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Asian Journal of Pharmaceutical Sciences 2023年第2期18卷 94-105页

作者： Meng Chen zhaowei qi Xianmin Meng Shuo Wang Xueying Zheng Miao Hu Xinrong Liu Yanzhi Song Yihui Deng School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China

Checkpoint inhibitors are designed to rejuvenate depleted or suppressed T cells in the tumor microenvironment,relying on the immune system to control and kill ***,accumulating evidence indicates that tumor-infiltrating neutrophils impede the proliferation and activation of T cells and determine the resistance to checkpoint blockade and *** this study,sialic acid ligand-modified colchicine derivative phospholipid complexes specifically targeted tumor-associated neutrophils in the peripheral blood,blocked neutrophil accumulation in tumors,and attenuated the inhibitory effect of infiltrating neutrophils on T *** blocking therapy enhanced the immunotherapy effect of the PD-L1 antibody in S180 advanced tumors and 4T1 breast *** study found that PD-L1 antibody monotherapy increased the tumor infiltration of immunosuppressive *** therapy with neutrophil blocking can greatly reduce tumor-infiltrating neutrophils and increase the proliferation of cytotoxic CD8^(+) T lymphocytes in the *** combination therapy significantly improved the survival rate of mice with advanced S180 tumors and increased the sensitivity of immune checkpoint inhibitors to 4T1 cold tumors.

关键词： Neutrophil blockade Combination immunotherapy Sialic acid

Sialic acid-mediated photochemotherapy enhances infiltration of CD8^(+)T cells from tumor-draining lymph nodes into tumors of immunosenescent mice

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Acta Pharmaceutica Sinica B 2023年第1期13卷 425-439页

作者： Dezhi Sui Changzhi Li Xueying Tang Xianmin Meng Junqiang Ding qiongfen Yang zhaowei qi Xinrong Liu Yihui Deng Yanzhi Song College of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China

Immunoscenescence plays a key role in the initiation and development of ***,immunoscenescence also impacts drug delivery and cancer therapeutic *** reduce the impact of immunosenescence on anti-tumor therapy,this experimental plan aimed to use neutrophils with tumor tropism properties to deliver sialic acid(SA)-modified liposomes into the tumor,kill tumor cells via SA-mediated photochemotherapy,enhance infiltration of neutrophils into the tumor,induce immunogenic death of tumor cells with chemotherapy,enhance infiltration of CD8^(+)T cells into the tumordraining lymph nodes and tumors of immunosenescent mice,and achieve SA-mediated *** found that CD8^(+)T cell and neutrophil levels in 16-month-old mice were significantly lower than those in 2-and 8-month-old mice;16-month-old mice exhibited *** anti-tumor efficacy of SA-mediated non-photochemotherapy declined in 16-month-old mice,and tumors recurred after ***-mediated photochemotherapy enhanced tumor infiltration by CD8^(+)T cells and neutrophils,induced crusting and regression of tumors in 8-month-old mice,inhibited metastasis and recurrence of tumors and eliminated the immunosenescence-induced decline in antitumor therapeutic efficacy in 16-month-old mice via the light-heat-chemical-immunity conversion.

关键词： Immunosenescence Sialic acid Photochemotherapy CD8^(+)T cells Doxorubicin Neutrophils Indocyanine green Liposomes

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井筒自循环技术开采干热岩地热的试验研究

水文地质工程地质 2022年第3期49卷 198-208页

作者：亓兆伟闫方平傅大庆邱建强河北华勘资环勘测有限公司河北承德067000 河北石油职业技术大学河北承德067000 承德市地热开发与应用技术创新中心河北承德067000

井筒自循环技术是开发干热岩地热的一种新技术,它采用油管和套管组成的U形通道作为换热器,目前对该项技术的现场和室内试验研究尚不够。文章建立了一个实验室规模的模拟装置来模拟干热岩局部井筒自循环的热交换过程,以水作为换热介质,... 详细信息

井筒自循环技术是开发干热岩地热的一种新技术,它采用油管和套管组成的U形通道作为换热器,目前对该项技术的现场和室内试验研究尚不够。文章建立了一个实验室规模的模拟装置来模拟干热岩局部井筒自循环的热交换过程,以水作为换热介质,进行一系列室内试验,对换热的影响因素及换热参数进行研究。试验结果表明:具有较大采热能力和热容量的花岗岩在高温下具有较高的采热速率;较高的注水速率会产生较高的采热速率,但出口温度会降低,因此,应慎重选择较高出口温度和较高采热量之间的平衡。相似性分析表明,876 m长的垂直井在602.8 m^(3)/d的注入速率下,可从150℃的干热岩中获取的采热量高达565 kW,该结果与现场实测数据很接近,可以证明相似性分析结果的合理性。建立的模拟装置及试验原理也同样适用于“取热不取水”的中深层同轴套管式地埋管换热技术,可以为中深层地热开发研究和实际应用提供一定的参考。

关键词：干热岩井筒自循环试验模拟装置换热参数相似性分析

某复杂边界形态尾矿库坝体三维渗流稳定性分析研究

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城市勘测 2016年第1期 164-167页

作者：付茂盛亓兆伟华北地质勘查局五一四地质大队河北承德067000

基于FLAC3D数值计算软件构建某"V"字型沟谷内存在多条支沟的复杂边界形态尾矿库数值计算分析模型,对尾矿库在库区正常水位及洪水位工况尾矿库坝体三维渗流分析模式下的尾矿库坝体及库区周边山体的位移场、速度场、剪切应变增量、位移破... 详细信息

基于FLAC3D数值计算软件构建某"V"字型沟谷内存在多条支沟的复杂边界形态尾矿库数值计算分析模型,对尾矿库在库区正常水位及洪水位工况尾矿库坝体三维渗流分析模式下的尾矿库坝体及库区周边山体的位移场、速度场、剪切应变增量、位移破坏场进行分析,圈定存在失稳破坏区域,揭示尾矿库坝体在干滩长度变化的三维渗流分析模式下坝体稳定性安全系数变化规律,评价尾矿坝基和坝体的稳定性,为尾矿库坝体继续加高、闭库设计、安全生产提供技术参考。

关键词：尾矿库数值计算干滩长度渗流分析 FLAC3D 复杂边界

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某浅层碎石土滑坡稳定性分析及治理措施研究

山西建筑 2016年第13期42卷 77-79页

作者：亓兆伟付茂盛华北地质勘查局五一四地质大队河北承德067000

以兴隆县某滑坡工程为背景,基于PLAXIS大型岩土工程有限元设计计算软件,构建了滑坡体有限元网格模型,对滑坡体的塑性区、剪切应变增量、总位移量等进行了分析,指出在实地条件允许的情况下宜优先采用削方减载进行滑坡治理,其次为支挡措施... 详细信息

以兴隆县某滑坡工程为背景,基于PLAXIS大型岩土工程有限元设计计算软件,构建了滑坡体有限元网格模型,对滑坡体的塑性区、剪切应变增量、总位移量等进行了分析,指出在实地条件允许的情况下宜优先采用削方减载进行滑坡治理,其次为支挡措施,可为同类的滑坡体治理提供一定的技术参考。

关键词：滑坡数值计算剪切应变总位移量 PLAXIS 塑性区

Newly discovered insect RNA viruses in China

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Science China(Life Sciences) 2013年第8期56卷 711-714页

作者： qiU Yang WANG zhaowei LIU YongXiang qi Nan SI Jie XIANG Xue XIA XiaoLing HU YuanYang ZHOU Xi State Key Laboratory of Virology College of Life SciencesWuhan University

Insects are a group of arthropods and the largest group of animals on Earth,with over one million species described to *** other life forms,insects suffer from viruses that cause disease and *** that are pathogenic to beneficial insects cause dramatic economic losses on *** contrast,viruses that are pathogenic to insect pests can be exploited as attractive biological control *** of these factors have led to an explosion in the amount of research into insect viruses in recent years,generating impressive quantities of information on the molecular and cellular biology of these *** to the wide variety of insect viruses,a better understanding of these viruses will expand our overall knowledge of their ***,we review studies of several newly discovered RNA insect viruses in China.

关键词： insect virus Wuhan Nodavirus Dendrolimus punctatus tetravirus Ectropis obliqua picorna-like virus

Aqueous Synthesis of Covalent Organic Frameworks as Photocatalysts for Hydrogen Peroxide Production

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CCS Chemistry 2022年第12期4卷 3751-3761页

作者： Fanglin Tan Yuanyuan Zheng Zhipeng Zhou Honglei Wang Xin Dong Jing Yang zhaowei Ou Haoyuan qi Wei Liu Zhikun Zheng Xudong Chen Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education School of ChemistryState Key Laboratory of Optoelectronic Materials and TechnologiesSun Yat-sen UniversityGuangzhou 510275 Key Laboratory of Low-Carbon Chemistry&Energy Conservation of Guangdong Province Key Laboratory for Polymeric Composite and Functional Materials of Ministry of EducationSchool of Materials Science and EngineeringSun Yat-sen UniversityGuangzhou 510275 Center for Advancing Electronics Dresden(cfaed)and Faculty of Chemistry and Food Chemistry Technical University of DresdenDresden 01069 Central Facility of Electron Microscopy Electron Microscopy Group of Materials ScienceUniversität UlmUlm 89081 Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education School of ChemistrySun Yat-sen UniversityGuangzhou 510275

Covalent organic frameworks(COFs)are crystalline porous polymers with designable structures and *** crystallization typically relies on trialand-error experimentation involving harsh conditions,including organic solvents,presenting significant obstacles for rational design and large-scale ***,we present a liquid crystal-directed synthesis methodology and its implementation for up to gram-scale production of highly crystalline COFs in water and *** is compatible with monomers of different structures,shape,size,length of side chains,and electron-donating,electron-accepting,and heterocyclic substitutions near reactive *** types of donor-acceptor two-dimensional COFs including four types of new ones and a three-dimensional COF with a yield of up to 94%were demonstrated,showing great generality of the *** as-synthesized donor-acceptor COFs are organic semiconductors and contain macropores besides intrinsic mesopores which make them attractive *** production of H_(2)O_(2)under visible light in water was studied and the structure-property relationships were *** production rate reached 4347μmol h^(−1)gcat^(−1),which is about 467%better than that of the benchmark photocatalyst g-C_(3)N_(4).This study will inspire the mild synthesis and scale-up of a wide spectrum of COFs and organic semiconductors as efficient catalysts,promote their structure-property investigation,and boost their applications.

关键词： covalent organic frameworks liquid crystal photocatalysis hydrogen peroxide production porous polymer

Production of monoclonal antibodies against AFLD(Nor-1),an early key protein involved in aflatoxin biosynthesis

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Oil Crop Science 2018年第1期3卷 50-56页

作者： Ting Wang Peiwu Li qi Zhang Wen Zhang zhaowei Zhang Xueli Dong Tong Wang Key Laboratory of Biology and Genetic Improvement of Oil Crops Ministry of AgricultureOil Crops Research Institute of the Chinese Academy of Agricultural Sciences Key Laboratory of Detection for Mycotoxins Ministry of Agriculture Laboratory of Risk Assessment for Oilseeds Products WuhanMinistry of Agriculture Quality Inspection and Test Center for Oilseeds Products Ministry of Agriculture

Aflatoxins are distributed worldwide throughout environment. As many as 30genes are involved in aflatoxin biosynthesis. aflD (nor-1) was predicted to encode a 31 kDa ketoreductase (AFLD), which catalyzed the earliest and first stable aflatoxin precursor in aflatoxin biosynthetic pathway. AFLD was proved to be necessary for conversion of norsolorinic acid (NA) to averatin (AVN) in aflatoxin biosynthesis. For this reason, aflD was cloned and specific monoclonal antibodies for AFLD were developed to better define potential pathways of AFLD involved in Aflatoxin B_1 (AFB_1) biosynthesis. Monoclonal antibodies 2A8-1E10 and 2F11-3D8 were successfully screened out by immunized mouse. Immunoblot analysis revealed that 2A8-1E10 had high sensitivity and specificity to identify native AFLD protein in A. flavus with detection limit of 3 ng/mL. These results showed that it was suitable for quantitative detection of AFLD in A. flavus isolate. Further investigation revealed that aflatoxin accumulations of various A. flavus were not dependent on AFLD ***, this is the first report for AFLD monoclonal antibody development and application in A. flavus quantitative detection.

关键词： aflatoxin biosynthesis AFLD monoclonal antibodies quantitative detection

Scalable and ultrafast epitaxial growth of single-crystal graphene wafers for electrically tunable liquid-crystal microlens arrays

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Science Bulletin 2019年第10期64卷 659-668页

作者： Bing Deng zhaowei Xin Ruiwen Xue Shishu Zhang Xiaozhi Xu Jing Gao Jilin Tang Yue qi Yani Wang Yan Zhao Luzhao Sun Huihui Wang Kaihui Liu Mark H. Rummeli Lu-Tao Weng Zhengtang Luo Lianming Tong Xinyu Zhang Changsheng Xie Zhongfan Liu Hailin Peng Center for Nanochemistry (CNC) Beijing Science and Engineering Center for Nanocarbons Beijing National Laboratory for Molecular Sciences (BNLMS) College of Chemistry and Molecular Engineering Peking University Beijing 100871 China Beijing Graphene Institute (BCl) Beijing 100094 China Wuhan National Laboratory for Optoelectronics School of Automation National Key Laboratory of Science and Technology on Multispectral Information Processing Huazhong University of Science & Technology Wuhan 430074 China Department of Chemical and Biological Engineering Materials Characterization and Preparation Facility The Hong Kong University of Science and Technology Hong Kong 999077 China State Key Laboratory for Mesoscopic Physics School of Physics Peking University Beijing 100871 China Institute of Functional Nano and Soft Materials (FUNSOM) J iangsu Key Laboratory for Carbon-Based Functional Materials and Devices and Joint International Research Laboratory of Carbon-Based Functional Materials and Devices Soochow University Suzhou 215123 China Academy for Advanced Interdisciplinary Studies Peking University Beijing 100871 China Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu Province College of Energy Soochow Institute for Energy and Materials Innovations Soochow University Suzhou 215006 China Centre of Polymer and Carbon Materials Polish Academy of Sciences Zabrze 41-819 Poland Wuhan National Laboratory for Optoelectronics Huazhong University of Science & Technology Wuhan 430074 China

The scalable growth of wafer-sized single-crystal graphene in an energy-efficient manner and compatible with wafer process is critical for the killer applications of graphene in high-performance electronics and optoelectronics. Here, ultrafast epitaxial growth of single-crystal graphene wafers is realized on singlecrystal Cu90Ni10(1 1 1) thin films fabricated by a tailored two-step magnetron sputtering and recrystallization process. The minor nickel(Ni) content greatly enhances the catalytic activity of Cu, rendering the growth of a 4 in. single-crystal monolayer graphene wafer in 10 min on Cu90Ni10(1 1 1), 50 folds faster than graphene growth on Cu(1 1 1). Through the carbon isotope labeling experiments, graphene growth on Cu90Ni10(1 1 1) is proved to be exclusively surface-reaction dominated, which is ascribed to the Cu surface enrichment in the Cu Ni alloy, as indicated by element in-depth profile. One of the best benefits of our protocol is the compatibility with wafer process and excellent scalability. A pilot-scale chemical vapor deposition(CVD) system is designed and built for the mass production of single-crystal graphene wafers, with productivity of 25 pieces in one process cycle. Furthermore, we demonstrate the application of single-crystal graphene in electrically controlled liquid-crystal microlens arrays(LCMLA), which exhibit highly tunable focal lengths near 2 mm under small driving voltages. By integration of the graphene based LCMLA and a CMOS sensor, a prototype camera is proposed that is available for simultaneous light-field and light intensity imaging. The single-crystal graphene wafers could hold great promising for highperformance electronics and optoelectronics that are compatible with wafer process.

关键词： Graphene Ultrafast growth CuNi(1 1 1)thin film Single crystal wafer Liquid crystal microlens arrays

An ultrasensitive time-resolved fluorescent immunoassay method for determination aflatoxins B1 in edible oil

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Oil Crop Science 2016年第3期1卷 57-64页

作者： Du Wang zhaowei Zhang Peiwu Li qi Zhang Jin Mao Li Yu Wen Zhang Xiaoxia Ding Oil Crops Research Institute Chinese Academy of Agricultural Sciences Wuhan China Key Laboratory of Biology and Genetic Improvement of Oil Crops Ministry of Agriculture Wuhan China Key laboratory of Detection for My cotoxins Ministry of Agriculture Wuhan China Laboratory of Risk Assessment for Oilseeds Products (Wuhan) Ministry of Agriculture Wuhan China Quality Inspection and Test Center for Oilseeds Products Ministry of Agriculture Wuhan China

Edible oil is one major nutritional ingredient to human and widely consumed directly. The contamination of aflatoxin B1 （AFB1） in edible oils has been attracted exten-sive efforts due to its hazard to human health and life. To avoid the digestion of edible oils contaminated by AFB1 the development of rapid and sensitive sensing method for AFB1 is required. Herein, a quantitative, sensitive and rapid method for AFB1 detection in edible oils was proposed by using ultrasensitive time-resolved fluorescent immunosensing （TRFIS） method. This method poses unique advantages from both time-resolved fluorescent sens-ing method and immunochromatographic assay format. The nanospheres were modified with fluorescent europium and then captured the home-made monoclonal antibody against AFB1 （3G1）. After optimization, by using a competitive immunosensing manner, this TRFIS method has a detectable linear range of 0.54-20.0 μg/kg with minimum detectable concen-tration of 0.18μg/kg. It can be completed merely within 10 min with recovery from 87.0% to 121.9%. The agreement was observed between the results by TRFIS and high perfor-mance liquid chromatography （HPLC） methods. This research provides a promising sens-ing method for sensitive and rapid determining AFB1 in edible oils.

关键词： time-resolved fluorescent immunosensing (TRFIS) europium label aflatoxin B1 (AFB1) edible oils