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Pivotal roles of tumor-draining lymph nodes in the abscopal effects from combined immunotherapy and radiotherapy

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Cancer Communications 2022年第10期42卷 971-986页

作者： zhaoyun liu Zhiyong Yu Dawei Chen Vivek Verma Chenxi Yuan Minglei Wang Fei Wang Qing Fan Xingwu Wang Yang Li Yuequn Ma Meng Wu Jinming Yu Department of Oncology Shandong University Cancer CenterJinanShandong 250117P.R.China Department of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinanShandong 250117P.R.China Breast Cancer Center Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinanShandong 250117P.R.China Department of Radiation Oncology The University of Texas MD Anderson Cancer CenterHoustonTexas 77030United States Department of Pharmacy Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinanShandong 250117P.R.China Research Unit of Radiation Oncology Chinese Academy of Medical SciencesJinanShandong 250117P.R.China

Background:Currently,due to synergy enhancement of anti-tumor effects and potent stimulation of abscopal effects,combination therapy with irradiation and programmed cell death protein 1/programmed death-ligand 1(PD-1/PD-L1)immune checkpoint inhibition(immuno-radiotherapy,iRT)has revolutionized the therapeutic *** has been demonstrated that tumor-draining lymph nodes(TDLN)are essential for effective antitumor immunity induced by radiotherapy,immunotherapy,or *** that the function of TDLN in iRT remains unclear,this study aimed to investigate the function and mechanism of TDLN in iRT-induced abscopal ***:The function of TDLN was evaluated using unilateral or bilateral MC38 and B16F10 subcutaneous tumor models with or without indicated *** flow cytometry,multiple immunofluorescence analysis,and NanoString analysis were utilized to detect the composition and function of the immune cells in the primary and abscopal tumor ***ally,we tempted to interrogate the possible mechanisms via RNA-sequencing of tumor-infiltrating lymphocytes and ***:TDLN deficiency impaired the control of tumor growth by monother*** TDLN removal rather than unilateral TDLN removal substantially curtailed iRT-stimulated anti-tumor and abscopal ***,in the absence of TDLN,the infiltration of CD45+and CD8+T cells was substantially reduced in both primary and abscopal tumors,and the anti-tumor function of CD8+T cells was attenuated as ***,the polarization of tumor-associated macrophages in primary and abscopal tumors were found to be dependent on intact bilateral ***-sequencing data indicated that impaired infiltration and anti-tumor effects of immune cells partially attributed to the altered secretion of components from the tumor ***:TDLN play a critical role in iRT by promoting the infiltration of CD8+T cells and maintaining the M1/M2 macrophage ratio.

关键词： immuno-radiotherapy tumor-draining lymph node T cells tumor-associated macrophage

A flame-retardant binder with high polysulfide affinity for safe and stable lithium–sulfur batteries

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Science China Chemistry 2024年第3期67卷 1028-1036页

作者： Guowei Yu Guofeng Ye Cheng Wang Chenyang Wang zhaoyun Wang Pu Hu Yu Li Xi-Xi Feng Shuang-Jie Tan Min Yan Sen Xin Zhitian liu Hubei Key Laboratory of Plasma Chemistry and Advanced Materials Hubei Engineering Technology Research Center of Optoelectronic and New Energy MaterialsSchool of Materials Science and EngineeringWuhan Institute of TechnologyWuhan 430205China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China CAS Key Laboratory of Molecular Nanostructure and Nanotechnology CAS Research/Education Center for Excellence in Molecular SciencesBeijing National Laboratory for Molecular Sciences(BNLMS)Institute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Lithium-sulfur(Li-S) batteries have shown promises for the next-generation, high-energy electrochemical storage, yet are hindered by rapid performance decay due to the polysulfide shuttle in the cathode and safety concerns about potential thermal runaway. To address the above challenges, herein, we show a flame-retardant cathode binder that simultaneously improves the electrochemical stability and safety of batteries. The combination of soft and hard segments in the polymer framework of binders allows high flexibility and mechanical strength for adapting to the drastic volume change during the Li(de)intercalation of the S cathode. The binder contains a large number of polar groups, which show the high affinity to polysulfides so that they help to anchor active S species at the cathode. These polar groups also help to regulate and facilitate the Li-ion transport, promoting the kinetics of polysulfide conversion reaction. The binder contains abundant phosphine oxide groups, which, in the case of battery's thermal runaway, decompose and release PO· radicals to quench the combustion reactions and stop the fire. Consequently, Li-S batteries using the new cathode binder show the improved electrochemical performance, including a low-capacity decay of 0.046% per cycle for 800 cycles at 1 C and favorable rate capabilities of up to 3 C. This work offers new insights on the practical realization of high-energy rechargeable batteries with stable storage electrochemistry and high safety.

关键词： lithium–sulfur battery polymer binder polysulfide affinity flame retardancy

Complement C3a activates osteoclasts by regulating the PI3K/PDK1/SGK3 pathway in patients with multiple myeloma

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Cancer Biology & Medicine 2021年第3期18卷 721-733页

作者： Fengjuan Jiang Hui liu Fengping Peng zhaoyun liu Kai Ding Jia Song Lijuan Li Jin Chen Qing Shao Siyang Yan Kim De Veirman Karin Vanderkerken Rong Fu Department of Hematology Tianjin Medical University General HospitalTianjin 300052China Department of Hematology and Immunology-Myeloma Center Brussels Vrije Universiteit BrusselBrussels 1090Belgium

Objective:Myeloma bone disease(MBD)is the most common complication of multiple myeloma(MM).Our previous study showed that the serum levels of C3/C4 in MM patients were significantly positively correlated with the severity of bone ***,the mechanism of C3 a/C4 a in osteoclasts MM patients remains ***:The formation and function of osteoclasts were analyzed after adding C3 a/C4 a in ***-seq analysis was used to screen the potential pathways affecting osteoclasts,and the results were verified by Western blot,q RT-PCR,and pathway ***:The osteoclast area per view induced by 1μg/m L(mean±SD:50.828±12.984%)and 10μg/m L(53.663±12.685%)of C3 a was significantly increased compared to the control group(0μg/m L)(34.635±8.916%)(P<0.001 and P<0.001,respectively).The relative m RNA expressions of genes,OSCAR/TRAP/RANKL/cathepsin K,induced by 1μg/m L(median:5.041,3.726,1.638,and 4.752,respectively)and 10μg/m L(median:5.140,3.702,2.250,and 5.172,respectively)of C3 a was significantly increased compared to the control group(median:3.137,2.004,0.573,and 2.257,respectively)(1μg/m L P=0.001,P=0.003,P<0.001,and P=0.008,respectively;10μg/m L:P<0.001,P=0.019,P<0.001,and P=0.002,respectively).The absorption areas of the osteoclast resorption pits per view induced by 1μg/m L(mean±SD:51.464±11.983%)and 10μg/m L(50.219±12.067%)of C3 a was also significantly increased(33.845±8.331%)(P<0.001 and P<0.001,respectively)compared to the *** was no difference between the C4 a and control ***-seq analysis showed that C3 a promoted the proliferation of osteoclasts using the phosphoinositide 3-kinase(PI3 K)signaling *** relative expressions of PIK3 CA/phosphoinositide dependent kinase-1(PDK1)/serum and glucocorticoid inducible protein kinases(SGK3)genes and PI3 K/PDK1/p-SGK3 protein in the C3 a group were significantly higher than in the control *** activation role of C3 a in osteoclasts of MM patients was reduced by the SGK inhibi

关键词： Multiple myeloma complement C3a osteoclasts PI3K/PDK1/SGK3 pathways SGK inhibitor

“绿色崛起”视角下欠发达山区经济发展对策——以梅州市为例

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热带地理 2010年第4期30卷 401-406页

作者：刘昭云嘉应学院经济与管理学院

地处粤东北的梅州市，由于历史、地理环境、发展基础等多方面原因，经济发展相对较为缓慢，属于经济欠发达山区。但梅州市是我国历史文化名城、中国最佳文化生态旅游目的地、广东省重要的生态屏障，与经济发达地区相比具有明显比较优势... 详细信息

地处粤东北的梅州市，由于历史、地理环境、发展基础等多方面原因，经济发展相对较为缓慢，属于经济欠发达山区。但梅州市是我国历史文化名城、中国最佳文化生态旅游目的地、广东省重要的生态屏障，与经济发达地区相比具有明显比较优势和后发优势。文中运用比较分析方法对梅州市主要经济指标进行对比分析，揭示经济发展存在的差距，依据科学发展观，在保护好生态环境的前提条件下，构建以农业经济为基础，以工业经济为支撑，以旅游经济为重点的绿色产业体系，培育符合时代发展要求的新型战略性支柱产业，建设特色专业小城镇，壮大县域经济，走出一条绿色崛起、科学发展的创新之路。

关键词：梅州市经济发展绿色崛起发展对策

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广东省梅州市经济发展战略思考

地域研究与开发 2010年第3期29卷 40-45页

作者：刘昭云谢莉嘉应学院经济与管理学院广东梅州514015 嘉应学院地理科学与旅游学院广东梅州514015

梅州市地处粤东北,由于历史、地理环境、发展基础等多方面原因,经济发展比较缓慢,属于经济欠发达山区。梅州市是我国历史文化名城、全国优秀旅游城市、世界客都、广东省重要的生态屏障,比较优势和后发优势明显。梅州市应在科学发展观的... 详细信息

梅州市地处粤东北,由于历史、地理环境、发展基础等多方面原因,经济发展比较缓慢,属于经济欠发达山区。梅州市是我国历史文化名城、全国优秀旅游城市、世界客都、广东省重要的生态屏障,比较优势和后发优势明显。梅州市应在科学发展观的指导下,把自身优势转化为支撑经济发展的强劲动力和科学发展的实际成果,大力发展绿色经济,构建符合节能减排时代主旋律的新型产业体系,实现经济的快速发展。通过比较分析,揭示了梅州市经济发展存在的主要问题,阐述了梅州市的比较优势,探索梅州市实现经济跨越式发展路径和战略选择。

关键词：经济发展发展思路战略选择梅州市

隐喻政治与政治隐喻:论美国政治家的政治隐喻

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外语教学 2009年第1期30卷 25-29页

作者：陈勇刘肇云湖南文理学院外国语学院湖南常德415000

政治隐喻因为其界定功能、信息处理功能和说服功能而受到当代美国政治家们的欢迎。美国政治家在使用政治隐喻的时候,由于他们各自的政治观点或个人的社会经历、爱好等因素而采取不同的隐喻表达。在劝说方面,体育隐喻和战争隐喻是最为常... 详细信息

政治隐喻因为其界定功能、信息处理功能和说服功能而受到当代美国政治家们的欢迎。美国政治家在使用政治隐喻的时候,由于他们各自的政治观点或个人的社会经历、爱好等因素而采取不同的隐喻表达。在劝说方面,体育隐喻和战争隐喻是最为常见的两种政治隐喻;而家庭、邻居和领袖隐喻是处理美国国内外事务中常用的概念隐喻。

关键词：概念隐喻当代美国政治家信息处理社会经历政治观点说服劝说

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基于有限元仿真的BGA焊点可靠性分析

电子器件 2022年第4期45卷 860-865页

作者：孙勤润杨雪霞刘昭雲王超彭银飞太原科技大学应用科学学院山西太原030024

集成化与微型化是芯片集成电路产业发展的特点,其中芯片封装热振失效是影响其可靠性的重要原因。为进一步优化BGA焊点结构并提高可靠性,运用ANSYS将TOPLINE的BGA器件建成了3D模型,进行了数值模拟仿真后,利用田口正交稳健设计进行了BGA... 详细信息

集成化与微型化是芯片集成电路产业发展的特点,其中芯片封装热振失效是影响其可靠性的重要原因。为进一步优化BGA焊点结构并提高可靠性,运用ANSYS将TOPLINE的BGA器件建成了3D模型,进行了数值模拟仿真后,利用田口正交稳健设计进行了BGA焊点结构优化。数值分析表明:芯片边角焊点为热失效关键焊点,距封装中心最远焊点为随机振动失效关键焊点;经田口正交优化热设计,焊点阵列为12×12,焊点径向尺寸为0.42 mm,焊点高度为0.38 mm,焊点间距为0.6 m;随机振动设计焊点间距为0.46 mm,焊点径向尺寸为0.42 mm,焊点阵列为10×10,焊点高度为0.30 mm。本研究中的分析成果对优化球珊阵列芯片封装焊点结构的设计,提升芯片封装器件结构稳定性具有重要意义,所提出的优化设计将对封测产业的生产具有一定的影响和价值。

关键词： BGA焊点有限元可靠性田口正交优化设计

SAC305焊料的准静态压缩性能及本构关系研究

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特种铸造及有色合金 2022年第5期42卷 601-605页

作者：王超杨雪霞张伟伟孙勤润刘昭雲彭银飞太原科技大学应用科学学院

采用UTM6202电子万能试验机对SAC305(Sn3.0Ag0.5Cu)铸态无铅焊料试样在恒温(20~140℃)下进行压缩试验。根据不同工况下的试验数据,对无铅焊料的流变应力、应变速率和变形温度的关系进行拟合,计算Arrhenius本构方程参数。结果表明,温度... 详细信息

采用UTM6202电子万能试验机对SAC305(Sn3.0Ag0.5Cu)铸态无铅焊料试样在恒温(20~140℃)下进行压缩试验。根据不同工况下的试验数据,对无铅焊料的流变应力、应变速率和变形温度的关系进行拟合,计算Arrhenius本构方程参数。结果表明,温度和应变速率对无铅焊料SAC305合金的真应力-应变关系具有显著的相关性。焊料的屈服强度随着应变温度的升高而降低,随着应变速率的增大而增大。将应变速率为5×10^(-4)、5×10^(-5)s^(-1)时测得的无铅焊料应力-应变关系和试验进行了比较,发现计算值与试验值符合较好。说明该双曲正弦本构关系可用于描述无铅焊料热变形过程中的流变应力,热变形激活能为61.86323kJ/mol。

关键词： SAC305无铅焊料压缩性能流变应力力学性能

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基于正交法的FBGA焊点可靠性优化研究

微电子学 2022年第1期52卷 144-149页

作者：孙勤润杨雪霞张伟伟王超刘昭云彭银飞太原科技大学应用科学学院太原030024

在芯片紧密度、功耗都在增加的微电子封装领域,FBGA封装在同体积下有较大的存储容量。基于有限元和正交法,进行了FBGA焊点热循环载荷下的可靠性分析,并进行了更稳健的焊点结构参数优化设计。结果表明,焊点阵列对FBGA结构热可靠性有重要... 详细信息

在芯片紧密度、功耗都在增加的微电子封装领域,FBGA封装在同体积下有较大的存储容量。基于有限元和正交法,进行了FBGA焊点热循环载荷下的可靠性分析,并进行了更稳健的焊点结构参数优化设计。结果表明,焊点阵列对FBGA结构热可靠性有重要影响;优化方案组合为12×12焊点阵列,焊点径向尺寸为0.42 mm,焊点高度为0.38 mm,焊点间距为0.6 mm。经过优化验证,该优化方案的等效塑性应变范围较原始设计方案降低了89.92%,信噪比提高到17.72 dB,实现了焊点参数优化目标。

关键词： FBGA焊点正交法有限元热循环载荷可靠性