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Infection-responsive polysaccharide-based drug-loaded nano-assembly for dual-modal treatment against drug-resistant bacterial lung infection

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BMEMat(BioMedical Engineering Materials) 2024年第3期2卷 123-136页

作者： Lin Han Zhonghua Yuan Hui-Min Ren Weizhuo Song Ruonan Wu Jie Li zhaoyan guo Bingran Yu Shun Duan Fu-Jian Xu State Key Laboratory of Chemical Resource Engineering Key Lab of Biomedical Materials of Natural Macromolecules(Beijing University of Chemical TechnologyMinistry of Education)Beijing Laboratory of Biomedical MaterialsBeijing University of Chemical TechnologyBeijingChina Beijing Research Institute of Chemical Industry SinopecBeijingChina

The escalating issue of lung infections induced by multi-drug resistant(MDR)bacteria is threatening human ***,the development of efficient drug delivery systems is essential to eliminate MDR bacterial lung infections ***,we designed inhalable drug-loaded nano-assemblies by the electrostatic interaction between negatively charged sodium alginate and a positively charged antibacterial polymer,quaternized polyethyleneimine(QPEI-C_(6)),as well as a kind of typical antibiotic for therapy of lung infection,azithromycin(AZT).By adjusting the feed ratios,we optimized the size of the nano-assembly to approximately 200 nm(STQ_(12)),which was beneficial for penetration through the mucus layer and *** the slightly acidic environment of the infected site,the nano-assembly could dissemble responsively and release AZT and QPEI-C_(6).Because of the combined bactericidal effect,STQ_(12)exhibited high bactericidal efficiency against MDR *** animal experiments,STQ_(12)showed notable efficacy against MDR bacterial lung *** transcriptomic results showed that the main effects of STQ_(12)against bacteria were through influencing the bacterial cell components and metabolic processes,and affecting their growth and *** work provides a promising strategy to treat MDR bacterium-induced lower respiratory tract infections.

关键词： antibacterial infection responsiveness multi-drug resistant bacteria nano-assembly polysaccharide

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有机磷酸盐聚丙烯成核剂细微化制备及分散技术研究进展

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石油化工 2024年第4期53卷 594-600页

作者：郭照琰赖金梅戚桂村茹越张晓红中石化(北京)化工研究院有限公司北京100013

有机磷酸盐类成核剂可改善聚丙烯(PP)的刚性和热性能,且具有热稳定性好、无毒、不易溶出等优势,应用范围广泛。但有机磷酸盐类成核剂与PP树脂的相容性有限,通常不易配混,需开发能够降低成核剂粒径、载体复配的细微化制备及分散技术,以... 详细信息

有机磷酸盐类成核剂可改善聚丙烯(PP)的刚性和热性能,且具有热稳定性好、无毒、不易溶出等优势,应用范围广泛。但有机磷酸盐类成核剂与PP树脂的相容性有限,通常不易配混,需开发能够降低成核剂粒径、载体复配的细微化制备及分散技术,以提高有机磷酸盐类成核剂在聚丙烯中的分散效果。随着聚烯烃市场竞争愈加激烈,开发低成本的成核剂细微化制备工艺及复配技术,改善成核剂在聚丙烯中的分散性,将更有利于提升国产成核剂以及高性能聚烯烃的市场竞争力。

关键词：有机磷酸盐成核剂聚丙烯细微化制备载体分散

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Natural tea-leaf-derived, ternary-doped 3D porous carbon as a high-performance electrocatalyst for the oxygen reduction reaction

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Nano Research 2016年第5期9卷 1244-1255页

作者： zhaoyan guo Zhen Xiao Guangyuan Ren guozheng Xiao Ying Zhu Liming Dai Lei Jiang Key Laboratory of Bio-inspired Smart Interfacial Science and Technology of Ministry of Education School of Chemistry and Environment Beihang University Beijing 100191 China Department of Macromolecular Science and Engineering Case Western Reserve University Cleveland 10900 USA Beijing National Laboratory for Molecular Sciences Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China

To commercialize fuel cells and metal-air batteries, cost-effective, highly active catalysts for the oxygen reduction reaction （ORR） must be developed. Herein, we describe the development of low-cost, heteroatom （N, P, Fe） ternary-doped, porous carbons （HDPC）. These materials are prepared by one-step pyrolysis of natural tea leaves treated with an iron salt, without any chemical and physical activation. The natural structure of the tea leaves provide a 3D hierarchical porous structure after carbonization. Moreover, heteroatom containing organic compounds in tea leaves act as precursors to functionalize the resultant carbon frameworks. In addition, we found that the polyphenols present in tea leaves act as ligands, reacting with Fe ions to form coordination compounds; these complexes acted as the precursors for Fe and N active sites. After pyrolysis, the as-prepared HDPC electrocatalysts, especially HDPC-800 （pyrolyzed at 800℃）, had more positive onsets, half-wave potentials, and higher catalytic activities for the ORR, which proceeds via a direct four-electron reaction pathway in alkaline media, similar to commercial Pt/C catalysts. Furthermore, HDPC-X also showed enhanced durability and better tolerance to methanol crossover and CO poisoning effects in comparison to commercial Pt/C, making them promising alternatives for state-of-the-art ORR electrocatalysts for electrochemical energy conversion. The method used here provides valuable guidelines for the design of high-performance ORR electrocatalysts from natural sources at the industrial scale.

关键词： green tea leaves oxygen reduction catalysts,heteroatoms doped hierarchically porous carbon,synergistic effect

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A bio-inspired Co304-polypyrrole-graphene complex as an efficient oxygen reduction catalyst in one-step ball milling

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Nano Research 2015年第11期8卷 3461-3471页

作者： Guangyuan Ren Yunan Li zhaoyan guo guozheng Xiao Ying Zhu Liming Dai Lei Jiang Key Laboratory of Bio-inspired Smart Interfacial Science and Technology of Ministry of Education School of Chemistry and Environment Beihang University Beijing 116023 China School of Chemistry Biology and Materials Science East China Institute of Technology Nanchang 330013 China Department of Macromolecular Science and Engineering Case Western Reserve University Cleveland Ohio 44106 USA

The development of non-precious metal-based electrocatalysts has attracted much research attention because of their high oxygen reduction reaction （ORR） activities, low cost, and good durability. By one-step in-situ ball milling of graphite, pyrrole, and cobalt salt without resorting to high-temperature annealing, we developed a general and facile strategy to synthesize bio-inspired cobalt oxide and polypyrrole coupled with a graphene nanosheet （Co3O4-PPy/GN） complex. Herein, the exfoliation of graphite and polymerization of pyrrole occurred simultaneously during the ball milling process. Meanwhile, the Co3O4 and Co-Nx ORR active sites were generated from the oxidized cobalt ion, cobalt-PPy, and the newly exfoliated graphene nanosheets via strong π-π stacking interactions. The resultant Co3O4-PPy/GN catalysts showed efficient electrocatalytic performances for ORRs in an alkaline medium with a positive onset and reduction potentials of -0.102 and -0.196 V （vs. Ag/AgCl）, as well as a high diffusion-limited current density （4.471 mA·cm^-2）, which was comparable to that of a Pt/C catalyst （4.941 mA·cm^-2）. Compared to Pt/C, Co3O4-PPy/GN catalysts displayed better long-term stability, methanol tolerance, and anti-CO-poisoning effects, which are of great significance for the design and development of advanced non-precious metal electrocatalysts.

关键词： graphene cobalt-polypyrrole oxygen reduction reaction electrocatalysts ball milling

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Mitochondrial transplantation confers protection against the effects of ischemic stroke by repressing microglial pyroptosis and promoting neurogenesis

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Neural Regeneration Research 2024年第6期19卷 1325-1335页

作者： Li Sun zhaoyan Zhao Jing guo Yuan Qin Qian Yu Xiaolong Shi Fei guo Haiqin Zhang Xude Sun Changjun Gao Qian Yang Department of Experimental Surgery The Second Affiliated Hospital of Air Force Medical UniversityXi’anShaanxi ProvinceChina Department of Anesthesiology The Second Affiliated Hospital of Air Force Medical UniversityXi’anShaanxi ProvinceChina

Transferring healthy and functional mitochondria to the lateral ventricles confers neuroprotection in a rat model of ischemia-reperfusion *** mitochondrial transplantation is also beneficial in pediatric patients with cardiac ischemia-reperfusion ***,transplantation of functional exogenous mitochondria may be a promising therapeutic approach for ischemic *** explore the neuroprotective effect of mitochondria transplantation and determine the underlying mechanism in ischemic stroke,in this study we established a photo-thrombosis-induced mouse model of focal ischemia and administered freshly isolated mitochondria via the tail vein or to the injury site(in situ).Animal behavior tests,immunofluorescence staining,2,3,5-triphenyltetrazolium chloride(TTC)staining,mRNA-seq,and western blotting were used to assess mouse anxiety and memory,cortical infarct area,pyroptosis,and neurogenesis,*** bioinformatics analysis,western blotting,co-immunoprecipitation,and mass spectroscopy,we identified S100 calcium binding protein A9(S100A9)as a potential regulator of mitochondrial function and determined its possible interacting *** between exogenous and endogenous mitochondria,as well as the effect of exogenous mitochondria on recipient microglia,were assessed in *** data showed that:(1)mitochondrial transplantation markedly reduced mortality and improved emotional and cognitive function,as well as reducing infarct area,inhibiting pyroptosis,and promoting cortical neurogenesis;(2)microglial expression of S100A9 was markedly increased by ischemic injury and regulated mitochondrial function;(3)in vitro,exogenous mitochondria enhanced mitochondrial function,reduced redox stress,and regulated microglial polarization and pyroptosis by fusing with endogenous mitochondria;and(4)S100A9 promoted internalization of exogenous mitochondria by the microglia,thereby amplifying their pro-proliferation and anti-inflammatory ***

关键词： ischemic stroke microglia mitochondria transplantation neurogenesis pyroptosis

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Natural variations of HvSRN1 modulate the spike rachis node number in barley

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Plant Communications 2024年第1期5卷 148-163页

作者： Chaofeng Fan Dongdong Xu Chunchao Wang zhaoyan Chen Tingyu Dou Dandan Qin Aikui guo Meng Zhao Honghong Pei Mengwei Zhao Renxu Zhang Ke Wang Jing Zhang Zhongfu Ni Ganggang guo Key Laboratory of Grain Crop Genetic Resources Evaluation and Utilization(MARA) The National Key Facility for Crop Gene Resources and Genetic ImprovementInstitute of Crop SciencesChinese Academy of Agricultural Sciences(ICS-CAAS)Beijing 100081China Hainan Yazhou Bay Seed Laboratory Sanya 572025China Institute of Industrial Crops Shandong Academy of Agricultural SciencesJinan 250100China Key Laboratory of Crop Heterosis and Utilization Beijing Key Laboratory of Crop Genetic ImprovementChina Agricultural UniversityBeijing 100193China Key Laboratory for Crop Molecular Breeding of Ministry of Agriculture and Rural Affairs Institute of Food CropsHubei Academy of Agricultural SciencesWuhan 430064China

Grain number,one of the major determinants of yield in Triticeae crops,is largely determined by spikelet number and spike rachis node number(SRN).Here,we identified three quantitative trait loci(QTLs)for SRN using 145 recombinant inbred lines derived from a barley R90/1815D ***1,the major-effect QTL,was mapped to chromosome 2H and explained up to 38.77%of SRN ***-based cloning revealed that qSRN1 encodes the RAWUL domain-containing protein *** analysis revealed that two key SNPs in the HvSRN1 promoter region(-2 kb upstream of the transcription start site)affect the transcript level of HvSRN1 and contribute to variation in *** to its orthologous proteins OsLAX2 and ZmBA2,HvSRN1 showed protein–protein interactions with HvLAX1,suggesting that the LAX2–LAX1 model for spike morphology regulation may be conserved in Poaceae ***-Cas9-induced HvSRN1 mutants showed reduced SRN but increased grain size and weight,demonstrating a trade-off *** results shed light on the role of HvSRN1 variation in regulating the balance between grain number and weight in barley.

关键词： barley fine-mapping grain number kernel weight

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LASSO及其拓展方法在回归分析变量筛选中的应用

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中华预防医学杂志 2023年第1期57卷 107-111页

作者：奚丽婧郭昭艳杨雪珂平智广郑州大学公共卫生学院流行病与卫生统计学系郑州450001

多重共线性是影响回归分析结果的一个重要问题,近年来发展的LASSO方法对于筛选解释性较高的变量、处理高维数据和解决多重共线性问题具有强大的优势。该方法是在模型估计中增加了惩罚项,能将一些不必要变量的回归系数压缩为零进而从模... 详细信息

多重共线性是影响回归分析结果的一个重要问题,近年来发展的LASSO方法对于筛选解释性较高的变量、处理高维数据和解决多重共线性问题具有强大的优势。该方法是在模型估计中增加了惩罚项,能将一些不必要变量的回归系数压缩为零进而从模型中剔除,达到变量筛选的目的。本文将重点介绍LASSO这一方法,并与最优子集、岭回归、自适应LASSO与弹性网络的结果进行比较,结果显示LASSO与自适应LASSO在解决自变量多重共线性问题以及增强模型解释性、预测精度方面均有较好的表现。

关键词：模型,统计学 LASSO 多重共线性回归分析

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断点回归设计在流行病学研究中的应用

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中华预防医学杂志 2021年第9期55卷 1168-1172页

作者：郭昭艳刘莉余方方王俊义高杨平智广郑州大学公共卫生学院流行病与卫生统计学系 450001 郑州大学基础医学院组织胚胎学系 450001

断点回归设计是一种严格的类实验方法,基于样本在临界值周围分布的随机性,使用两侧数据分别进行回归,从而避免潜在混杂因素的干扰,为因果关联的推断提供强有力的证据。本研究对断点回归方法以及其研究进展进行了介绍,并结合案例对其应... 详细信息

断点回归设计是一种严格的类实验方法,基于样本在临界值周围分布的随机性,使用两侧数据分别进行回归,从而避免潜在混杂因素的干扰,为因果关联的推断提供强有力的证据。本研究对断点回归方法以及其研究进展进行了介绍,并结合案例对其应用方法进行了详细阐述,以期为断点回归在流行病学研究中的使用提供参考。

关键词：流行病学方法因果律断点回归设计

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抗菌聚丙烯的制备及其性能

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合成树脂及塑料 2020年第5期37卷 5-10页

作者：李杰初立秋张师军郭照琰高达利中国石油化工股份有限公司北京化工研究院北京市100013

利用异噻唑啉酮类抗菌剂开发抗菌聚丙烯,研究了造粒温度、注射温度、紫外光老化,变色抑制剂等对抗菌聚丙烯黄色指数和色差的影响,并通过热失重/红外同步热分析仪对异噻唑啉酮的热稳定性进行了分析。结果表明:当耐变色抗菌聚丙烯中4,5-二... 详细信息

利用异噻唑啉酮类抗菌剂开发抗菌聚丙烯,研究了造粒温度、注射温度、紫外光老化,变色抑制剂等对抗菌聚丙烯黄色指数和色差的影响,并通过热失重/红外同步热分析仪对异噻唑啉酮的热稳定性进行了分析。结果表明:当耐变色抗菌聚丙烯中4,5-二氯-2-正辛基-4-异噻唑啉-3-酮含量达到0.25%(w)时,试样在50℃水煮16 h后,对大肠杆菌和金黄色葡萄球菌的抗菌率大于99%。

关键词：聚丙烯异噻唑啉酮黄色指数色差抗菌率

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建立基于CT影像的胆囊体积计算方法及其运动功能分析

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医用生物力学 2024年第2期39卷 332-338页

作者：郭佳雯宋成利顾倩芸王波蒋兆彦胡海上海理工大学健康科学与工程学院上海200093 同济大学附属东方医院胆石中心上海200120

目的评价基于CT影像三维重建胆囊体积计算方法的准确性,并研究胆囊运动中的生物力学变化,探索胆囊动力学变化与胆结石形成的关系。方法提出一种基于CT影像三维重建胆囊模型来计算胆囊体积的方法,并与椭球体法进行比较;构建胆囊有限元模... 详细信息

目的评价基于CT影像三维重建胆囊体积计算方法的准确性,并研究胆囊运动中的生物力学变化,探索胆囊动力学变化与胆结石形成的关系。方法提出一种基于CT影像三维重建胆囊模型来计算胆囊体积的方法,并与椭球体法进行比较;构建胆囊有限元模型并进行流体力学分析,模拟胆囊出口胆囊管与胆总管汇合不同角度下及伴有结石状态下的胆囊运动功能变化。结果比较50位患者的特异性胆囊模型体积和椭球体法体积,对应平均误差分别为7.26%和25.35%。梨形胆囊再充盈期最大压力、最大变形和最大流速都明显大于葫芦形胆囊。胆囊管与胆总管之间的夹角对胆汁流型影响不大,夹角为120°时胆汁流速最大。伴有结石胆囊的胆汁流速小于无结石胆囊,且在结石附近产生漩涡。结论基于CT影像三维重建计算胆囊体积较传统椭球体法更准确。相对于梨形胆囊,葫芦形胆囊的胆囊壁收缩和胆汁流速较小,运动功能差。伴结石胆囊的胆汁流速较慢,更易导致结石增大或新结石形成。

关键词：胆囊胆结石体积计算胆汁流速有限元分析

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