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Mitochondrial transplantation confers protection against the effects of ischemic stroke by repressing microglial pyroptosis and promoting neurogenesis

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Neural Regeneration Research 2024年第6期19卷 1325-1335页

作者： Li Sun zhaoyan zhao Jing Guo Yuan Qin Qian Yu Xiaolong Shi Fei Guo Haiqin Zhang Xude Sun Changjun Gao Qian Yang Department of Experimental Surgery The Second Affiliated Hospital of Air Force Medical University Department of Anesthesiology The Second Affiliated Hospital of Air Force Medical University

Transferring healthy and functional mitochondria to the lateral ventricles confers neuroprotection in a rat model of ischemia-reperfusion injury. Autologous mitochondrial transplantation is also beneficial in pediatric patients with cardiac ischemia-reperfusion injury. Thus, transplantation of functional exogenous mitochondria may be a promising therapeutic approach for ischemic disease. To explore the neuroprotective effect of mitochondria transplantation and determine the underlying mechanism in ischemic stroke, in this study we established a photo-thrombosis-induced mouse model of focal ischemia and administered freshly isolated mitochondria via the tail vein or to the injury site(in situ). Animal behavior tests, immunofluorescence staining, 2,3,5-triphenyltetrazolium chloride(TTC) staining, mRNA-seq, and western blotting were used to assess mouse anxiety and memory, cortical infarct area, pyroptosis, and neurogenesis, respectively. Using bioinformatics analysis, western blotting, co-immunoprecipitation, and mass spectroscopy, we identified S100 calcium binding protein A9(S100A9) as a potential regulator of mitochondrial function and determined its possible interacting proteins. Interactions between exogenous and endogenous mitochondria, as well as the effect of exogenous mitochondria on recipient microglia, were assessed in vitro. Our data showed that:(1) mitochondrial transplantation markedly reduced mortality and improved emotional and cognitive function, as well as reducing infarct area, inhibiting pyroptosis, and promoting cortical neurogenesis;(2) microglial expression of S100A9 was markedly increased by ischemic injury and regulated mitochondrial function;(3) in vitro, exogenous mitochondria enhanced mitochondrial function, reduced redox stress, and regulated microglial polarization and pyroptosis by fusing with endogenous mitochondria; and(4) S100A9 promoted internalization of exogenous mitochondria by the microglia, thereby amplifying their pro-proliferation and anti-inflammatory effects. Taken togeth

关键词： ischemic stroke microglia mitochondria transplantation neurogenesis pyroptosis

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Effects of NO_(2) and SO_(2) on the secondary organic aerosol formation fromβ-pinene photooxidation

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Journal of Environmental Sciences 2024年第2期136卷 151-160页

作者： Xiangyu Zang zhaoyan Zhang Yingqi zhao Gang Li Hua Xie Weiqing Zhang Guorong Wu Xueming Yang Ling Jiang Zhang Dayu School of Chemistry Dalian University of TechnologyDalian 116024China State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry School of ScienceSouthern University of Science and TechnologyShenzhen 518055China

Elucidating the effects of anthropogenic pollutants on the photooxidation of biogenic volatile organic compounds is crucial to understanding the fundamental mechanisms of secondary organic aerosol(SOA)formation.Here,the impacts of NO_(2)and SO_(2)on SOA formation from the photooxidation of a representative monoterpene,β-pinene,were investigated by a number of laboratory studies.The results indicated NO_(2)enhanced the SOA mass concentrations and particle number concentrations under both low and highβ-pinene conditions.This could be rationalized that the increased O_(3)concentrations upon the NO_(x)photolysis was helpful for the generation of more amounts of O_(3)-oxidized products,which accelerated the SOA nucleation and growth.Combing with NO_(2),the promotion of the SOA yield by SO_(2)was mainly reflected in the increase of mass concentration,which might be due to the elimination of the newly formed particles by the initially formed particles.The observed low oxidation degree of SOA might be attributed to the fast growth of SOA,resulting in the uptake of less oxygenated gas-phase species onto the particle phase.The present findings have important implications for SOA formation affected by anthropogenic–biogenic interactions in the ambient atmosphere.

关键词： Secondary organic aerosol Volatile organic compound Anthropogenic pollutant Beta-pinene Photooxidation

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Mesenchymal stromal cells modulate unfolded protein response and preserve β-cell mass in type 1 diabetes

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BIOCELL 2024年第7期48卷 1115-1126页

作者： SIYUAN LIU YUAN zhao YU YU DOU YE QIAN WANG zhaoyan WANG ZUO LUAN Department of Pediatrics The Sixth Medical CenterChinese PLA General HospitalBeijing100037China

Introduction:Transplantation of mesenchymal stromal cells(MSCs)is a promising therapy for type 1 diabetes(T1D).However,whether the infused MSCs affect the endoplasmic reticulum stress or subsequent unfolded protein response inβcells remains unclear.Methods:To investigate this,we induced early-onset T1D in non-obese diabetic mice using streptozotocin.Subsequently,T1D mice were randomly assigned to receive either MSCs or phosphate-buffered saline.We observed the in vivo homing of MSCs and assessed their effectiveness by analyzing blood glucose levels,body weight,histopathology,pancreatic protein expression,and serum levels of cytokines,proinsulin,and C-peptide.Results:Infused MSCs were found in the lungs,liver,spleen,and pancreas of T1D mice.They exhibited various effects,including reducing blood glucose levels,regulating immunity,inhibiting inﬂammation,increasingβ-cell areas,and reducing the expression of key proteins in the unfolded protein response pathway.Fasting serum proinsulin and C-peptide levels were signiﬁcantly higher in the MSCs treatment group than in the T1D model group.However,there was no signiﬁcant difference in the biomarker ofβ-cell endoplasmic reticulum stress,the ratio of fasting serum proinsulin to C-peptide,between the two groups.Conclusion:Ourﬁndings reveal that MSCs infusion does not alleviate endoplasmic reticulum stress inβcells directly but modulates the unfolded protein response pathway to preserveβ-cell mass and function in T1D mice.

关键词： Type 1 diabetes Mesenchymal stromal cells Endoplasmic reticulum stress Unfolded protein response Non-obese diabetic mice

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水土保持生态建设下的黄土高原典型流域水沙响应

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中国水土保持科学 2024年第1期22卷 21-26页

作者：赵阳张永娥王昭艳张国军辛艳刘冰魏小燕中国水利水电科学研究院北京100048 宁夏回族自治区水土保持监测总站银川750002

为探讨黄土高原多沙粗沙区流域水沙关系演变特征及其对水土流失治理的响应,以黄河中游无定河流域为研究对象,综合采用水沙关系曲线、数理统计等多种方法,系统分析1956—2019年间无定河流域水沙关系多时间尺度演变特征及其与水土流失治... 详细信息

为探讨黄土高原多沙粗沙区流域水沙关系演变特征及其对水土流失治理的响应,以黄河中游无定河流域为研究对象,综合采用水沙关系曲线、数理统计等多种方法,系统分析1956—2019年间无定河流域水沙关系多时间尺度演变特征及其与水土流失治理的协同响应。研究结果表明:1)研究时段内,无定河流域年径流及年输沙量呈锐减趋势(P<0.05),且均在1970年左右发生减少突变;2)流域水沙关系在年际和场次洪水尺度上均发生深刻变化。2010年以后,暴雨频发导致流域内侵蚀物源头供应明显增加,流域河道泥沙输送能力小幅提高;3)水土保持措施实施对流域水沙锐减影响较大。2000年前后在相似降雨条件下,单位降雨量径流量和单位降雨量输沙量较20世纪70年代减少47%和62%。水土保持措施面积增加与流域径流输沙减少呈现较好的一致性,流域水土流失治理在提高黄河多沙粗沙区流域下垫面抗侵蚀能力等方面发挥重要作用。研究结果可为科学认知区域水土流失治理成效及入黄泥沙锐减成因提供参考。

关键词：水沙关系极端暴雨土壤侵蚀治理成效黄河

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扫描式葡萄糖监测在2型糖尿病妊娠患者管理中的作用

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中国糖尿病杂志 2024年第6期32卷 418-422页

作者：张朝燕娄秀清王雪芳赵月苏旭东聊城市妇幼保健院妇产科聊城市人民医院内分泌科

目的探讨扫描式葡萄糖监测系统（FGM）对T2DM妊娠患者的BG控制效果及对不良结局的影响。方法本研究为前瞻、开放性随机对照试验。选取2018年6月至2022年6月于聊城市人民医院及聊城市妇幼保健院就诊的孕16～18周T2DM患者109例，随机分... 详细信息

目的探讨扫描式葡萄糖监测系统（FGM）对T2DM妊娠患者的BG控制效果及对不良结局的影响。方法本研究为前瞻、开放性随机对照试验。选取2018年6月至2022年6月于聊城市人民医院及聊城市妇幼保健院就诊的孕16～18周T2DM患者109例，随机分为FGM组（n=54）和对照组（Con n=55）。FGM组于孕20、24、28及32周分别佩戴14 d的FGM;Con组于相同时间段检测末梢BG；根据FGM图谱及末梢BG结果调整Ins剂量；孕18周及孕36周检测BG及Hb A1c，统计不良妊娠结局相关信息。结果 FGM组孕36周FBG、2 hBG、Hb A1c低于Con组（P0.05）;FGM组新生儿低血糖发生率低于Con组（P<0.05）。FGM组32周时葡萄糖在目标范围内时间、葡萄糖低于目标范围时间百分比、葡萄糖高于目标范围时间百分比、平均葡萄糖波动幅度等，均较20周时改善（P<0.05）。结论孕期多次间断应用FGM可改善T2DM妊娠患者的BG控制，减少新生儿低血糖发生。

关键词：糖尿病,2型妊娠扫描式葡萄糖监测

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A Rapid Estimation Method for Post-earthquake Building Losses

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International Journal of Disaster Risk Science 2023年第3期14卷 428-439页

作者： Dengke zhao Zifa Wang Jianming Wang Dongliang Wei Yang Zhou zhaoyan Li Institute of Engineering Mechanics China Earthquake AdministrationHarbin 150080China CEAKJ ADPRHexa Inc. Shaoguan 512000China

Rapid estimation of post-earthquake building damage and loss is very important in urgent response efforts.The current approach leaves much room for improvement in estimating ground motion and correctly incorporating the uncertainty and spatial correlation of the loss.This study proposed a new approach for rapidly estimating post-earthquake building loss with reasonable accuracy.The proposed method interpolates ground motion based on the observed ground motion using the Ground Motion Prediction Equation(GMPE)as the weight.It samples the building seismic loss quantile considering the spatial loss correlation that is expressed by Gaussian copula,and kriging is applied to reduce the dimension of direct sampling for estimation speed.The proposed approach was validated using three historical earthquake events in Japan with actual loss reports,and was then applied to predict the building loss amount for the March 2022 Fukushima Mw7.3 earthquake.The proposed method has high potential in future emergency efforts such as search,rescue,and evacuation planning.

关键词： Earthquake building loss estimation Fukushima earthquake 2022 Gaussian copula sampling Japan Spatial correlation of earthquake losses Spatial interpolation of ground motion

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基于Stacking模型融合策略的日本俯冲带板缘地震动预测

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世界地震工程 2024年第1期40卷 80-95页

作者：党浩天王自法赵登科位栋梁王祥琪 WANG Jianming 李兆焱河南大学土木建筑学院河南开封475001 中国地震局工程力学研究所黑龙江哈尔滨150080 地震灾害防治应急管理部重点实验室黑龙江哈尔滨150080 中震科建(广东)防灾减灾研究院广东韶关512000

高精度的地震动预测模型有助于提高地震灾害的预警和应对能力。传统回归方法构建地震动预测模型时提前设定了方程的形式,此种方法存在一定局限性,难以反映地震动传播过程中的复杂规律,因此越来越多的学者尝试应用机器学习方法构建地震... 详细信息

高精度的地震动预测模型有助于提高地震灾害的预警和应对能力。传统回归方法构建地震动预测模型时提前设定了方程的形式,此种方法存在一定局限性,难以反映地震动传播过程中的复杂规律,因此越来越多的学者尝试应用机器学习方法构建地震动预测模型。但采用单一的机器学习算法,难以从数据中捕捉到更多规律,最终导致模型精度难以提升。本文基于日本KiK-net和K-Net强震台网收集到的俯冲带板缘地震动记录,使用Stacking模型融合策略,以LightGBM、XGBoost和CatBoost算法作为基学习器,线性回归算法作为元学习器,引入客观且高效的贝叶斯优化算法对模型进行超参数优化,最终训练并提出了一种适用于日本俯冲带板缘地震动预测的融合模型Stacking-Interface。对比分析所提出模型、单一机器学习模型和传统模型,发现机器学习模型的精度普遍高于传统模型,且相较于单一的机器学习模型,融合模型的预测能力有一定的提升;通过与实际地震动记录的对比和特征参数敏感性分析,验证了所提模型的可靠性和泛化能力。研究方法和结果能够为地震风险分析提供参考。

关键词：地震动预测 Stacking 俯冲带板缘地震部分依赖图

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Efficacy of luteolin on the human gastric cancer cell line MKN45 and underlying mechanism

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Journal of Traditional Chinese Medicine 2023年第1期43卷 34-41页

作者： DING Yajie LIU Feng LI zhaoyan Xu Yan CAO Nida ZHANG Guangao WANG Rui zhao Aiguang Department of Oncology Medicine Longhua Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200032China

OBJECTIVE:To investigate the antitumour efficacy of luteolin on gastric cancer(GC)and study the mechanism underpinning the action.METHODS:Effects of luteolin on cell growth inhibition,apoptosis,and cell cycle arrest in MKN45 cells were investigated using the cell counting kit-8 assay.Changes in the mitochondrial membrane potential after luteolin treatment were assessed using 5,5′,6,6’-tetra-chloro-1,1’,3,3’-tetraethy lbenzimidazolcar bocyanineiodi-de(JC-1)staining.To investigate whether apoptotic effect by luteolin is related to the phosphoinositide 3-kinase/v-akt murine thymoma viral oncogene(PI3K/Akt)pathway,cells were additionally treated with LY294002,a PI3K/Akt pathway inhibitor.Moreover,the expressions of apoptosis-related proteins,namely B-cell lymphoma 2(Bcl-2),Bcl-2 associated X protein(Bax),Akt,p-Akt,caspase-3,and cytochrome C,were detected after luteolin treatment.RESULTS:The study revealed that in MKN45 cells,luteolin could inhibit the cell proliferation in a time-and dose-dependent manner;block the cell cycle in the Sphase;induce apoptosis;reduce the mitochondrial membrane potential;increase the expression of Bax,caspase-3,and cytochrome C;and decrease the expression of Bcl-2 and p-Akt.Luteolin might be involved in the PI3K/Akt signalling pathway,indicating that this pathway could be a therapeutic target for GC treatment.CONCLUSION:Luteolin could inhibit the proliferation of GC cells and block the cell cycle in the S-phase.The mechanism of inducing apoptosis in these cells was related to the PI3K/Akt signalling pathway.

关键词： stomach neoplasms luteolin apoptosis phosphoinositide 3-kinase Akt signal transduction

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Oxygen-vacancy-rich TiO_(2)enables highly active and durable water electrolysis of urchin-like RuO_(2)catalyst

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Science China(Technological Sciences) 2022年第10期65卷 2317-2324页

作者： GAO HongMei XIAO MeiLing LI GuoQiang GAO LiQin MENG QingLei LUO zhaoyan LUO ErGui LIU ChangPeng JIN zhao GE JunJie XING Wei State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Laboratory of Advanced Power Sources Jilin Province Key Laboratory of Low Carbon Chemical Power SourcesChangchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China.

The material innovation is prerequisite to accelerating sluggish oxygen evolution reaction(OER)kinetics,thus promoting the realization of hydrogen energy community.Herein,we develop an oxygen-vacancy-rich TiO_(2)supported RuO_(2)catalyst(RuO_(2)@r-TiO_(2))towards improved OER activity and stability.The oxygen vacancy on TiO_(2)not only supplies electrons to produce lower valence Ru,but also provides sufficient anchoring site for the deposition of RuO_(2)nanocrystal.Beyond that,it can generate strong electronic interaction between TiO_(2)and supported RuO_(2),and thereby tailors the intermediates’adsorption energy on the RuO_(2)surface.As a result,the derived RuO_(2)@r-TiO_(2)catalyst exhibits superior OER activity and stability with the overpotential of 211 mV at a current density of 10 mA cm^(−2)and negligible activity degradation after 6 h operation,outperforming the non-oxygen-vacancy counterpart(223.3 mV,12.75%activity loss)and RuO_(2)catalyst(234.6 mV,42.86%activity loss).

关键词： oxygen evolution reaction oxygen vacancy electronic interaction stability

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基于花状MoS_(2)/RGO自清洁吸波纺织品的制备

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印染 2024年第6期50卷 1-5,12页

作者：赵诗怡徐丽慧蔡央芳侯雅淇罗伟储召艳戴思骏王黎明上海工程技术大学纺织服装学院上海201620 国家先进印染技术创新中心山东泰安271000

采用水热反应制备花状硫化钼/还原氧化石墨烯复合材料(MoS_(2)/RGO),并将MoS_(2)/RGO复合材料与聚二甲基硅氧烷(PDMS)协同整理到聚多巴胺(PDA)改性棉织物上,制备自清洁吸波棉织物。探讨了MoS_(2)/RGO复合材料用量、PDMS用量、浸渍时间... 详细信息

采用水热反应制备花状硫化钼/还原氧化石墨烯复合材料(MoS_(2)/RGO),并将MoS_(2)/RGO复合材料与聚二甲基硅氧烷(PDMS)协同整理到聚多巴胺(PDA)改性棉织物上,制备自清洁吸波棉织物。探讨了MoS_(2)/RGO复合材料用量、PDMS用量、浸渍时间等因素对整理棉织物疏水性能及吸波性能的影响。结果显示,当MoS_(2)/RGO质量分数为1.5%,PDMS质量分数为4.0%,浸渍时间为30 min时,整理棉织物的疏水性能最佳,水滴接触角(WCA)可达到155.2°,在波段8.2~12.4 GHz范围,匹配厚度为3.5 mm下最小反射损耗(RL_(min))值为-42.81 dB,有效吸收带宽(EAB)为2.08 GHz,展现出优异的吸波性能。同时,整理棉织物对常见液滴具有优异的防污性,可实现良好的自清洁吸波效果。

关键词：花状硫化钼/还原氧化石墨烯复合材料超疏水吸波多功能纺织品

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