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Disease and Economic Burden of Kashin-Beck Disease—China,2021

China CDC weekly 2024年第2期6卷 40-44页

作者： Silu Cui Wenjun Que zhe jiao Qing Deng Xufeng Zhang Yanhong Cao Ning Liu Ailin Li Alphonse Sowanou zhe Li Tuo Wang Yang Li Jun Yu Junrui Pei NHC Key Laboratory of Etiology and Epidemiology(Harbin Medical University) Key Laboratory of Etiology and EpidemiologyEducation Bureau of Heilongjiang ProvinceInstitute of Kashin-Beck Disease ControlCenter for Endemic Disease ControlChinese Center for Disease Control and PreventionHarbin Medical UniversityHarbin CityHeilongjiang ProvinceChina NHC Key Laboratory of Etiology and Epidemiology(Harbin Medical University) Heilongjiang Provincial Key Laboratory of Trace Elements and Human HealthKey Laboratory of Etiology and EpidemiologyEducation Bureau of Heilongjiang ProvinceInstitute of Endemic Fluorosis ControlCenter for Endemic Disease ControlChinese Center for Disease Control and PreventionHarbin Medical UniversityHarbin CityHeilongjiang ProvinceChina

What is already known about this topic?Kashin-Beck disease(KBD)is a chronic and degenerative osteoarthropathy characterized by cartilage degeneration.It is an endemic disease that is highly prevalent among the Chinese population and poses a significant health risk.What is added by this report?This is the first national report on the economic burden of KBD in China.According to the data from 2021,KBD has caused significant disease and economic burdens.The most substantial reduction in healthy life expectancy was observed among patients with degree II severity and those aged 60 years and older,resulting in a total indirect economic burden of 112.74 million Chinese Yuan(CNY).What are the implications for public health practice?The results of this study will contribute to informing the development of tailored prevention and control strategies by the government.These strategies will include targeted policies and recommendations for appropriate healthcare and financial subsidies,which will be based on the demographic characteristics of the endemic areas.

关键词： prevention degeneration burden

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Investigations of an enclosed annular rotor-stator system with LES method

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Science China(Physics,Mechanics & Astronomy) 2018年第11期61卷 50-60页

作者： zhe jiao Song Fu School of Aerospace Engineering Tsinghua University

In this study, the flows in an enclosed annular rotor-stator system with the Reynolds number ranging from 0.75×105 to 3.75×105 and an aspect ratio of 36.5 are investigated using the LES method. Few studies have explored such a rotor-stator system with this aspect ratio and the flow structure on the rotor side. The mean flow structure varies from a torsional Couette type to a Batchelor type as the Reynolds number increases. The onset of the instability in the B?dewadt layer adjacent to the stator is delayed,whereas it is promoted in the Ekman layer adjacent to the rotor. Both the layers demonstrate rich spiral structures. Turbulent spirals are observed to occur at the rotor disk side that also generates TS-wave-like(Tollmien-Schlichting) structures between adjacent spiral arms. Further, the turbulence at the stator is complex and interesting. Statistically, the turbulence is highly anisotropic near both the rotating and nonrotating disks, which is depicted by the Reynolds stresses.

关键词：定子系统 LES 转子环形流动结构不稳定性各向异性邻近

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Review on formation mechanism analysis method and control strategy of urban haze in China

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Chinese Journal of Chemical Engineering 2019年第7期27卷 1572-1577页

作者： Weiqing Huang Lirong Cai Haifeng Dang zhe jiao Hongbo Fan Faliang Cheng School of Environment and Civil Engineering Guangdong Engineering and Technology Research Center for Advanced NanomaterialsDongguan University of TechnologyDongguan 523808China Guangdong Provincial Key Lab of Green Chemical Product Technology South China University of TechnologyGuangzhou 510640China

Due to the rapid urbanization and industrialization,and excessive consumption of fossil fuel,haze weather characterized by PM2.5 has become a severe pollution problem in major Chinese cities recently,which has harmful effect on the air quality,visibility,clime system and human health.To indicate suitable directions for the prevention and control of haze pollution,the pollutant source apportionment and formation mechanism of urban haze should be figured out firstly.In this work,we briefly review the frequently-used methods for PM2.5 source apportionment and formation mechanism analysis of urban haze based on normal perspective in recent years.Furthermore,based on the new perspective of systematic methodology,the utilization of fault tree approach for the causation mechanism analysis of urban haze is significantly introduced and discussed.Finally,the recent progress on controlling strategies of urban haze in China is also synoptically introduced and discussed.It is expected that more effective tool/method can be found,developed and employed for the causation mechanism analysis and risk management of urban haze in China.

关键词： Urban haze Fossil fuel Formation Sustainability

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基于磁性纳米材料Fe_(3)O_(4)@PPy和聚集诱导发光材料(TTAPE)检测肝素药品中的多硫酸软骨素残留

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现代化工 2024年第2期44卷 246-251页

作者：王玥婷焦哲曾燕艳东莞理工学院广东东莞523808

合成了一种聚吡咯修饰的磁性纳米颗粒(Fe_(3)O_(4)@PPy),通过结合AIE荧光探针四苯基乙烯衍生物(TTAPE)建立了一种检测肝素药品中多硫酸软骨素的检测方法。肝素和多硫酸软骨素与TTAPE结合导致运动受限,进而释放荧光,而Fe_(3)O_(4)@PPy加... 详细信息

合成了一种聚吡咯修饰的磁性纳米颗粒(Fe_(3)O_(4)@PPy),通过结合AIE荧光探针四苯基乙烯衍生物(TTAPE)建立了一种检测肝素药品中多硫酸软骨素的检测方法。肝素和多硫酸软骨素与TTAPE结合导致运动受限,进而释放荧光,而Fe_(3)O_(4)@PPy加入后可以猝灭其荧光。研究了肝素和多硫酸软骨素与TTAPE结合后荧光增强规律和Fe_(3)O_(4)@PPy对它们的荧光猝灭规律,建立了不同的猝灭曲线,进而同时检测肝素和多硫酸软骨素。实验确定了肝素和多硫酸软骨素的最佳荧光检测波长为482 nm,Fe_(3)O_(4)@PPy的使用量为5 mg,检测浓度的线性范围为0~3.5 mg/L,肝素浓度的相对偏差在0.5%以下。肝素实际样品中多硫酸软骨素的回收率为90%和96.67%,相对标准偏差为4.4%和4.1%。

关键词：肝素多硫酸软骨素聚集诱导发光磁性纳米材料淬灭荧光探针

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Advances in mesenchymal stem cells therapy for tendinopathies

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Chinese Journal of Traumatology 2024年第1期27卷 11-17页

作者： Xu-Feng Mao Xi-Qian Zhang zhe-Yu Yao Hai-jiao Mao Department of Orthopaedic Surgery The First Affiliated Hospital of Ningbo UniversityNingbo315010Zhejiang provinceChina

Tendinopathies are chronic diseases of an unknown etiology and associated with inflammation.Mesenchymal stem cells(MSCs)have emerged as a viable therapeutic option to combat the pathological progression of tendinopathies,not only because of their potential for multidirectional differentiation and self-renewal,but also their excellent immunomodulatory properties.The immunomodulatory effects of MSCs are increasingly being recognized as playing a crucial role in the treatment of tendinopathies,with MSCs being pivotal in regulating the inflammatory microenvironment by modulating the immune response,ultimately contributing to improved tissue repair.This review will discuss the current knowledge regarding the application of MSCs in tendinopathy treatments through the modulation of the immune response.

关键词： Mesenchymal stem cells Tendinopathy Immunomodulation Treatment Review

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Porous nanofibrous dressing enables mesenchymal stem cell spheroid formation and delivery to promote diabetic wound healing

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Chinese Journal of Chemical Engineering 2024年第4期68卷 156-164页

作者： Kexin Zhang Wenmin Zhang Heng An zhe Huang Yanzhen Wen Xiangyu jiao Yongqiang Wen College of Chemical Engineering and Technology Taiyuan University of Science and TechnologyTaiyuan 030024China Beijing Key Laboratory for Bioengineering and Sensing Technology Daxing Research InstituteSchool of Chemistry&Biological EngineeringUniversity of Science&Technology BeijingBeijing 100083China

Delayed and nonhealing of diabetic wounds imposes substantial economic burdens and physical pain on patients.Mesenchymal stem cells(MSCs)promote diabetic wound healing.Particularly when MSCs aggregate into multicellular spheroids,their therapeutic effect is enhanced.However,traditional culture platforms are inadequate for the efficient preparation and delivery of MSC spheroids,resulting in inefficiencies and inconveniences in MSC spheroid therapy.In this study,a three-dimensional porous nanofibrous dressing(NFD)is prepared using a combination of electrospinning and homogeneous freeze-drying.Using thermal crosslinking,the NFD not only achieves satisfactory elasticity but also maintains notable cytocompatibility.Through the design of its structure and chemical composition,the NFD allows MSCs to spontaneously form MSC spheroids with controllable sizes,serving as MSC spheroid delivery systems for diabetic wound sites.Most importantly,MSC spheroids cultured on the NFD exhibit improved secretion of vascular endothelial growth factor,basic fibroblast growth factor,and hepatocyte growth factor,thereby accelerating diabetic wound healing.The NFD provides a competitive strategy for MSC spheroid formation and delivery to promote diabetic wound healing.

关键词： Electrospinning Homogenization Biomedical engineering Nanomaterials Stem cell spheroids Diabetic wound healing

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Development of multi-functional anchorage support dynamic-static coupling performance test system and its application

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International Journal of Mining Science and Technology 2024年第3期34卷 339-349页

作者： Qi Wang Shuo Xu Bei Jiang Chong Zhang zhe Sun Jingxuan Liu Cailin jiao State Key Laboratory for Tunnel Engineering China University of Mining&Technology-BeijingBeijing 100083China Research Center of Geotechnical and Structural Engineering Shandong UniversityJinan 250061China

In underground engineering with complex conditions,the bolt(cable)anchorage support system is in an environment where static and dynamic stresses coexist,under the action of geological conditions such as high stresses and strong disturbances and construction conditions such as the application of high prestress.It is essential to study the support components performance under dynamic-static coupling conditions.Based on this,a multi-functional anchorage support dynamic-static coupling performance test system(MAC system)is developed,which can achieve 7 types of testing functions,including single component performance,anchored net performance,anchored rock performance and so on.The bolt and cable mechanical tests are conducted by MAC system under different prestress levels.The results showed that compared to the non-prestress condition,the impact resistance performance of prestressed bolts(cables)is significantly reduced.In the prestress range of 50–160 k N,the maximum reduction rate of impact energy resisted by different types of bolts is 53.9%–61.5%compared to non-prestress condition.In the prestress range of 150–300 k N,the impact energy resisted by high-strength cable is reduced by76.8%–84.6%compared to non-prestress condition.The MAC system achieves dynamic-static coupling performance test,which provide an effective means for the design of anchorage support system.

关键词： Anchorage support system Development of test system Dynamic-static coupling test Combined stress

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Computational Prediction of the Specificities of Proteasome Interaction With Antigen Protein

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Cellular & Molecular Immunology 2009年第2期6卷 135-142页

作者： Tao Liu Wei Liu zhe Song Chunbo jiao Minghua Zhu Xiaogang Wang College of Advanced Science and Technology Dalian University of Technology Dalian 116023 China

In the processing and presentation of antigenic peptides bound by the major histocompatibility complex （MHC） class I molecule, the ubiquitin-proteasome system of the eukaryotic cells plays an important role in proteolysis and degradation. The ubiquitinated protein substrate is delivered into the 26S proteasome to be digested and degraded. The proteasome degrading substrate is actually protein-protein interactions. Some researches of predicting proteasome cleave site rarely gave the information of the proteasome interacting with its substrate, and so the accuracy and reliability of these proteasome cleavage predictive methods still need to be improved. This paper used support vector machine method （SVM） to predict the proteasomal cleavage sites, and the predictive accuracy of the model was 82.8%. We showed analytically that the cleavage specificities of the cleavage sites ＂ ι＂ and its adjacent positions, and gave the information about the proteasome interacting with its substrate from our research results. It demonstrates that the proteasome cleaving to target protein is selective, but not random.

关键词： proteasome major histocompatibility complex support vector machine

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聚己内酯负载萘酐衍生物纳米纤维膜的制备及性能研究

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化学研究与应用 2024年第1期36卷 163-169页

作者：庄泽钊郑楠林管铮彭鸿靖蔡海东曾燕艳焦哲赵晓芳王玥婷梁志辉生态环境与建筑工程学院东莞理工学院广东东莞523808 国际微电子学院东莞理工学院广东东莞523808

本文通过静电纺丝法成功制备了掺杂2-氨基-6-肼基-1h-苯并[de]异喹啉-1,3-(2H)-二酮(AHB)分子的聚己内酯(PCL)纳米纤维膜(AHB-PCL),通过改变纺丝液浓度、纺丝工艺参数,确定最优纺丝工艺并对纤维微观形貌和荧光特性进行了测试。实验结果... 详细信息

本文通过静电纺丝法成功制备了掺杂2-氨基-6-肼基-1h-苯并[de]异喹啉-1,3-(2H)-二酮(AHB)分子的聚己内酯(PCL)纳米纤维膜(AHB-PCL),通过改变纺丝液浓度、纺丝工艺参数,确定最优纺丝工艺并对纤维微观形貌和荧光特性进行了测试。实验结果表明,该复合荧光纳米纤维膜具有良好的荧光性能,其平均直径为110.0 nm。纤维膜与甲醛接触后,在254 nm紫外光激发下,纤维上负载的AHB分子与甲醛分子结合,使得AHB分子的化学结构发生变化,从而抑制光诱导电子转移效应,使得纤维发出明亮的黄绿色荧光,且发光强度随甲醛浓度的增大而增大,随暴露时间的延长而加强。该复合纳米纤维膜最佳反应时间为20 min,当甲醛浓度为0.03-9.0 mmol/m~3范围内呈现良好的线性相关。本研究为工作场所中宽浓度范围甲醛的可视化检测提供一种便捷的方法,同时拓展了荧光薄膜的学科内涵。

关键词：纳米纤维膜光诱导电子转移荧光检测甲醛

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A recyclable method for titanium extraction and oxygen evolution from Ti-bearing slags

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Fundamental Research 2024年第1期4卷 86-94页

作者： zhenghao Pu Wei Wang zhe Wang Mingyin Kou Yiwa Luo Jianbang Ge Xin Tao Mingyong Wang Shuqiang jiao State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519080China

Despite its existence for more than 80 years,the titanium industry is still challenged by massive carbon emissions,high production costs,and large resource waste.More than one hundred million tons of Ti-bearing blast furnace slag(TB-slag)has been discarded in China because of the difficulty of reutilization,which requires efficient titanium extraction and recovery technologies.This paper describes a low-cost,carbon-emission-free method for Ti extraction and oxygen evolution via molten oxide electrolysis(MOE)vacuum distillation.After a comprehensive analysis of the binding energies and activities of liquid metals,the highlights of our study are as follows.1)Sb has the best preferential deposition of Ti among a series of high-Ti-affinitive liquid metal cathodes(Cu,Ni,Pb,Sn,and Sb).2)The Ir anode was first used in TB-slag with IrO_(2) formed on its surface to protect it from further corrosion.3)An alloy containing Ti and Ca can be obtained by MOE,and Ti and Ca metals can be refined by further vacuum distillation.4)A closed loop is formed in the overall process owing to the recyclable Sb cathode and continuous feeding of TB-slag into the electrolyte.This simple,low-cost,and environmentally friendly method can realize the efficient utilization of Ti resources and achieve carbon neutrality.

关键词： Titanium Molten oxide electrolysis Inert anodeLiquid cathode Depolarization

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