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Acta Pharmaceutica Sinica B 2020年第4期10卷 628-645页

作者： Lei Pang Chun-Yan Liu Guo-Hua Gong zhe-shan quan Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain Affiliated Ministry of EducationCollege of PharmacyYanbian UniversityYanji 133002China Affiliated Hospital of Inner Mongolia University for Nationalities Tongliao 028000China

Lappaconitine(LA),a natural compound with a novel C18-diterpenoid alkaloid skeleton,displayed extensive biological *** research on LA is focused mainly on its anti-tumor and analgesic effects,and therefore we aimed to investigate its anti-inflammatory potential.A series of novel LA derivatives with various substituents on the 20-N position was designed and *** the initial screening of LA derivatives against NO production,all the target compounds,except compound E2,exhibited excellent inhibitory ability relative to that of ***,compound A4 exhibited the most potent inhibition with IC50 of 12.91 mmol/*** elementary structureeactivity relationships(SARs)of NO inhibitory activity indicated that replacement of the benzene ring with an electron donating group could improve the anti-inflammatory ***,compound A4 shows an anti-inflammatory mechanism by inhibiting NO,PGE2,and TNF-a generation via the suppression of NF-kB and MAPK signaling ***,compound A4 could exert a significant therapeutic effect on LPS-induced acute lung injury(ALI)in *** on the above research,we further investigated the preliminary pharmacokinetic property of A4 in ***,compound A4 could be a promising candidate for the development of anti-inflammatory agents in the future.

关键词： Lappaconitine Anti-inflammatory activity NF-kB MAPK Acute lung injury Pharmacokinetic study

Synthesis and positive inotropic evaluation of 1-(benzylamino)-3-(4,5-di-hydro[1,2,4]trizaolo[4,3-a]quinolin-7-yloxy)propan-2-ol derivatives

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Chinese Chemical Letters 2009年第2期20卷 175-177页

作者： Ting Ting Li Ling Zhang zhe shan quan Hai Bo Zhu Hu Ri Piao Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain Affiliated Ministry of Education Yanbian University College of Pharmacy Yanji 133000 China Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 China

In an attempt to search for more potent positive inotropic agents, a series of 1-（benzylamino）-3-（4,5-dihydro[ 1,2,4]trizaolo[4,3- a]quinolin-7-yloxy）propan-2-ol derivatives was synthesized in four steps using 6-hydroxy-3,4-dihydro-2（1H）-quinolinone as a starting material, and their positive inotropic activities were evaluated by measuring the coronary blood flow （CBF） and the left ventricular pressure （LVP） followed by calculating the rate of pressure development （dp/dtmax values） in the preparation of rat Langendorff＇s heart. Three compounds （5d, 5g, 5j） showed favorable activities, among which 5g was shown the most potent with dp/dtmax value of 9.7% and CBF value of 17.8% at a concentration of 1×10^-5 mol/L in our in vitro study.

关键词： 3,4-Dihydrotrizaolo[4,3-a]quinoline Positive inotropic activity Synthesis

Acyldesilylation of 5-Trimethylsilyl-2-furancarboxaldehyde

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Chinese Chemical Letters 1999年第1期10卷 11-12页

作者： Hu Ri PIAO zhe shan quan Kouji NAKAYAMA Akira TANAKA(School of Pharmacy，Yanbian University，Yanji，133000)(Faculty of Pharmaceutical Sciences，Josai University,Saitama，Japan 350-02) Yanbian Univ Sch Pharm Yanji 133000 Peoples R China Josai Univ Fac Pharmaceut Sci Sakado Saitama 35002 Japan

Acyldesilylation of 5-trimethylsilyl-2-furancarboxaldehyde with acyl chlorides was investigated and the unexpected 5-acyl-2-dichloromethylfuran were obtained as main products. The expected 5-acyl-2-furancarboxaldehyde... 详细信息

关键词： 2-acyl-5-dichloromethylfuran 5-acyl-2-furancarboxaldehyde 5-trimethyisilyl-2-furancarboxaldehyde acyldesilylation

Design,Synthesis of 6-Substituted-pyrido[3,2-d]pyridazine Derivatives with Anticonvulsant Activity

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Design,Synthesis of 6-Substituted-pyrido[3,2-d]pyridazine De...

双轴应变对NbSe_(2)/MoSi_(2)N_(4)肖特基势垒的调控

2011年全国药物化学学术会议——药物的源头创新

作者： Guo-Hua Gong Xiao-Mei Liu Cheng-Xi Wei zhe-shan quan~* College of Pharmacy,Yanbian University,Yanji,Jilin,133000,China,

＜正＞Aim to find new compounds with stronger anticonvulsant activity and lower neurotoxicity,a novel series of 6-substituted-pyrido[3,2-d]pyridazine derivatives was synthesized using furo[3,4-b] pyridine-5,7-dione as the starting *** anticonvulsant activities were evaluated by the maximal electroshock test（MES） and their neurotoxicities were measured by the rotarod ***

关键词： Pyrido[3,2-d]pyridazine Anticonvulsant Maximal electroshock Neurotoxicity

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原子与分子物理学报 2025年第5期42卷 182-188页

作者：张宇哲安梦雅谢泉贵州大学大数据与信息工程学院新型光电子材料与技术研究所贵阳550025

最近一种高质量的二维(Two-dimensional,2D)半导体材料MoSi_(2)N_(4)(MSN)在实验上被成功合成,具有优异的电气和机械性能.尽管最近有大量的研究致力于揭示MSN的材料特性,但到目前为止,对MSN的电接触物理特性的探索还比较少.在这项工作中... 详细信息

最近一种高质量的二维(Two-dimensional,2D)半导体材料MoSi_(2)N_(4)(MSN)在实验上被成功合成,具有优异的电气和机械性能.尽管最近有大量的研究致力于揭示MSN的材料特性,但到目前为止,对MSN的电接触物理特性的探索还比较少.在这项工作中,构建了金属-半导体NbSe_(2)/MSN肖特基结并使用第一性原理密度泛函理论计算研究了该肖特基结的材料特性.发现NbSe_(2)/MSN接触具有超低肖特基势垒高度(Schottky barrier height,SBH),这有利于纳米电子学应用.SBH可以通过施加双轴应变的方式进行有效的调控.当施加拉伸应变时能实现NbSe_(2)/MSN肖特基结由p型肖特基接触转变为p型欧姆接触,而当施加较大的压缩应变时能实现p型肖特基接触和n型肖特基接触之间的转换.我们的研究结果为MSN的2D电触点的物理特性提供了见解,并将为设计基于MSN的2D纳米器件的高性能电触点提供关键的一步.

关键词： MoSi_(2)N_(4) NbSe_(2) 肖特基结欧姆接触

Effect of Oscillation Parameters to Flow Field in the Pool during the Oscillating Twin-Roll Strip Casting Process

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Chinese Journal of Mechanical Engineering 2018年第6期31卷 187-194页

作者： Zhi-Qiang Xu zhe-Ru Meng Shun-Hui Xue De-quan Zhang Feng-shan Du School of Mechanical Engineering Yanshan University Qinhuangdao 066004 China National Engineering Research Center for Equipment and Technology of Cold Strip Rolling Yanshan University Qinhuangdao 066004 China shanghai XZS Heavy Machinery Integration Co. Ltd Shanghai 201900 China

During the oscillating twin?roll strip casting process, the quality of final products is directly influenced by the flow field distribution of molten metal in the pool. The variation in the flow field is caused by oscillating roller benefits, for homogeneous distribution of strip impurity, and decreasing the grain size. Thus, the quality of the strip could be improved. A numerical model was developed using the multiphase flow technology, coupled with heat transfer, fluid flow, solidification, and oscillation. Furthermore, a transient algorithm was adopted for simulating the oscillating twin?roll strip casting process of AlSi9Cu3 and 3104 aluminum alloy. This paper focuses on the flow distribution in the pool, in comparison with the traditional vertical twin?roll strip casting process, while the amplitude or frequency is chang?ing with the definite value of casting velocity, roller diameter, nozzle angle, and the strip thickness. Consequently, the conclusions were experimentally validated by oscillating twin?roll 3104 aluminum alloy strip casting. Vibrating casting technology can change the flow field in the pool by vibration, which can improve the quality of the strip core.

关键词： Flow field Oscillating twin?roll strip casting Solidification Twin?roll strip casting

Synthesis of Bisphenols Carrying Long Hydrocarbon Side Chains

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Chemical Research in Chinese Universities 2005年第1期21卷 65-68页

作者： XUJing-zhe JIANGNan-zhe ZHANGJian JIANGRi-shan DepartmentofChemistry YanbianUniversityYanji133002P.R.China

Bisphenols containing long aliphatic hydrocarbon side chains were synthesized by the condensation of phenol with aldehyde or ketone in the presence of heteropolyacid. Their structures were characterized by IR, 1H NMR, 13C NMR and element analysis. The experiment results show that when heteropolyacid was used as a catalyst, these bisphenols were obtained in high selectivity and high yields.

关键词： Bisphenols Heteropolyacid Phenol Condensation

Quasi-potential Method to Study Nonlinear Surface Shallow Water Waves

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Communications in Theoretical Physics 2004年第1X期42卷 117-120页

作者： DUANWen-shan DOUFu-quan DepartmentofPhysics NorthwestNormalUniversityLanzhou730070China

By using the potential method and the perturbation method under the condition of small amplitude and shallow water waves, we analytically get the KdV-type equation for a viscous shallow water. It indicates that for on... 详细信息

关键词：浅水波微扰理论孤立势粘滞效应流体力学

Constraining Ω with the fluctuation of the local Hubble flow

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Chinese Journal of Astronomy and Astrophysics 2009年第2期9卷 151-156页

作者： quan Guo Huan-Yuan shan National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China Graduate School of Chinese Academy of Sciences Beijing 100049 China

We present an analysis of the fluctuation of the local Hubble flow using 350 galaxies in the Local Volume （D 〈 5 Mpc, hereafter LV） with accurate measurements of distances, positions and radial velocities, and compare the results with the theoretical prediction of the local Hubble flow induced by density perturbations. This allows us to set a useful constraint on the local Ω parameters： ΩM - 0.6 and ΩA - 0.7, which may serve as compelling evidence for the existence of dark energy in the local Universe.

关键词： cosmology dark matter -- cosmology large-scale structure of universe --galaxies peculiar -- techniques radial velocities

Infrared optical coatings in SITP

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光学精密工程 2005年第4期13卷 483-486页

作者： LIU Ding-quan ZHANG Feng-shan shanghai Institute of Technical Physics Chinese Academy of Sciences Shanghai 200083 China

Infrared optical coatings in SITP (shanghai Institute of Technical Physics) mainly cover the spectrum range from 0.7 μm to 15 μm, and visible and near-UV range are also been included. The coatings are mainly used for metal-reflectance mirrors, Anti-reflection(AR) lens and windows, filters, and dichroic beam splitters. Coatings passed some dependability tests. These optical coated devices usually consist in a remote observing instrument. Most coating materials are commercial products. And one kind of special material PbTe is made by ourselves. Some main results of our research department are reported.

关键词：上海物理研究所光学涂覆技术红外线光谱