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河南省濮阳市105例成人急性髓系白血病流行病学特征

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河南医学研究 2024年第7期33卷 1160-1163页

作者：王志龙苗朝旭郭学军河南省医学交流和项目推进中心河南郑州450003 河南省医师协会河南郑州450003 新乡医学院河南新乡453003 新乡医学院附属濮阳市油田总医院河南濮阳457001

目的分析濮阳地区成人急性髓系白血病(AML)临床病例,探讨发病情况、预后分层和发病趋势,了解该地区成人AML流行病学特征。方法对2014年12月至2022年7月在濮阳市人民医院和油田总医院收治的105例初发AML患者进行回顾性分析,分析形态学分... 详细信息

目的分析濮阳地区成人急性髓系白血病(AML)临床病例,探讨发病情况、预后分层和发病趋势,了解该地区成人AML流行病学特征。方法对2014年12月至2022年7月在濮阳市人民医院和油田总医院收治的105例初发AML患者进行回顾性分析,分析形态学分型、性别、年龄、基因突变、染色体异常、生存时间、预后转归和发病趋势等。结果濮阳地区AML患者亚型以M2、M4和M5为主,共90例(85.71%);男性多于女性,发病年龄多在>30~60岁;城镇患者生存期超过1 a的生存率高于农村患者,差异有统计学意义(P<0.05);基因突变检测中,CEBPA基因突变率最高(21.57%);染色体检测中,染色体数目和(或)结构异常率最高(82.47%),进行危险分层的患者,预后中等的人数最高(48.57%)。结论濮阳地区成人AML发病趋势呈现上升趋势,农村地区发病率较高且1 a生存率低,农村应该成为濮阳地区成人AML重点防控地区。

关键词：急性髓系白血病流行病学濮阳地区

聚合物纤维载体对L929细胞的增殖及毒性研究

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现代塑料加工应用 2024年第2期36卷 5-8页

作者：李长金李杰李晓敏张朝旭张正郭子芳中石化(北京)化工研究院有限公司北京100013

研究了进口聚合物纤维载体(1#)与国产聚合物纤维载体(2#和3#)对L929细胞增殖与毒性的影响。用CCK-8法在不同浸提液含量、不同培养时间下检测L929细胞在聚合物纤维载体中的相对增殖率。按通用标准评价材料的细胞毒性,并对载体表面和内部... 详细信息

研究了进口聚合物纤维载体(1#)与国产聚合物纤维载体(2#和3#)对L929细胞增殖与毒性的影响。用CCK-8法在不同浸提液含量、不同培养时间下检测L929细胞在聚合物纤维载体中的相对增殖率。按通用标准评价材料的细胞毒性,并对载体表面和内部的细胞黏附性进行表征。结果表明:浸提液质量分数在6.25%~100.00%时,1#组、2#组、3#组均没有潜在细胞毒性,1#组、2#组、3#组的细胞毒性级别分别为“1”“0”和“1”级。体外细胞培养试验表明:在24 h的培养时间内,2#组、3#组的细胞增殖率和1#组基本接近;48~72 h的培养时间内,2#组、3#组的细胞增殖率略低于1#组。细胞黏附试验表明:2#组、3#组的细胞增殖率高于1#组,且细胞倾向于在纤维载体的内部生长。国产聚合物纤维载体的生物相容性、细胞毒性以及细胞黏附性均达到理想效果,其中3#组聚合物纤维载体的细胞增殖和细胞黏附效果最理想。

关键词：纤维载体细胞毒性 L929细胞 CCK-8试验

Ultralow-Energy-Barrier H_(2)O_(2)Dissociation on Coordinatively Unsaturated Metal Centers in Binary Ce-Fe Prussian Blue Analogue for Efficient and Stable Photo-Fenton Catalysis

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Energy & Environmental Materials 2023年第6期6卷 427-435页

作者： Wenting Zheng Hui guo Changqing Zhu Cailiang Yue Wenlei Zhu Fuqiang Liu zhaoxu Chen State Key Laboratory of Pollution Control and Resource Reuse School of the EnvironmentNanjing UniversityNanjing 210023China Institute of Theoretical and Computational Chemistry Key Laboratory of Mesoscopic Chemistry of MOESchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

The low intrinsic activity of Fenton catalytic site and high demand for light-energy input inhibit the organic-pollution control efficiency of photo-Fenton ***,through structural design with density functional theory(DFT)calculations,Ce is predicted to enable the construction of coordinatively unsaturated metal centers(CUCs)in Prussian blue analogue(PBA),which can strongly adsorb H_(2)O_(2)and donate sufficient electrons for directly splitting the O-O bond to *** a substitution-co-assembly strategy,binary Ce-Fe PBA is then prepared,which rapidly degrades sulfamethoxazole with the pseudo-first-order kinetic rate constant exceeding reported values by 1-2 orders of ***,the photogenerated electrons reduce Fe(Ⅲ)and Ce(Ⅳ)to promote the metal valence cycle in CUCs and make sulfamethoxazole degradation efficiency only lose 6.04%in 5 ***,by introducing rare earth metals into transition metal-organic frameworks,this work guides the whole process for highly active CUCs from design and construction to mechanism exploration with DFT calculations,enabling ultrafast and stable photo-Fenton catalysis.

关键词： Ce substitution coordinatively unsaturated metal centers photo-Fenton Prussian blue analogue

Effect of intra-operative chemotherapy with 5-fluorouracil and leucovorin on the survival of patients with colorectal cancer after radical surgery: a retrospective cohort study

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Chinese Medical Journal 2023年第7期136卷 830-839页

作者： Xuhua Hu zhaoxu Zheng Jing Han Baokun Li Ganlin guo Peiyuan guo Yang Yang Daojuan Li Yiwei Yan Wenbo Niu Chaoxi Zhou Zesong Meng Jun Feng Bin Yu Qian Liu Guiying Wang The Second Department of General Surgery The Fourth Hospital of Hebei Medical UniversityShijiazhuangHebei 050001China Department of Colorectal Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Medical Oncology The Fourth Hospital of Hebei Medical UniversityShijiazhuangHebei 050001China Department of Cancer Institute The Fourth Hospital of Hebei Medical UniversityShijiazhuangHebei 050001China Department of Pediatrics The Fourth Hospital of Hebei Medical UniversityShijiazhuangHebei 050001China Department of General Surgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei 050050China

Background:The effect of intra-operative chemotherapy(IOC)on the long-term survival of patients with colorectal cancer(CRC)remains *** this study,we evaluated the independent effect of intra-operative infusion of 5-fluorouracil in combination with calcium folinate on the survival of CRC patients following radical ***:1820 patients were recruited,and 1263 received IOC and 557 did *** and demographic data were collected,including overall survival(OS),clinicopathological features,and treatment *** factors for IOC-related deaths were identified using multivariate Cox proportional hazards models.A regression model was developed to analyze the independent effects of ***:Proportional hazard regression analysis showed that IOC(hazard ratio[HR]=0.53,95%confidence intervals[CI][0.43,0.65],P<0.001)was a protective factor for the survival of *** mean overall survival time in IOC group was 82.50(95%CI[80.52,84.49])months,and 71.21(95%CI[67.92,74.50])months in non-IOC *** OS in IOC-treated patients were significantly higher than non-IOC-treated patients(P<0.001,log-rank test).Further analysis revealed that IOC decreased the risk of death in patients with CRC in a non-adjusted model(HR=0.53,95%CI[0.43,0.65],P<0.001),model 2(adjusted for age and gender,HR=0.52,95%CI[0.43,0.64],P<0.001),and model 3(adjusted for all factors,95%CI 0.71[0.55,0.90],P=0.006).The subgroup analysis showed that the HR for the effect of IOC on survival was lower in patients with stage II(HR=0.46,95%CI[0.31,0.67])or III disease(HR=0.59,95%CI[0.45,0.76]),regardless of pre-operative radiotherapy(HR=0.55,95%CI[0.45,0.68])or pre-operative chemotherapy(HR=0.54,95%CI[0.44,0.66]).Conclusions:IOC is an independent factor that influences the survival of CRC *** improved the OS of patients with stages II and III CRC after radical *** registration:***,ChiCTR 2100043775.

关键词： Colorectal cancer Intra-operative chemotherapy Overall survival Retrospective cohort study Stage

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现浇钢筋桁架楼承板受力性能试验研究

工业安全与环保 2020年第11期46卷 27-30页

作者：王金波刘利先赵振郭召旭李坤昆明理工大学建筑工程学院昆明650500 云南云智工程检测鉴定有限公司昆明650000 云南工程建设总承包股份有限公司昆明650011

以实际工程为依托,开展现浇钢筋桁架楼承板混凝土浇筑和混凝土硬化阶段弦杆钢筋及混凝土应变监测的试验。结果显示:现浇钢筋桁架楼承板在混凝土浇筑后易产生较多塑性坍落裂缝;无论是否设置临时支撑,现浇钢筋桁架楼承板均能满足施工阶段... 详细信息

以实际工程为依托,开展现浇钢筋桁架楼承板混凝土浇筑和混凝土硬化阶段弦杆钢筋及混凝土应变监测的试验。结果显示:现浇钢筋桁架楼承板在混凝土浇筑后易产生较多塑性坍落裂缝;无论是否设置临时支撑,现浇钢筋桁架楼承板均能满足施工阶段的要求,设置支撑的现浇楼板有更好的受力性能;对于现浇钢筋桁架楼承板,其楼板体系的刚度、传力方式和受力状态随混凝土的硬化和强度发展发生着改变;对比有临时支撑的现浇钢筋桁架楼承板,无支撑楼板存在上弦钢筋压应力超前和受压区混凝土压应力超前现象。

关键词：钢筋桁架楼承板现浇受力性能应变

河曲丝叶蜂对寄主白柳部分挥发物的触角电位和行为反应

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高原农业 2024年第4期8卷 357-366页

作者：唐晓琴宋振浩孙兆旭郭鑫楠董晓臧建成俞焜赵远西藏农牧学院植物科学学院西藏高原资源昆虫与应用昆虫实验室西藏高原森林生态教育部重点实验室西藏林芝860000 西藏自治区农牧科学院农业研究所西藏拉萨850000

根据河曲丝叶蜂(Nematus hequensis)对不同寄主挥发物的触角电位和行为反应,以期筛选出对该害虫成虫具有较强引诱作用的白柳植物挥发物和其最佳浓度,为该害虫的无害防治提供理论依据。在河曲丝叶蜂成虫羽化高峰期,使用固相微萃取和气相... 详细信息

根据河曲丝叶蜂(Nematus hequensis)对不同寄主挥发物的触角电位和行为反应,以期筛选出对该害虫成虫具有较强引诱作用的白柳植物挥发物和其最佳浓度,为该害虫的无害防治提供理论依据。在河曲丝叶蜂成虫羽化高峰期,使用固相微萃取和气相色谱质谱联用仪(GC-MS)鉴定白柳(Salix alba L.)挥发物成分;以正己烷为对照,利用触角电位仪(electroantennogram,EAG)测定河曲丝叶蜂1日龄未交配雌雄成虫对5种寄主植物挥发物的EAG反应,使用Y型嗅觉仪测试其对5种寄主挥发物不同浓度的行为反应。EAG反应结果表明:河曲丝叶蜂雌、雄成虫对于5种化合物均有较明显的电生理反应,雄虫在叶醇为1 000 ng·μL^(-1)和10 000 ng·μL^(-1)时引起较显著的EAG反应,并与其余4种化合物之间差异明显;雌虫在叶醇、丁香酚为1 000 ng·μL^(-1)时引起较明显的EAG反应,并与其余3种化合物之间差异明显。Y型嗅觉仪生测结果表明:只有丁香酚在1 000 ng·μL^(-1)、10 000 ng·μL^(-1)时对河曲丝叶蜂雌、雄成虫的引诱率与对照相比差异性显著(P<0.05)或极显著(P<0.01)。白柳挥发物中的丁香酚对河曲丝叶蜂未交配雌雄成虫有较好的引诱活性,说明其在河曲丝叶蜂识别寄主过程中有重要作用,可以用于开发该害虫的植物源引诱剂。

关键词：河曲丝叶蜂寄主挥发物触角电位行为反应

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基于六步法的显微镜下精索静脉结扎术的疗效

山东第一医科大学（山东省医学科学院）学报 2024年第6期45卷 331-335页

作者：钟浩李伟房志卿张永振高泽郭兆新孟力维刘照旭临沂市第三人民医院泌尿外科山东临沂276023 临沂市第三人民医院妇产科山东临沂276023 山东大学齐鲁医院泌尿外科山东济南250012

目的分析基于六步法的显微镜下精索静脉结扎术的临床效果。方法回顾性分析山东大学齐鲁医院闵傲外科收治的102例精索静脉曲张患者在2021年9月—2022年12月进行显微镜下精索静脉结扎术的疗效,对照组(2021年9月—2022年6月,共47例)患者... 详细信息

目的分析基于六步法的显微镜下精索静脉结扎术的临床效果。方法回顾性分析山东大学齐鲁医院闵傲外科收治的102例精索静脉曲张患者在2021年9月—2022年12月进行显微镜下精索静脉结扎术的疗效,对照组(2021年9月—2022年6月,共47例)患者行常规显微镜下精索静脉结扎术,试验组(2022年7月—2022年12月,共55例)采用基于六步法的行显微镜下精索静脉结扎术,对比两组患者手术指标和并发症发生情况。结果试验组手术时间较对照组明显缩短(32.54±1.68)vs.(47.76±1.43)min,组间差异有统计学意义(P 0.05)。结论基于六步法的显微镜下精索静脉结扎术,通过建立正确的手术层面,规范了手术步骤和流程,从而减少了手术时间,同时有效结扎静脉、保留动脉及淋巴管,术后并发症少,临床疗效良好。

关键词：六步法精索静脉曲张显微镜

Clinical practice guideline on liver transplantation for hepatocellular carcinoma in China(2021 edition)

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Chinese Medical Journal 2022年第24期135卷 2911-2913页

作者： Jun Chen Tian Shen Jianhui Li Sunbin Ling Zhe Yang guoying Wang Liying Sun zhaoxu Yang Li Zhuang Jie Gao Wenyuan guo Jie Li Shengjun Xu Qiang Wei Shusen Zheng Xiao Xu Department of Hepatobiliary and Pancreatic Surgery The Affiliated Hangzhou First HospitalZhejiang University School of MedicineKey Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang ProvinceHangzhouZhejiang 310006China Department of Liver Transplantation The First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalHangzhouZhejiang 310004China Department of Hepatobiliary Surgery The First Affiliated HospitalGuangzhou Medical UniversityGuangzhouGuangdong 510120China Liver Transplantation Center Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Hepatobiliary Surgery Xijing HospitalAir Force Medical UniversityXi’anShaanxi 710032China Department of Hepatobiliary Surgery People’s HospitalPeking UniversityBeijing 100044China Department of Liver Surgery and Organ Transplantation Changzheng HospitalNaval Medical UniversityShanghai 200003China

Hepatocellular carcinoma(HCC)is the main cause of cancer-related deaths in adult men under the age of 60 years in China.^([1])Liver transplantation(LT)is generally recognized as one of the most effective therapeutic approaches for end-stage liver *** guidelines for HCC were firstly launched in 2014 and were updated in ***,further updates are required to adapt to the new situation of LT in China and to continue advancing the recommendations.(Full version in Supplementary file,http://***/CM9/B362).

关键词： liver Liver Clinical

Carbon nitride with encapsulated nickel for semi-hydrogenation of acetylene: pyridinic nitrogen is responsible for hydrogen dissociative adsorption

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Science China Chemistry 2018年第8期61卷 1014-1019页

作者： Teng Fu Tao Wang Hongfang Sun Yida Xu Zhen Dong Xiangke guo Luming Peng Yan Zhu zhaoxu Chen Weiping Ding Key Laboratory of Mesoscopic Chemistry School of Chemistry and Chemical Engineering Nanjing University

A new mechanism of catalyst has been demonstrated in this article. With the interaction between carbon nitride(CN) and encapsulated nickel, the CN in the catalyst has been endowed with new active sites for the adsorption and activation of hydrogen while nickel itself is physically isolated from the contact with reactive molecules. For the selective hydrogenation of acetylene in large amount of ethylene, the catalyst shows excellent ethylene selectivity than the nickel catalyst itself, which is almost totally unselective. Meanwhile, the CN itself is inactive for the reaction. The results of characterization demonstrate that pyridinic nitrogen doped in the carbon matrix should be the active sites for hydrogen dissociative adsorption. The theoretical calculations further confirm the results and provide with the detail in the electron transfer between nickel and CN in the catalyst. The current results supply a new concept for design of high performance catalyst.

关键词：镍催化剂碳氮化物选择加氢吸附乙炔分离高效催化剂相互作用