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The PI3K/Akt/GSK-3β/ROS/eIF2B pathway promotes breast cancer growth and metastasis via suppression of NK cell cytotoxicity and tumor cell susceptibility

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Cancer Biology & Medicine 2019年第1期16卷 38-54页

作者： Fengjiao Jin zhaozhen wu Xiao Hu Jiahui Zhang Zihe Gao Xiao Han Junfang Qin Chen Li Yue Wang School of Medicine Nankai University Institute of Biomedical Engineering Chinese Academy of Medical Sciences & Peking Union Medical College State Key Laboratory of Medicinal Chemical Biology Nankai University

Objective: To examine the effect of pSer9-GSK-3β on breast cancer and to determine whether the underlying metabolic and immunological mechanism is associated with ROS/eIF2B and natural killer(NK) ***: We employed TWS119 to inactivate GSK-3β by phosphorylating Ser9 and explored its effect on breast cancer and NK cells. The expression of GSK-3β, natural killer group 2 member D(NKG2D) ligands, eIF2B was quantified by PCR and Western blot. We measured intracellular reactive oxygen species(ROS) and mitochondrial ROS using DCFH-DA and MitoSOX^(TM) probe,respectively, and conducted quantitative analysis of cellular respiration on 4T1 cells with mitochondrial respiratory chain complex Ⅰ/Ⅲ ***: Our investigation revealed that TWS119 downregulated NKG2D ligands(H60 a and Rae1), suppressed the cytotoxicity of NK cells, and promoted the migration of 4T1 murine breast cancer cells. Nevertheless, LY290042, which attenuates p-GSK-3β formation by inhibiting the PI3K/Akt pathway, reversed these effects. We also found that higher expression of p Ser9-GSK-3β induced higher levels of ROS, and observed that abnormality of mitochondrial respiratory chain complex Ⅰ/Ⅲ function induced the dysfunction of GSK-3β-induced electron transport chain, naturally disturbing the ROS level. In addition, the expression of NOX3 and NOX4 was significantly up-regulated, which affected the generation of ROS and associated with the metastasis of breast cancer. Furthermore, we found that the expression of pSer535-eIF2B promoted the expression of NKG2D ligands(Mult-1 and Rae1) following by expression of pSer9-GSK-3β and generation of ***: The PI3K/Akt/GSK-3β/ROS/eIF2B pathway could regulate NK cell activity and sensitivity of tumor cells to NK cells,which resulted in breast cancer growth and lung metastasis. Thus, GSK-3β is a promising target of anti-tumor therapy.

关键词： GSK-3β NK cells NKG2D/NKG2DLs ROS eIF2B breast cancer

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奥拉帕尼联合帕博利珠单抗二线治疗广泛期小细胞肺癌的疗效和安全性

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中华肿瘤杂志 2020年第7期42卷 590-593页

作者：吴朝真张素洁胡毅南开大学医学院天津300071 解放军总医院第一医学中心肿瘤内科北京100853

目的:分析40~80岁广泛期小细胞肺癌(SCLC)患者接受二线奥拉帕尼联合帕博利珠单抗治疗以及帕博利珠单抗单药治疗的疗效和安全性。方法:选取2017年3月至2019年10月就诊于解放军总医院的一线标准化疗方案后进展或复发的SCLC患者21例,联合... 详细信息

目的:分析40~80岁广泛期小细胞肺癌(SCLC)患者接受二线奥拉帕尼联合帕博利珠单抗治疗以及帕博利珠单抗单药治疗的疗效和安全性。方法:选取2017年3月至2019年10月就诊于解放军总医院的一线标准化疗方案后进展或复发的SCLC患者21例,联合组接受奥拉帕尼(300 mg口服,每日2次)联合帕博利珠单抗(200 mg静脉滴注,每3周1次)治疗;单药组接受帕博利珠单抗(200 mg静脉滴注,每3周1次)治疗。结果:联合组和单药组患者的客观有效率分别为45.5%和10.0%(P=0.149),疾病控制率分别为81.8%和70.0%(P=0.635),中位无进展生存时间分别为5.93和3.53个月(P=0.036),中位总生存时间分别为10.43和8.43个月(P=0.063)。联合组和单药组患者的不良反应发生率分别为90.9%和70.0%(P=0.311),Ⅲ级及以上不良反应包括骨髓抑制(36.4%和10.0%,P=0.311)、胃肠道反应(9.1%和10.0%,P=1.000)和其他免疫相关不良反应(18.2%和30.0%,P=1.000)。多因素分析显示,转移灶数目(P=0.006)、铂类敏感性(P=0.036)和乳酸脱氢酶水平(P=0.022)为影响患者联合用药疗效的独立因素。结论:帕博利珠单抗联合奥拉帕尼初步显示较好的疗效,安全性可耐受,或可成为SCLC患者二线治疗方案的选择。

关键词：癌,小细胞肺奥拉帕尼帕博利珠单抗二线治疗

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超早期与非超早期介入栓塞治疗颅内破裂动脉瘤的临床疗效评价

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立体定向和功能性神经外科杂志 2020年第5期33卷 288-292页

作者：李登锋吴昭镇许光汕尾市人民医院神经外科汕尾市516600

目的探讨超早期与非超早期动脉瘤介入栓塞术治疗在颅内动脉瘤破裂患者中的临床差异。方法选择我院收治的60例颅内动脉瘤破裂病人作为研究对象,随机分为试验组和对照组,试验组患者在超早期采用介入栓塞术治疗,对照组患者在非超早期采用... 详细信息

目的探讨超早期与非超早期动脉瘤介入栓塞术治疗在颅内动脉瘤破裂患者中的临床差异。方法选择我院收治的60例颅内动脉瘤破裂病人作为研究对象,随机分为试验组和对照组,试验组患者在超早期采用介入栓塞术治疗,对照组患者在非超早期采用介入栓塞术治疗,比较两组患者一般资料、手术相关指标、住院相关指标,以及临床疗效和预后指标,进而评估两种治疗策略的临床差异。结果两组患者在性别、年龄、烟酒史、高血压病史、Hunt-Hess分级、动脉瘤位置、入院时NIHSS评分上无统计学差异,具有可比性(P>0.05)。手术相关指标中,超早期治疗组患者在术前动脉瘤破裂再出血例数较非超早期治疗组更少,差异有统计学意义(P<0.05)。在住院相关指标中,超早期治疗组患者的术后卧床时间、住院时间、治疗费用均较非超早期治疗组更少,差异有统计学意义(P<0.05)。在临床治疗效果和预后指标中,超早期治疗组患者术后第6个月时的mRS评分、MoCA评分均较非超早期治疗组患者更好,差异有统计学意义(P<0.05)。结论超早期介入栓塞治疗动脉瘤可有效降低术前动脉瘤破裂再出血发生率,减少住院时间和降低医疗费用,并改善了患者的临床预后,但需要注意超早期治疗术中脑血管痉挛、动脉瘤破裂出血的预防。

关键词：动脉瘤超早期治疗非超早期治疗临床效果临床预后

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Occlusion Effect of a Long-pulsed 532nm Laser on Veins

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光机电信息 2005年第4期22卷 28-31页

作者： ZHANGLai-ming YANGGui-long LIDian-jun LUQi-peng GUHua-dong ZHULin-lin zhaozhen-wu LIXin WANGJing-ping TANGYu-guo GUOJin ChangchunInstituteofOptics FineMechanicsandPhysicsChineseAcadcmyofSciencesChangchun130033China

Laser treatment represents an attractive option to other methods of vessel diseases especially varicose veins. A long pulse (30-50ms) 532nm laser was used in our experiments, with the pulse duration matching the thermal relaxation time of the vessels and the green laser matching the absorption spectrum peak of the *** irradiates nude vein vessels directly or exterior skin to finish operation faster and to acquire the practical data for upper enteron varicose vein treatment in several animal experiments performed in vivo. The 5Jenergy pulse allows us to finely occlude rabbit or dog's vein vessels up to 2 mm in diameter when irradiating them off external skin. Blood vessels are occluded at once, and later biopsy specimens show the immediate and long-term lasting occlusion effect. While vessels are irradiated directly, they are usually irradiated to perforate, detailed causes are still under investigation. Animal experiments showed that the long pulse green laser therapy is a safe and effective solution to the vein's occlusion, which promises such laser with high energy of each pulse and 30-50 ms duration is an ideal candidate for vessel diseases treatment.

关键词：长脉冲激光器静脉血管封闭效应 EVLT 静脉曲张

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晚期尿路上皮癌患者一线应用PD-1单抗联合化疗与单纯化疗临床疗效及安全性比较

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解放军医学院学报 2021年第3期42卷 241-245页

作者：韩馥馨吴朝真李晓燕张素洁胡毅解放军总医院研究生院/解放军医学院北京100853 解放军总医院第一医学中心肿瘤内科全军肿瘤学重点实验室肿瘤靶向治疗和抗体药物教育部重点实验室北京100853 首都医科大学附属北京胸科医院肿瘤二科北京101149

背景免疫检查点抑制剂在尿路上皮癌(urothelial carcinoma,UC)的治疗中显示出较好疗效,但PD-1单抗联合化疗作为晚期UC患者一线治疗方案的疗效鲜有研究。目的比较晚期尿路上皮癌患者一线应用PD-1单抗联合化疗与单纯化疗的疗效及安全性。... 详细信息

背景免疫检查点抑制剂在尿路上皮癌(urothelial carcinoma,UC)的治疗中显示出较好疗效,但PD-1单抗联合化疗作为晚期UC患者一线治疗方案的疗效鲜有研究。目的比较晚期尿路上皮癌患者一线应用PD-1单抗联合化疗与单纯化疗的疗效及安全性。方法收集解放军总医院第一医学中心肿瘤内科2017年3月-2020年4月一线治疗的局部进展期或转移性UC患者。51例接受吉西他滨或紫杉醇(白蛋白结合型)联合铂类化疗的患者为化疗组,30例接受PD-1单抗联合化疗的患者为免疫联合化疗组。结果两组基线资料差异无统计学意义(P>0.05)。免疫联合化疗组的中位无进展生存期为15.8个月(95%CI:8.135~23.598),较化疗组的7.17个月(95%CI:5.94~8.40)显著延长(P=0.020)。免疫联合化疗组与化疗组的客观缓解率分别为46.7%和49.0%(P=0.999),疾病控制率分别为90.0%和80.4%(P=0.353),不良反应发生率分别为83.3%和84.3%(P=0.908),Ⅲ~Ⅳ级不良反应发生率分别为33.3%和35.3%(P=0.858),差异均无统计学意义。结论在晚期尿路上皮癌患者的一线治疗中,PD-1单抗联合化疗较单纯化疗有更好的疗效,两组不良反应相当。

关键词：尿路上皮癌 PD-1单抗化疗无进展生存期药物不良反应

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Review of precipitation strengthening in ultrahigh-strength martensitic steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 256-269页

作者： Zhihao Tian Chunlei Shang Chaolei Zhang Xiaoye Zhou Honghui wu Shuize Wang Guilin wu Junheng Gao Jiaming Zhu Xinping Mao Institute for Carbon Neutrality University of Science and Technology BeijingBeijing 100083China Institute of Steel Sustainable Technology Liaoning Academy of MaterialsShenyang 110004China Department of Materials Science and Engineering Shenzhen MSU-BIT UniversityShenzhen 518172China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China School of Civil Engineering Shandong UniversityJinan 250061China

Martensite is an important microstructure in ultrahigh-strength steels,and enhancing the strength of martensitic steels often involves the introduction of precipitated phases within the martensitic *** considerable research efforts devoted to this area,a systematic summary of these advancements is *** review focuses on the precipitates prevalent in ultrahigh-strength martensitic steel,primarily carbides(e.g.,MC,M_(2)C,and M_(3)C)and intermetallic compounds(e.g.,Ni Al,Ni_(3)X,and Fe_(2)Mo).The precipitation-strengthening effect of these precipitates on ultrahigh-strength martensitic steel is discussed from the aspects of heat treatment processes,microstructure of precipitate-strengthened martensite matrix,and mechanical ***,a perspective on the development of precipitation-strengthened martensitic steel is presented to contribute to the advancement of ultrahigh-strength martensitic *** review highlights significant findings,ongoing challenges,and opportunities in the development of ultrahigh-strength martensitic steel.

关键词： ultrahigh-strength martensitic steel precipitation strengthening mechanical property carbide intermetallic compound

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Superhydrophobic and corrosion-resistant siloxane-modified MgAl-LDHs coatings on magnesium alloy prepared under mild conditions

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 450-463页

作者： Wenxi Zhang Zhangzelong Zhuo Dan Xu Liang wu Zhihui Xie Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province College of Chemistry and Chemical EngineeringChina West Normal UniversityNanchong 637002China College of Materials Science and Engineering/National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China

We have developed a superhydrophobic and corrosion-resistant LDH-W/PFDTMS composite coating on the surface of Mg *** composite comprised a tungstate-intercalated(LDH-W)underlayer that was grown at low temperature(relative to hydrothermal reaction conditions)under atmospheric pressure and an outer polysiloxane layer created from a solution containing perfluorodecyltrimethoxysilane(PFDTMS)using a simple immersion *** successful intercalation of tungstate into the LDH phase and the following formation of the polysiloxane layer were confirmed through X-ray diffraction(XRD),Fourier transform infrared(FTIR)spectroscopy,and X-ray photoelectron spectroscopy(XPS).The corrosion resistance of the LDH-W film,both before and after the PFDTMS modification,was evaluated using electrochemical impedance spectroscopy(EIS),Tafel curves,and immersion *** results showed that Mg coated with LDH-W/PFDTMS exhibited significantly enhanced corrosion protection compared to the unmodified LDHW film,with no apparent signs of corrosion after exposure to 3.5wt%NaCl solution for 15 ***,the LDH-W/PFDTMS coating demonstrated superior superhydrophobicity and self-cleaning properties against water and several common beverages,as confirmed by static contact angle and water-repellency *** results offer valuable insights into preparing superhydrophobic and corrosion-resistant LDH-based composite coatings on Mg alloy surfaces under relatively mild reaction conditions.

关键词： Mg alloy corrosion coating layered double hydroxide

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Multi-layer multi-pass friction rolling additive manufacturing of Al alloy:Toward complex large-scale high-performance components

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 425-438页

作者： Haibin Liu Run Hou Chenghao wu Ruishan Xie Shujun Chen College of Mechanical&Energy Engineering Beijing University of TechnologyBeijing 100124China Chongqing Research Institute of Beijing University of Technology Chongqing 401121China

At present,the emerging solid-phase friction-based additive manufacturing technology,including friction rolling additive man-ufacturing(FRAM),can only manufacture simple single-pass *** this study,multi-layer multi-pass FRAM-deposited alumin-um alloy samples were successfully prepared using a non-shoulder tool *** material flow behavior and microstructure of the over-lapped zone between adjacent layers and passes during multi-layer multi-pass FRAM deposition were studied using the hybrid 6061 and 5052 aluminum *** results showed that a mechanical interlocking structure was formed between the adjacent layers and the adja-cent passes in the overlapped center *** friction and rolling of the tool head led to different degrees of lateral flow and plastic deformation of the materials in the overlapped zone,which made the recrystallization degree in the left and right edge zones of the over-lapped zone the highest,followed by the overlapped center zone and the non-overlapped *** tensile strength of the overlapped zone exceeded 90%of that of the single-pass deposition *** is proved that although there are uneven grooves on the surface of the over-lapping area during multi-layer and multi-pass deposition,they can be filled by the flow of materials during the deposition of the next lay-er,thus ensuring the dense microstructure and excellent mechanical properties of the overlapping *** multi-layer multi-pass FRAM deposition overcomes the limitation of deposition width and lays the foundation for the future deposition of large-scale high-performance components.

关键词： aluminum alloy additive manufacturing solid-state friction stir welding multi-layer multi-pass

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Nanostructured ZnO/BiVO_(4)I-scheme heterojunctions for piezocatalytic degradation of organic dyes via harvesting ultrasonic vibration energy

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 488-497页

作者： Yiling Li Xiaoyao Yu Yingjie Zhou Yao Lin Ying wu Key Laboratory of the Ministry of Education for Advanced Catalysis Materials College of Chemistry and Materials ScienceZhejiang Normal UniversityJinhua 321004China

BiVO_(4)porous spheres modified by ZnO were designed and synthesized using a facile two-step *** resulting ZnO/BiVO_(4)composite catalysts have shown remarkable efficiency as piezoelectric catalysts for degrading Rhodamine B(RhB)unde mechanical vibrations,they exhibit superior activity compared to pure *** 40wt%ZnO/BiVO_(4)heterojunction composite displayed the highest activity,along with good stability and *** enhanced piezoelectric catalytic activity can be attributed to the form ation of an I-scheme heterojunction structure,which can effectively inhibit the electron-hole ***,hole(h+)and superoxide radical(·O_(2)^(-))are proved to be the primary active ***,ZnO/BiVO_(4)stands as an efficient and stable piezoelectric catalyst with broad potential application in the field of environmental water pollution treatment.

关键词： piezoelectric catalytic heterojunction dye degradation ultrasonic vibration

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Plasmonic tandem heterojunctions enable high-efficiency charge transfer for broad spectrum photocatalytic hydrogen production

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Journal of Energy Chemistry 2025年第1期100卷 710-720页

作者： Wenxuan Chen Xiu-Qing Qiao Guo Hui Bojing Sun Dongfang Hou Meidi Wang Xueqian wu Tao wu Dong-Sheng Li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University Hubei Three Gorges Laboratory College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semiconductor photocatalysts for efficient hydrogen production is of great significance but still challenging,primarily due to the limitations in charge transfer ***,a fascinating plasmonic tandem heterojunction with the hc-CdS/Mo2C@C heterostructure is aimfully prepared for effectively promoting the charge separation kinetics of the CdS photocatalyst via the synergistic strategy of phase junction,Schottky junction,and photothermal *** difference in atomic configuration between cubic-CdS （c-CdS） and hexagonal-CdS （h-CdS） leads to effective charge separation through a typical Ⅱ charge transfer mechanism,and plasmonic Schottky junction further extracts the electrons in the hc-CdS phase junction to realize gradient charge ***,the photothermal effect of Mo2C@C helps to expand the light absorption,accelerate charge transfer kinetics,and reduce the hydrogen evolution energy *** carbon layer provides a fast channel for charge transfer and protects the photocatalyst from *** a result,the optimized hc-CMC photocatalyst exhibits a significantly high photocatalytic H2production activity of 28.63 mmol/g/h and apparent quantum efficiency of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhance the charge transfer kinetics and photocatalytic activity of CdS by constructing plasmonic tandem heterogeneous junctions.

关键词： Heterojunctions LSPR Photocatalyst Phase junction Schottky junction Photothermal effect

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