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Nano Research 2024年第6期17卷 5087-5094页

作者： Chenhao Xiao Yaxiao guo Jiayuan Sun Tao guo Xinyuan Jia Shinuo guo Guancheng Wu Yue Sun zhaoyang Yao Yi Liu State Key Laboratory of Separation Membranes and Membrane Processes School of ChemistryTiangong UniversityTianjin 300387China Key Laboratory of Functional Polymer Materials College of ChemistryNankai UniversityTianjin 300071China School of Chemical and Environmental Engineering Wuhan Polytechnic UniversityWuhan 430023China

Electrocatalytic nitrate reduction to ammonia(NO3−RR)for removing nitrate from wastewater is a promising but challengeable technology that is increasingly studied.Herein,we developed an efficient CuO_(x)and CoCuO_(x)composed hybrid catalyst(CoCuO_(x)@CuO_(x)/copper foam(CF)),characteristic of distinctive shell-core nanowires grown on CF substrate with CuO_(x)core and CoCuO_(x)shell.The built-in electric field formed at the interface of the CoO/Cu_(2)O heterostructure promotes NO3−adsorption by modulating the charge distribution at the interface,which greatly improves the ammonia yield rate and Faradaic efficiency.At−0.2 V vs.reversible hydrogen electrode(RHE),CoCuO_(x)@CuO_(x)/CF achieves not only an excellent ammonia yield rate of up to 519.1μg·h^(−1)·cm^(−2)and Faradaic efficiency of 99.83%at 1 mM NO3−concentration,but also excellent mechanical stabilities.This study provides a novel pathway to design electrocatalyst for the removal of nitrate from dilute nitric acid solutions(≤2 mM).

关键词： CoCuO_(x)@CuO_(x)/copper foam(CF) shell-core nanowires heterostructure low concentration nitrate electroreduction to ammonia

Role of adhesion molecules in cancer and targeted therapy

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Science China(Life Sciences) 2024年第5期67卷 940-957页

作者： Chunmei Fan Fang Xiong Shanshan Zhang Zhaojian Gong Qianjin Liao Guiyuan Li Can guo Wei Xiong He Huang zhaoyang Zeng NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410000China Department of Histology and Embryology Xiangya School of MedicineCentral South UniversityChangsha410013China Department of Stomatology Xiangya HospitalCentral South UniversityChangsha 410078China Department of Oral and Maxillofacial Surgery The Second Xiangya HospitalCentral South UniversityChangsha 410011China Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Cancer Research InstituteCentral South UniversityChangsha 410078China

Adhesion molecules mediate cell-to-cell and cell-to-extracellular matrix interactions and transmit mechanical and chemical signals among them.Various mechanisms deregulate adhesion molecules in cancer,enabling tumor cells to proliferate without restraint,invade through tissue boundaries,escape from immune surveillance,and survive in the tumor microenvironment.Recent studies have revealed that adhesion molecules also drive angiogenesis,reshape metabolism,and are involved in stem cell self-renewal.In this review,we summarize the functions and mechanisms of adhesion molecules in cancer and the tumor microenvironment,as well as the therapeutic strategies targeting adhesion molecules.These studies have implications for furthering our understanding of adhesion molecules in cancer and providing a paradigm for exploring novel therapeutic approaches.

关键词： adhesion molecules tumor microenvironment invasion and metastasis reshaping metabolism angiogenesis immune evasion tumor stemness therapeutic strategy

CAS-ESM2.0 Dataset for the Carbon Dioxide Removal Model Intercomparison Project(CDRMIP)

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Advances in Atmospheric Sciences 2024年第5期41卷 989-1000页

作者： Jiangbo JIN Duoying JI Xiao DONG Kece FEI Run guo Juanxiong HE Yi YU zhaoyang CHAI He ZHANG Dongling ZHANG Kangjun CHEN Qingcun ZENG International Center for Climate and Environment Sciences Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China State Key Laboratory of Earth Surface Processes and Resource Ecology College of Global Change and Earth System ScienceBeijing Normal UniversityBeijing 100875China State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China

Understanding the response of the Earth system to varying concentrations of carbon dioxide(CO_(2))is critical for projecting possible future climate change and for providing insight into mitigation and adaptation strategies in the near future.In this study,we generate a dataset by conducting an experiment involving carbon dioxide removal(CDR)—a potential way to suppress global warming—using the Chinese Academy of Sciences Earth System Model version 2.0(CASESM2.0).A preliminary evaluation is provided.The model is integrated from 200–340 years as a 1%yr^(−1) CO_(2) concentration increase experiment,and then to~478 years as a carbon dioxide removal experiment until CO_(2) returns to its original value.Finally,another 80 years is integrated in which CO_(2) is kept constant.Changes in the 2-m temperature,precipitation,sea surface temperature,ocean temperature,Atlantic meridional overturning circulation(AMOC),and sea surface height are all analyzed.In the ramp-up period,the global mean 2-m temperature and precipitation both increase while the AMOC weakens.Values of all the above variables change in the opposite direction in the ramp-down period,with a delayed peak relative to the CO_(2) peak.After CO_(2) returns to its original value,the global mean 2-m temperature is still~1 K higher than in the original state,and precipitation is~0.07 mm d^(–1) higher.At the end of the simulation,there is a~0.5°C increase in ocean temperature and a 1 Sv weakening of the AMOC.Our model simulation produces similar results to those of comparable experiments previously reported in the literature.

关键词： CAS-ESM2.0 CDRMIP carbon dioxide removal AMOC temperature precipitation sea surface height

GTF2H4 regulates partial EndMT via NF-κB activation through NCOA3 phosphorylation in ischemic diseases

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The Innovation 2024年第2期5卷 27-41页

作者： Zheyan Fang Gang Zhao Shuang Zhao Xueting Yu Runyang Feng You-en Zhang Haomin Li Lei Huang Zhenyang guo Zhentao Zhang Mukaddas Abdurahman Hangnan Hong Peng Li Bing Wu Jinhang Zhu Xin Zhong Dong Huang Hao Lu Xin Zhao zhaoyang Chen Wenbin Zhang Junjie guo Hongchao Zheng Yue He Shengying Qin Haojie Lu Yun Zhao Xiangdong Wang Junbo Ge Hua Li Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesShanghai 200032China Department of Cardiology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Medical Examination Shanghai Xuhui District Central HospitalShanghai 200031China Department of Cardiology and Institute of Clinical Medicine Renmin HospitalHubei University of MedicineShiyan 442000China Clinical Data Center Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Molecular Celland Cancer BiologyUniversity of Massachusetts Chan Medical SchoolWorcesterMA 01605USA Bio-X Institute Key Laboratory for The Genetics of Developmental and Neuropsychiatric DisordersShanghai Jiao Tong UniversityShanghai 200030China Department of Cardiology Heart Center of Fujian ProvinceFujian Medical University Union HospitalFuzhou 350001China Department of Cardiology Sir Run Run Shaw Hospitalaffiliated with Zhejiang University School of MedicineHangzhou 310020China Department of Cardiology The Affiliated Hospital of Qingdao UniversityQingdao 266003China Department of Cardiology Shanghai Xuhui District Central HospitalShanghai 200031China Department of Cardiology Shanghai Eighth People’s HospitalShanghai 200235China Department of Chemistry and Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China School of Life Science and Technology Shanghai Tech University100 Haike RoadShanghai 201210China Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Department of Pulmonary and Critical Care Medicine Zhongshan Hospital

Partial endothelial-to-mesenchymal transition(EndMT)is an intermediate phenotype observed in endothelial cells(ECs)undergoing a transition toward a mesenchymal state to support neovascularization during(patho)physiological angiogenesis.Here,we investigated the occurrence of partial EndMT in ECs under hypoxic/ischemic conditions and identified general transcription factor IIH subunit 4(GTF2H4)as a positive regulator of this process.In addition,we discovered that GTF2H4 collaborates with its target protein excision repair cross-complementation group 3(ERCC3)to co-regulate partial EndMT.Furthermore,by using phosphorylation proteomics and site-directed mutagenesis,we demonstrated that GTF2H4 was involved in the phosphorylation of receptor coactivator 3(NCOA3)at serine 1330,which promoted the interaction between NCOA3 and p65,resulting in the transcriptional activation of NF-κB and the NF-kB/Snail signaling axis during partial EndMT.In vivo experiments confirmed that GTF2H4 significantly promoted partial EndMT and angiogenesis after ischemic injury.Collectively,our findings reveal that targeting GTF2H4 is promising for tissue repair and offers potential opportunities for treating hypoxic/ischemic diseases.

关键词： ischemic activation GTF

松花江流域NPP时空演变及其对极端气候的响应机制

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南水北调与水利科技（中英文） 2024年第1期22卷 131-147页

作者：贾朝阳郭亮崔嵩付强刘东东北农业大学水利与土木工程学院哈尔滨150030 东北农业大学松花江流域生态环境保护研究中心哈尔滨150030 哈尔滨理工大学经济与管理学院哈尔滨150086

为探究全球气候变化条件下松花江流域陆地生态系统健康程度的变化特征,基于2000—2020年MODIS MOD17A3HGF数据集,采用趋势分析、相关性分析、M-K检验、地理探测器和相对重要性分析等方法,结合气象站点数据和土地利用数据,分析植被净初... 详细信息

为探究全球气候变化条件下松花江流域陆地生态系统健康程度的变化特征,基于2000—2020年MODIS MOD17A3HGF数据集,采用趋势分析、相关性分析、M-K检验、地理探测器和相对重要性分析等方法,结合气象站点数据和土地利用数据,分析植被净初级生产力(net primary productivity,NPP)时空演变特征及其对极端气候事件的响应机制。结果表明:松花江流域年均NPP值为407.45 g/m^(2)(以C计,下同),以年均4.82 g/m的速率显著上升(p<0.01);极端降水事件对植被NPP空间分异性的影响强于极端气温事件,极端气候指数间交互作用的影响大于单一极端气候指数的影响,流域及农田和草地生态系统NPP主要受总降水量(PRCPTOT)与年平均最低气温(TMIN)交互作用的影响,森林、湿地和聚落生态系统NPP分别受中雨日数(R10 mm)与年平均最高气温(TMAX)交互作用、强降水量(R95P)与TMIN交互作用和R10 mm与暖夜日数(TN90P)交互作用的影响;时间尺度上PRCPTOT、TMAX和TMIN是植被NPP的主要影响因素,空间尺度上PRCPTOT和TMIN是多年平均NPP的主要影响因素。研究结果可为量化气候变化背景下区域生态系统健康程度和应对极端气候事件措施的制定提供科学依据。

关键词：松花江流域净初级生产力极端气候事件陆地生态系统时空演变规律驱动因素地理探测器

Leukocyte/platelet hybrid membrane-camouflaged dendritic large pore mesoporous silica nanoparticles co-loaded with photo/chemotherapeutic agents for triple negative breast cancer combination treatment

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Bioactive Materials 2021年第11期6卷 3865-3878页

作者： Tao Zhang Hui Liu Ling Li zhaoyang guo Jia Song Xiaoying Yang guoyun Wan Rongshan Li Yinsong Wang Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics(Theranostics) The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical EpigeneticsDepartment of PharmaceuticsSchool of PharmacyTianjin Medical UniversityTianjin300070China The Key Laboratory of Biomedical Material School of Life Science and TechnologyXinxiang Medical UniversityXinxiang453003China

Triple-negative breast cancer(TNBC)is an aggressive subset of breast cancer and currently lacks effective therapeutic targets.As two main phototherapeutic methods,photothermal therapy(PTT)and photodynamic therapy(PDT)show many advantages in TNBC treatment,and their combination with chemotherapy can achieve synergistic therapeutic effects.In the present study,a biomimetic nanoplatform was developed based on leukocyte/platelet hybrid membrane(LPHM)and dendritic large pore mesoporous silicon nanoparticles(DLMSNs).A near infrared(NIR)fluorescent dye IR780 and a chemotherapeutic drug doxorubicin(DOX)were co-loaded into the large pores of DLMSNs to prepare DLMSN@DOX/IR780(DDI)nanoparticles(NPs),followed by camouflage with LPHM to obtain LPHM@DDI NPs.Through the mediation of LPHM,LPHM@DDI NPs showed an excellent TNBC-targeting ability and very high PTT/PDT performances in vitro and in vivo.Upon NIR laser irradiation,LPHM@DDI NPs exhibited synergistic cytotoxicity and apoptosis-inducing activity in TNBC cells,and effectively suppressed tumor growth and recurrence in TNBC mice through tumor ablation and anti-angiogenesis.These synergistic effects were sourced from the combination of PTT/PDT and chemotherapy.Altogether,this study offers a promising biomimetic nanoplatform for efficient co-loading and targeted delivery of photo/chemotherapeutic agents for TNBC combination treatment.

关键词： Leukocyte/platelet hybrid membrane Dendritic large pore mesoporous silica nanoparticles Triple-negative breast cancer Phototherapy Chemotherapy

Bandgap characteristics of the two-dimensional missing rib lattice structure

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Applied Mathematics and Mechanics(English Edition) 2022年第11期43卷 1631-1640页

作者： Fan YANG zhaoyang MA Xingming guo Shanghai Institute of Applied Mathematics and Mechanics Shanghai Key Laboratory of Mechanics in Energy EngineeringShanghai UniversityShanghai 200072China

In this paper,the bandgap characteristics of a missing rib lattice structure composed of beam elements are investigated by using the Floquet-Bloch theorem.The tuning of the width and position of the bandgap is achieved by changing the local structural parameters,i.e.,the rotation angle,the short beam length,and the beam thickness.In order to expand the regulation of the bandgap,the influence of the material parameters of the crossed long beams inside the structure on the bandgap is analyzed.The results show that the mass density and stiffness of the structure have significant effects on the bandgap,while Poisson’s ratio has no effect on the bandgap.By analyzing the first ten bands of the reference unit cell,it can be found that the missing rib lattice structure generates multiple local resonance bandgaps for vibration reduction,and these bandgap widths are wider.The modal analysis reveals that the formation of the bandgap is due to the dipole resonance of the lattice structure,and this dipole resonance originates from the coupling of the bending deformation of the beam elements.In the band structure,the vibrational mode of the 9th band with a negative slope corresponds to a rotational resonance,which is different from that with the conventional negative slope formed by the coupling of two resonance modes.This study can provide a theoretical reference for the design of simple and lightweight elastic metamaterials,as well as for the regulation of bandgaps and the suppression of elastic waves.

关键词： elastic metamaterial missing rib structure Floquet-Bloch theorem bandgap vibration mode

氧等离子处理的二硫化钼场效应晶体管表面掺杂和湿度传感研究

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Journal of Donghua University(English Edition) 2024年第2期41卷 130-136页

作者：江海洋吴静远温朝阳郭冰博东华大学理学院上海201620

二维半导体过渡金属二硫属化物(transition metal dichalcogenide,TMD)具有独特的电学、光学和力学性能,在数字电路、光伏器件和能量存储等多个领域中具有巨大的应用潜力。通过表面掺杂控制TMD的电学性能为实现灵敏传感提供了有效的方... 详细信息

二维半导体过渡金属二硫属化物(transition metal dichalcogenide,TMD)具有独特的电学、光学和力学性能,在数字电路、光伏器件和能量存储等多个领域中具有巨大的应用潜力。通过表面掺杂控制TMD的电学性能为实现灵敏传感提供了有效的方法。本文开展了氧等离子体对二硫化钼(MoS_(2))掺杂特性的研究。首先,测试了MoS_(2)场效应晶体管(field-effect transistor,FET)的输运特性,发现氧等离子体处理对FET具有p型掺杂作用。随后,通过拉曼光谱研究了掺杂机制的成因,并证实了沟道表面类MoO_(3)缺陷的形成。最后,研究了经等离子体处理的晶体管的湿度传感特性,由于氧等离子体处理使得沟道对水分子的吸收中心增加,在潮湿环境下晶体管具有十分灵敏的响应特性,源漏电流值变化了约54%。这项工作不仅提供了一种调控TMD电学性能的简单方法,也展示了低维材料化学传感器的发展潜力。

关键词：场效应晶体管(FET) 二硫化钼(MoS2) 氧等离子体表面掺杂湿度传感

Quantification of traffic-induced compaction based on soil and agricultural implement parameters

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International Journal of Agricultural and Biological Engineering 2020年第5期13卷 134-140页

作者： Xianliang Wang Xiangcai Zhang Xiaona Lin Luming Sha Hanyu Yang zhaoyang guo Zeyu Chen Rongyan Sun College of Agricultural Engineering and Food Science Shandong University of TechnologyZibo 255000ShandongChina

Vehicle-induced soil compaction occurs when agricultural machinery is working in the fields.The accumulated soil compaction could destroy soil structure and inhibit crop growth.The low degree of visualization of soil compaction has always been an important reason for restricting the development of compaction alleviation technology.Therefore,the main objective of this study was to predict soil compaction based on soil and agricultural implement parameters.The component of soil compaction prediction includes traffic-induced stress transmission evaluation and the quantitative relationship between soil stress and bulk density.The modified FRIDA model was used to elucidate the soil stress propagation,which has been validated by previous studies.The Bailey formula was used to establish the intrinsic relationship between soil stress and bulk density.The soil uniaxial compression test was applied to obtain the parameters of the Bailey formula,and soil samples were prepared with three different levels of water content.After fitting with the Bailey formula,under the condition that the soil moisture contents were 16%,20%,and 24%,the fitting coefficients of soil bulk density were respectively 0.980,0.959,and 0.975,which were close to 1.The results indicated that the Bailey formula could be used to calculate soil bulk density based on the stress conditions of the soil.To verify the practicality of the soil compaction prediction model,a field experiment was carried out in Zhuozhou City,Hebei Province,China.The treatment was set for 1,3,5,7,and 9 times compaction with two different loads of compaction equipment.The results showed that the fit coefficient between the predicted and measured values of soil bulk density was greater than 0.641.The slope of the equation was greater than 0.782,proving that the soil bulk density prediction model based on agricultural implements and soil parameters has a good predictive effect on soil bulk density.The soil compaction evaluation model can provide a theoretical basis to further understand

关键词： soil traffic-induced compaction agricultural implement soil bulk density no-tillage soil structure quantification

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煤气化炉渣对煤矸石膏体充填材料性能影响

河南理工大学学报（自然科学版） 2024年第1期43卷 165-171页

作者：张海波郭朝阳郭晋辉赵冬陈玉泰王菲河南理工大学材料科学与工程学院河南焦作454000 潞安化工集团有限公司山西长治046299

目的利用煤气化炉渣颗粒的球形特征,研究其对煤矿采空区膏体充填材料流动性和强度的影响规律,并分析其影响机理。方法以质量分数为85%的煤矸石骨料充填膏体为对照组,煤气化炉渣等质量取代膏体中煤矸石细骨料10%,20%,30%,40%,50%,分别测... 详细信息

目的利用煤气化炉渣颗粒的球形特征,研究其对煤矿采空区膏体充填材料流动性和强度的影响规律,并分析其影响机理。方法以质量分数为85%的煤矸石骨料充填膏体为对照组,煤气化炉渣等质量取代膏体中煤矸石细骨料10%,20%,30%,40%,50%,分别测试新拌膏体泌水率、坍落度、扩展度、流变屈服应力和塑性黏度等浆体性能,同时测试膏体结石体抗压强度。结果结果表明,随着炉渣取代率增加,膏体泌水率增加,坍落度和扩展度增加,流变屈服应力和塑性黏度减小;与对照组相比,炉渣取代率为10%时,膏体屈服应力和塑性黏度分别降低16.7%,1.6%;与10%取代组相比,炉渣取代率为20%时,膏体屈服应力和塑性黏度分别降低47.4%,15.0%,降低速率大幅增加;继续增加炉渣取代率,膏体屈服应力和塑性黏度又缓慢增加;膏体结石体早期强度(3,7 d)随着炉渣取代率增加而小幅降低,后期强度(28,60 d)无显著变化。结论煤气化炉渣作为骨料取代膏体充填材料中的煤矸石细骨料,可以改善新拌膏体流动性,取代率达到20%时,可以充分发挥球状炉渣颗粒在多棱角煤矸石骨料间的滚珠润滑作用,减小矸石骨料机械咬合,大幅降低充填膏体屈服应力和塑性黏度;且炉渣对充填膏体结石体后期强度无显著影响。

关键词：膏体充填煤气化炉渣流变性机械咬合强度