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Chinese Fetal Growth:A Multicenter Cohort Study Based on Fetal Ultrasound Measurements

Maternal-Fetal Medicine 2023年第1期5卷 16-26页

作者： Xiaoli Gong Tianchen Wu Xiaoli Wang Lizhen Zhang Yiping You Hongwei Wei Xifang Zuo Ying Zhou Xinli Xing zhaoyan meng Qi Lyu Zhaodong Liu Jian Zhang Liyan Hu Junnan Li Li Li Chulin Chen Chunyan Liu Guoqiang Sun Aiju Liu Jingsi Chen Yuan Lyu Yuan Wei Yangyu Zhao Department of Obstetrics and Gynecology Peking University Third HospitalNational Clinical Research Center for Obstetrics andGynecologyBeijing 100191China Department of Maternal and Child Health School of Public HealthPeking UniversityBeijing100191China Department of Obstetrics and Gynecology Maternaland Child Health Hospital of QinhuangdaoQinhuangdaoShijiazhuang 066000China Department of Obstetrics Maternal and Child Health Hospital of HunanChangsha 410007China Department of Obstetrics Maternal and Child Health Hospital of Guangxi Zhuang Autonomous RegionNanning 530000China Department of Obstetrics Tongzhou Maternal and Child Health Hospital of BeijingBeijing 101100China Department of Obstetrics and Gynecology The First Affiliated Hospital of Xiamen UniversityXiamen 361003China Department of Obstetrics and Gynecology Maternal and Child Health Hospital of Dongchangfu DistrictLiaochengJinan 252004China Department of Obstetrics Gansu Maternal and Child Health HospitalLanzhou 730050China Department of Obstetrics and Gynecology Changchun Obstetrics-Gynecology HospitalChangchun 130042China Department of Obstetrics and Gynecology Fujian Maternity and Child Health HospitalAffiliated Hospital of Fujian Medical UniversityFuzhou 350122China Department of Function Maternaland Child Health Hospital of ShijiazhuangShijiazhuang 050051China Department of Obstetrics Shanxi Maternal and Child Health HospitalTaiyuan 030013China Department of Obstetrics The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China Department of Obstetrics Zhengzhou Central HospitalZhengzho 450007China Department of Obstetrics Maternal and Child Health Hospital of ChangzhiChangzhiTaiyuan 046011China Department of Obstetrics Maternity and Infant Hospital of ShenyangShenyang 110014China Department of Obstetrics Hubei Maternaland Child Health HospitalWuhan 430070China Department of Obstetrics Inner Mongolia Maternal and Child Health HospitalHohhot 010060China Department of Prenatal Diagnos

Objective:To build a reference fetal growth chart for the Chinese population based on fetal ultrasound measurements.Methods:This was a multicenter,population-based retrospective cohort study.Longitudinal ultrasound measurement data were collected from 24 hospitals in 18 provinces of China from 1st September through 31st October of 2019.The estimated fetal weight(EFW)was calculated based on head circumference,abdominal circumference,and femur length using Hadlock formula 3.Fetal growth curves were estimated using a two-level linear regression model with cubic splines.All participants were divided into two groups:the northern group(n=5829)and the southern group(n=3246)based on the geographical division of China and male fetus group(n=4775)and female fetus group(n=4300)based on fetal gender.The EFW was compared by fetal gender and geographical group.All statistical models were adjusted for maternal sociodemographic characteristics.Results:A total of 9075 participants with 31,700 ultrasound measurement records were included in this study.Male fetuses demonstrated significantly larger EFW compared to female ones starting at 16 weeks of gestation and extending to delivery(global testP<0.01).The overall geographic difference in EFW was significant(global testP=0.03),and week-specific comparisons showed that the northern group had a greater EFW starting at 15 weeks of gestation and extending to 29 weeks of gestation,although this difference did not extend to the time of delivery.TheZ-score of EFW confirmed that our Chinese fetal growth charts differed from previously published standards.Conclusion:This study provides EFW and ultrasound biometric reference measurements for Chinese fetuses and reveals differences from other fetal growth charts.The chart is worth promoting in more regions of China but should be tested prudently before use.

关键词： Growth charts Fetal development Epidemiology

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心理预算与控制感和网络消费决策风格的关系

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校园心理 2024年第2期22卷 110-117页

作者：党玉敬孟赵艳齐欢任军帅孟雪雪杨美荣华北理工大学心理与精神卫生学院河北唐山063000 辽宁师范大学心理学院辽宁大连116000

目的探讨大学生心理预算对网络消费决策风格的影响,并检验控制感的中介作用。方法采用心理预算量表、控制感量表以及网络消费决策风格量表,对364名有网络购物经历的大学生进行问卷调查。结果①心理预算、控制感与网络消费决策风格的各... 详细信息

目的探讨大学生心理预算对网络消费决策风格的影响,并检验控制感的中介作用。方法采用心理预算量表、控制感量表以及网络消费决策风格量表,对364名有网络购物经历的大学生进行问卷调查。结果①心理预算、控制感与网络消费决策风格的各个维度间呈正相关(P<0.01);②心理预算正向预测网络消费决策风格的各个维度(P<0.01),心理预算正向预测控制感(P<0.01);③心理预算和控制感正向预测网络消费决策风格各个维度,控制感在心理预算与网络消费决策风格各个维度间起部分中介作用品质导向的95%CI(0.209,0.472),间接效应值=0.333;冲动导向的95%CI(0.184,0.372),间接效应值=0.274;品牌导向的95%CI(0.110,0.209),间接效应值=0.157;忠诚习惯导向的置信区间(0.094,0.211),间接效应值=0.152;决策困扰导向的95%CI(0.124,0.302),间接效应值=0.212;时尚导向的95%CI(0.059,0.194)(0.077,0.185)间接效应值=0.124;时间节省导向的95%CI(0.029,0.173),间接效应值=0.099;完美导向的95%CI,间接效应值=0.130。结论大学生心理预算可以通过控制感的中介作用影响其网络消费决策风格的变化。

关键词：心理预算控制感网络消费决策风格

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膜状胎盘19例临床妊娠结局分析

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安徽医药 2024年第3期28卷 509-512,I0005页

作者：刘小晖李莲英王玥元董燕高丽娜刘小玲何晓春孟照琰甘肃省妇幼保健院(甘肃省中心医院)产科甘肃兰州730050 甘肃省妇幼保健院(甘肃省中心医院)病理科甘肃兰州730050

目的探讨膜状胎盘发病机制及对妊娠结局的影响。方法检索2010年4月至2021年6月甘肃省妇幼保健院产前检查并住院终止妊娠的170 621例孕妇的临床资料,选取其中产前超声诊断并经产后病理证实的19例膜状胎盘或部分性膜状胎盘病人作为研究... 详细信息

目的探讨膜状胎盘发病机制及对妊娠结局的影响。方法检索2010年4月至2021年6月甘肃省妇幼保健院产前检查并住院终止妊娠的170 621例孕妇的临床资料,选取其中产前超声诊断并经产后病理证实的19例膜状胎盘或部分性膜状胎盘病人作为研究对象。查阅病历收集19例孕妇的年龄、孕次、孕周、超声检查资料、胎儿宫内生长情况、终止妊娠的孕周、分娩方式、产前及产后出血情况及围产儿结局等资料进行回顾性分析。结果膜状胎盘的发生率0.011 1%(19/170 621),其中既往有刮宫史12例、胎儿生长受限的16例、羊水过少15例、15例出现脐动脉血流异常、11例出现产前出血、引产经阴道分娩16例、剖宫产3例;围产儿17例死胎分娩、2例新生儿存活。结论膜状胎盘可导致早产、流产、胎死宫内、羊水过少、胎儿宫内生长受限等严重不良围产儿结局,也可导致产前及产后大量出血,对于膜状胎盘孕妇,需要制定合理的诊疗方案,早诊断,早干预。

关键词：胎盘疾病膜状胎盘超声诊断绒毛发病机制妊娠结局

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Dietary intake and serum levels of copper and zinc and risk of hepatocellular carcinoma:A matched case-control study

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Chinese Medical Journal 2024年第5期137卷 596-603页

作者： Xiaozhan Liu Yaojun Zhang Dinuerguli Yishake Yan Luo zhaoyan Liu Yuming Chen Huilian Zhu Aiping Fang Guangdong Provincial Key Laboratory of Food Nutrition and HealthSchool of Public HealthSun Yat-sen UniversityGuangzhouGuangdong 510080China State Key Laboratory of Oncology in South China Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060China

Background:Copper and zinc are involved in the development of multiple malignancies;yet,epidemiological evidence on hepatocellular carcinoma(HCC)is limited.This study aimed to investigate the association between dietary intake and serum levels of copper and zinc with the risk of HCC.Methods:A total of 434 case-control pairs matched for sex and age(±1 year)were included in this study.Cases with newly diagnosed HCC were from the Guangdong Liver Cancer Cohort(GLCC)study,and healthy controls were from the Guangzhou Nutrition and Health Study(GNHS).A semi-quantitative 79-item food frequency questionnaire(FFQ)was used to assess habitual dietary intakes of copper and zinc.Serum levels of copper and zinc were measured by using inductively coupled plasma mass spectrometry.The copper(Cu)/zinc(Zn)ratio was computed by dividing copper levels by zinc levels.Conditional logistic regression models were performed to calculate the odds ratio(OR)and 95%confidence intervals(CI)for per 1 standard deviation increase(per-SD increase)in copper and zinc levels.Results:Higher dietary intake(OR_(per-SD increase)=0.65,95%CI:0.44,0.96,P_(trend)=0.029)and serum levels of zinc(OR_(per-SD increase)=0.11,95%CI:0.04,0.30,P_(trend)<0.001)were both associated with a lower risk of HCC.Subgroup analyses showed that the inverse association was only pronounced in men but not in women(P_(interaction)=0.041 for dietary zinc intake and 0.010 for serum zinc levels).Serum copper levels(OR_(per-SD increase)=2.05,95%CI:1.39,3.03,P_(trend)=0.020)and serum Cu/Zn ratio(OR_(per-SD increase)=6.53,95%CI:2.52,16.92,P_(trend)<0.001)were positively associated with HCC risk,while dietary copper intake and dietary Cu/Zn ratio were not associated with HCC risk.Conclusion:Zinc may be a protective factor for HCC,especially among men,but the effects of copper on HCC risk are not clear.

关键词： Copper Zinc Hepatocellular carcinoma risk Case-control studies Dietary intake Serum

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Effects of NO_(2) and SO_(2) on the secondary organic aerosol formation fromβ-pinene photooxidation

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Journal of Environmental Sciences 2024年第2期136卷 151-160页

作者： Xiangyu Zang zhaoyan Zhang Yingqi Zhao Gang Li Hua Xie Weiqing Zhang Guorong Wu Xueming Yang Ling Jiang Zhang Dayu School of Chemistry Dalian University of TechnologyDalian 116024China State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry School of ScienceSouthern University of Science and TechnologyShenzhen 518055China

Elucidating the effects of anthropogenic pollutants on the photooxidation of biogenic volatile organic compounds is crucial to understanding the fundamental mechanisms of secondary organic aerosol(SOA)formation.Here,the impacts of NO_(2)and SO_(2)on SOA formation from the photooxidation of a representative monoterpene,β-pinene,were investigated by a number of laboratory studies.The results indicated NO_(2)enhanced the SOA mass concentrations and particle number concentrations under both low and highβ-pinene conditions.This could be rationalized that the increased O_(3)concentrations upon the NO_(x)photolysis was helpful for the generation of more amounts of O_(3)-oxidized products,which accelerated the SOA nucleation and growth.Combing with NO_(2),the promotion of the SOA yield by SO_(2)was mainly reflected in the increase of mass concentration,which might be due to the elimination of the newly formed particles by the initially formed particles.The observed low oxidation degree of SOA might be attributed to the fast growth of SOA,resulting in the uptake of less oxygenated gas-phase species onto the particle phase.The present findings have important implications for SOA formation affected by anthropogenic–biogenic interactions in the ambient atmosphere.

关键词： Secondary organic aerosol Volatile organic compound Anthropogenic pollutant Beta-pinene Photooxidation

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Mitochondrial transplantation confers protection against the effects of ischemic stroke by repressing microglial pyroptosis and promoting neurogenesis

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Neural Regeneration Research 2024年第6期19卷 1325-1335页

作者： Li Sun zhaoyan Zhao Jing Guo Yuan Qin Qian Yu Xiaolong Shi Fei Guo Haiqin Zhang Xude Sun Changjun Gao Qian Yang Department of Experimental Surgery The Second Affiliated Hospital of Air Force Medical University Department of Anesthesiology The Second Affiliated Hospital of Air Force Medical University

Transferring healthy and functional mitochondria to the lateral ventricles confers neuroprotection in a rat model of ischemia-reperfusion injury. Autologous mitochondrial transplantation is also beneficial in pediatric patients with cardiac ischemia-reperfusion injury. Thus, transplantation of functional exogenous mitochondria may be a promising therapeutic approach for ischemic disease. To explore the neuroprotective effect of mitochondria transplantation and determine the underlying mechanism in ischemic stroke, in this study we established a photo-thrombosis-induced mouse model of focal ischemia and administered freshly isolated mitochondria via the tail vein or to the injury site(in situ). Animal behavior tests, immunofluorescence staining, 2,3,5-triphenyltetrazolium chloride(TTC) staining, mRNA-seq, and western blotting were used to assess mouse anxiety and memory, cortical infarct area, pyroptosis, and neurogenesis, respectively. Using bioinformatics analysis, western blotting, co-immunoprecipitation, and mass spectroscopy, we identified S100 calcium binding protein A9(S100A9) as a potential regulator of mitochondrial function and determined its possible interacting proteins. Interactions between exogenous and endogenous mitochondria, as well as the effect of exogenous mitochondria on recipient microglia, were assessed in vitro. Our data showed that:(1) mitochondrial transplantation markedly reduced mortality and improved emotional and cognitive function, as well as reducing infarct area, inhibiting pyroptosis, and promoting cortical neurogenesis;(2) microglial expression of S100A9 was markedly increased by ischemic injury and regulated mitochondrial function;(3) in vitro, exogenous mitochondria enhanced mitochondrial function, reduced redox stress, and regulated microglial polarization and pyroptosis by fusing with endogenous mitochondria; and(4) S100A9 promoted internalization of exogenous mitochondria by the microglia, thereby amplifying their pro-proliferation and anti-inflammatory effects. Taken togeth

关键词： ischemic stroke microglia mitochondria transplantation neurogenesis pyroptosis

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Mesenchymal stromal cells modulate unfolded protein response and preserve β-cell mass in type 1 diabetes

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BIOCELL 2024年第7期48卷 1115-1126页

作者： SIYUAN LIU YUAN ZHAO YU YU DOU YE QIAN WANG zhaoyan WANG ZUO LUAN Department of Pediatrics The Sixth Medical CenterChinese PLA General HospitalBeijing100037China

Introduction:Transplantation of mesenchymal stromal cells(MSCs)is a promising therapy for type 1 diabetes(T1D).However,whether the infused MSCs affect the endoplasmic reticulum stress or subsequent unfolded protein response inβcells remains unclear.Methods:To investigate this,we induced early-onset T1D in non-obese diabetic mice using streptozotocin.Subsequently,T1D mice were randomly assigned to receive either MSCs or phosphate-buffered saline.We observed the in vivo homing of MSCs and assessed their effectiveness by analyzing blood glucose levels,body weight,histopathology,pancreatic protein expression,and serum levels of cytokines,proinsulin,and C-peptide.Results:Infused MSCs were found in the lungs,liver,spleen,and pancreas of T1D mice.They exhibited various effects,including reducing blood glucose levels,regulating immunity,inhibiting inﬂammation,increasingβ-cell areas,and reducing the expression of key proteins in the unfolded protein response pathway.Fasting serum proinsulin and C-peptide levels were signiﬁcantly higher in the MSCs treatment group than in the T1D model group.However,there was no signiﬁcant difference in the biomarker ofβ-cell endoplasmic reticulum stress,the ratio of fasting serum proinsulin to C-peptide,between the two groups.Conclusion:Ourﬁndings reveal that MSCs infusion does not alleviate endoplasmic reticulum stress inβcells directly but modulates the unfolded protein response pathway to preserveβ-cell mass and function in T1D mice.

关键词： Type 1 diabetes Mesenchymal stromal cells Endoplasmic reticulum stress Unfolded protein response Non-obese diabetic mice

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Building Fe atom–cluster composite sites using a site occupation strategy to boost electrochemical oxygen reduction

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Carbon Energy 2024年第3期6卷 276-286页

作者： Tingyi Zhou Yi Guan Changjie He Lei Zhang Xueliang Sun Zhongxin Song Qianling Zhang Chuanxin He Xiantao Jiang zhaoyan Luo Wei Xing Xiangzhong Ren College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhenGuangdongChina Department of Mechanical and Materials Engineering University of Western OntarioLondonOntarioCanada State Key Laboratory of Electroanalytical Chemistry Jilin Province Key Laboratory of Low Carbon Chemical PowerChangchun Institute of Applied ChemistryChinese Academy of SciencesJilinChangchunChina

The high-temperature pyrolysis process for preparing M–N–C single-atom catalyst usually results in high heterogeneity in product structure concurrently contains multiscale metal phases from single atoms(SAs),atomic clusters to nanoparticles.Therefore,understanding the interactions among these components,especially the synergistic effects between single atomic sites and cluster sites,is crucial for improving the oxygen reduction reaction(ORR)activity of M–N–C catalysts.Accordingly,herein,we constructed a model catalyst composed of both atomically dispersed FeN4 SA sites and adjacent Fe clusters through a site occupation strategy.We found that the Fe clusters can optimize the adsorption strength of oxygen reduction intermediates on FeN4 SA sites by introducing electron-withdrawing–OH ligands and decreasing the d-band center of the Fe center.The as-developed catalyst exhibits encouraging ORR activity with halfwave potentials(E1/2)of 0.831 and 0.905 V in acidic and alkaline media,respectively.Moreover,the catalyst also represents excellent durability exceeding that of Fe–N–C SA catalyst.The practical application of Fe(Cd)–CNx catalyst is further validated by its superior activity and stability in a metalair battery device.Our work exhibits the great potential of synergistic effects between multiphase metal species for improvements of singleatom site catalysts.

关键词： d-band center metal clusters oxygen reduction reaction single-atom catalyst site occupations strategy

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单亲家庭大学生婚姻态度与安全感和自尊的关系

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中国心理卫生杂志 2023年第8期37卷 717-722页

作者：孟赵艳杨美荣齐欢党玉敬任军帅刘柏汐华北理工大学心理与精神卫生学院河北唐山063210 唐山学院智能与信息工程学院河北唐山063000

目的:探讨单亲家庭大学生婚姻态度、安全感和自尊之间的关系。方法:选取河北某高校在校大学生435人(单亲家庭199人,双亲家庭236人),采用婚姻态度量表(MAS)、安全感量表(SQ)、自尊量表(RSES)进行调查。结果:单亲家庭大学生的MAS、SQ、RSE... 详细信息

目的:探讨单亲家庭大学生婚姻态度、安全感和自尊之间的关系。方法:选取河北某高校在校大学生435人(单亲家庭199人,双亲家庭236人),采用婚姻态度量表(MAS)、安全感量表(SQ)、自尊量表(RSES)进行调查。结果:单亲家庭大学生的MAS、SQ、RSES得分均低于双亲家庭大学生(均P<0.001)。单亲家庭大学生的SQ总分与MAS总分正向关联(β=0.40),RSES得分与MAS总分正向关联(β=0.61),RSES得分在SQ总分与MAS总分中起调节作用(β=0.02,P<0.001)。结论:单亲家庭大学生的婚姻态度与安全感、自尊有关。

关键词：单亲家庭大学生婚姻态度安全感自尊

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基于特征融合与注意力机制的CNN抑郁症识别

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传感技术学报 2024年第4期37卷 658-664页

作者：尚照岩乔晓艳山西大学物理电子工程学院山西太原030006

快速准确识别、筛查和预警轻度抑郁症具有重要现实意义,利用脑电数据和深度学习算法可以对精神心理疾病进行机器识别。提出一种基于特征融合的卷积神经网络(CNN)模型,实现抑郁症的有效识别。将注意力机制引入CNN模型,提取高效的时空特征... 详细信息

快速准确识别、筛查和预警轻度抑郁症具有重要现实意义,利用脑电数据和深度学习算法可以对精神心理疾病进行机器识别。提出一种基于特征融合的卷积神经网络(CNN)模型,实现抑郁症的有效识别。将注意力机制引入CNN模型,提取高效的时空特征图,增强特征的多样性,降低个体差异性的影响。结果表明:采用脑电gamma节律,模型对抑郁症平均识别准确率达到(99.39±0.14)%。此外,通过对卷积层特征图的可视化分析,获得了抑郁症和正常被试脑电差异性电极,并进行少电极抑郁症分类,识别准确率达到(91.41±1.11)%。由此可见,该深度学习模型能够对轻度抑郁症进行有效识别和筛查。

关键词：机器学习抑郁症识别卷积神经网络注意力机制特征融合

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