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Chemical Research in Chinese Universities 2022年第2期38卷 562-571页

作者： WU Liting XIN Yujia GUO zhaoyang GAO wei ZHU Yanpeng WANG Yinsong RAN Ruixue YANG Xiaoying Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics(Theranostics) School of PharmacyTianjin Medical UniversityTianjin 300070P.R.China

Combining photothermal therapy and radiotherapy(PTT-RT) with reducing tumor hypoxia acts as an important antitumor modality. However, it is a great challenge to realize photothermal therapy, radiotherapy and exogenous oxygen supply in one nanosystem. To realize a combination of the three functions, we fabricated a red blood cell membrane(RBCm)-camouflaged, red blood cell content(RBCc) and the copper sulfide(CuS) co-loaded dendritic large pore mesoporous silica nanoparticle(DLMSN/CuS/RBCc/ RBCm). The cell membrane coating endowed the nanoparticles with good stability in the physiological environment, and CuS allowed the nanoparticle exhibiting good photothermal and radiosensitization properties. RBCc loaded nanoparticle DLMSN/CuS/RBCc enhanced superior anti-tumor effect than DLMSN/CuS during combined PTT-RT therapy because the introduction of RBCc increased the exogenous oxygen supply. The in vitro study further demonstrated that the combination of photothermal therapy and radiotherapy induced superior antitumor efficacy than single therapy. Our work thus presents a unique multifunctional nanoscale platform favorable for combined PTT and RT.

关键词： Dendritic large pore mesoporous silica nanoparticle Photothermal therapy Radiosensitization Red blood cell membrane Oxygen carrying

Vertically stacked holey graphene/polyaniline heterostructures with enhanced energy storage for on-chip micro-supercapacitors

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Nano Research 2016年第4期9卷 1012-1021页

作者： Xiaocong Tian Bei Xiao Xu Xu Lin Xu Zehua Liu zhaoyang Wang Mengyu Yan Qiulong wei Liqiang Mai State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Wuhan 430070 China Department of Chemistry and Biochemistry University of California Los Angeles California 90095 USA Department of Chemistry and Chemical Biology Harvard University Cambridge Massachusetts 02138 USA These authors contributed equally to this work.

Planar micro-supercapacitors （MSCs） have drawn extensive research attention owing to their unique structural design and size compatibility for microelectronic devices. Graphene has been widely used to improve the performance of microscale electrochemical capacitors. However, investigations of an intrinsic electrochemical mechanism for graphene-based microscale devices are still not sufficient. Here, micro-supercapacitors with various typical architectures are fabricated as models to study the graphene effect, and their electrochemical performance is also evaluated. The results show that ionic accessibility and adsorption are greatly improved after the introduction of the holey graphene intermediate layer. This study provides a new route to understand intrinsic electrochemical behaviors and possesses exciting potential for highly efficient on-chip micro-energy storage.

关键词： micro-supercapacitors holey graphene heterostructures ionic accessibility intrinsic electrochemical behaviors

Genome-wide association study of callus induction variation to explore the callus formation mechanism of rice

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Journal of Integrative Plant Biology 2019年第11期61卷 1134-1150页

作者： zhaoyang Zhang Hu Zhao wei Li Jiemin Wu Zaihui Zhou Fei Zhou Hao Chen Yongjun Lin National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University

Rice(Oryza sativa) is one of the most widely cultivated food crops, worldwide. Tissue culture is extensively used in rice breeding and functional genome research. The ability to induce callus determines whether a particular rice variety can be subjected to tissue culture and Agrobacterium-mediated transformation. Over the past two decades, many quantitative trait loci(QTLs)related to callus induction traits have been identified;however, individual genes associated with rice callus induction have not been reported. In this study, we characterized three callus-induction traits in a global collection of 510 rice accessions. A genome-wide association study of the rice population in its entirety as well as subpopulations revealed 21 significant loci located in rice callus induction QTLs. We identified three candidate callus induction genes, namely CRL1, Os BMM1, and Os SET1, which Rese are orthologs of Arabidopsis LBD17/LBD29, BBM, and SWN,respectively, which are known to affect callus ***, we predicted that 14 candidate genes might be involved in rice callus induction and showed that RNA interference(RNAi)-mediated disruption of Os IAA10 inhibited callus formation on tissue culture *** growth in the Os IAA10 RNAi line was not inhibited by synthetic auxin(2,4-D) treatment, suggesting that Os IAA10 may perceive auxin and activate the expression of downstream genes, such as CRL1, to induce callus formation. The significant loci and candidate genes identified here may provide insight into the mechanism underlying callus formation in rice.

关键词： breeding crops

Cloning and characterization of an apolipoprotein C2 promoter in the mouse central nervous system

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Neural Regeneration Research 2013年第2期8卷 156-161页

作者： zhaoyang Li Bing Du Shengyang Li Xiangchuan Lv Shenglai Zhou Yang Yu wei Wang Zhihong Zheng Key Laboratory of Transgenetic Animal Research Department of Laboratory Animal China Medical University College of Animal Science & Veterinary Medicine Shenyang Agricultural University

Apolipoprotein C2 is an important member of the apolipoprotein C family, and is a potent activator of lipoprotein lipase. In the central nervous system, apolipoprotein C2 plays an important role in the catabolism of triglyceride-rich lipoproteins. Studies into the exact regulatory mechanism of mouse apolipoprotein C2 expression have not been reported. In this study, seven luciferase expression vectors, which contained potential mouse apolipoprotein C2 gene promoters, were constructed and co-transfected with pRL-TK into HEK293T cells to investigate apolipoprotein C2 promoter activity. Luciferase assays indicated that the apolipoprotein C2 promoter region was mainly located in the ＋104 bp to ＋470 bp region. The activity of the different lengths of apolipoprotein C2 promoter region varied. This staggered negative-positive-negative arrangement indicates the complex regulation of apolipoprotein C2 expression and provides important clues for elucidating the regulatory mechanism of apolipoprotein C2 gene transcription.

关键词： neural regeneration basic research apolipoprotein C2 promoter dual-luciferase reporter assay transcriptional activity regulatory elements grants-supported paper neuroregeneration

OBH-RSI:Object-Based Hierarchical Classification Using Remote Sensing Indices for Coastal Wetland

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Journal of Beijing Institute of Technology 2021年第2期30卷 159-171页

作者： zhaoyang Lin Jianbu Wang wei Li Xiangyang Jiang Wenbo Zhu Yuanqing Ma Andong Wang Beijing Key Laboratory of Fractional Signals and Systems Beijing Institute of TechnologyBeijing 100081China Laboratory of Marine Physics and Remote Sensing First Institute of OceanographyMinistry of Natural ResourcesQingdao 266061China Shandong Provincial Key Laboratory of Restoration for Marine Ecology Shandong Marine Resources and Environment Research InstituteYantai 264006China Shandong Yellow River Delta National Nature Reserve Administration Committee Dongying 257091China

With the deterioration of the environment,it is imperative to protect coastal *** multi-source remote sensing data and object-based hierarchical classification to classify coastal wetlands is an effective *** object-based hierarchical classification using remote sensing indices(OBH-RSI)for coastal wetland is proposed to achieve fine classification of coastal ***,the original categories are divided into four groups according to the category ***,the training and test maps of each group are extracted according to the remote sensing ***,four groups are passed through the classifier in ***,the results of the four groups are combined to get the final classification result *** experimental results demonstrate that the overall accuracy,average accuracy and kappa coefficient of the proposed strategy are over 94%using the Yellow River Delta dataset.

关键词： Yellow River Delta vegetation index object-based hierarchical classification wetland multi-source remote sensing

急性胰腺炎患者外周血TLR4、IL-1β、NLR水平与疾病进展和预后的关系

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天津医药 2024年第6期52卷 648-652页

作者：叶朝阳马建中李后俊魏鲲鹏安徽医科大学附属六安医院(安徽省六安市人民医院)急诊外科 237000

目的研究急性胰腺炎(AP)患者外周血Toll样受体4(TLR4)、白细胞介素(IL)-1β、中性粒细胞/淋巴细胞比值(NLR)与疾病进展、预后的关系。方法 250例AP患者按病情分为轻症组(121例)、中重症组(89例)、重症组(40例),依据治疗5 d后预后情况... 详细信息

目的研究急性胰腺炎(AP)患者外周血Toll样受体4(TLR4)、白细胞介素(IL)-1β、中性粒细胞/淋巴细胞比值(NLR)与疾病进展、预后的关系。方法 250例AP患者按病情分为轻症组(121例)、中重症组(89例)、重症组(40例),依据治疗5 d后预后情况分为预后不良组(33例)、预后良好组(217例)。对比不同时间点、不同病情及不同预后AP患者外周血TLR4、IL-1β、NLR水平,采用Pearson相关分析外周血TLR4、IL-1β、NLR与Ranson评分、淀粉酶的相关性,绘制受试者工作特征(ROC)曲线分析各指标诊断重症AP的价值,多因素Logistic回归分析预后危险因素。结果 AP患者入院24 h TLR4、IL-1β、NLR水平较入院48 h、72 h高(P<0.05);随病情加重,AP患者入院24 h TLR4、IL-1β水平升高,重症组NLR水平高于中重症组和轻症组(P<0.05);AP患者入院24 h TLR4、IL-1β、NLR水平与入院48 h Ranson评分及入院24 h淀粉酶水平均呈正相关(P<0.05);入院24 h TLR4、IL-1β、NLR联合预测重症AP的ROC曲线下面积、敏感度、特异度分别为0.895、84.53%、81.69%;预后不良组入院24 h TLR4、IL-1β、NLR水平高于预后良好组(P<0.05),且多因素Logistic回归分析显示入院24 h TLR4、IL-1β、NLR升高为AP患者预后不良的独立危险因素(P<0.05)。结论 AP患者外周血TLR4、IL-1β、NLR水平与疾病进展、预后有密切关联,可作为重要监测指标。

关键词：胰腺炎 Toll样受体4 白细胞介素4 预后中性粒细胞/淋巴细胞比值

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Phase-transforming mechanical metamaterials with dynamically controllable shape-locking performance

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National Science Review 2023年第9期10卷 270-285页

作者： Yiding Zhong wei Tang Huxiu Xu Kecheng Qin Dong Yan Xujun Fan Yang Qu zhaoyang Li Zhongdong Jiao Huayong Yang Jun Zou State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang University School of Mechanical Engineering Zhejiang University Institute of Process Equipment College of Energy EngineeringZhejiang University

Active mechanical metamaterials with customizable structures and deformations,active reversible deformation,dynamically controllable shape-lo cking performance and stretchability are highly suitable for applications in soft robotics and flexible electronics,yet it is challenging to integrate them due to their mutual ***,we introduce a class of phase-transforming mechanical metamaterials(PMMs) that integrate the above *** arranging basic actuating units according to the designed pattern configuration and positional relationship,PMMs can customize complex and diverse structures and ***-vapor phase transformation provides active reversible large deformation while a silicone matrix offers *** contained carbonyl iron powder endows PMMs with dynamically controllable shape-lo cking performance,thereby achieving magnetically assisted shape locking and energy storing in different working *** build a theoretical model and finite element simulation to guide the design process of PMMs,so as to develop a variety of PMMs with different functions suitable for different applications,such as a programmed PMM,reconfigurable antenna,soft lens,soft mechanical memory,biomimetic hand,biomime tic flytrap and self-contained soft *** are applicable to achieve various 2D deformations and 2D-to-3D deformations,and integrate multiple properties,including customizable structures and deformations,active reversible deformation,rapid reversible shape locking,adjustable energy storing and stretchability,which could open a new application avenue in soft robotics and flexible ele ctronics.

关键词： active mechanical metamaterials shape locking energy storage liquid–vapor phase transform soft robotics

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三电平牵引逆变器电流谐波最小调制策略

机车电传动 2024年第2期 33-42页

作者：蒋威李赵烊殷振环邱腾飞王琛琛北京纵横机电科技有限公司北京100094 北京交通大学电气工程学院北京100044

使用三电平变流器拓扑结构,可有效降低单个开关器件所承受的电压等级,为碳化硅(SiC)器件在高压大功率牵引变流器领域的应用提供解决方案。文章根据牵引逆变器的应用需求,针对三电平二极管中点箝位(Neutral-Point-Clamped,NPC)型逆变器... 详细信息

使用三电平变流器拓扑结构,可有效降低单个开关器件所承受的电压等级,为碳化硅(SiC)器件在高压大功率牵引变流器领域的应用提供解决方案。文章根据牵引逆变器的应用需求,针对三电平二极管中点箝位(Neutral-Point-Clamped,NPC)型逆变器拓扑的电流谐波最小脉宽调制(Current harmonic minimum pulse width modulation,CHMPWM)策略开展了研究,通过求解不同开关角个数下开关角度随调制比的变化曲线,实现了三电平逆变器脉冲数较低情况下的电流谐波的总体优化,理论分析了CHMPWM不同开关角个数下的各次电流谐波和加权总谐波畸变(weighted total harmonic distortion,WTHD)特征,介绍了CHMPWM的脉冲产生方式及基于定子磁链偏差矢量的调制模式切换方法。最后,利用小功率试验平台对三电平逆变器CHMPWM及调制模式切换策略进行了试验研究,结果表明,三电平逆变器CHMPWM策略具有较好的动态和稳态性能,能满足牵引逆变器的技术应用需求。

关键词：三电平逆变器脉宽调制电流谐波最小同步调制调制切换

Application of the sodium hyaluronate-CNTF scaffolds in repairing adult rat spinal cord injury and facilitating neural network formation

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Science China(Life Sciences) 2018年第5期61卷 559-568页

作者： Yabin Xie wei Song Wen Zhao Yudan Gao Junkui Shang Peng Hao zhaoyang Yang Hongmei Duan Xiaoguang Li Department of Neurobiology School of Basic Medical Sciences Capital Medical University Beijing 100069 China Sehool of Rehabilitation Medicine China Rehabilitation Research Centre Capital Medical University Beijing 100069 China

The present study aimed to explore the potential of the sodium hyaluronate-CNTF (ciliary neurotrophic factor) scaffold in activating endogenous neurogenesis and facilitating neural network re-formation after the adult rat spinal cord injury (SCI). After completely cutting and removing a 5-mm adult rat T8 segment, a sodium hyaluronate-CNTF scaffold was implanted into the lesion area. Dil tracing and immunofluorescence staining were used to observe the proliferation, differentiation and integration of neural stem cells (NSCs) after SCI. A planar multielectrode dish system (MED64) was used to test the electrophysiological characteristics of the regenerated neural network in the lesioned area. Electrophysiology and behavior evaluation were used to evaluate functional recovery of paraplegic rat hindlimbs. The Dil tracing and immunofluorescence results suggest that the sodium hyaluronate-CNTF scaffold could activate the NSCs originating from the spinal cord ependymal, and facilitate their migration to the lesion area and differentiation into mature neurons, which were capable of forming synaptic contact and receiving glutamatergic excitatory synaptic input. The MED64 results suggest that functional synapsis could be established among regenerated neurons as well as between regenerated neurons and the host tissue, which has been evidenced to be glutamatergic excitatory synapsis. The electrophysiology and behavior evaluation results indicate that the paraplegic rats’ sensory and motor functions were recovered in some degree. Collectively, this study may shed light on paraplegia treatment in clinics.

关键词： spinal cord injury endogenous neural stem cells neural network reconstruction CNTF new born neuron

结直肠癌伴同时性肝转移行腹腔镜同步切除手术的疗效:回顾性队列研究

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中国普外基础与临床杂志 2024年第5期31卷 547-554页

作者：杨洋郑兆阳陈鹏冯曦魏永刚杨烈周总光四川大学华西医院普外科胃肠外科病房成都610041 四川大学华西医院普外科肝脏外科病房成都610041 四川大学华西医院普外科研究所成都610041

目的探讨腹腔镜同步切除的手术策略在结直肠癌伴同时性肝转移患者中的安全性和近远期疗效。方法回顾性收集2015年3月至2021年12月间于四川大学华西医院胃肠外科接受腹腔镜同步手术切除结直肠癌和肝转移灶的36例患者的临床资料,对围手术... 详细信息

目的探讨腹腔镜同步切除的手术策略在结直肠癌伴同时性肝转移患者中的安全性和近远期疗效。方法回顾性收集2015年3月至2021年12月间于四川大学华西医院胃肠外科接受腹腔镜同步手术切除结直肠癌和肝转移灶的36例患者的临床资料,对围手术期情况、术后并发症和生存状况进行分析。结果36例患者均完成手术,手术时间(328.9±85.8)min,术中失血量100(50,150)mL,其中有4例(11.1%)术中输血;首次排气时间(2.9±0.8)d,首次进食时间(3.2±1.0)d,术后1~3 d平均视觉模拟量表评分(1.9±0.3)分,术后住院时间(6.8±4.3)d。术后30 d内5例(13.9%)出现并发症,均经保守治疗后痊愈,无严重并发症及死亡病例。中位随访24.7个月,15例(41.7%)复发转移,1例(2.8%)死亡。术后1、2、3年无病生存率分别为89.8%、55.0%、29.2%,1、2、3年总体生存率分别为100%、100%、87.5%。新辅助治疗组与未行新辅助治疗组患者的无病生存(χ^(2)=1.675,P=0.196)和总体生存(χ^(2)=0.600,P=0.439)比较差异均无统计学意义。结论本研究初步结果表明,对结直肠癌伴同时性肝转移患者实施腔镜同步切除的手术策略安全可行,手术切口小、术中失血量少、术后恢复快、并发症发生率低,生存获益满意,未来亟需更多高质量研究进一步证实此种手术策略的临床安全性与可行性。

关键词：结直肠癌同时性肝转移腹腔镜手术一期同步切除