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Neural Regeneration Research 2025年第1期20卷 203-204页

作者： Vishal Singh Arnab Choudhury Hyung jin Ahn Department of Pharmacology Physiology and NeurosciencesRutgers-New Jersey Medical SchoolNewarkNJUSA Brain Health Institute Rutgers UniversityPiscatawayNJUSA

Alzheimer’s disease(AD)stands out as the primary manifestation of age-related dementia,portraying a chronic neurodegenerative disorder distinguished by the accumulation of fibrillar amyloid-β(Aβ)plaques and neurofibrillary tangles of hyperphosphorylated ***,from a clinical standpoint,AD presents itself as a complex condition with a spectrum of dysfunctions rather than a singular pathological *** often-overlooked aspect of the disease is the presence of extensive cerebrovascular abnormalities,given that the majority of AD patients experience altered cerebral blood flow,damaged vasculature,increased microinfarcts and *** models of AD further support this observation,showing cerebrovascular dysfunction such as impaired cerebral blood flow and altered cerebrovascular reactivity(Tataryn et al.,2021;Gareau et al.,2023).

关键词： cerebrovascular dysfunction Alzheimer

High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon Koh Hyo jin Cho Xuelian jin Byung Gon Kim Jun Young Choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

Micromorphology and safety properties of meager and meager-lean coal for blast furnace injection

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International Journal of Minerals,Metallurgy and Materials 2021年第5期28卷 774-781页

作者： Long-zhe jin Xiao-meng Niu School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China

Four types of meager and meager-lean coal and one type of high-quality anthracite were selected based on the safety requirements for blast furnace coal injection and domestic coal quality to conduct microstructure and component *** analyses of the organic and inorganic macerals and the chemical compositions of the selected coal samples indicate that the four types of meager and meager-lean coal have low volatilization,low ash content,and low sulfur content;these qualities are suitable for blast furnace *** test was conducted on the four types of meager and meager-lean coal and the anthracite mixed coal *** indicate that the mixture of meager and meager-lean coal and anthracite is beneficial to improve the grindability of pulverized *** explosive tests reveal that the selected coal samples are non-explosive or weakly *** the proportion of meager and meager-lean coal is less than 40wt%,the mixed coal powder would not explode during the blowing *** minimum ignition temperature test determines that the minimum ignition temperatures of the four types of meager and meager-lean coal and anthracite are 326,313,310,315,and 393°C,*** study provides a guiding research idea for the safety of meager and meager-lean coal used in blast furnace injection.

关键词： meager coal meager-lean coal microstructure safety property blast furnace injection

Sporadic E responds to the 2022 Tonga volcano eruptions recorded by the Meridian Project

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Earth and Planetary Physics 2025年第1期9卷 20-28页

作者： YangYi Sun Tao Yu jin Wang Chi Long School of Geophysics and Geomatics China University of Geosciences(Wuhan)Wuhan 430047China School of Physics and Electronic Science Guizhou Normal UniversityGuizhou 550001China

In this study,ionosonde observations over Fuke(19.5°N,109.1°E),Wuhan(30.5°N,114.4°E),and Mohe(53.5°N,122.3°E)were analyzed to demonstrate the responses of the sporadic E()to the severe atmospheric disturbances caused by the Tonga volcanic eruptions on January 15,*** most prominent signature was the disappearance of the layer after~10:00 UT over Wuhan and Fuke,which was attributed to the vertical drift caused by the *** occurred intermittently after 13:00 UT following the arrival of the tropospheric Lamb *** examine the causal mechanism for the intermittence,we also included data of horizontal winds in the mesosphere and lower thermosphere region recorded by the meteor radars at Wuhan and Mohe in this *** wind disturbances with periods of~20 hours contributed to the formation of the layer in the nighttime on January 15.

关键词： sporadic E Tonga eruptions neutral wind disturbances

Isolation, Identification, and Herbicidal Activity of Metabolites Produced by Pseudomonas aeruginosa CB-4

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Journal of Integrative Agriculture 2014年第8期13卷 1719-1726页

作者： YANG Juan CAO Hong-zhe WANG Wei ZHANG Li-hui DONG jin-gao Mycotoxin and Molecular Plant Pathology Laboratory Agricultural University of Hebei

CB-4, a bacterial strain with highly effective herbicidal activity, was isolated from infected corn leaves. Through morphology, physiological and biochemical tests, and 16 S ribosomal DNA gene sequencing methods, CB-4 was identified as Pseudomonas aeruginosa. We conducted activity-evaluation experiments in the laboratory to assess the herbicidal potential of metabolites produced by strain CB-4. Crude extracts of strain CB-4 have high inhibition activity on Digitaria sanguinalis. In general, the root and shoot growth parameters of D. sanguinalis were significantly reduced by metabolites of strain CB-4. The IC50 of the culture filtrate extracts for the radicula and coleoptile of D. sanguinalis were 0.299 and 0.210 mg mL-1, respectively. Component 2 of the herbicidal activity of the crude toxin from strain CB-4 was successfully purified for the first time by using high-speed counter current chromatography with a two-phase solvent system composed of petroleum ether-ethyl acetate-methanol-water（4：5：4：5, v/v） and high-performance liquid chromatography. We concluded that the metabolites of strain CB-4 have the potential to be developed as a microbe-based herbicide.

关键词： Pseudomonas aeruginosa bioherbicide biocontrol HSCCC HPLC

Volterra series based predistortion for broadband RF power amplifiers with memory effects

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Journal of Systems Engineering and Electronics 2008年第4期19卷 666-671页

作者： jin zhe Song Zhihuan He Jiaming zhejiang Univ. of Science and Technology Hangzhou 310023 P. R. China Coll. of Information Science and Engineering Zhejiang Univ. Hangzhou 310027 P. R. China Inst. of Communication Technologies Ningbo Univ. Ningbo 315211 P. R. China

RF power amplifiers （PAs） are usually considered as memoryless devices in most existing predistortion techniques. However, in broadband communication systems, such as WCDMA, the PA memory effects are significant, and memoryless predistortion cannot linearize the PAs effectively. After analyzing the PA memory effects, a novel predistortion method based on the simplified Volterra series is proposed to linearize broadband RF PAs with memory effects. The indirect learning architecture is adopted to design the predistortion scheme and the reeursive least squares algorithm with forgetting factor is applied to identify the parameters of the predistorter. Simulation results show that the proposed predistortion method can compensate the nonlinear distortion and memory effects of broadband RF PAs effectively.

关键词： power amplifiers predistortion memory effects Volterra series

Positron Spectroscopy of Free Volume in Poly(vinylidene fluoride) after Helium Ions Irradiation

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Chinese Journal of Polymer Science 2019年第5期37卷 527-534页

作者： jin-zhe Lyu Roman Laptev Natalya Dubrova Division for Experimental Physics School of Nuclear Science & EngineeringNational Research Tomsk Polytechnic University

Free volume is an extremely important intrinsic defect in polymers. Structurally, free volume is the randomly distributed holes in the polymer molecular chain segments. In proton exchange membrane fuel cells, free volume is also the space needed for the directional conduction of protons. Irradiation by α particles to grafting sulfonated poly(vinylidene fluoride)(PVDF) is one of the methods to produce proton exchange membrane with good proton channel rate. Positron annihilation lifetime spectroscopy was used to study the free volume size at different absorbed dose levels from 0.13 MGy to 0.65 MGy. Measurement method of positron annihilation lifetime spectroscopy for PVDF based on ^(44) Ti positron source was developed. For low dose irradiation at 0.26 MGy, a decrease in free volume and practically unchanged crystallinity were observed. Further increase of absorbed dose range from 0.26 MGy to 0.39 MGy led to an increasing crystallinity with the same free volume level. For the absorbed dose from 0.39 MGy to 0.65 MGy, crystallinity was decreased but free volume remained almost constant.

关键词： Positron annihilation Free volume XRD Poly(vinylidene fluoride) Helium ions Connection Degradation

The gut-eye axis:from brain neurodegenerative diseases to age-related macular degeneration

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Neural Regeneration Research 2025年第10期20卷 2741-2757页

作者： Qianzi jin Suyu Wang Yujia Yao Qin Jiang Keran Li Department of Ophthalmology The Affiliated Eye Hospital of Nanjing Medical UniversityNanjingJiangsu ProvinceChina The Fourth School of Clinical Medicine Nanjing Medical UniversityNanjingJiangsu ProvinceChina

Age-related macular degeneration is a serious neurodegenerative disease of the retina that significantly impacts ***,the specific pathogenesis remains unclear,and effective early treatment options are consequently *** microbiome is defined as a large ecosystem of microorganisms living within and coexisting with a *** intestinal microbiome undergoes dynamic changes owing to age,diet,genetics,and other *** dysregulation of the intestinal flora can disrupt the microecological balance,resulting in immunological and metabolic dysfunction in the host,and affecting the development of many *** recent decades,significant evidence has indicated that the intestinal flora also influences systems outside of the digestive tract,including the ***,several studies have demonstrated the critical role of the gut-brain axis in the development of brain neurodegenerative diseases,including Alzheimer’s disease and Parkinson’s ***,the role of the“gut-eye axis”has been confirmed to play a role in the pathogenesis of many ocular ***,age-related macular degeneration and many brain neurodegenerative diseases have been shown to share several risk factors and to exhibit comparable *** such,the intestinal flora may play an important role in age-related macular *** the above context,the present review aims to clarify the gut-brain and gut-eye connections,assess the effect of intestinal flora and metabolites on age-related macular degeneration,and identify potential diagnostic markers and therapeutic ***,direct research on the role of intestinal flora in age-related macular degeneration is still relatively limited,while studies focusing solely on intestinal flora are insufficient to fully elucidate its functional role in age-related macular ***-on-a-chip technology has shown promise in clarifying the gut-eye interactions,while integrating analysis of the inte

关键词： age-related macular degeneration biological agents blinding eye disease dietary nutrition fecal microbial transplantation gut-eye axis intestinal flora metabolite microecology neurodegenerative disease

Domain wall dynamics driven by a circularly polarized magnetic field in ferrimagnet:effect of Dzyaloshinskii-Moriya interaction

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Rare Metals 2022年第11期41卷 3815-3822页

作者： Ting-Ting Liu Yi-Fei Hu Yang Liu zhe-Jun-Yu jin zheng-Hua Tang Ming-hui Qin Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum Materials and Institute for Advanced Materials South China Academy of Advanced OptoelectronicsSouth China Normal UniversityGuangzhou510006China School of Physics and Electronic and Electrical Engineering Xiangnan UniversityChenzhou423000China

In this work,we study the domain wall motion in ferrimagnet driven by a circularly polarized magnetic field using the collective coordinate theory and atomistic micromagnetic simulations,and we pay particular attention to the effect of Dzyaloshinskii-Moriya interaction(DMI).Similar to the case of antiferromagnetic domain wall,ferrimagnetic wall moves at a speed which is linearly dependent on the DMI *** addition,it is revealed that the DMI plays a role in modulating the domain wall dynamics similar to that of the net spin density,which suggests another internal parameter for controlling domain wall in ***,the results show that the domain wall dynamics in ferrimagnets is much faster than that in ferromagnets,which confirms again the great potential of ferrimagnets in future spintronic applications.

关键词： Domain wall dynamics Spintronics Circularly polarized magnetic field Ferrimagnets

Application of Short Sequential Extraction Procedure(SSEP) for the Determination of Zn, Cu, and Cd Contents in Riverbed Sludge in Hejiagou, Harbin, China

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Chemical Research in Chinese Universities 2006年第6期22卷 696-702页

作者： LI Yu WANG zhe ZHAO Wen-jin Energy and Environment Research Center North China Electric Power University Beijing 102206 P. R. China College of Enviromnent and Resources Jilin University Changchun 130012 P. R. China Department of Internal Medicine of Digestion China -Japan Union Hospital Jilin University Changchun 130033 P. R. China

A short sequential extraction procedure（SSEP） was applied to the determination of more readily available metal fractions of Zn, Cu, and Cd in the riverbed sludge in Hejiagou, Harbin, China. From the results, a potential order of metal availability in seven sludge samples was proposed： Cd 〈 Cu 〈 Zn, and samples S1 , S2, and S4 were used for the determination of total Zn content, and sample S3 used for the determination of total Cu content in the mobile and the mobilizable fractions showed the highest pollution risk. The results with regard to metal mobility in sludge samples were confirmed by the individual and global contamination factors that were calculated from the nonresidual and residual metal contents. The results obtained from metal-release experiments after exposure of sludge to environmental conditions agreed well with those obtained from both SSEP and the individual and global contamination factors, indicating that the maximum metal release could be an additional factor to evaluate the heavy metal availability in contaminated sludge. A substantial time saving was achieved by using the metal-release method in the present study.

关键词： Riverbed sludge Zn, Cu, and Cd Metal bioavailability Retention Release Sequential extraction procedure