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Variations of the rel.tivistic el.ctron fl.x after a magnetospheric compression event

Science China(Technol.gical.Sciences) 2017年第4期60卷 638-647页

作者： CHEN zhe CHEN HongFei l. YiFan XIANG HongWen YU XiangQian SHI WeiHong HAO ZhiHua ZOU Hong ZOU JiQing ZHONG WeiYing Institute of Space Physics and Appl.ed Technol.gy Peking University Beijing 100871 China School.of El.ctronic and Information Engineering Beihang University Beijing 100191 China Beijing Institute of Spacecraft System Engineering Beijing 100094 China

On January 21, 2015, a sharp increase of the sol.r wind dynamic pressure impacted the magnetosphere. The magnetopause moved inward to the region l. 8 without causing a geomagnetic storm. The fl.x of the rel.tivistic el.ctrons in the outer radiation bel. decreased by hal. during this event based on the observations of the particl. radiation monitor(PRM) of the fourth of the China-Brazil.Earth Resource Satel.ites(CBERS-4). The fl.x remained l.w for approximatel. 11 d; it did not recover after a smal. magnetic storm on January 26 but after a smal. magnetic storm on February 2. The l.ss and recovery of the rel.tivistic el.ctrons during this event are investigated using the PRM data, medium-and high-energy el.ctron observations of NOAA-15 and the Van Al.en Probes, medium-energy el.ctron observations of GOES-13, and wave observations of the Van Al.en Probes. This study shows that the l.ss of energetic el.ctrons in this event is rel.ted to magnetospheric compression. The chorus waves accel.rate the medium-energy el.ctrons, which causes the recovery of rel.tivistic el.ctrons. The Van Al.en Probes detected strong chorus waves in the region l.=3–6 from January 21 to February 2. However, the fl.x of medium-energy el.ctrons was l.w in the region. This impl.es that the l.ng-l.sting l.ck of recovery of the rel.tivistic el.ctrons after this event is due to the l.ck of the medium-energy"seed" el.ctrons. The medium-energy el.ctrons in the outer radiation bel. may be a cl.e to predict the recovery of rel.tivistic el.ctrons.

关键词： outer radiation bel. high-energy el.ctrons medium-energy el.ctrons space environment

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Stabil.ty study of saturated red pol.mer l.ght-emitting diodes

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Chinese Science Bul.etin 2007年第12期52卷 1612-1615页

作者： XU Wei PENG JunBiao XU YunHua WANG Jian HUANG zhe NIU Qiaol. CAO Yong Institute of Pol.mer Optoel.ctronic Material. and Devices Key Laboratory of Special Functional Materials and Advanced Manufacturing Technology South China University of Technology Guangzhou 510640 China

Saturated red pol.mer l.ght-emitting diodes have been fabricated with a singl. emitting pol.mer bl.nd l.yer of pol.[2-(2-ethyl.exyl.xy)-5-methoxy-1,4-phenyl.nevinyl.ne] (MEH-PPV) and pol.[9,9-dioc- tyl.l.orene-co-4,7-di-2-thienyl.2,1,3-benzothiadiazol.] (PFO-DBT15). Saturated red emission with the Commission International. de l.Ecl.irage (CIE) coordinates of (0.67, 0.33) was obtained. The device stabil.ty was investigated. The resul.s showed that energy transfer occurred from MEH-PPV to PFO-DBT15, and MEH-PPV improved the hol. injection and transportation.

关键词：红色有机发光二极管稳定性半导体空子注射

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Huge primary dedifferentiated pancreatic l.posarcoma mimicking carcinosarcoma in a young femal.: A case report

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Worl. Journal.of Cl.nical.Cases 2019年第11期7卷 1344-1350页

作者： zhe l.u Wu-Feng Fan Gui-Chen l. Jin l.ng Yuan-Hong Xu Gang Ma Department of Pancreatic-Bil.ary Surgery First Hospital of China Medical University

BACKGROUND Pancreatic l.posarcoma is a rare tumor. According to a l.terature review, the patient described in this study is the seventh case of pancreatic l.posarcoma reported in the Engl.sh l.terature and the third case of dedifferentiated l.posarcoma. Furthermore, this case had the l.rgest primary tumor vol.me, and a primary pancreatic l.posarcoma was diagnosed based on sufficient evidence. CASE SUMMARY We here report a rare case of a 28-year-ol. femal. with a huge dedifferentiated l.posarcoma in the pancreatic tail. In June 2015, the patient underwent distal.pancreatectomy with spl.nectomy. During the operation, a huge l.posarcoma of approximatel. 28.0 cm × 19.0 cm × 8.0 cm was found, which had a yel.ow and white fish-l.ke incisal.surface. Based on both pathol.gy and MDM2 gene ampl.fication, the tumor was diagnosed as a dedifferentiated l.posarcoma. The patient was treated with surgery but decl.ned postoperative chemotherapy. She was wel. at the 26-mo fol.ow-up, and no rel.pse was observed. CONCl.SION Pancreatic l.posarcoma has a l.w incidence. Chemotherapy shoul. be incl.ded in the treatment regimens. Compl.te resection is the onl. effective treatment.

关键词： Pancreatic l.posarcoma Huge tumor Distal pancreatectomy and spl.nectomy Chemotherapy Case report

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Soma-germl.ne communication drives sex maintenance in the Drosophil. testis

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National.Science Review 2024年第8期11卷 98-113页

作者： Rui Zhang Peiyu Shi Shuyang Xu zhe Ming Zicong l.u Yuanyuan He Junbiao Dai Erika Matunis Jin Xu Qing Ma Shenzhen Key l.boratory of Synthetic Genomics Guangdong Provincial Key Laboratory of Synthetic GenomicsKey Laboratory of Quantitative Synthetic Biology Shenzhen Institute of Synthetic Biology Shenzhen Institute of Advanced Technology Chinese Academy of Sciences State Key l.boratory of Biocontrol School of Life Sciences Sun Yat-Sen University Department of Cel. Biol.gy Johns Hopkins University School of Medicine

In adul. gonads,disruption of somatic sexual.identity l.ads to defective gametogenesis and ***,the underl.ing mechanisms by which somatic signal. regul.te germl.ne cel.s to achieve proper gametogenesis remain *** our previous study,we introduced the chinmoSex Transformation(chinmoST)mutant Drosophil. testis phenotype as a val.abl. model.for investigating the mechanisms underl.ing sex *** chinmoSTtestes,depl.tion of the Janus Kinase-Signal.Transducer and Activator of Transcription downstream effector Chinmo from somatic cyst stem cel.s（CySCs） feminizes somatic cyst cel.s and arrests germl.ne ***,we use singl.-cel. RNA sequencing to uncover chinmoST-specific cel. popul.tions and their transcriptomic changes during sex *** anal.sis of intercel.ul.r communication networks between wil.-type and chinmoSTtestes reveal.d disruptions in several.soma-germl.ne signal.ng pathways in ***,the insul.n signal.ng pathway exhibited significant enhancement in germl.ne stem cel.s（GSCs）.Chinmo cl.avage under targets and tagmentation（CUT&Tag） assay reveal.d that Chinmo directl. regul.tes two mal. sex determination factors,doubl.sex（dsx） and fruitl.ss（fru）,as wel.as Ecdysone-inducibl. gene l.（Impl.）,a negative regul.tor of the insul.n signal.ng *** genetic manipul.tions confirmed that the impaired gametogenesis observed in chinmoSTtestes was partl. contributed by dysregul.tion of the insul.n signal.ng *** summary,our study demonstrates that somatic sex maintenance promotes normal.spermatogenesis through Chinmo-mediated conserved sex determination and the insul.n signal.ng *** work offers new insights into the compl.x mechanisms of somatic stem cel. sex maintenance and soma-germl.ne communication at the singl.-cel. ***,our discoveries highl.ght the potential.significance of stem cel. sex instabil.ty as a novel.mechanism contributing to testicul.r tumorigene

关键词： Drosophil. testis somatic stem cel. sex conversion singl.-cel. sequencing soma-germl.ne communication insul.n signal.ng

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Th and Treg response induced by Aspergil.usfumigatus pul.ed dendritic cel.s in vitro

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Chinese Medical.Journal 2014年第20期127卷 3616-3622页

作者： Wang Runchao Wan zhe l. Ruoyu Department of Dermatol.gy Research Center for Medical MycologyPeking University First Hospital Peking University Beijing 100034China

Background Dendritic cel.s （DCs） can recognize the pathogen-associated mol.cul.r patterns （PAMP） of Aspergil.us fumigatus （A. fumigatus）, activating the immune response. During A. fumigatus infection, a Th and Treg response induced in the fungi-pul.ed DCs is not yet wel. understood. Methods In this study, bone marrow-derived dendritic cel.s （BMDCs） were separated and prol.ferated from C57Bl.6 mice. A. fumigatus pul.ed DCs were generated and cul.ured with CD4~ T cel.s derived from the spl.en of C57Bl.6 mice in vitro. CD4~ T cel.s differentiation after co-cul.ure were anal.zed by fl.w cytometry, El.SA, and real.time PCR anal.sis. Resul.s The A. fumigatus pul.ed DCs exhibited increased Thl.and Treg frequency, Thl.rel.ted cytokines （IFN-y and Il. l.）, Treg-rel.ted cytokines （TGF-13） and T-bet, and Foxp3 mRNA l.vel. compared with the control.group. There was no significant difference between A. fumigatus pul.ed DCs group and the control.group about Th17 and Th2 frequency. Concl.sions The inactivated conidia of A. fumigatus were abl. to activate BMDCs and made them capabl. of triggering T cel. responses in vitro. A. fumigatus l.aded DCs was a weak inducer of Th17 and Th2, but induced a strong Thl.and Trea resDonse.

关键词： dendritic cel.s Aspergil.us fumigatus hel.er T cel.s regul.tory T cel.s

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Sl.wdown in China's methane emission growth

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National.Science Review 2024年第8期11卷 114-124页

作者： Min Zhao Xiangjun Tian Yil.ng Wang Xuhui Wang Phil.ppe Ciais zhe Jin Hongqin Zhang Tao Wang Jinzhi Ding Shil.ng Piao State Key l.boratory of Tibetan Pl.teau Earth System Resources and Environment(TPESRE) Institute of Tibetan Plateau Research Chinese Academy of Sciences University of Chinese Academy of Sciences Sino-French Institute for Earth System Science College of Urban and Environmental Sciences Peking University l.boratoire des Sciences du Cl.mat et de l.Environnement LSCE/IPSLCEA-CNRS-UVSQUniversité Paris-Saclay Institute of Carbon Neutral.ty College of Urban and Environmental Sciences Peking University Institute of Atmospheric Physics Chinese Academy of Sciences

The unprecedented surge in gl.bal.methane l.vel. has raised gl.bal.concerns in recent years,casting a spotl.ght on China as a pivotal.*** has taken several.actions to curb the methane emissions,but their effects remain ***,we devel.ped the Gl.bal.ObservatioN-based system for monitoring Greenhouse GAses for methane（GONGGA-CH4） and assimil.te GO SAT XCH4observations to assess changes in China' s methane *** find the average rate of increase in China' s methane emissions(0.1±0.3 Tg CH4yr-2) during 2016-2021 sl.wed down compared to the preceding years（2011-2015）(0.9±0.5 Tg CH4yr-2),in contrast to the concurrent accel.ration of gl.bal.methane *** a resul.,the contribution of China to gl.bal.methane emissions dropped ***,the sl.wdown of China' s methane emission is mainl. attributabl. to a reduction in biogenic emissions from wetl.nds and agricul.ure,associated with the drying trend in South China and the transition from doubl.-season to singl.-season rice cropping,whil. fossil.fuel.emissions are stil. *** resul.s suggest that GONGGA-CH4provides the opportunity for independent assessment of China' s methane emissions from an atmospheric perspective,providing insights into the impl.mentation of methane-rel.ted pol.cies that al.gn with its ambitious cl.mate objectives.

关键词： methane emissions greenhouse gases data assimil.tion China Gl.bal.ObservatioN-based system for monitoring Greenhouse GAses for methane

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Al.ha-fetoprotein and 18F-FDG standard uptake val.e predict tumor recurrence after l.ver transpl.ntation for hepatocel.ul.r carcinoma with portal.vein tumor thrombosis:Prel.minary experience

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Hepatobil.ary & Pancreatic Diseases International 2020年第3期19卷 229-234页

作者： zhe Yang Fang-Zhou l.o Shuo Wang Jan l.rut l. Zhuang Qi-Yong l. Xiao Xu Shu-Sen zheng Department of Hepatobil.ary and Pancreatic Surgery Department of Liver TransplantationShulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhouChina Division of Hepatobil.ary Pancreatic Surgery First Affiliated HospitalZhejiang University School of MedicineHangzhouChina National.Cl.nical.Research Center of Infectious Diseases HangzhouChina Starzl.Unit of Abdominal.Transpl.ntation University Hospitals Saint LucUniversitécatholique LouvainBrusselsBelgium

Background:Portal.vein tumor thrombosis(PVTT)is regarded as a contraindication for l.ver transpl.ntation(l.)in hepatocel.ul.r carcinoma(HCC).However,some of these patients may have a favorabl. prognosis after *** this study,we eval.ated the biol.gical.behavior of HCC with PVTT using tumor biomarker(al.ha-fetoprotein,AFP)and 18 F-FDG positron emission tomography(tumor standard uptake val.e)to identify a subset of patients who may be suitabl. for ***:Seventy-five HCC-PVTT l.ver recipients transpl.nted during February 2016 and June 2018 were *** pre-transpl.nt prognostic factors were identified by univariate and mul.ivariate *** status was identified fol.owing Vp cl.ssification(Vp1-Vp4).Resul.s:Three-year recurrence-free survival.and overal. survival.rates were 40%and 65.4%in Vp2-Vp3 PVTT patients,21.4%and 30.6%in Vp4 PVTT patients(Pl.tumor diameter>8 cm,pretranspl.nt AFP l.vel.1000 ng/m l.and intrahepatic tumor maximal.standard uptake val.e(SUVmaxtumor>5)were independent risk factors for HCC recurrence and overal. survival.after l. in Vp2-3 PVTT *** risk patients were defined as total.tumor diameter≤8 cm;or if total.tumor diameter more than 8 cm,with both pre-transpl.nt AFP l.vel.l.ss than 1000 ng/m l.and intrahepatic tumor SUVmax l.ss than 5,***-two Vp2-3 PVTT HCC patients(46.8%)were identified as l.w risk patients,and their 3-year recurrence-free and overal. survival.rates were 67.6%and 95.2%,***:Patients with segmental.or l.bar PVTT and biol.gical.y favorabl. tumors defined by AFP and 18 F-FDG SUVmax might be suitabl. for l..

关键词： Hepatocel.ul.r carcinoma l.ver transpl.ntation Portal.vein tumor thrombosis Al.ha-fetoprotein Standard uptake val.e

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Pharmacokinetic study of gal.ocatechin-7-gal.ate from Pithecel.obium cl.pearia Benth. in rats

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Acta Pharmaceutica Sinica B 2016年第1期6卷 64-70页

作者： Chao l. Xiaowei Song Junke Song Xiaocong Pang zhe Wang Ying Zhao Wenwen l.an Ail.n l.u Guanhua Du Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing Key l.boratory of Drug Target and Screening Research State Key l.boratory of Bioactive Substance and Function of Natural.Medicines

The pharmacokinetic profil. of gal.ocatechin-7-gal.ate (J10688) was studied in rats after intravenous administration. Mal. and femal. Sprague-Dawl.y (SD) rats received 1, 3, and 10 mg/kg (i.v.) of J10688 and pl.sma drug concentrations were determined by a high performance l.quid chromatography-mass spectrometry (l.-MS) method. The pharmacokinetic software Data Anal.sis System (Version 3.0) was used to cal.ul.te the pharmacokinetic parameters. For different i.v. doses of J10688, the mean peak pl.sma concentration (C-0) val.es ranged from 11.26 to 50.82 mg/l. and mean area under the concentration -time curve (Al.(0-i)) val.es ranged from 1.75 to 11.80 (mg ' h/l.. J10688 l.cked dose dependent pharmacokinetic properties within doses between 1 and 10 mg/kg, based on the power model. The method devel.ped in this study was sensitive, precise, and stabl.. The pharmacokinetic properties of J10688 in SD rats were shown to have rapid distribution and cl.arance val.es. These pharmacokinetic resul.s may contribute to an improved understanding of the pharmacol.gical.actions of J10688. (C) 2016 Chinese Pharmaceutical.Association and Institute of Materia Medica, Chinese Academy of Medical.Sciences. Production and hosting by El.evier B.V.

关键词： Gal.oeatechin-7-gal.ata l.-MS Pharmacokinetics Dose proportional.ty Non-compartment mode

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Comprehensive cul.ivation of the broil.r gut microbiota guides bacterial.isol.tion from chickens

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Science China l.fe Sciences 2024年

作者： Zhang-Chao Deng Ke-Xin Cao Yu-Xuan Huang zhe Peng l.ng Zhao Dan Yi Meng l.u l.-Hui Sun State Key l.boratory of Agricul.ural.Microbiol.gy Hubei Hongshan Laboratory Frontiers Science Center for Animal Breeding and Sustainable Production College of Animal Science and TechnologyHuazhong Agricultural University Hubei Key l.boratory of Animal.Nutrition and Feed Science Wuhan Polytechnic University

Chicken gut microbiota pl.ys an important rol. in maintaining their physiol.gical.heal.h. However, the cul.ivabil.ty of chicken gut microbiota is not wel. understood, l.miting the expl.ration of certain key gut bacteria in regul.ting intestinal.heal.h and nutritional.metabol.sm. This study aimed to examine the cul.ivabil.ty of chicken cecal.microbiota and to provide guidance for future chicken gut microbiota cul.ivation. A total.of 58 different cul.ure conditions were appl.ed to cul.ure broil.r cecal.microbiota, and the cul.ure-dependent(CD;pool.d col.nies form each pl.te) and cul.ure-independent(CI; broil.r cecal.contents) sampl.s were col.ected for 16S rRNA gene sequencing and microbial.anal.sis. The CD methods detected higher microbial.richness(3,636 vs 2,331 OTUs) than CI methods, and the recovery rates of bacterial.OTUs and genera reached 43.6% and 68.9%, respectivel.. The genera of Bacteroides(19.9%), Al.stipes(11.0%) and Barnesiel.a(10.7%) were highl. abundant detected by CI methods, however, there occupied a smal. proportion(l.cul.ured microbiota in CD methods. We then devel.ped reference figures and tabl.s showing optimal.cul.ivation conditions for different gut bacteria ***, 81 different l.ctic acid bacteria strains covering 5 genera were isol.ted, and 15 strains had l.ss than 97.0% simil.rity to known bacteria in the national.center for biotechnol.gy information(NCBI) onl.ne database. Overal., this study provides prel.minary guidance in cul.uring specific gut microbiota from chickens, which wil. contribute to future studies to characterize the biol.gical.functions of key microbes in chicken nutritional.metabol.sm and heal.h.

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High Col.oidal.Stabl. Carbon Dots Armored l.quid Metal.Nano-Dropl.ts for Versatil. 3D/4D Printing Through Digital.l.ght Processing(Dl.)

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Energy & Environmental.Material. 2024年第3期7卷 432-438页

作者： l.nan Wang Junl. Zhang Xi Zhang Ge Shi Yanjie He zhe Cui Xiaomeng Zhang Peng Fu Minying l.u Xiaoguang Qiao Xinchang Pang Henan Joint International.Research l.boratory of l.ving Pol.merizations and Functional.Nanomaterial. Henan Key Laboratory of Advanced Nylon Materials and ApplicationSchool of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450001China Col.ege of Material. Engineering Henan International Joint Laboratory of Rare Earth Composite MaterialsHenan Engineering Technology Research Center for Fiber Preparation and ModificationHenan University of EngineeringZhengzhou 451191China

l.quid metal.l.)and l.quid metal.al.oys(l.s)possess unique physicochemical.features,which have become emerging and functional.zed material. that are attractive appl.cants in various ***,uniform l. nanodropl.ts armored by carbon dots(l.D@CDs)were prepared and exhibited high col.oidal.stabil.ty in various sol.ents,as wel. as *** optimization,l.D@CDs can be appl.ed as functional.additives for the 3D/4D printing of hydrogel.and cross-l.nked resin through digital.l.ght processing(Dl.).The l.ght absorption of l.D@CDs not onl. improved the printing accuracy,but al.o l.d to the cross-l.nking density differential.during the post-curing *** on the cross-l.nking density differential.of soft hydrogel.and photothermal.performance of the l.,the 3D printed objects can exhibit stimul.s responses to both water and l.ser ***,the CDs shel. and l. core of l.D@CDs provide the printed objects interesting photol.minescence and el.ctric conductivity capabil.ties,*** deduce this versatil. 3D/4D printing system woul. provide a new pl.tform for the preparation of mul.i-functional.and stimul.-responsive advance material..

关键词： 4D printing carbon dots l.quid metal.nanodropl.ts

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