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Trends of alkaline phosphatase to prealbumin ratio in patients with hepatitis B linked to hepatocellular carcinoma development

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World Journal of Gastroenterology 2025年第2期31卷 42-51页

作者： Wen-Chong zhen Jing Sun Xue-Ting bai Qian Zhang Zi-Han Li Yi-Xin Zhang Rong-Xuan Xu Wei Wu Zhi-Han Yao chun-Wen Pu Xiao-Feng Li School of Public health Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Graduate School Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Dalian Public health Clinical Center Dalian Municipal Research Institute for Public HealthDalian 116001Liaoning ProvinceChina Department of Epidemiology and health Statistics Dalian Medical UniversityDalian 116044Liaoning ProvinceChina

BACKGROUND Chronic hepatitis B often progresses silently toward hepatocellular carcinoma(HCC),a leading cause of mortality *** detection of HCC is crucial,yet *** To investigate the role of dynamic changes in alkaline phosphatase to prealbumin ratio(APR)in hepatitis B progression to *** Data from 4843 patients with hepatitis B(January 2015 to January 2024)were *** incidence rates in males and females were compared using the log-rank *** were evaluated using Kaplan–Meier *** Linear Mixed-Effects Model was applied to track the fluctuation of APR levels over ***,Joint Modeling of Longitudinal and Survival data was employed to investigate the temporal relationship between APR and HCC *** The incidence of HCC was higher in *** ensure the model’s normality assumption,this study applied a logarithmic transformation to APR,yielding *** levels were higher in females(t=5.26,Pher risk of HCC in males(95%CI:1.653-2.431)and a 2.273-fold higher risk in females(95%CI:1.620-3.190).CONCLUSION Males are more prone to HCC,while females have higher APR *** no baseline APR link,rising APR indicates a higher HCC risk.

关键词： Alkaline phosphatase to prealbumin ratio Chronic hepatitis B patients hepatocellular carcinoma Retrospective cohort study Linear Mixed-Effect Mode Joint Modelling of Longitudinal and Survival data

Microstructure and mechanical properties of F_(GBA)/B_G air cooling bainitic steels containing niobium

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International Journal of Minerals,Metallurgy and Materials 2010年第4期17卷 429-434页

作者： chun Feng Hong-sheng Fang Bing-zhe bai Yan-kang zheng Department of Materials Science and Engineering Tsinghua University Beijing 100084 China

The effect of different Nb additions on the mechanical properties and microstrucmre evolution of grain boundary allotriomorphic ferrite （FGBA） / granular bainite （BG） air cooling bainitic steels was investigated. The results indicate that the tensile strength and yield strength increase by 157 and 97 MPa, respectively with the addition of 0.02wt% Nb. The steel acquires superior strength and toughness with the addition of 0.06wt% Nb. The results of scanning electron microscopy and transmission electron microscopy reveal that the addition of Nb not only refines the size of granular bainite but also increases the volume fraction of granular bainite in FGBA/BG steels. The refinement effect of granular bainite is improved with the increase of Nb content.

关键词： granular bainite microstructure evolution mechanical properties Nb

Statistical Measure for Risk-seeking Stochastic Wind Power Offering Strategies in Electricity Markets

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Journal of Modern Power Systems and Clean Energy 2022年第5期10卷 1437-1442页

作者： Dongliang Xiao Haoyong chen chun Wei Xiaoqing bai School of Electric Power South China University of TechnologyGuangzhou 510641China College of Information Engineering Zhejiang University of TechnologyHangzhouChina School of Electrical Engineering Guangxi UniversityNanningChina

This study proposes a statistical measure and a stochastic optimization model for generating risk-seeking wind power offering strategies in electricity markets. Inspired by the value at risk(VaR) to quantify risks in the worst-case scenarios of a profit distribution, a statistical measure is proposed to quantify potential high profits in the best-case scenarios of a profit distribution,which is referred to as value at best(VaB)in the best-case scenarios. Then, a stochastic optimization model based on VaB is developed for a risk-seeking wind power producer, which is formulated as a mixed-integer linear programming problem. By adjusting the parameters in the proposed model, the wind power producer can flexibly manage the potential high profits in the best-case scenarios from the probabilistic perspective. Finally, the proposed statistical measure and riskseeking stochastic optimization model are verified through case studies.

关键词： Electricity market risk-seeking statistical measure stochastic optimization wind power

Mn-Series Low-Carbon Air-Cooled bainitic Steel Containing Niobium of 0.02%

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Journal of Iron and Steel Research International 2010年第4期17卷 53-58页

作者： FENG chun FANG Hong-sheng zheNG Yan-kang bai Bing-zhe Department of Materials Science and Engineering Tsinghua University Beijing 100084 China

A new hot rolled low-carbon air-cooled bainitic steel containing Nb of 0.02% has been developed based on alloying design of the grain boundary allotriomorphic ferrite （FGBA）/granular bainite （BG） duplex steel. The as-rolled microstructure and mechanical properties of bainitie steel containing Nb of 0. 02% were investigated by tensile test, optical microscopy （OM）, scanning electron microscopy （SEM）, and transmission electron microscopy （TEM）. The results show that adding 0.02 % of Nb obviously improves the strength without sacrificing toughness of the FGBA/BG steel. Adding 0.02% of Nb not only refines the grain boundary allotriomorphic ferrite grains but also promotes the refinement of granular bainite including its bainitic ferrite and M/A island. Any Nb（C,N） has been hardly observed in the steel containing Nb of 0.02%. It is suggested that the strengthening mechanism of Nb of 0.02% can be mainly attributed to the effect of Nb in solution （solute drag-like effect） on the phase transformation rather than the precipitation strengthening of Nb（C, N） particles.

关键词： low-carbon air-cooled bainitic steel niobium microstructure mechanical property

Impact of finite-range tensor terms in the Gogny force on theβ-decay of magic nuclei

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Nuclear Science and Techniques 2021年第7期32卷 83-89页

作者： Da-Zhuang chen Dong-Liang Fang chun-Lin bai College of Physics Sichuan UniversityChengdu 610065China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China

Effects of finite-range tensor force onβ-decay of magic and semimagic nuclei of^(34)Si,^(68,78)Ni,and^(132)Sn have been investigated using the self-consistent Hartree–Fock plus random-phase approximation *** tensor force shifts the low-lying Gamow–Teller states downward and systematically improves the calculations of Q and logft ***,it systematically reduces the deviations between the theoretical and experimental data and significantly improves the calculation ofβ-decay *** effect is similar to that of zero-range tensor force.

关键词： tensor decay finite

Online social network model with renewal and accelerated growth

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The Journal of China Universities of Posts and Telecommunications 2014年第4期21卷 54-63页

作者： WU zhe GUO Yu-chun chen Chang-jia School of Electrical and Computer Engineering Beijing Jiaotong University

Based on observation of the growing mechanism in Twitter-like online social networks, an online social network （OSN） evolution model was proposed, a renewal mechanism for the old nodes and an accelerated growth mechanism was introduced for the new nodes, comparing with the native copying model. Topological characteristics of the generated networks, such as degree distribution, average shortest-path length and clustering coefficient, are analyzed and numerized. These properties are validated with some crawled datasets of real online social networks.

关键词： online social network network evolution model degree distribution average shortest-path length clustering coefficient

Multifunctional oxygen-enriching nano-theranostics for cancer-specific magnetic resonance imaging and enhanced photodynamic/photothermal therapy

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Nano Research 2020年第5期13卷 1389-1398页

作者： Li Zhang zhe Yang Jinghua Ren Li Ba Wenshan he chun-Yuen Wong Department of Chemistry City University of Hong KongHong KongChina Department of Breast and Thyroid Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China State Key Laboratory of Terahertz and Millimeter Waves City University of Hong KongHong KongChina Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

The combination of photodynamic therapy(PDT)and photothermal therapy(PTT)has attracted much interest in recent years,but non-specific distribution of photosensitizers and intrinsic tumor hypoxic microenvironment have continued to limit its therapeutic *** herein report a nano-theranostic system,denoted as Ce6-CuS/MSN@PDA@MnO2-FA NPs,which combines PDT,PTT,magnetic resonance(MR)imaging with hypoxia-relieving and tumor-targeting *** to this design is the use of mussel-inspired polydopamine(PDA)coating to encapsulate the chlorin e6(Ce6)and copper sulfide nanoparticles(CuS NPs)loaded mesoporous silica nanoparticle(MSN)*** PDA coating not only acts as pH sensitive gatekeeper to prevent the premature release of Ce6 under non-acidic tumor microenvironment(TME),but also facilitates post-functionalization so that hypoxia-relieving MnO2 nano-sheets and tumor-targeting ligand folic acid-PEG-thiol(FA-PEG-SH)can be decorated on the outer part of the drug *** vitro and in vivo measurements clearly demonstrated that all these functionalities worked synergistically as *** system,having a low dark cytotoxicity,can be effectively internalized by 4T1 cells and decrease the cell viability to 2%upon 660 nm/808 nm laser *** in 4T1 tumor-bearing mice can almost be completely destroyed in 2 weeks via combined PDT/*** with the TME-sensitive MR imaging performance demonstrated,Ce6-CuS/MSN@PDA@MnO2-FA NPs represent a multifunctional prototype which holds great potential to be developed into clinical theranostics.

关键词： hypoxia relief MnO2 nano-sheet photodynamic therapy photothermal therapy magnetic resonance imaging

Extremum response surface method of reliability analysis on two-link flexible robot manipulator

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Journal of Central South University 2012年第1期19卷 101-107页

作者： ZHANG chun-yi bai Guang-chen School of Jet Propulsion Beijing University of Aeronautics and AstronauticsBeijing 100191China School of Mechanical and Power Engineering Harbin University of Science and TechnologyHarbin 150080China

In order to present a new method for analyzing the reliability of a two-link flexible robot manipulator,Lagrange dynamics differential equations of the two-link flexible robot manipulator were established by using the integrated modal method and the multi-body system dynamics *** using the Monte Carlo method,the random sample values of the dynamic parameters were obtained and Lagrange dynamics differential equations were solved for each random sample value which revealed their displacement,speed and *** this basis,dynamic stresses and deformations were *** taking the maximum values of the stresses and the deformations as output responses and the random sample values of dynamic parameters as input quantities,extremum response surface functions were established.A number of random samples were then obtained by using the Monte Carlo method and then the reliability was analyzed by using the extremum response surface *** results show that the extremum response surface method is an efficient and fast reliability analysis method with high-accuracy for the two-link flexible robot manipulator.

关键词： reliability Monte Carlo method extremum response surface function flexible manipulator dynamic strength dynamicstiffness

Efficacy of the WINROP algorithm for retinopathy of prematurity screening in Southern China

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International Journal of Ophthalmology(English edition) 2021年第1期14卷 127-132页

作者： Yi-chen bai Rong Wu Si-zhe chen Shi-Yu Wei Hui-Jie chen Yan-chen chen Song-Fu Feng Xiao-he Lu Department of Ophthalmology Zhujiang HospitalSouthern Medical UniversityGuangzhou 510282Guangdong ProvinceChina Department of Ophthalmology Liuzhou People’s HospitalLiuzhou 545006Guangxi Zhuang Autonomous RegionChina Department of Pediatric Zhujiang HospitalSouthern Medical UniversityGuangzhou 510282Guangdong ProvinceChina

AIM:To evaluate the predicting efficacy of severe retinopathy of prematurity(ROP)by the WINROP algorithm(http://***)in Southern ***:All preterm infants with the gestational age(GA)less than 32 wk were *** ROP screening results and serial postnatal body weight were analysed *** body weight was entered into and measured by the WINROP *** outcomes were analysed,and the sensitivity,specificity,positive predictive value and negative predictive value(NPV)were ***:Totally 432 infants with a median GA of 30.0(24.0-31.9)wk,and a median birth weight(BW)of 1360(540-2700)g were *** these 432 infants,50 were diagnosed as type 1 ROP but only 28 were identified by the WINROP *** sensitivity was 56%(28/50)and the NPV was 92%(252/274).However,for infants with BWhe sensitivity was 93.8%(15/16)and 93.3%(14/15),***,with several postnatal complications added as additional risk factors,the sensitivity was increased to 96%(48/50).CONCLUSION:The sensitivity of the WINROP algorithm from the Southern Chinese cohort is not as high as that reported in developed *** algorithm is effective for detecting severe ROP from extremely small or preterm *** of the algorithm with additional risk factors could improve the predictive value for infants with a GA>28 wk in China.

关键词： retinopathy of prematurity WINROP preterm infants