen species(ROS).Non-thermal plasma(NTP)and circulating fan are introduced to facilitate the regeneration of catalytic activity and improve mass transfer.The FeSAs-MnO_(2) cleaner module demonstrates exceptional performance in trimethylamine(TMA)removal,achieving a conversion efficiency of 98.9%for 9 ppm within just 9 min.Furthermore,accelerated aging tests predict an extended service life of up to 45 years for the FeSAs-MnO_(2) cleaner module,surpassing the expected lifespan of refrigerators significantly.

关键词： single atom catalysts volatile organic compounds(VOCs) trimethylamine(TMA) non-thermal plasma(NTP) refrigerator

Mesenteric adipose tissue B lymphocytes promote intestinal injury in severe acute pancreatitis by mediating enteric pyroptosis

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 300-309页

作者： Qing Huang Jia-Wen Liu Hai-Bin Dong zheng-Jie Wei jin-zhe Liu yu-Tang Ren Xuan Jiang Bo Jiang Department of Gastroenterology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China

Background:Visceral adipose tissue(VAT)has been linked to the severe acute pancreatitis(SAP)prognosis,although the underlying mechanism remains unclear.It has been reported that pyroptosis worsens SAP.The present study aimed to verify whether mesenteric adipose tissue(MAT,a component of VAT)can cause secondary intestinal injury through the pyroptotic pathway.Methods:Thirty-six male Sprague Dawley(SD)rats were divided into six different groups.Twelve rats were randomly divided into the SAP and control groups.We monitored the changes of MAT and B lymphocytes infiltration in MAT of SAP rats.Twelve SAP rats were injected with MAT B lymphocytes or phosphate buffer solution(PBS).The remaining twelve SAP rats were first injected with MAT B lymphocytes,and then with MCC950(NLRP3 inhibitor)or PBS.We collected blood and tissue samples from pancreas,gut and MAT for analysis.Results:Compared to the control rats,the SAP group showed inflammation in MAT,including higher expression of tumor necrosis factor(TNF-α)and interleukin-6(IL-6),lower expression of IL-10,and histological changes.Flow cytometry analysis revealed B lymphocytes infiltration in MAT but not T lymphocytes and macrophages.The SAP rats also exhibited intestinal injury,characterized by lower expression of zonula occludens-1(ZO-1)and occludin,higher levels of lipopolysaccharide and diamine oxidase,and pathological changes.The expression of NLRP3 and n-GSDMD,which are responsible for pyroptosis,was increased in the intestine of SAP rats.The injection of MAT B lymphocytes into SAP rats exacerbated the inflammation in MAT.The upregulation of pyroptosis reduced tight junction in the intestine,which contributed to the SAP progression,including higher inflammatory indicators and worse histological changes.The administration of MCC950 to SAP+MAT B rats downregulated pyroptosis,which subsequently improved the intestinal barrier and ameliorated inflammatory response of SAP.Conclusions:In SAP,MAT B lymphocytes aggravated local inflammation,and promoted the injury to the int

关键词： Acute pancreatitis Mesenteric adipose tissue B lymphocyte Intestinal barrier Pyroptosis

Physics of cavitation near particles

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Journal of Hydrodynamics 2024年第1期36卷 102-118页

作者： Jia-xin yu Xiao-yu Wang jun-wei Shen jin-sen Hu Xiang-qing Zhang Da-qing He yu-ning Zhang Key Laboratory of Power Station Energy Transfer Conversion and System(Ministry of Education) School of Energy Power and Mechanical EngineeringNorth China Electric Power UniversityBeijing102206China

The combined effect of cavitation and silt abrasion presents a great challenge and threat to secure the operation and the efficiency of hydraulic machineries working in sediment-laden fluid.The present paper critically reviews the current research progress on the interaction mechanisms of the bubbles and the particles.Firstly,the analytical models including boundary treatment methods for predicting the jet dynamics of the bubble collapse near particles are demonstrated.Secondly,the bubble collapsing dynamics,jet dynamics and shock wave characteristics near particles are revealed both experimentally and numerically.Finally,the bubble-particle-wall system is investigated with a focus on microjets.

关键词： Cavitation bubble particle jet shock wave

Quantifying freeze-melt dynamics of lakes on the Tibetan Plateau using Sentinel-1 synthetic aperture radar imagery

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Journal of Mountain Science 2024年第3期21卷 805-819页

作者： jin Lu CHEN jun CAI yu KONG Yecheng WANG Yongfeng DUAN zheng School of Environment and Energy Engineering Anhui Jianzhu UniversityHefei 230601China Anhui Engineering and Technology Research Center for Smart City Anhui Jianzhu UniversityHefei 230601China School of Geographic and Oceanographic Sciences Nanjing UniversityNanjing 210023China Department of Physical Geography and Ecosystem Science Lund UniversityLund 22362Sweden

The ice phenology of alpine lakes on the Tibetan Plateau(TP)is a rapid and direct responder to climate changes,and the variations in lake ice exhibit high temporal frequency characteristics.MODIS and passive microwave data are widely used to monitor lake ice changes with high temporal resolution.However,the low spatial resolutions make it difficult to effectively quantify the freeze-melt dynamics of lakes.This work used Sentinel-1 synthetic aperture radar(SAR)data to derive high-resolution ice maps(about 6 days),then with the aid of Sentinel-2 optical images to quantify freeze-melt processes in three typical lakes on the TP(e.g.Selin Co,Ayakekumu Lake,and Nam Co).The results showed that three lakes had an average annual ice period of 125-157 days and a complete ice cover period of 72-115 days,from 2018 to 2022.They exhibit different ice phenology patterns.Nam Co is characterized by repeated episodes of freezing,melting,and refreezing,resulting in a prolonged freeze-up period.Meanwhile,the break-up period of Nam Co lasts for a longer duration(about 19 days),and the break-up exhibits a smooth process.Similarly,Ayakekumu Lake showed more significant inter-annual fluctuations in the freeze-up period,with deviations of up to 28 days observed among different years.Compared to the other two lakes,Selin Co experienced a relatively short freeze-up and break-up period.In short,Sentinel-1 SAR data can effectively monitor the weekly and seasonal variations in lake ice on the TP.Particularly,this data facilitates quantification of the freeze-melt dynamics.

关键词： Lake ice Sentinel-1 SAR Tibetan Plateau Climate change

Genome-wide analysis of Panonychus citrimicro RNAs witha focus on potential insecticidal activity of 4 micro RNAs toeggs and nymphs

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Insect Science 2024年第2期31卷 354-370页

作者： Chuan-zhen Li yu-Hang Liu Deng Pan Meng-Hao Xia Qiang Zhang yu-Chuang Li Guo-Rui yuan jin-jun Wang Wei Dou Key Laboratory of Entomology and Pest Control Engineering College of Plant ProtectionAcademy of Agricultural SciencesSouthwestUniversityChongqingChina Key Laboratory of Agricultural Biosafety and Green Production of Upper Yangtze River(Ministry of Education) Academy of Agricultural SciencesSouthwest UniversityChongqingChina

Panonychus citriMcGregor(Acari:Tetranychidae),a destructive citrus pest,causes considerable annual economic losses due to its short lifespan and rapid resistancedevelopment.MicroRNA(miRNA)-induced RNA interference is a promising approachfor pest control because of endogenous regulation of pest growth and development.Tosearch for miRNAs with potential insecticidal activity inP.citri,genome-wide analysis ofmiRNAs at different developmental stages was conducted,resulting in the identificationof 136 miRNAs,including 73 known and 63 novel miRNAs.A total of 17 isomiRNAsand 12 duplicated miRNAs were characterized.MiR-1 and miR-252-5p were identified asreference miRNAs forP.citriandTetranychus urticae.Based on differential expressionanalysis,treatments with miR-let-7a and miR-315 mimics and the miR-let-7a antagomirsignificantly reduced the egg hatch rate and resulted in abnormal egg development.Over-expression or downregulation of miR-34-5p and miR-305-5p through feeding significantlydecreased the adult eclosion rate and caused molting defects.The 4 miRNAs,miR-let-7a,miR-315,miR-34-5p,and miR-305-5p,had important regulatory functions and insectici-dal properties in egg hatching and adult eclosion.In general,these data advance our un-derstanding of miRNAs in mite biology,which can assist future studies on insect-specificmiRNA-based green pest control technology.

关键词： growth and development microRNAs Panonychus citri referencemiRNAs regulation small RNA libraries