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A flame-retardant binder with high polysulfide affinity for safe and stable lithium–sulfur batteries

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Science China Chemistry 2024年第3期67卷 1028-1036页

作者： Guowei Yu Guofeng Ye Cheng Wang Chenyang Wang zhaoyun Wang Pu Hu Yu Li Xi-Xi Feng Shuang-Jie Tan Min Yan Sen Xin Zhitian liu Hubei Key Laboratory of Plasma Chemistry and Advanced Materials Hubei Engineering Technology Research Center of Optoelectronic and New Energy MaterialsSchool of Materials Science and EngineeringWuhan Institute of TechnologyWuhan 430205China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China CAS Key Laboratory of Molecular Nanostructure and Nanotechnology CAS Research/Education Center for Excellence in Molecular SciencesBeijing National Laboratory for Molecular Sciences(BNLMS)Institute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Lithium-sulfur(Li-S) batteries have shown promises for the next-generation, high-energy electrochemical storage, yet are hindered by rapid performance decay due to the polysulfide shuttle in the cathode and safety concerns about potential thermal runaway. To address the above challenges, herein, we show a flame-retardant cathode binder that simultaneously improves the electrochemical stability and safety of batteries. The combination of soft and hard segments in the polymer framework of binders allows high flexibility and mechanical strength for adapting to the drastic volume change during the Li(de)intercalation of the S cathode. The binder contains a large number of polar groups, which show the high affinity to polysulfides so that they help to anchor active S species at the cathode. These polar groups also help to regulate and facilitate the Li-ion transport, promoting the kinetics of polysulfide conversion reaction. The binder contains abundant phosphine oxide groups, which, in the case of battery's thermal runaway, decompose and release PO· radicals to quench the combustion reactions and stop the fire. Consequently, Li-S batteries using the new cathode binder show the improved electrochemical performance, including a low-capacity decay of 0.046% per cycle for 800 cycles at 1 C and favorable rate capabilities of up to 3 C. This work offers new insights on the practical realization of high-energy rechargeable batteries with stable storage electrochemistry and high safety.

关键词： lithium–sulfur battery polymer binder polysulfide affinity flame retardancy

Pivotal roles of tumor-draining lymph nodes in the abscopal effects from combined immunotherapy and radiotherapy

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Cancer Communications 2022年第10期42卷 971-986页

作者： zhaoyun liu Zhiyong Yu Dawei Chen Vivek Verma Chenxi Yuan Minglei Wang Fei Wang Qing Fan Xingwu Wang Yang Li Yuequn Ma Meng Wu Jinming Yu Department of Oncology Shandong University Cancer CenterJinanShandong 250117P.R.China Department of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinanShandong 250117P.R.China Breast Cancer Center Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinanShandong 250117P.R.China Department of Radiation Oncology The University of Texas MD Anderson Cancer CenterHoustonTexas 77030United States Department of Pharmacy Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinanShandong 250117P.R.China Research Unit of Radiation Oncology Chinese Academy of Medical SciencesJinanShandong 250117P.R.China

Background:Currently,due to synergy enhancement of anti-tumor effects and potent stimulation of abscopal effects,combination therapy with irradiation and programmed cell death protein 1/programmed death-ligand 1(PD-1/PD-L1)immune checkpoint inhibition(immuno-radiotherapy,iRT)has revolutionized the therapeutic guidelines.It has been demonstrated that tumor-draining lymph nodes(TDLN)are essential for effective antitumor immunity induced by radiotherapy,immunotherapy,or iRT.Given that the function of TDLN in iRT remains unclear,this study aimed to investigate the function and mechanism of TDLN in iRT-induced abscopal effects.Methods:The function of TDLN was evaluated using unilateral or bilateral MC38 and B16F10 subcutaneous tumor models with or without indicated TDLN.The flow cytometry,multiple immunofluorescence analysis,and NanoString analysis were utilized to detect the composition and function of the immune cells in the primary and abscopal tumor microenvironment.Additionally,we tempted to interrogate the possible mechanisms via RNA-sequencing of tumor-infiltrating lymphocytes and TDLN.Results:TDLN deficiency impaired the control of tumor growth by monotherapy.Bilateral TDLN removal rather than unilateral TDLN removal substantially curtailed iRT-stimulated anti-tumor and abscopal effects.Furthermore,in the absence of TDLN,the infiltration of CD45+and CD8+T cells was substantially reduced in both primary and abscopal tumors,and the anti-tumor function of CD8+T cells was attenuated as well.Additionally,the polarization of tumor-associated macrophages in primary and abscopal tumors were found to be dependent on intact bilateral TDLN.RNA-sequencing data indicated that impaired infiltration and anti-tumor effects of immune cells partially attributed to the altered secretion of components from the tumor microenvironment.Conclusions:TDLN play a critical role in iRT by promoting the infiltration of CD8+T cells and maintaining the M1/M2 macrophage ratio.

关键词： immuno-radiotherapy tumor-draining lymph node T cells tumor-associated macrophage

Complement C3a activates osteoclasts by regulating the PI3K/PDK1/SGK3 pathway in patients with multiple myeloma

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Cancer Biology & Medicine 2021年第3期18卷 721-733页

作者： Fengjuan Jiang Hui liu Fengping Peng zhaoyun liu Kai Ding Jia Song Lijuan Li Jin Chen Qing Shao Siyang Yan Kim De Veirman Karin Vanderkerken Rong Fu Department of Hematology Tianjin Medical University General HospitalTianjin 300052China Department of Hematology and Immunology-Myeloma Center Brussels Vrije Universiteit BrusselBrussels 1090Belgium

Objective:Myeloma bone disease(MBD)is the most common complication of multiple myeloma(MM).Our previous study showed that the serum levels of C3/C4 in MM patients were significantly positively correlated with the severity of bone disease.However,the mechanism of C3 a/C4 a in osteoclasts MM patients remains unclear.Methods:The formation and function of osteoclasts were analyzed after adding C3 a/C4 a in vitro.RNA-seq analysis was used to screen the potential pathways affecting osteoclasts,and the results were verified by Western blot,q RT-PCR,and pathway inhibitors.Results:The osteoclast area per view induced by 1μg/m L(mean±SD:50.828±12.984%)and 10μg/m L(53.663±12.685%)of C3 a was significantly increased compared to the control group(0μg/m L)(34.635±8.916%)(P<0.001 and P<0.001,respectively).The relative m RNA expressions of genes,OSCAR/TRAP/RANKL/cathepsin K,induced by 1μg/m L(median:5.041,3.726,1.638,and 4.752,respectively)and 10μg/m L(median:5.140,3.702,2.250,and 5.172,respectively)of C3 a was significantly increased compared to the control group(median:3.137,2.004,0.573,and 2.257,respectively)(1μg/m L P=0.001,P=0.003,P<0.001,and P=0.008,respectively;10μg/m L:P<0.001,P=0.019,P<0.001,and P=0.002,respectively).The absorption areas of the osteoclast resorption pits per view induced by 1μg/m L(mean±SD:51.464±11.983%)and 10μg/m L(50.219±12.067%)of C3 a was also significantly increased(33.845±8.331%)(P<0.001 and P<0.001,respectively)compared to the control.There was no difference between the C4 a and control groups.RNA-seq analysis showed that C3 a promoted the proliferation of osteoclasts using the phosphoinositide 3-kinase(PI3 K)signaling pathway.The relative expressions of PIK3 CA/phosphoinositide dependent kinase-1(PDK1)/serum and glucocorticoid inducible protein kinases(SGK3)genes and PI3 K/PDK1/p-SGK3 protein in the C3 a group were significantly higher than in the control group.The activation role of C3 a in osteoclasts of MM patients was reduced by the SGK inhibitor(EMD638683).Conclusions:C3 a activated osteoc

关键词： Multiple myeloma complement C3a osteoclasts PI3K/PDK1/SGK3 pathways SGK inhibitor

婴幼儿家庭支持对育龄农民工再生育意愿的影响——基于CFPS2020年的数据分析

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武汉科技大学学报（社会科学版） 2024年第2期26卷 17-26页

作者：汤兆云刘科成华侨大学政治与公共管理学院福建泉州362021

不同的照护服务模式对再生育意愿产生重要影响。在我国婴幼儿照护服务社区和社会等主体短缺情况下,家庭支持承担了婴幼儿照护服务的主要职责。基于“中国家庭追踪调查”项目2020年数据分析发现,育龄农民工再生育意愿与其婴幼儿家庭支持... 详细信息

不同的照护服务模式对再生育意愿产生重要影响。在我国婴幼儿照护服务社区和社会等主体短缺情况下,家庭支持承担了婴幼儿照护服务的主要职责。基于“中国家庭追踪调查”项目2020年数据分析发现,育龄农民工再生育意愿与其婴幼儿家庭支持呈现出显著关系,但育龄农民工能够获得的家庭支持情况不容乐观。进一步完善育龄农民工婴幼儿家庭支持,对于提升其生育意愿,实现三孩政策预期效果具有重要意义。本研究政策建议主要有:建立健全婴幼儿家庭支持的制度框架和政策法规体系;加大财政等公共资源投入,强化婴幼儿家庭支持能力;提高用人单位、社会等方面婴幼儿照护服务功能,弥补婴幼儿家庭支持的不足。

关键词：婴幼儿照护服务家庭支持育龄农民工再生育意愿

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骨盆后环损伤3D打印导板辅助骶髂螺钉固定

中国矫形外科杂志 2024年第10期32卷 889-894页

作者：李文龙刘振兴孙兆云王星山东第一医科大学附属人民医院山东济南271100

[目的]探究应用3D打印导板辅助骶髂螺钉固定在骨盆后环损伤中的临床价值。[方法]回顾性分析2020年1月—2023年2月收住本院创伤骨科病区中心的45例骨盆后环损伤患者的临床资料,依据术前医患沟通结果,21例采用3D导板辅助,24例采用徒手置... 详细信息

[目的]探究应用3D打印导板辅助骶髂螺钉固定在骨盆后环损伤中的临床价值。[方法]回顾性分析2020年1月—2023年2月收住本院创伤骨科病区中心的45例骨盆后环损伤患者的临床资料,依据术前医患沟通结果,21例采用3D导板辅助,24例采用徒手置钉。比较两组围手术期、随访和影像资料。[结果]导板组手术时间[(84.8±2.6)min vs(113.3±2.2)min,P<0.001]、螺钉置入时间[(40.9±0.4)min vs(65.3±1.6)min,P<0.001]、导针调整次数[(0.8±0.7)次vs(4.0±0.9)次,P<0.001]和X线曝光时间[(35.2±0.8)s vs(77.3±1.4)s,P<0.001]均显著优于徒手组。随访时间平均(24.1±7.5)个月。导板组患者完全负重活动时间[(85.6±2.7)d vs(95.1±0.6)d,P=0.046]显著早于徒手组。与术后1个月相比,末次随访时,两组患者VAS评分、髋伸屈和内外旋ROM、Majeed评分均显著改善(P<0.05)。术后1个月,导板组VAS评分[(2.6±0.3)vs(3.7±0.2),P=0.042]、髋伸-屈ROM[(121.2±1.1)°vs(103.2±1.6)°,P=0.046]和髋内外旋ROM[(78.0±0.5)°vs(55.5±0.9)°,P<0.001]、Majeed评分[(36.5±2.3)vs(26.8±0.3),P<0.001]均显著优于徒手组。影像方面,导板组置钉位置[优/良/差,例(%),19(90.4)/1(4.8)/1(4.8)vs 14(58.3)/7(29.2)/3(12.5),P<0.001]、骨折复位质量[优/良/差,例(%),18(85.7)/2(9.5)/1(4.8)vs 11(45.8)/9(37.5)/4(16.7),P<0.001]、骨折愈合时间[<10周/10~16周/≥16周,例(%),17(80.9)/3(14.3)/1(4.8)vs 11(45.8)/10(41.7)/3(12.5),P<0.001]显著优于徒手组。[结论]3D打印导板辅助骶髂螺钉固定骨盆后环骨折损伤小,可以取得更佳的早期治疗效果。

关键词：骨盆骨折 3D打印骶髂螺钉回顾性研究

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煤岩体剪切破裂“缓释”构造及其演进特征

岩石力学与工程学报 2024年第1期43卷 170-183页

作者：刘向御柴肇云肖畅沈玉旭辛子朋李天宇孙浩程闫珂刘新雨段碧英太原理工大学原位改性采矿教育部重点实验室山西太原030024 太原理工大学矿业工程学院山西太原030024

含煤建造的成层及层理特性使得围岩更多地体现为剪切灾变。为进一步探究循环荷载条件下煤岩体的剪切破坏行为,采用等幅循环与逐级一次循环加卸载方式,并联合CT扫描开展了砂质泥岩的单轴压缩试验。通过岩样破裂形态及全过程应力–应变曲... 详细信息

含煤建造的成层及层理特性使得围岩更多地体现为剪切灾变。为进一步探究循环荷载条件下煤岩体的剪切破坏行为,采用等幅循环与逐级一次循环加卸载方式,并联合CT扫描开展了砂质泥岩的单轴压缩试验。通过岩样破裂形态及全过程应力–应变曲线,分析了岩样剪切破坏显现的“多米诺骨牌”构造及其演进特征。结果表明:单轴等幅、逐级一次循环加卸载下,岩样均发生剪切破坏,且逐级一次加卸载循环下岩样破坏形成的剪切破碎带包括若干呈“多米诺骨牌”构造的应变局部化带,破坏过程对应的应力–应变曲线呈特殊的滞回–往复–滞回–往复状振荡波动;应变局部化带呈现成核、启裂、外扩、衰损、传导的演化过程;具有“多米诺骨牌”构造的碎裂块体发生旋转–回旋运动,使峰后输入能量及弹性储能在块体相互摩擦中多级耗散,延长了破坏时长,具有显著的“缓释”效应。剪切破裂形态演化与应力–应变隐蔽信息相互协同,共同将剪切破坏过程划分为6个破坏阶段,分别为:裂缝启裂微扩展(Ⅰ)、裂缝初始扩展(Ⅱ)、主剪切裂缝扩展(Ⅲ)、裂缝扩展亚稳态(Ⅳ)、裂缝快速扩展(Ⅴ)和加速破坏(Ⅵ)。“多米诺骨牌”构造是剪切破坏的一种特有形式,其所起到的能量“缓释”效应可能是煤矿巷道利用围岩自身结构进行卸压护巷的一个新思路。

关键词：岩石力学剪切破裂 “多米诺骨牌”构造应变局部化循环荷载

基于改进A^(*)算法的矿用机器人救援路径规划及仿真分析

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太原理工大学学报 2024年第2期55卷 231-241页

作者：段碧英柴肇云辛子朋闫珂肖畅刘向御李天宇刘新雨太原理工大学原位改性采矿教育部重点实验室太原030024

【目的】煤矿井下灾后现场情况复杂,针对传统A^(*)算法的煤矿机器人救援路径规划存在路径不安全、效率低等问题,结合栅格地图及救援机器人可沿任意方向移动的特点,多方面对传统A^(*)算法进行改进。【方法】首先,引入了机器人尺寸叠加到... 详细信息

【目的】煤矿井下灾后现场情况复杂,针对传统A^(*)算法的煤矿机器人救援路径规划存在路径不安全、效率低等问题,结合栅格地图及救援机器人可沿任意方向移动的特点,多方面对传统A^(*)算法进行改进。【方法】首先,引入了机器人尺寸叠加到障碍物的概念,以确保路径的安全性。其次,通过优化启发函数,降低偏离最佳路径节点的扩展数量,减少冗余节点与路径转折,降低了计算复杂度。最后,采用动态调整算法将路径转折角圆弧化,对所得路径平滑处理,提高了路径的可操作性。最终获得路径代价更小、耗时更短、转弯次数更少的优化路径。基于改进的A^(*)算法,利用MATLAB开展了不同尺寸及不同障碍物覆盖率下救援机器人路径规划的仿真模拟试验。【结果】结果表明:相较于传统A^(*)算法,在崎岖环境地图中改进的A^(*)算法使搜索节点降低了26.51%、计算时长减少了80.42%、路径长度缩短了31.85%、转向次数减少了44.44%,提高了路径的搜索效率和平滑程度。【结论】改进的A^(*)算法为复杂工况环境下煤矿机器人的救援工作提供了一定的理论基础。

关键词： A^(*)算法优化煤矿救援机器人路径规划启发函数动态调整算法

纳米硅溶胶−EVA−粉煤灰水泥基复合浆材配比正交优化及对其物性的影响

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煤炭学报 2024年第6期49卷 2643-2659页

作者：沈玉旭柴肇云孙浩程刘向御郭俊庆肖畅李天宇辛子朋史沁彬太原理工大学原位改性采矿教育部重点实验室山西太原030024 山西能源学院矿业工程系山西晋中030600 山西潞安环保能源开发股份有限公司常村煤矿山西长治046000

针对传统水泥基浆材不能满足煤矿大变形巷道注浆加固实际需求的难题,通过添加纳米硅溶胶、乙烯−醋酸乙烯共聚物(EVA)和粉煤灰对普通硅酸盐水泥进行改性获得高性能复合浆材。采用正交试验和极差分析法系统研究复合浆材物理力学性能的变... 详细信息

针对传统水泥基浆材不能满足煤矿大变形巷道注浆加固实际需求的难题,通过添加纳米硅溶胶、乙烯−醋酸乙烯共聚物(EVA)和粉煤灰对普通硅酸盐水泥进行改性获得高性能复合浆材。采用正交试验和极差分析法系统研究复合浆材物理力学性能的变化规律,确定最优配比,并进一步分析最优配比复合浆材与纯水泥的物性差异,构建复合浆材的水化反应机理模型,阐明其加固破碎岩石的力学特性。研究结果表明,复合浆材最优配比为:水灰比0.7,粉煤灰掺量15%,硅溶胶掺量2%,EVA掺量7.5%;相较于纯水泥,复合浆材流变性略有下降,但浆液稳定性、力学性能等均有显著提升,初凝时间缩短了38.9%,终凝时间缩短了53.8%,析水率降低了60%,结石率提高了3.3%,单轴抗压强度提高了39.1%,抗拉强度提高了97.2%,拉压比提高了41.7%;硅溶胶和粉煤灰在不同时期与Ca(OH)2发生火山灰反应生成更多水化硅酸钙(C-S-H)和水化铝酸钙(CA-H),促进复合浆材的水化反应,并加速EVA成膜,使结石体更加致密;复合浆材注入量和胶结体单轴抗压强度均随注浆压力的增大而增加,随Talbot指数的增加,抗压强度先增大后减小,破坏形式多呈鼓状,剪胀变形明显;当注浆压力大于2 MPa,Talbot指数为0.5时,胶结体强度较大,破坏较小。本研究为水泥基复合浆材早期强度、增韧改性提供了可行途径。

关键词：纳米硅溶胶 EVA 粉煤灰普通硅酸盐水泥正交试验

艾博韦泰对HIV/AIDS合并肾功能损伤患者的疗效和安全性

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中国皮肤性病学杂志 2024年第7期38卷 784-789页

作者：杨萱安永辉焦敏杨舒格葛良友陈昭云刘金瑾孙燕郑州市第六人民医院感染科河南郑州450015

目的观察艾博韦泰(ABT)联合蛋白酶抑制剂(PIs)或整合酶抑制剂(INSTIs)的抗逆转录病毒治疗(ART)方案在HIV/AIDS合并肾功能损伤患者的疗效和安全性。方法2021年3月—2023年3月期间,从郑州市第六人民医院感染科住院患者中筛选伴有肾功能损... 详细信息

目的观察艾博韦泰(ABT)联合蛋白酶抑制剂(PIs)或整合酶抑制剂(INSTIs)的抗逆转录病毒治疗(ART)方案在HIV/AIDS合并肾功能损伤患者的疗效和安全性。方法2021年3月—2023年3月期间,从郑州市第六人民医院感染科住院患者中筛选伴有肾功能损伤的HIV/AIDS初治或经治患者进入12周开放治疗。观察和比较基线及各治疗时间点HIV病毒载量(HIV RNA)、CD4^(+)T淋巴细胞(CD4^(+)T细胞)计数、肾功能等生化指标变化。结果入组30例患者,26例完成12周治疗。26例患者基线情况:男性为主(88.46%),平均年龄(51.77±14.49)岁,初治患者占50%,69.23%和46.15%患者分别合并机会性感染和慢性合并症。急性肾损伤5例,慢性肾损伤21例,平均肾小球滤过率(eGFR)为38.30(14.94,69.57)mL/(min·1.73 m^(2)),18例慢性肾损伤伴尿蛋白或尿微量白蛋白(ALB)阳性。4例HIV RNA≥105 CPs/mL,HIV RNA在最低检测线(40 CPs/mL)~10^(5)CPs/mL者12例;CD4^(+)T细胞计数<100个/μL 16例;ART治疗12周:初治、平稳转换、治疗失败患者病毒抑制率分别为76.92%(10/13)、100%(10/10)、100%(3/3)。CD4^(+)T细胞计数从基线75(28.75,203.75)个/μL升至156(90.25,359.25)个/μL,CD4^(+)/CD8^(+)比值从0.16(0.06,0.68)升至0.21(0.14,0.68),差异均有统计学意义(P<0.05)。12周eGFR、血清肌酐(Scr)、血红蛋白(Hb)较基线有好转,差异有统计学意义(P<0.05);12周后25例患者转换为口服ART方案,其中17例完成12个月随访。12个月时:15例HIV RNA低于最低检测线,平均CD4^(+)T细胞计数上升至212.00(102.50,333.00)个/μL,较12周时CD4^(+)T细胞计数130.00(95.00,229.00)个/μL相比,差异有统计学意义(P<0.05)。结论含有艾博韦泰ART方案治疗26例HIV/AIDS合并肾功能损伤患者取得良好的病毒抑制和免疫应答,同时具有良好的安全性,后续扩大样本值得进一步研究。

关键词：抗逆转录病毒治疗 HIV/AIDS 艾博韦泰肾功能损伤