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机器学习模型评估裹浆改性再生骨料形态特征及分布规律

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硅酸盐通报 2024年第7期43卷 2490-2502页

作者：张嘉豪陈正发宋艳陈昭言常州大学城市建设学院常州213164 常州大学材料科学与工程学院常州213164 武汉昭舍装饰设计有限公司武汉430070

再生骨料(RA)的高吸水率、高压碎值、表面微裂纹及其不规则形态特征等缺陷限制了RA的再生利用。裹浆改性再生骨料(SRA)表面形成的壳膜结构不仅能够提高RA的力学性能,且对RA的形态特征有着显著影响。为了评估裹浆改性对RA形态特征的影响... 详细信息

再生骨料(RA)的高吸水率、高压碎值、表面微裂纹及其不规则形态特征等缺陷限制了RA的再生利用。裹浆改性再生骨料(SRA)表面形成的壳膜结构不仅能够提高RA的力学性能,且对RA的形态特征有着显著影响。为了评估裹浆改性对RA形态特征的影响,本文采用粉煤灰基地聚物浆体对再生混凝土骨料(RCA)和再生砖骨料(RBA)进行裹浆改性,并通过图像处理技术分别获取并建立裹浆改性前后RCA和RBA两种常见RA的形态特征数据集。此外,文中还结合机器学习技术提取数据集中的关键信息,从而量化RA的形态特征。经过定量分析发现,与改性前相比,改性后的RA轴向系数、棱角度和球形度的分布范围均有不同程度的改善,其中裹浆改性对棱角度改善效果最为明显,裹浆改性再生混凝土骨料(SRCA)最大改善幅度达132.2%,裹浆改性再生砖骨料(SRBA)最大改善幅度达69.2%。

关键词：再生骨料裹浆改性形态特征参数量化形态特征参数分布机器学习

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河北省高等教育投入与经济增长耦合协调研究

石家庄铁道大学学报（社会科学版） 2024年第2期18卷 98-104页

作者：邵静雯陈昭彦青海民族大学政治与公共管理学院青海西宁810007

基于2008—2020年河北省高等教育与区域经济发展数据,构建河北省高等教育投入系统与经济增长系统协同发展的评价指标体系,运用耦合协调模型对两个系统进行实证分析。结果表明:从综合评价指数来看,河北省高等教育投入与经济增长两个系统... 详细信息

基于2008—2020年河北省高等教育与区域经济发展数据,构建河北省高等教育投入系统与经济增长系统协同发展的评价指标体系,运用耦合协调模型对两个系统进行实证分析。结果表明:从综合评价指数来看,河北省高等教育投入与经济增长两个系统均呈上升趋势。从耦合协调关系来看,河北省2008—2020年两个系统的耦合协调关系依次表现为高等教育投入系统滞后型、经济增长系统滞后型、高等教育投入系统滞后型、经济增长系统滞后型。从耦合协调程度来看,两个系统的耦合协调性愈发加强,耦合协调等级提升至优质协调水平。基于此,河北省应加大高等教育投入力度,同时统筹两者协调发展以及兼顾关联因素对两者的影响效力。

关键词：高等教育投入经济增长耦合协调度河北省

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日照市6221例女性HPV流行病学调查

分子诊断与治疗杂志 2024年第4期16卷 616-620页

作者：刘根贤战倩苗文静陈兆艳王朋陈新骏日照市妇幼保健院保健科山东日照276800 日照市妇幼保健院检验科山东日照276800 日照市妇幼保健院医学遗传中心山东日照276800 日照市疾病预防控制中心山东日照276800

目的分析山东省日照市妇幼保健院门诊就诊女性中人乳头瘤病毒(HPV)感染的流行特征,为日照市HPV的检测,预防和治疗策略提供理论依据。方法收集2019年1月至2021年12月在日照市妇幼保健院就诊的6221例女性宫颈生物脱落细胞为研究样本,采用P... 详细信息

目的分析山东省日照市妇幼保健院门诊就诊女性中人乳头瘤病毒(HPV)感染的流行特征,为日照市HPV的检测,预防和治疗策略提供理论依据。方法收集2019年1月至2021年12月在日照市妇幼保健院就诊的6221例女性宫颈生物脱落细胞为研究样本,采用PCR-反向点杂交法定性检测28种HPV基因型并统计分析。结果在受检的6221例女性中,HPV的检出率为38.74%(2410/6221)。受检人数年均增长率为34.69%,检出率年均增长率为16.49%。HPV检出率与受检月份之间的差异有统计学意义(χ^(2)=43.125,P60岁和21~25岁。检出率前四的HPV亚型都是高危型,依次是HR-HPV16、HR-HPV52、HR-HPV58、HR-HPV53。HR-HPV总检出率为29.66%(1845/6221),构成比为75.81%(2285/3014)。LR-HPV总检出率为10.24%(637/6221),排名前四的亚型依次是LR-HPV54、LR-HPV61、LR-HPV81、LR-HPV42。HR-HPV的检出率在年龄之间的差异有统计学意义(χ^(2)=145.737,P60岁是易感年龄段,并以单一高危型HPV16和HPV52感染为主。

关键词：子宫颈癌人乳头瘤病毒高危亚型流行病学调查

Genome-wide linkage mapping of QTL for root hair length in a Chinese common wheat population

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The Crop Journal 2020年第6期8卷 1049-1056页

作者： Feng Huang zhaoyan chen Dejie Du Panfeng Guan Lingling Chai Weilong Guo Zhaorong Hu Mingming Xin Huiru Peng Yingyin Yao Zhongfu Ni Key Laboratory of Crop Heterosis and Utilization(MOE)/State Key Laboratory for Agrobiotechnology/Key Laboratory of Crop Genetic Improvement China Agricultural UniversityBeijing 100193China National Plant Gene Research Center Beijing 100193China Zhoukou Academy of Agriculture Sciences Zhoukou 466001HenanChina

Root hairs are fast growing,ephemeral tubular extensions of the root epidermis that aid nutrient and water *** aim of the present study was to identify QTL for root hair length(RHL)using 227 F8 recombinant inbred lines(RILs)derived from a cross of Zhou 8425 B(Z8425 B)and Chinese Spring(CS),and to develop convenient molecular markers for markerassisted breeding in *** of variance of root hair length showed significant differences(P2.5)for RHL were identified on chromosomes 1 B(2),2 D and 6 D and four putative QTL(2≤LOD≤2.5)were detected on chromosomes 1 A,3 A,6 B,and 7 B,explaining 3.32%–6.52%of the phenotypic *** positive alleles for increased RHL of QTL on chromosomes 2 D,6 B and 6 D(***-2 D,q ***-6 B,and ***-6 D)were contributed by Z8425 B,and CS contributed positive QTL alleles on chromosomes 1 A(q ***-1 A),1 B(***-1 B.1 and ***-1 B.2),3 A(q ***-3 A)and 7 B(q ***-7 B).STARP markers were developed for ***-1 B.1,***-2 D,***-6 D,and q ***-7 *** and association analysis indicated that the positive allele of ***-6 D had been strongly selected in Chinese wheat breeding ***,the identified QTL for root hair length are likely to be useful for marker-assisted selection.

关键词： GWAS QTL mapping STARP marker Triticum aestivum

SecReT6 update:a comprehensive resource of bacterial TypeⅥSecretion Systems

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Science China(Life Sciences) 2023年第3期66卷 626-634页

作者： Jianfeng Zhang Jiahao Guan Meng Wang Gang Li Marko Djordjevic Cui Tai Hui Wang Zixin Deng zhaoyan chen Hong-Yu Ou State Key Laboratory of Microbial Metabolism Shanghai-Islamabad-Belgrade Joint Innovation Center on Antibacterial ResistancesJoint International Laboratory on Metabolic&Developmental SciencesSchool of Life Sciences&BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China Intensive Care Unit First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Department of Laboratory Medicine Jinshan HospitalShanghai Medical CollegeFudan UniversityShanghai 201500China Quantitative Biology Group Institute of Physiology and BiochemistryFaculty of BiologyUniversity of BelgradeBelgrade 11000Serbia State Key Laboratory of Pathogens and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China Shanghai Key Laboratory of Veterinary Biotechnology Shanghai Jiao Tong UniversityShanghai 200240China

TypeⅥSecretion System(T6SS)plays significant roles in microbial activities via injecting effectors into adjacent cells or environments.T6SS increasingly gained attention due to its important influence on pathogenesis,microbial competition,etc.T6SS-associated research is explosively expanding on numerous grounds that call for an efficient *** SecReT6 version3 provides comprehensive information on T6SS and the interactions between T6SS and T6SS-related proteins such as T6SS regulators and T6SS *** assist T6SS researches like microbial competition and regulatory mechanisms,SecReT6 v3developed online tools for detection and analysis of T6SS and T6SS-related proteins and estimation of T6SS-dependent killing *** have identified a novel T6SS regulator and T6SS-dependent killing capacity in Acinetobacter baumannii clinical isolates with the aid of SecReT6 v3.17,212 T6SSs and plentiful T6SS-related proteins in 26,573 bacterial complete genomes were also detected,analyzed and incorporated into the *** database is freely available at https://***/SecReT6/.

关键词： TypeⅥSecretion System T6SS-related protein database prediction Acinetobacter baumannii

TaACTIN7-D regulates plant height and grain shape in bread wheat

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Journal of Genetics and Genomics 2023年第11期50卷 895-908页

作者： Xiongtao Li Beilu Cao Dejie Du Long Song Lulu Tian Xiaoming Xie zhaoyan chen Yanpeng Ding Xuejiao cheng Yingyin Yao Weilong Guo Zhenqi Su Qixin Sun Zhongfu Ni Lingling Chai Jie Liu Frontiers Science Center for Molecular Design Breeding China Agricultural UniversityBeijing 100193China State Key Laboratory for Crop Genetics and Germplasm Enhancement Nanjing Agricultural UniversityNanjingJiangsu 210095China

Exploitation of new gene resources and genetic networks contributing to the control of crop yield-related traits,such as plant height,grain size,and shape,may enable us to breed modern high-yielding wheat varieties through molecular *** this study,via ethylmethanesulfonate mutagenesis,we identify a wheat mutant plant,mu-597,that shows semi-dwarf plant architecture and round grain *** bulked segregant RNA-seq and map-based cloning,the causal gene for the semi-dwarf phenotype of mu-597 is *** find that a single-base mutation in the coding region of TaACTIN7-D(TaACT7-D),leading to a Gly-to-Ser(G65S)amino acid mutation at the 65th residue of the deduced TaACT7-D protein,can explain the semi-dwarfism and round grain shape of *** evidence shows that the G65S mutation in TaACT7-D hinders the polymerization of actin from monomeric(G-actin)to filamentous(F-actin)status while attenuates wheat responses to multiple phytohormones,including brassinosteroids,auxin,and ***,these findings not only define a new semi-dwarfing gene resource that can be potentially used to design plant height and grain shape of bread wheat but also establish a direct link between actin structure modulation and phytohormone signal transduction.

关键词： Wheat(Triticum aestivum L.) Plant height Grain shape TaACT7-D Phytohormone signaling

抗生素降阶梯方案治疗重症肺炎有效性和安全性的Meta分析

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中国循证医学杂志 2018年第1期18卷 52-58页

作者：陈昭燕占美徐珽四川大学华西医院临床药学部成都610041

目的系统评价抗生素降阶梯方案治疗重症肺炎患者的有效性与安全性。方法计算机检索PubMed、EMbase、The Cochrane Library、CBM、CNKI、VIP和WanFang Data数据库,同时检索中国临床试验注册中心(***),搜集关于抗生素降阶梯方案治疗重症... 详细信息

目的系统评价抗生素降阶梯方案治疗重症肺炎患者的有效性与安全性。方法计算机检索PubMed、EMbase、The Cochrane Library、CBM、CNKI、VIP和WanFang Data数据库,同时检索中国临床试验注册中心(***),搜集关于抗生素降阶梯方案治疗重症肺炎患者的随机对照试验(RCT),检索时限均从建库至2017年6月。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.3软件进行Meta分析。结果共纳入13个RCT,包括1 860例患者。Meta分析结果显示:与对照组相比,抗生素降阶梯组的临床治愈率明显更高[RR=1.28,95%CI(1.20,1.35),P<0.000 01],总住院时间[MD=–6.74,95%CI(–8.65,–4.82),P<0.000 01]、并发症控制时间[MD=–6.86,95%CI(–9.12,–4.59),P<0.000 01]明显缩短,病死率明显降低[RR=0.48,95%CI(0.28,0.82),P=0.008]。纳入研究报道的不良反应较少,且程度均为轻、中度,安全性尚可。结论当前证据表明,抗生素降阶梯治疗方案在重症肺炎患者治疗过程中相比常规治疗疗效更佳,能够显著缩短总住院时间、降低病死率。受纳入研究质量和数量限制,上述结论尚待更多高质量研究予以验证。

关键词：降阶梯治疗抗生素重症肺炎系统评价 Meta分析随机对照试验

Ectopic expression of VRT-A2 underlies the origin of Triticum polonicum and Triticum petropavlovskyi with long outer glumes and grains

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Molecular Plant 2021年第9期14卷 1472-1488页

作者： Jing Liu zhaoyan chen Zhihui Wang Zhaoheng Zhang Xiaoming Xie Zihao Wang Lingling Chai Long Song Xuejiao cheng Man Feng Xiaobo Wang Yanhong Liu Zhaorong Hu Jiewen Xing Zhenqi Su Huiru Peng Mingming Xin Yingyin Yao Weilong Guo Qixin Sun Jie Liu Zhongfu Ni State Key Laboratory for Agrobiotechnology and Key Laboratory of Crop Heterosis and Utilization(MOE)and Beijing Key Laboratory of Crop Genetic Improvement China Agricultural UniversityBeijing 100193P.R.China

Polish wheat (Triticum polonicum) is a unique tetraploid wheat species characterized by an elongated outer glume. The genetic control of the long-glume trait by a single semi-dominant locus, P1 (from Polish wheat), was established more than 100 years ago, but the underlying causal gene and molecular nature remain elusive. Here, we report the isolation of VRT-A2, encoding an SVP-clade MADS-box transcription factor, as the P1 candidate gene. Genetic evidence suggests that in T. polonicum, a naturally occurring sequence rearrangement in the intron-1 region of VRT-A2 leads to ectopic expression of VRT-A2 in floral organs where the long-glume phenotype appears. Interestingly, we found that the intron-1 region is a key ON/OFF molecular switch for VRT-A2 expression, not only because it recruits transcriptional repressors, but also because it confers intron-mediated transcriptional enhancement. Genotypic analyses using wheat accessions indicated that the P1 locus is likely derived from a single natural mutation in tetraploid wheat, which was subsequently inherited by hexaploid T. petropavlovskyi. Taken together, our findings highlight the promoter-proximal intron variation as a molecular basis for phenotypic differentiation, and thus species formation in Triticum plants.

关键词： long glume P1 species differentiation T.polonicum VRT-A2

A natural variation in Ribonuclease H-like gene underlies Rht8 to confer“Green Revolution”trait in wheat

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Molecular Plant 2022年第3期15卷 377-380页

作者： Lingling Chai Mingming Xin Chaoqun Dong zhaoyan chen Huijie Zhai Junhong Zhuang Xuejiao cheng Naijiao Wang Jia Geng Xiaobo Wang Ruolin Bian Yingyin Yao Weilong Guo Zhaorong Hu Huiru Peng Guihua Bai Qixin Sun Zhenqi Su Jie Liu Zhongfu Ni State Key Laboratory for Agrobiotechnology and Key Laboratory of Crop Heterosis and Utilization(MOE)and Beijing Key Laboratory of Crop Genetic Improvement China Agricultural UniversityBeijingChina School of Life Science and Technology Henan Institute of Science and TechnologyXinxiangChina Center for Crop Functional Genomics and Molecular Breeding China Agricultural UniversityBeijingChina State Key Laboratory for Crop Genetics and Germplasm Enhancement Nanjing Agricultural UniversityNanjingChina USDA–ARS Hard Winter Wheat Genetics Research UnitManhattanKSUSA

Dear Editor,Introduction of gibberellin(GA)-insensitive Reduced height(Rht)genes,Rht-B1b and Rht-D1b,has resulted in the“Green Revolution”in modern wheat cultivars(Triticum aestivum)that has skyrocketed wheat grain yields worldwide since the 1960s(Peng et al.,1999;Velde et al.,2021).However,Rht-B1b/D1b also reduce coleoptiles,which is undesired in dryland regions where deep planting is essential for seedling establishment(Rebetzke et al.,1999,Rebetzke et al.,2001;Ellis et al.,2004).

关键词： aestivum seedling cultivar