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Hepatoprotective effects of Xiaoyao San formula on hepatic steatosis and inflammation via regulating the sex hormones metabolism

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World Journal of Hepatology 2024年第7期16卷 1051-1066页

作者： Xiao-Li Mei Shu-Yi Wu Si-Lan Wu Xiao-Lin Luo Si-Xing Huang Rui Liu zhe qiang Department of Pharmacology and Toxicology Sichuan-Chongqing Joint Key Laboratory of New Chinese Medicine Creation LaboratoryChongqing Academy of Chinese Materia MedicaChongqing 400061China College of Chinese Medicine Chongqing College of Traditional Chinses MedicineChongqing 402760China Department of Oncology The Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China College of Pharmacy Chongqing Medical UniversityChongqing 400010China

BACKGROUND The modified Xiaoyao San(MXS)formula is an adjuvant drug recommended by the National Health Commission of China for the treatment of liver cancer,which has the effect of preventing postoperative recurrence and metastasis of hepatocellular carcinoma and prolonging patient ***,the molecular mechanisms underlying that remain *** To investigate the role and mechanisms of MXS in ameliorating hepatic injury,steatosis and *** A choline-deficient/high-fat diet-induced rat nonalcoholic steatohepatitis(NASH)model was used to examine the effects of MXS on lipid accumulation in primary *** tissues were collected for western blotting and immunohisto chemistry(IHC)*** accumulation and hepatic fibrosis were detected using oil red staining and Sirius red *** serum samples were collected for biochemical assays and NMR-based metabonomics *** inflammation/lipid metabolism-related signaling and regulators in liver tissues were also detected to reveal the molecular mechanisms of MXS against *** MXS showed a significant decrease in lipid accumulation and inflammatory response in hepatocytes under metabolic *** western blotting and IHC results indicated that MXS activated AMPK pathway but inhibited the expression of key regulators related to lipid accumulation,inflammation and hepatic fibrosis in the pathogenesis of *** metabonomics analysis systemically indicated that the arachidonic acid metabolism and steroid hormone synthesis are the two main target metabolic pathways for MXS to ameliorate liver inflammation and hepatic ***,we found that MXS protected against NASH by attenuating the sex hormone-related metabolism,especially the metabolism of male *** MXS ameliorates inflammation and hepatic steatosis of NASH by inhibiting the metabolism of male *** male hormone related metabolic pathways may be the potential therapeutic app

关键词： Hepatic steatosis Inflammation Sex hormone metabolism Male hormone Phosphatase and tensin homolog deleted on chromosome ten

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聚醚醚酮椎间融合器与自体髂骨在经椎间孔椎体间融合术治疗腰椎间盘突出症中的应用价值

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河北医科大学学报 2024年第6期45卷 735-739页

作者：张杰刘煊文周强陈丹强喆西南医科大学附属成都三六三医院骨科四川成都610000

目的比较聚醚醚酮(polyether-ether-ketone, PEEK)椎间融合器与自体髂骨在经椎间孔椎体间融合术(transforaminal interbody fusion, TLIF)治疗腰椎间盘突出症中的应用价值。方法选取行TLIF的腰椎间盘突出症患者70例为研究对象,采用随... 详细信息

目的比较聚醚醚酮(polyether-ether-ketone, PEEK)椎间融合器与自体髂骨在经椎间孔椎体间融合术(transforaminal interbody fusion, TLIF)治疗腰椎间盘突出症中的应用价值。方法选取行TLIF的腰椎间盘突出症患者70例为研究对象,采用随机数字表法将患者分为2组,观察组35例采用自体髂骨治疗,对照组35例采用PEEK椎间融合器治疗。观察2组术中出血量、手术时间、住院时间、并发症发生率,比较2组术前及术后不同时间点的视觉模拟疼痛(visual analogue scale, VAS)评分、Oswestry功能障碍指数(Oswestry disability index, ODI)及椎间隙高度情况,比较2组术后植骨融合率。结果观察组术中出血量、手术时间明显高于对照组(P0.05)。2组VAS评分均随着术前术后时间的推移一直降低,时点间比较差异有统计学意义(P0.05),2组ODI评分随着术前术后时间的推移一直降低,时点间比较差异有统计学意义(P0.05)。2组术前椎间隙高度随着术前术后时间的推移先增大后减小,时点间比较差异有统计学意义(P0.05)。观察组术后3个月及术后6个月植骨融合率均高于对照组(P0.05)。结论在TLIF手术中使用自体髂骨与PEEK椎间融合器均能有效治疗腰椎间盘突出症,但自体髂骨治疗前期的融合率更具有优势。

关键词：椎间盘移位椎间融合器椎间孔椎体间融合术

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Organelle-targeted therapies: a comprehensive review on system design for enabling precision oncology

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Signal Transduction and Targeted Therapy 2022年第12期7卷 4325-4351页

作者： Jingjing Yang Anthony Griffin zhe qiang Jie Ren Institute of Nano and Biopolymeric Materials School of Materials Science and EngineeringTongji University201804ShanghaiChina School of Polymer Science and Engineering University of Southern MississippiHattiesburgMS39406USA

Cancer is a major threat to human *** various treatment methods,precision therapy has received significant attention since the inception,due to its ability to efficiently inhibit tumor growth,while curtailing common shortcomings from conventional cancer treatment,leading towards enhanced survival ***,organelle-targeted strategies enable precise accumulation of therapeutic agents in organelles,locally triggering organelle-mediated cell death signals which can greatly reduce the therapeutic threshold dosage and minimize *** this review,we comprehensively discuss history and recent advances in targeted therapies on organelles,specifically including nucleus,mitochondria,lysosomes and endoplasmic reticulum,while focusing on organelle structures,organelle-mediated cell death signal pathways,and design guidelines of organelle-targeted nanomedicines based on intervention ***,a perspective on future research and clinical opportunities and potential challenges in precision oncology is *** demonstrating recent developments in organelle-targeted therapies,we believe this article can further stimulate broader interests in multidisciplinary research and technology development for enabling advanced organelle-targeted nanomedicines and their corresponding clinic translations.

关键词： targeted dosage comprehensive

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微流控技术制备微米级DAP-4基含能复合微球及性能研究

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含能材料 2024年第3期32卷 249-255页

作者：李佳伟李佳飞张东旭薛志华李柘嫱雷金山王晶禹武碧栋中北大学环境与安全工程学院山西太原030051

为提高分子钙钛矿含能材料(DAP-4)的装药工艺安全性,采用同轴型液滴微流控技术,改变黏结剂聚叠氮缩水甘油醚(GAP)和硝化纤维素(NC)的复合比例(占DAP-4质量的2%)实现了DAP-4基含能复合微球的球形化造粒。通过扫描电镜、X射线衍射仪、差... 详细信息

为提高分子钙钛矿含能材料(DAP-4)的装药工艺安全性,采用同轴型液滴微流控技术,改变黏结剂聚叠氮缩水甘油醚(GAP)和硝化纤维素(NC)的复合比例(占DAP-4质量的2%)实现了DAP-4基含能复合微球的球形化造粒。通过扫描电镜、X射线衍射仪、差热扫描量热仪、热失重分析仪、高速摄影、撞击感度测试仪和摩擦感度测试仪等系统测试和分析了样品的宏微观形貌、晶体结构、热性能、燃烧性能、机械感度等。结果表明:黏结剂GAP与NC的比例为4∶1时,DAP-4基复合微球(GN41)的球形化效果最好;对DAP-4进行球形化造粒后不会改变其晶体结构,热分解峰温略有提前;DAP-4基复合微球的燃烧时间比原料有轻微延长,总体依然表现出非常平稳的持续燃烧,保留了其优异的燃烧性能;GN41微球在降低机械感度的同时显著改善了流动性,提高了装药工艺安全性。

关键词：微流控分子钙钛矿含能材料(DAP-4) 微球流散性燃烧

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Boosting oxygen reduction activity and CO_(2) resistance on bismuth ferrite-based perovskite cathode for low-temperature solid oxide fuel cells below 600℃

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Journal of Energy Chemistry 2024年第3期90卷 600-609,I0013页

作者： Juntao Gao Zhiyun Wei Mengke Yuan zhe Wang zhe Lü qiang Li Lingling Xu Bo Wei School of Physics Harbin Institute of TechnologyHarbin 150001HeilongjiangChina Key Laboratory of Functional Inorganic Material Chemistry Ministry of EducationSchool of Chemistry and Materials ScienceHeilongjiang UniversityHarbin 150080HeilongjiangChina School of Physics and Electronic Engineering Harbin Normal UniversityHarbin 150025HeilongjiangChina

Developing efficient and stable cathodes for low-temperature solid oxide fuel cells(LT-SOFCs) is of great importance for the practical ***,we propose a series of Sm-modified Bi_(0.7-x)Sm_xSr_(0.3)FeO_(3-δ) perovskites as highly-active catalysts for *** doping can significantly enhance the electrocata lytic activity and chemical stability of *** 600℃,Bi_(0.675)Sm_(0.025)Sr_(0.3)FeO_(3-δ)(BSSF25) cathode has been found to be the optimum composition with a polarization resistance of 0.098 Ω cm^2,which is only around 22.8% of Bi_(0.7)Sr_(0.3)FeO_(3-δ)(BSF).A full cell utilizing BSSF25 displays an exceptional output density of 790 mW cm^(-2),which can operate continuously over100 h without obvious *** remarkable electrochemical performance observed can be attributed to the improved O_(2) transport kinetics,superior surface oxygen adsorption capacity,as well as O_(2)p band centers in close proximity to the Fermi ***,larger average bonding energy(ABE) and the presence of highly acidic Bi,Sm,and Fe ions restrict the adsorption of CO_(2) on the cathode surface,resulting in excellent CO_(2) *** work provides valuable guidance for systematic design of efficient and durable catalysts for LT-SOFCs.

关键词： Low-temperature solid oxide fuel cell Perovskite cathode DFT calculations CO_(2) tolerance

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小甘沟煤矿综放采空区三维流场演化规律及自燃区域判定

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煤矿现代化 2024年第3期33卷 58-62页

作者：刘庆林刘辉张玉彬马彬柘强新疆呼图壁县煤炭多种经营有限责任公司小甘沟煤矿新疆昌吉831200 新疆准南煤矿有限责任公司新疆塔城834700 新疆呼图壁县石梯子西沟煤炭有限责任公司新疆昌吉831200

针对放顶煤开采采空区遗煤量大的实际特点,采用现场测试和数值模拟的方式开展小甘沟煤矿11121综放工作面复杂氧化条件煤体下采空区三维流场演化规律研究及自燃危险区域判定。通过FLUENT模拟不同配风量及压注参数等条件下采空区流场演化... 详细信息

针对放顶煤开采采空区遗煤量大的实际特点,采用现场测试和数值模拟的方式开展小甘沟煤矿11121综放工作面复杂氧化条件煤体下采空区三维流场演化规律研究及自燃危险区域判定。通过FLUENT模拟不同配风量及压注参数等条件下采空区流场演化规律。结合束管及温度动态监控系统,提出以采空区氧浓度、漏风风速和孔隙率相结合的采空区自燃危险区划分方法,精准判断采空区自燃“三带”范围,综合判定小甘沟工作面自然发火危险区域,有效提高采空区自燃危险性预测准确性。

关键词：放顶煤开采厚煤层工作面数值模拟孔隙率采空区自燃“三带”

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Characterization and degradation of β-Sn particles in thermal aged Pb-rich solder joint for low-temperature co-fired ceramic(LTCC) applications

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Rare Metals 2024年第10期43卷 5346-5361页

作者： Jin-Hong Liu zhe Zhu qiang-qiang Nie Jun-Fu Liu Peng He Shu-Ye Zhang State Key Laboratory of Advanced Welding and Joining Harbin Institute of Technology Anhui Key Laboratory of Microsystem East China Research Institute of Microelectronics School of Materials Science and Engineering Hefei University of Technology

High-lead solder joints are still playing an indispensable role in military and space ***, in-depth characterization of high-lead solder joints and the underlying degradation mechanisms remain unexplored. This research first performed aging tests on Sn10Pb90 solder joints, the shear strength at room and elevated temperatures gradually reduced, and the resistance increased. Here, a two-layered Ni–Sn intermetallic compound(IMC) structure was identified using transmission electron microscopy(TEM), which could be attributed to the change of Sn content in the solder. Moreover, the internal annealing twin of a Sn particle was discovered,which could be attributed to creeping induced by thermal expansion coefficient(CTE) difference between Sn and *** analysis of partial and whole annealing twins was conducted through high-resolution TEM(HRTEM).Finally, four degradation mechanisms were *** of the IMC layer would result in increased brittleness and resistivity. For particle coarsening, apart from diminishing the ductility and toughness of the solder joint, it would also accelerate the creeping rate by weakening the phase boundary strength. Regarding voids and cracks induced by phase boundary sliding, wedgeshaped cracking and pore-shaped cracking were discovered and their formation was analyzed. Most importantly, the consumption of Sn resulted in a depletion of wettable layer,leading to the formation of Pb streams and isolated IMC islands, also known as the spalling and delamination of IMCs. Pb diffusion followed a spiral path, which was mutually influenced by orientation misfit and concentration gradient. A technique to prevent cracking was *** research is expected to provide significant technical references for high-lead solder joints.

关键词： Aging Degradation mechanisms High-lead solder joints Properties TEM characterization

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Investigating effect of coke porosity on blast furnace performance based on multi-physical fields

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Journal of Iron and Steel Research International 2024年第2期31卷 357-367页

作者： Ji Chen Zhao Lei zhe Yao Li Wang qiang Ling Ping Cui Anhui Province Key Laboratory of Coal Clean Conversion and High Valued Utilization School of Chemistry and Chemical EngineeringAnhui University of TechnologyMa’anshan243002AnhuiChina Shanxi Academy of Printing Technology Research Institute Co. Ltd.Xi’an710077ShaanxiChina

Reducing coke use is an effective measure to reduce carbon emission and energy consumption in the blast furnace(BF)***,BF is a high-temperature moving bed reactor,where complex physical transformations coupled with complicated reactions *** makes it challenging to investigate the factors determining BF performance with the conventional method.A multi-physical field coupling mathematical model of BF was thus developed to describe its mass and heat transfer as well as its intrinsic ***,the proposed model was validated with the production *** coupling conditions,influences of dominating reactions on BF performance(temperature distribution,gas distribution,iron formation reaction,and direct reduction degree)were *** results indicated that coke combustion,indirect reduction,and direct reduction of iron ore mainly took place nearby the shaft tuyere,cohesive zone,and dripping zone,***,the rate of coke solution loss reaction was increased with the rising coke porosity in the cohesive *** the effect of coke porosity on the efficiency and stability of BF,the coke porosity of 0.42 was regarded as a reasonable value.

关键词： Blast furnace Mathematical model Multi-physical field Simulation Coke porosity

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Facilitated Prediction of Micropollutant Degradation via UV-AOPs in Various Waters by Combining Model Simulation and Portable Measurement

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Engineering 2024年第6期37卷 87-95页

作者： Yanyan Huang Mengkai Li zhe Sun Wentao Li James R.Bolton Zhimin qiang Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China Department of Civil and Environmental Engineering University of AlbertaEdmontonAB T6G 1H9Canada State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China

The degradation of micropollutants in water via ultraviolet(UV)-based advanced oxidation processes(AOPs)is strongly dependent on the water *** reactive radicals(RRs)formed in UV-AOPs have different reaction selectivities toward water matrices and degradation efficiencies for target ***,process selection and optimization are *** study developed a facilitated prediction method for the photon fluence-based rate constant for micropollutant degradation(K′_(p,MP))in various UV-AOPs by combining model simulation with portable *** methods for measuring the scavenging capacities of the principal RRs(RRSCs)involved in UV-AOPs(i.e.,HO^(·),SO_(4)^(·-),and Cl^(·))using a mini-fluidic photoreaction system were *** simulation models consisted of photochemical,quantitative structure–activity relationship,and radical concentration steady-state approximation *** RRSCs were determined in eight test waters,and a higher RRSC was found to be associated with a more complex water ***,by taking sulfamethazine,caffeine,and carbamazepine as model micropollutants,the k′_(p,MP) values in various UV-AOPs were predicted and further verified experimentally.A lower k′_(p,MP) was found to be associated with a higher RRSC for a stronger RR competition;for example,k′_(p,MP) values of 130.9 and 332.5 m^(2) einstein^(–1),respectively,were obtained for carbamazepine degradation by UV/H_(2)O_(2) in the raw water(RRSC=9.47×10^(4) s^(-1))and sand-filtered effluent(RRSC=2.87×10^(4) s^(-1))of a drinking water treatment *** developed method facilitates process selection and optimization for UV-AOPs,which is essential for increasing the efficiency and cost-effectiveness of water treatment.

关键词： UV-AOPs Micropollutant degradation Reactive radicals Water matrix Model simulation

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Purification performance on molten steel of novel Al_(2)O_(3)-based ceramic filter prepared from microporous powder and nano-Al_(2)O_(3) powder

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Journal of Iron and Steel Research International 2024年第6期31卷 1535-1546页

作者： zhe Chen Wen Yan Ying Liu Guang-qiang Li Shao-song Hong Nan Li The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Jiangsu Shengnai New Materials Co. Ltd.Taizhou 225534JiangsuChina

Reticulated ceramic foam filters provide an effective way to purify molten steel by removing non-metallic *** proposed a novel strategy to improve the purification performance of Al_(2)O_(3)-based ceramic filters by using microporous corundum-spinel raw materials to replace dense raw *** kinds of Al_(2)O_(3)-based ceramic filters fabricated from dense α-Al_(2)O_(3) micro-powder or microporous corundum-spinel powder were selected to carry out the immersion tests with molten *** the one hand,the higher surface roughness of the filter skeleton prepared from microporous raw materials increased the adsorption capacity of skeleton surface on inclusions in molten *** the other hand,the higher apparent porosity and larger pore size of the filter skeleton were more beneficial to the penetration of molten steel in the micropores of *** reaction process at the solid-liquid interface also improved the wettability of the interface between skeleton and molten steel,resulting in a larger penetration depth and a better adsorption effect on the *** summary,the novel Al_(2)O_(3)-based ceramic filter prepared with microporous corundum-spinel powder and addition of 5 wt.% nano-Al_(2)O_(3) powder reduced the total oxygen content of the steel from 40.2×10^(-4) to 12.7×10^(-4) wt.% by 68.4% and the Al content from 0.46 to 0.18 wt.% by 60.9% after immersion test,presenting the most excellent purification performance on molten steel.

关键词： Al_(2)O_(3)-based ceramic filter Microporous corundum-spinel powder Non-metallic inclusion-Microstructure Molten steel purification

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