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The bone alterations in hind limb amputation rats in vivo

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Medicine in Novel Technology and Devices 2020年第4期8卷 31-35页

作者： Huiqin Luan Huiru gu Zhongjun Mo Weiyan Ren Huan guo zhaowei Chu Yubo Fan Key Laboratory of Intelligent Control and Rehabilitation Technology of the Ministry of Civil Affairs National Research Center for Rehabilitation Technical AidsBeijing100176China Beijing Key Laboratory of Rehabilitation Technical Aids for Old-Age Disability Beijing100176China Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical EngineeringBeihang UniversityBeijing100191China Key Laboratory of Rehabilitation Technical Aids Analysis and Identification of the Ministry of Civil Affairs Beijing100176China

Osteoporosis,which is characterized by bone loss,increases the risk of fractures and s and seriously affected the amputee’s *** mass is an important factor affecting bone mineral density(BMD).Muscular atrophy and decreased muscle mass can cause BMD to *** bone quantity and quality are used to assess by Microcomputer tomography(micro-CT)with *** investigate the performance of micro-CT in evaluating amputation-induced osteopenia in rats,the micro-CT was used to evaluate the change of the microstructure in trabecular bone and cortical bone of *** morphology was analyzed by micro-CT and transmission electron *** Sprague–Dawley rats(8 week old)were divided into two groups:control(CON)groups and left hind limb amputation(LHLA).At 35 days,microstructure and volumetric bone mineral density(vBMD)of the tibia and femur were detected through *** results showed:(1)the trabecular and cortical vBMD of the proximal tibia and distal femur in the LHLA group were significantly lower than those in the CON group.(2)Compared with the CON group,the trabecular number,bone volume fraction and trabecular thickness of proximal tibia and distal femur in LHLA group decreased significantly,whereas the trabecular separation,structure model index and bone surface/bone volume increased significantly in LHLA group.(3)The whole cross-sectional area(CSA)of whole calf muscles of left limb in LHLA group decreased significantly compared with CON *** general,hind limb amputation could cause bone loss,changes in the microstructure of trabecular bone and muscle ***-CT is sensitive in evaluating bone microstructure destruction caused by amputation,and can be used for early diagnosis or monitor the development of bone loss in amputation in vivo.

关键词： Amputation Micro-CT Microstructure Bone loss BMD

ADVISING score:a reliable grading scale based on injury and response for intracerebral haemorrhage

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Stroke & Vascular Neurology 2023年第2期8卷 111-118页

作者： Yan Wan Hongxiu guo Shaoli Chen Jiang Chang David Wang Rentang Bi Man Li Ke Shi zhaowei Wang Daokai Gong Jingwen Xu Quanwei He Bo Hu Department of Neurology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina School of Public Health Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Neurovascular Division Department of NeurologyBarrow Neurological Institute/Saint Joseph Hospital Medical CenterPhoenixArizonaUSA Department of Neurology Qianjiang Central HospitalQianjiangHubeiChina Department of Neurology Jingzhou Central HospitalJingzhouHubeiChina Department of Neurology Honghu People's HospitalHonghuHubeiChina

Background Intracerebral haemorrhage(ICH)is the most devastating form of stroke causing high morbidity and *** aimed to develop a novel clinical score incorporating multisystem markers to predict functional dependence at 90 days after *** We analysed data from Chinese Cerebral Hemorrhage:Mechanism and Intervention *** logistic regression analysis was used to identify the factors associated with 90-day functional dependency(the modified Rankin Scale≥3)after ICH and develop the ADVISING scoring *** test the scoring system,a total of 2111 patients from Hubei province were included as the training cohort,and 733 patients from other three provinces in China were included as an external validation *** We found nine variables to be significantly associated with functional dependency and included in the ADVISING score system:age,deep location of haematoma,volume of haematoma,National Institutes of Health Stroke Scale,aspartate transaminase,international normalised ratio,neutrophil-lymphocyte ratio,fasting blood glucose and glomerular filtration *** were divided into 12 different categories by using these nine potential *** proportion of patients who were functionally dependent increased with higher ADVISING scores,which showed good discrimination and calibration in both the training cohort(C-statistic,0.866;p value of Hosmer-Lemeshow test,0.195)and validation cohort(C-statistic,0.884;p value of Hosmer-Lemeshow test,0.853).The ADVISING score also showed better discriminative performance compared with the other five existing ICH scores(p<0.001).Conclusions ADVISING score is a reliable tool to predict functional dependency at 90 days after ICH.

关键词： score statistic reliable

Clinical Signifi cance of Angiographically Detectable Neovascularity in Patients with Cardiac Myxoma

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Cardiovascular Innovations and Applications 2021年第4期6卷 99-108页

作者： Xiaofan Peng Yichao Xiao Yanan guo zhaowei Zhu Liyan Liao Xiaobo Liao Xinqun Hu Zhenfei Fang Xuping Li Shenghua Zhou Department of Cardiovascular Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunanChina Department of Pathology The Second Xiangya HospitalCentral South UniversityChangshaHunanChina Department of Cardiovascular and Thoracic Surgery The Second Xiangya HospitalCentral South UniversityChangshaHunanChina

Background:Myxomas are the most common primary cardiac *** detectable neovascularity(ADN)of myxoma is increasingly being reported as a result of the use of coronary angiography(CAG)to detect coronary artery ***,the clinical signifi cance of these fi ndings is not fully ***:We enrolled 59 patients with cardiac myxoma who also underwent CAG between January 2013 and October *** were followed up for a mean of 28.9 months(range 1-69 months).The clinical features,echocardiography measurements,pathological examination fi ndings,CAG results,and outcomes during follow-up were compared between patients with ADN and patients without ***:ADN was found in 25 patients(42.4%).The arteries feeding the ADN included the right coronary artery(n=15),the left circumfl ex coronary artery(n=7),and both arteries(n=3).The patients with ADN had a higher proportion of eosinophils(3.2%vs.2.2%,P=0.03)and higher low-density lipoprotein cholesterol level(2.7 mmol/L vs.2.2 mmol/L,P=0.02).Myxoma pedicles were more likely to be located in the interatrial septum in patients with ADN(96%vs.73.5%,P=0.02).No signifi cant correlation was observed between the groups in clinical manifestations,atrial arrhythmia,myxoma size,cardiac chamber size,left ventricular ejection fraction,and the prevalence of complication with coronary artery disease[16%in the ADN group(n=4)vs.20.6%in the non-ADN group(n=7),P=0.66].However,patients with ADN tended to have a lower incidence of major adverse cardiac and cerebrovascular events on long-term follow-up(0%vs.14.7%,P=0.07).Conclusion:CAG-detected ADN in patients with cardiac myxoma is associated with a borderline lower rate of major adverse cardiac and cerebrovascular events.

关键词： Cardiac myxomas coronary angiography angiographically detectable neovascularity major adverse cardiac and cerebrovascular events

H∞ Attitude Control with Initiative Morphing Strategy Based on Linearization for Gull-wings

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H∞ Attitude Control with Initiative Morphing Strategy Based...

活体生物药的应用及在遗传性代谢缺陷病治疗中的展望

第36届中国控制会议

作者： Tianhao guo Zhongxi Hou zhaowei Liu Wenkai Wang College of Aerospace Science and Engineering National University of Defense Technology

Morphing is usually designed to adapt the structure properties to different missions,while in this paper,it is also a method of flight control of the *** morphing aircrafts taken as bodies with variable center of mass and inertia tensor,the centroid dynamic equations are analyzed to build the nonlinear dynamic model,which are then simplified for gull-wings with folding angles as the morphing *** the purpose of further analysis and controller design,the nonlinear equations are linearized based on perturbation *** H synthesis is introduced to develop the attitude tracking *** proposed approach is validated by the nonlinear simulations,which show that the initiative morphing strategy works well and will improve the robustness of the system.

关键词： Morphing Aircraft Gull-wing Initiative Morphing Strategy Modelling Linearization H∞ Control

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生物工程学报 2023年第4期39卷 1290-1303页

作者：陈钊炜郭敏郑华军复旦大学上海市生物医药技术研究院国家卫生健康委员会计划生育药具重点实验室上海200032 华东理工大学鲁华生物技术研究所生物反应器工程国家重点实验室上海200237

活体生物药(live biotherapeutic products,LBPs)是指来自于人体肠道内或自然界中能够治疗人类疾病的活性菌。但天然筛选的活菌存在治疗效果不明显、差异性较大等缺点,难以满足个性化诊疗的需要。近年来,随着合成生物学的发展,研究者利... 详细信息

活体生物药(live biotherapeutic products,LBPs)是指来自于人体肠道内或自然界中能够治疗人类疾病的活性菌。但天然筛选的活菌存在治疗效果不明显、差异性较大等缺点,难以满足个性化诊疗的需要。近年来,随着合成生物学的发展,研究者利用生命科学及工程科学手段,设计并构建了若干可响应外界复杂环境信号的工程菌株,加快了活体生物药的研发和应用过程。遗传性代谢缺陷病(inherited metabolic disease)是因体内某些酶的遗传缺陷致使体内相应的代谢物不能正常代谢而引发一系列临床症状的一类疾病,因此利用合成生物学技术,针对特定缺陷的酶设计重组活体生物药,未来有希望用于遗传性代谢缺陷病的治疗。本综述以活体生物药为切入点,并结合国内外文献综述,来探讨活体生物药在疾病治疗中的应用,以及对遗传性代谢缺陷病治疗的潜力。

关键词：活体生物药遗传性代谢缺陷病合成生物学基因编辑工程菌

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基于柔性多体动力学的地铁车辆动态行为研究

武汉大学学报（工学版） 2022年第8期55卷 840-849,856页

作者：朱国陈兆玮重庆交通大学机电与车辆工程学院重庆400074 重庆交通大学城市轨道交通车辆系统集成与控制重庆市重点实验室重庆400074

为了更准确地研究地铁车辆的动态特性,详细考虑了地铁车辆关键零部件的结构弹性,提出一种基于柔性多体动力学的地铁车辆动态行为研究方法。首先,建立地铁车体和构架等关键零部件的有限元模型,然后基于子结构理论及Guyan缩减矩阵法对其... 详细信息

为了更准确地研究地铁车辆的动态特性,详细考虑了地铁车辆关键零部件的结构弹性,提出一种基于柔性多体动力学的地铁车辆动态行为研究方法。首先,建立地铁车体和构架等关键零部件的有限元模型,然后基于子结构理论及Guyan缩减矩阵法对其进行缩减,并结合多体动力学理论形成最终的地铁车辆刚柔耦合动力学模型,采用该模型研究不同线路条件下的地铁车辆动态特性。同时,建立地铁车辆刚体动力学模型,与上述刚柔耦合模型进行对比,研究结构弹性对地铁车辆动态特性的影响。研究发现:在不同线路激扰条件下,刚柔耦合模型与刚体模型的计算结果有较大差别,考虑结构弹性会增大车体振动和脱轨系数等指标。因此,在对地铁车辆运行安全性和乘坐舒适性进行评估时,应考虑车辆的结构弹性。

关键词：地铁车辆柔性多体动力学动态特性子结构理论

SnNb2O6纳米片的合成及对达氟沙星的吸附

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高等学校化学学报 2019年第6期40卷 1121-1127页

作者：赵洁宋强郭笑吴飞田昊川卢朝薇西安理工大学理学院

通过水热反应制备了新型SnNb2O6纳米片吸附剂,并利用X射线衍射(XRD)、扫描电子显微镜(SEM)和比表面积及孔径分析等手段对其结构和形貌进行了表征.以第三代喹诺酮类抗生素达氟沙星为吸附质,进行了影响因素实验、吸附动力学实验及等温吸... 详细信息

通过水热反应制备了新型SnNb2O6纳米片吸附剂,并利用X射线衍射(XRD)、扫描电子显微镜(SEM)和比表面积及孔径分析等手段对其结构和形貌进行了表征.以第三代喹诺酮类抗生素达氟沙星为吸附质,进行了影响因素实验、吸附动力学实验及等温吸附实验,探究了SnNb2O6对达氟沙星的吸附性能和吸附机理.实验结果表明,SnNb2O6吸附剂具有片状形貌,层状单斜相晶体结构,比表面积为52.89m^2/g.吸附剂用量、吸附温度、溶液pH值及吸附时间均对吸附率有一定影响.相应的等温吸附曲线可以较好地拟合Freundlich方程,且动力学实验数据可以用拟二级动力学方程描述,其中液膜扩散为主要控制步骤.在35℃下,吸附剂用量为0.09g,控制溶液pH值为6.02时,吸附30min即可达到较好效果,此时达氟沙星的吸附去除率为93.1%.

关键词：吸附剂 SnNb2O6 纳米片达氟沙星

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涵道风扇外形参数对气动特性的影响

国防科技大学学报 2016年第4期38卷 28-33页

作者：李晓华郭正柳兆伟陈清阳国防科技大学航天科学与工程学院湖南长沙410073

以某涵道风扇为原型,从理论上分析涵道扩张角对涵道风扇气动特性的影响。运用滑移网格模型,采用三维不可压黏性Navier-Stokes控制方程,利用SST k-ω湍流模型,计算两叶桨气动特性,并与试验结果对比,验证该方法的可行性。分别计算涵道风... 详细信息

以某涵道风扇为原型,从理论上分析涵道扩张角对涵道风扇气动特性的影响。运用滑移网格模型,采用三维不可压黏性Navier-Stokes控制方程,利用SST k-ω湍流模型,计算两叶桨气动特性,并与试验结果对比,验证该方法的可行性。分别计算涵道风扇在悬停状态下,3000-8500 r/min转速范围内,涵道唇口外形、扩张角和涵道高度对气动特性的影响,并对流场进行分析。椭圆形唇口的涵道风扇总拉力系数小,气动效率低;当涵道扩张角在8.2°附近时,功率系数相对最小,随着扩张角增大,在桨盘下方靠近涵道壁面附近出现气流分离;涵道拉力系数对涵道风扇高度的变化敏感度低,随着高度增加功率系数略有下降。

关键词：涵道风扇外形参数气动特性唇口外形扩张角涵道高度

融合TKEO和Goerztel算法的感应电机转子断条故障诊断

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电工技术学报 2024年第12期39卷 3679-3690页

作者：王照伟郭雯君宋向金赵文祥江苏大学电气信息工程学院镇江212013 南京工程学院电力工程学院南京211167

针对电机电流信号特征分析进行转子断条故障诊断时,在低负载工况或早期,转子断条故障存在故障特征微弱以及难以分离等问题,同时需借助速度传感器获取转速信息,增加了硬件成本,该文提出了融合Teager-Kaiser能量算子(TKEO)和Goertzel算法... 详细信息

针对电机电流信号特征分析进行转子断条故障诊断时,在低负载工况或早期,转子断条故障存在故障特征微弱以及难以分离等问题,同时需借助速度传感器获取转速信息,增加了硬件成本,该文提出了融合Teager-Kaiser能量算子(TKEO)和Goertzel算法的感应电机转子断条故障诊断方法。首先,采用Teager-Kaiser能量算子对定子电流进行解调处理,将基频分量转化为直流分量并去除,实现边带故障特征分量到转子断条故障特征分量以及固有偏心谐波分量到转子速度谐波分量的转变,抑制基频频谱泄露对故障诊断和转速估计造成的干扰;其次,利用Goertzel算法对归一化解调信号进行频谱分析,完成转子断条故障特征分量和转子速度谐波分量的快速提取,进而实现不同负载和不同严重程度工况下转子断条的故障诊断。此外,与归一化频域能量算子进行比较,分析其计算效率和稳定性。实验结果表明,所提方法在不同负载和不同严重程度工况下均能够有效地识别转子断条故障特征分量,并且计算量少、可靠性高、实时性强以及硬件成本低。

关键词：转子断条 Goertzel算法固有偏心 Teager-Kaiser能量算子归一化频域能量算子