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Journal of Energy Chemistry 2025年第1期100卷 702-709页

作者： Yiman Gu Yanchao Zhang Zhanyu Li Yijia Lei Baozeng Sun Xiaoyu Yu zhe wang College of Chemistry and Life Science Changchun University of Technology College of Chemical Engineering Changchun University of Technology School of Materials Science and Engineering Changchun University of Technology Key Laboratory of Advanced Functional Polymer Membrane Materials of Jilin Province

The development of alkaline fuel cells is moving forward at an accelerated pace,and the application of ether-free bonded polymers to anion exchange membranes （AEMs） has been widely ***,the question of the“trade-off”between AEM ionic conductivity and dimensional stability remains *** strategy of inducing microphase separation to improve the performance of AEM has attracted much attention recently,but the design of optimal molecular structures is still being ***,this work introduced different ratios of 3-bromo-1,1,1-trifluoroacetone （x=40,50,and 60） into the main chain of poly（p-terphenylene isatin）.Because fluorinated groups have excellent hydrophobicity,hydrophilic hydroxyl-containing side chains are introduced to jointly adjust the formation of phase separation *** results show that PTI-PTF50-NOH AEM with the appropriate fluorinated group ratio has the best ionic conductivity and alkali stability under the combined effect of *** has an ionic conductivity of 133.83 mS cm-1at 80°*** addition,the OH-conductivity remains at 89%of the initial value at 80°C and 3 M KOH for 1056 h of *** cell polarization curve based on PTI-PTF50-NOH shows a power density of 734.76 mW cm-2at a current density of 1807.7 mA cm-2.

关键词： Potassium hydroxide

FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

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Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： Jing Yao Yuan Li Xi Liu Wenping Liang Yu Li Liyong Wu zhe wang Weihong Song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor

An investigation on the wind profiles and gravity wave dynamics in MLT region based on the meteor radars from the Meridian Project

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Earth and Planetary Physics 2025年第1期9卷 29-38页

作者： Tai Liu zhe wang MengXi Shi Willie Soon ShiCan Qiu Department of Geophysics College of the Geology Engineering and GeomaticsChang’an UniversityXi’an 710054China Center for Environmental Research and Earth Sciences(CERES) SalemMA 01970USA Institute of Earth Physics and Space Science(ELKH EPSS) 9400SopronHungary

The meteor radar can detect the zenith angle,azimuth,radial velocity,and altitude of meteor trails so that one can invert the wind profiles in the mesosphere and low thermosphere(MLT)region,based on the Interferometric and Doppler *** this paper,the horizontal wind field,gravity wave(GW)disturbance variance,and GW fluxes are analyzed through the meteor radar observation from 2012−2022,at Mohe(53.5°N,122.4°E)and Zuoling(30.5°N,114.6°E)stations of the(Chinese)Meridian *** Lomb−Scargle periodogram method has been utilized to analyze the periodic variations for time series with observational data *** results show that the zonal winds at both stations are eastward dominated,while the meridional winds are southward *** variance of GW disturbances in the zonal and meridional directions increases gradually with height,and there is a strong pattern of annual *** zonal momentum flux of GW changes little with height,showing weak annual *** meridional GW flux varies gradually from northward to southward with height,and the annual periodicity is *** both stations,the maximum values of zonal and meridional wind occur close to the peak heights of GW flux,with opposite *** observational evidence is consistent with the filtering *** horizontal wind velocity,GW flux,and disturbance variance of the GW at Mohe are overall smaller than those at Zuoling,indicating weaker activities in the MLT at *** power spectral density(PSD)calculated by the Lomb−Scargle periodogram shows that there are 12-month period and 6-month period in horizontal wind field,GW disturbance variance and GW flux at both stations,and especially there is also a 4-month cycle in the disturbance *** PSD of the 12-month and 6-month cycles exhibits maximum values below 88 km and above 94 km.

关键词： meteor radar wind field gravity wave Lomb−Scargle method

THE DISTANCE BETWEEN DIFFERENT COMPONENTS OF THE UNIVERSAL TEICHMULLER SPACE

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Chinese Annals of Mathematics,Series B 2005年第4期26卷 537-542页

作者： wang zhe School of Mathematical Sciences Fudan University Shanghai 200433 China.

The model of the universal Teichmuller union of infinite disconnected components. between different components is 0, and the every other component is 2. space by the derivatives of logarithm is the In this paper, it i... 详细信息

关键词： Universal Teichmuller space Logarithmic derivative Quasiconformal extension

不同干细胞来源外泌体及其携非编码RNA诊疗骨性关节炎

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中国组织工程研究 2025年第19期29卷 4122-4131页

作者：王喆齐岩松徐永胜内蒙古自治区人民医院骨科中心(运动医学中心) 内蒙古自治区呼和浩特市010017

背景:外泌体可在骨性关节炎患者滑液和血浆中检测出来,其水平随着骨性关节炎的进展而不断变化,并且可以对骨性关节炎的局部炎症、软骨钙化和关节退化起缓解作用。目的:旨在全面了解不同干细胞来源外泌体在骨性关节炎诊疗中的作用和机制... 详细信息

背景:外泌体可在骨性关节炎患者滑液和血浆中检测出来,其水平随着骨性关节炎的进展而不断变化,并且可以对骨性关节炎的局部炎症、软骨钙化和关节退化起缓解作用。目的:旨在全面了解不同干细胞来源外泌体在骨性关节炎诊疗中的作用和机制,并提出了外泌体治疗骨性关节炎的前景和挑战。方法:检索PubMed及中国知网数据库,英文检索词为“exosomes,osteoarthritis,mesenchymal stem cells,stem cells”,中文检索词为“外泌体,骨性关节炎,间充质干细胞,干细胞”,对2003年10月至2023年10月发表的文献进行检索,最终纳入99篇文献进行综述。结果与结论:外泌体的出现给骨性关节炎的诊断和治疗带来了希望。外泌体内含RNA、蛋白质及脂类的差异能够作为骨性关节炎的生物标志物用于诊断。同时,来自不同干细胞的外泌体均能够有效保护软骨细胞、缓解炎症、维持软骨基质代谢以及调节血管生成和软骨下骨重塑,表现出治疗骨性关节炎的优秀潜力。工程化外泌体则突破传统局限,通过调节特定非编码RNA表达增强治疗特异性与效率,为骨性关节炎的治疗提供新策略。

关键词：外泌体骨性关节炎间充质干细胞干细胞软骨修复软骨再生软骨细胞 RNA 工程化外泌体

Seasonal freeze-thaw processes impact microbial communities of soil aggregates associated with soil pores on the Qinghai–Tibet Plateau

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Ecological Processes 2024年第2期13卷 279-292页

作者： Rui-zhe wang Xia Hu State Key Laboratory of Earth Surface Processes and Resource Ecology Faculty of Geographical Science Beijing Normal University School of Natural Resources Faculty of Geographical Science Beijing Normal University

Background Seasonal freeze-thaw(FT) processes alter soil formation and cause changes in soil microbial communi-ties, which regulate the decomposition of organic matter in alpine ecosystems. Soil aggregates are basic structural units and play a critical role in microbial habitation. However, the impact of seasonal FT processes on the distribution of microbial communities associated with soil pores in different aggregate fractions under climate change has been overlooked. In this study, we sampled soil aggregates from two typical alpine ecosystems(alpine meadow and alpine shrubland) during the seasonal FT processes(UFP: unstable freezing period, SFP: stable frozen period, UTP: unstable thawing period and STP: stable thawed period). The phospholipid fatty acid(PLFA) method was used to determine the biomass of living microbes in different aggregate *** The microbial biomass of 0.25–2 mm and 0.053–0.25 mm aggregates did not change significantly dur-ing the seasonal FT process while the microbial biomass of > 2 mm aggregates presented a significant difference between the STP and UTP. Bacterial communities dominated the microbes in aggregates, accounting for over 80% of the total PLFAs. The microbial communities of soil aggregates in the surface layer were more sensitive to the sea-sonal FT process than those in other soil layers. In the thawing period, Gram positive bacteria(GP) was more dominant. In the freezing period, the ratio of Gram-positive to Gram-negative bacterial PLFAs(GP/GN) was low because the enrichment of plant litter facilitated the formation of organic matter. In the freezing process, pores of 30–80 μm(mesopores) favored the habitation of fungal and actinobacterial communities while total PLFAs and bacterial PLFAs were negatively correlated with mesopores in the thawing *** The freezing process caused a greater variability in microbial biomass of different aggregate fractions. The thawing process increased the differences in

关键词： Phospholipid fatty acid Seasonal freeze-thaw process Soil aggregate Soil microbial biomass Soil pore

Late Cenozoic Deformation Sequence of a Thrust System along the Eastern Margin of Pamir,Northwest China

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Acta Geologica Sinica(English Edition) 2016年第5期90卷 1664-1678页

作者： wang zhe wang Xin School of Earth Sciences Zhejiang University

A thrust belt formed in the basin along the eastern margin of *** thrust belt is about 50 km wide,extends about 200 km,and includes three compressive structures from south to north：the blind Qipan structural wedge and Qimugen structural wedge,and the exposed Yengisar *** thrust belt displays a right-stepping en echelon *** Qipan structural wedge dies out northward to the west of the Qimugen structural wedge,and the Qimugen structural wedge dies out northward to the west of the Yengisar *** analysis of seismic reflection profiles of the western Tarim Basin reveal that fan-shaped growth strata were deposited in the shallow part of the thrust belt,recording the deformation sequence of the thrust *** depth of the Cenozoic growth strata decreases from south to *** growth strata of the Qipan structural wedge is located in the middle-lower section of the Pliocene Artux Formation（N2a）,the growth strata of the Qimugen structural wedge is close to the bottom of the Pleistocene Xiyu Formation（Q1x）,and the growth strata of the Yengisar anticline is located in the middle section of the Xiyu Formation（Q1x）.Combined with magnetostratigraphic studies in the western Tarim basin,it can be preliminarily inferred that the deformation sequence of the thrust belt along the eastern margin of Pamir is progressively younger *** geometry and kinematic evolution of the thrust belt in the eastern margin of Pamir can be compared with previous analogue modeling experiments of transpressional deformation,suggesting that the thrust belt was formed in a transpressional tectonic setting.

关键词： Pamir Tarim thrust belt growth Strata deformation sequence

Effect of cavity defect on the triaxial mechanical properties of high-performance concrete

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Frontiers of Structural and Civil Engineering 2022年第5期16卷 600-614页

作者： Yanbin ZHANG zhe wang Mingyu FENG School of Civil Engineering Beijing Jiaotong UniversityBeijing100044China

The stress concentration of pipe structure or cavity defect has a great effect on the mechanical properties of the high-performance concrete(HPC)members in deep underground ***,the behaviour of HPC with cavities under triaxial compression is not understood,especially when pressurized liquid flows into the fractures from the *** study aims to investigate the effect of the cavity and the confining pressure on the failure mechanisms,strengths,and deformation properties of HPC with a new experimental *** this experiment,the pressurized liquid can only contact the surface of the sample in the cavity,while the other surfaces are isolated from the pressurized *** further explore the effect of the cavity,the same experiments are also conducted on sealed and unsealed intact samples without a *** failure modes and stress-strain curves of all types of the samples are *** various confining pressures,all the samples with a cavity suffer shear failure,and there are always secondary tensile fractures initiating from the cavity ***,it can be determined from the failure modes and the stress-strain curves that the shear fractures result from the sidewall *** on the different effects of the cavity on the lateral deformations in different directions,the initiation of the sidewall fracture is well *** experimental results show that both the increase of the confining pressure and the decrease of the cavity size are conducive to the initiation of sidewall ***,the cavity weakens the strength of the sample,and this study gives a modified Power-law criterion in which the cavity size is added as an impact factor to predict the strength of the sample.

关键词： high-performance concrete cavity conventional triaxial compression pressurized liquid modified power-law criterion

Mechanical properties of thermal aged HTPB composite solid propellant under confining pressure

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Defence Technology（防务技术） 2022年第4期18卷 618-625页

作者： zhe-jun wang Hong-fu Qiang 206 Staff Room Xi’an Hi-Tech InstituteXi'an710025PR China

With the purpose of investigating the effects of confining pressure and aging on the mechanical properties of Hydroxyl-terminated polybutadiene(HTPB)based composite solid propellant,tensile tests of thermal accelerated aged propellant samples under room temperature and different confining pressure conditions were performed through the use of a self-made confining pressure device and conventional testing ***,the maximum tensile stressσmand the corresponding strainεm for the propellant under different test conditions were obtained and *** results indicate that confining pressure and aging can significantly affect the mechanical properties of HTPB propellant,and the coupled effects are very *** the one hand,the stressσmincreases as a whole when confining pressure becomes higher or thermal aging time ***,this stress is more sensitive to aging with increasing confining *** are almost three regions in the stress increments(σm P-σm0)/σm0and thermal aging time curves for HTPB *** maximum value of the stress increment(σm P-σm0)/σm0for the propellant is about 98%at 7.0 MPa and 170 *** the other hand,the strainεm decreases with increasing thermal aging time under the whole confining pressure ***,the variation of this strain with confining pressure is more complex at various thermal aging time,which is different from that of unaged solid propellant in previous *** addition,this strain is slightly less sensitive to aging as the confining pressure ***,there is also a critical confining pressure in this investigation,whose value is between 0.15 MPa and 4.0 *** this critical pressure,the trends of the stressσmand the corresponding strainεm all ***,there are some critical thermal aging time for the stress increment(σm P-σm0)/σm0and strain increment(εm P-εm0)/εm0of HTPB propellant in this investigation,which are about at 35,50 and 170 ***,based on the tw

关键词： Thermal accelerated aging Confining pressure Hydroxyl-terminated polybutadiene propellant Mechanical properties Strength criterion

Ozonation of aromatic monomer compounds in water: factors determining reaction outcomes

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Frontiers of Environmental Science & Engineering 2023年第5期17卷 13-25页

作者： zhe wang Wenjuan Zhang Zhiwei wang Jing Chang School of Environmental Science and Safety Engineering Tianjin University of TechnologyTianjin 300384China School of Environmental and Municipal Engineering Tianjin Key Laboratory of Aquatic Science and TechnologyTianjin Chengjian UniversityTianjin 300384China Tianjin Municipal Engineering Design&Research Institute Co. Ltd.Tianjin 300384China

For aromatic monomer compounds (AMCs), ozonation outcomes were usually predicted by the substituents of the benzene ring based on the electron inductive effect. However, the predicted results were occasionally unreliable for complex substituents, and other factors caused concern. In this study, p-chloronitrobenzene (p-CNB) and ibuprofen (IBP) were selected for ozonation. According to the electron inductive theory, p-CNB should be less oxidizable, but the opposite was true. The higher rates of p-CNB were due to various sources of assistance. First, the hydroxyl radical (•OH) contributed 90 % to p-CNB removal at pH 7.0, while its contribution to IBP removal was 50 %. Other contributions came from molecular O3 oxidation. Second, p-CNB achieved 40 % of the total organic carbon (TOC) removal and fewer by-product types and quantities, when compared to the results for IBP. Third, the oxidation of p-CNB started with hydroxyl substitution reactions on the benzene ring;then, the ring opened. However, IBP was initially oxidized mainly on the butane branched chain, with a chain-shortening process occurring before the ring opened. Finally, the degradation pathway of p-CNB was single and consumed fewer oxidants. However, both branches of IBP were attacked simultaneously, and three degradation pathways that relied on more oxidants were proposed. All of these factors were determinants of the rapid removal of p-CNB.

关键词： Ozonation Aromatic compound Oxidizing specie By-product Initial reaction position Degradation pathway