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Liposome-coated CaO_(2)nanoblockers for enhanced checkpoint blockade therapy by inhibiting PD-L1 de novo biosynthesis

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Nano Research 2023年第5期16卷 7227-7236页

作者： Ruijun Che Dandan Han Fei wang Huifang Liu Miao Fan Hongyu Yan Tingshan Xiao zhaoshuo wang Xiaohan Zhou Xueyi wang Kaihan Zhang Caiwen Ou Jinchao Zhang Zhenhua Li College of Chemistry&Environmental Science Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of EducationChemical Biology Key Laboratory of Hebei ProvinceHebei UniversityBaoding 071002China Affiliated Dongguan Hospital Southern Medical UniversityDongguan 523059China Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation Guangzhou 510515China College of Pharmaceutical Science Key Laboratory of Pharmaceutical Quality Control of Hebei ProvinceHebei UniversityBaoding 071002China Department of Chemistry the University of ManchesterManchester M139PLUK

The blocking of the immune checkpoint pathway with antibodies,especially targeting to programmed death-1/programmed death ligand-1(PD-1/PD-L1)pathway,was currently a widely used treatment strategy in clinical practice.However,the shortcomings of PD-L1 antibodies were constantly exposed with the deepening of its research and their therapeutic effect was limited by the translocation and redistribution of intracellular PD-L1.Herein,we proposed to improve immune checkpoint blockade therapy by using liposomes-coated CaO_(2)(CaO_(2)@Lipo)nanoparticles to inhibit the de novo biosynthesis of PD-L1.CaO_(2)@Lipo would produce oxygen and reduce hypoxia-inducible factor-1α(HIF-1α)level,which then downregulated the expression of PD-L1.Our in vitro and in vivo results have confirmed CaO_(2)@Lipo promoted the degradation of HIF-1αand then downregulated the expression of PD-L1 in cancer cells for avoiding immune escape.Furthermore,to mimicking the clinical protocol of anti-PD-L1 antibodies+chemo-drugs,CaO_(2)@Lipo was combined with doxorubicin(DOX)to investigate the tumor inhibition efficiency.We found CaO_(2)@Lipo enhanced DOX-induced immunogenic cell death(ICD)effect,which then promoted the infiltration of T cells,strengthened the blocking effect,thus provided an effective means to overcome the traditional immune checkpoint blockade treatment.

关键词： immune checkpoint blockade therapy oxygen-producing hypoxia-inducible factor-1α(HIF-1α) programmed death ligand-1(PD-L1)redistribution immunogenic cell death

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含苯并咪唑结构双马来酰亚胺的合成与表征

工程塑料应用 2024年第3期52卷 132-139页

作者：周赞民李根臣孔国强王义师王昭硕马海艇杨传超山东非金属材料研究所济南250031

针对结构复合材料高耐温等级的应用需求,从改善双马来酰亚胺(BMI)树脂基体性能出发,采用分子设计的方法,将刚性苯并咪唑环结构引入单体主链中,以共沸甲苯法合成出含单苯并咪唑结构双马来酰亚胺单体(BZ-BMI)和含邻苯并咪唑结构双马来酰... 详细信息

针对结构复合材料高耐温等级的应用需求,从改善双马来酰亚胺(BMI)树脂基体性能出发,采用分子设计的方法,将刚性苯并咪唑环结构引入单体主链中,以共沸甲苯法合成出含单苯并咪唑结构双马来酰亚胺单体(BZ-BMI)和含邻苯并咪唑结构双马来酰亚胺单体(OBZ-BMI)。采用核磁共振氢谱与傅里叶变换红外(FTIR)光谱对中间产物和目标产物的结构进行表征。采用差示扫描量热(DSC)法和热重(TG)分析法研究了单体的固化行为及固化物的热稳定性。DSC曲线结果表明,BZ-BMI与OBZ-BMI在210~370℃温度范围内进行交联固化,其固化行为受链段长度、分子结构规整性与相互作用力影响较大;同时,结合DSC曲线确定了单体的固化工艺为200℃/2 h+250℃/2 h+330℃/6 h;FTIR分析表明此工艺可以完全固化。TG分析表明,其热分解温度与二苯甲烷型双马来酰亚胺(BDM)相当,而P(BZ-BMI)与P(OBZ-BMI)在800℃下残炭率分别为74.7%与70.4%,远高于P(BDM)的测试值(48.3%),说明苯并咪唑结构的引入有效提高了BMI的耐热阻燃性能;OBZ-BMI共聚改性体系保持了优异的力学性能,较传统二烯丙基双酚A改性BMI体系的冲击强度提高了20%,拓宽了BMI在耐高温树脂基结构复材领域的应用范围。

关键词：苯并咪唑双马来酰亚胺合成聚合物耐热性能

Improvement of maximum power point tracking in photovoltaic arrays in different environments using hybrid algorithms

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Optoelectronics Letters 2024年第1期20卷 28-34页

作者： ZHANG Jiuchao REN Guangjun XUE Yuming XIA Dan wang Jiangchao HU zhaoshuo Institute of New Energy Intelligence Equipment School of Integrated Circuit Science and EngineeringTianjin University of TechnologyTianjin 300384China

When the photovoltaic(PV)system is generating PV power,the partial shading(PS)condition will cause multiple peaks in the power-voltage curve,and changes in light intensity and ambient temperature will cause the curve to shift.Traditional maximum power point tracking(MPPT)methods,such as the incremental conductance(INC)method,have the problem of being trapped in the local optimal solution.Biomimetic optimization algorithms,such as particle swarm optimization(PSO),have problems with oscillation and low tracking efficiency near the global maximum power point(GMPP).As a result,a hybrid algorithm CS-INC based on the cuckoo search(CS)algorithm and the perturb and observe(P&O)approach is proposed in this study.The light intensity remains constant,the light intensity changes in steps,and the partial shade scenario are simulated.Simulation results show that the MPPT improves accuracy,speed,and stability.

关键词： power maximum optimization

Study on RF Excited Waveguide CO2 Laser with Two Different Channels

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Chinese Journal of Lasers 1999年第6期8卷 3-5页

作者： TIAN zhaoshuo wang Qi WAN Yusan LIU Fengmei (National Key Laboratory of Tunable Laser Technology, Harbin Institute of Technology, Harbin 150001, China) 哈尔滨工业大学可调谐（气体）激光技术国防科技重点实验室黑龙江哈尔滨 150001 哈尔滨工业大学可调谐（气体）激光技术国防科技重点实验室黑龙江哈尔滨

In this paper a waveguide CO 2 laser with two unequal long channels excited by radio frequency (RF) is presented. The volume is 2.25×2.25×400 mm 3 for the long channel and 2.25×2.25×200 mm 3 for the short waveguid... 详细信息

关键词： two unequal long channels RF excited waveguide CO 2 laser

N掺杂活性炭负载Pd催化对甲酰基苯甲酸选择性加氢

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石油化工 2024年第5期53卷 625-633页

作者：袁兆朔刘玉洁王震房旭张铁珍张鑫中国石油大学(北京)化学工程与环境学院北京102249 中国石油大庆化工研究中心黑龙江大庆163714

采用等体积浸渍法制备了N掺杂活性炭负载的Pd(Pd/WH-C)催化剂,通过N_(2)吸附-脱附、FTIR、SEM、TEM、XRD、XPS、H_(2)-TPR等手段对催化剂进行了表征,并将Pd/WH-C催化剂用于对甲酰基苯甲酸(4-CBA)选择性加氢反应,比较了它与商业Pd/C催化... 详细信息

采用等体积浸渍法制备了N掺杂活性炭负载的Pd(Pd/WH-C)催化剂,通过N_(2)吸附-脱附、FTIR、SEM、TEM、XRD、XPS、H_(2)-TPR等手段对催化剂进行了表征,并将Pd/WH-C催化剂用于对甲酰基苯甲酸(4-CBA)选择性加氢反应,比较了它与商业Pd/C催化剂的催化性能。表征结果显示,N掺杂提高了活性炭载体的比表面积、介孔体积及Pd纳米颗粒的分散度,增强了Pd纳米颗粒与活性炭之间的相互作用,有效抑制了Pd纳米颗粒的流失和烧结。实验结果表明,在280℃和7.7 MPa条件下反应1 h,Pd/WH-C催化剂上4-CBA的初始转化率为97.5%,催化剂循环使用6次后4-CBA转化率下降38.4百分点,优于商业Pd/C催化剂,显示出良好的稳定性。

关键词：对苯二甲酸 Pd/C催化剂加氢对甲酰基苯甲酸 N掺杂

Structural,electrochemical and cycling properties of Nb^(5+)doped LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)cathode materials at different calcination temperatures for lithium-ion batteries

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Optoelectronics Letters 2023年第9期19卷 548-555页

作者： wang Jiangchao XUE Yuming DAI Hongli wang Luoxin ZHANG Jiuchao HU zhaoshuo Institute of New Energy Intelligence Equipment School of Integrated Circuit Science and EngineeringTianjin University of TechnologyTianjin 300384China

LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)cathode material is prepared by sol-gel method and the effects of Nb^(5+)doping and different calcination temperatures on cathode materials were deeply investigated.Structural and morphological characterizations revealed that the optimal content of 1 mol%Nb^(5+)can stabilize layered structures,mitigate Ni^(2+)migration to Li layers,improve lithium diffusion capacity,and reduce lattice expansion/shrinkage while cycling.And calcination temperature at 800℃can not only ensure good morphology,but also suppress the mixed discharge of lithium and nickel in the internal structure.Electrochemical performance evaluation revealed that Nb^(5+)doping improves the discharge-specific capacity of the material,which is conducive to ameliorating its rate capability and cycle performance.And the material at 800℃exhibits the highest discharge specific capacity,the best magnification performance,low polarizability,and the best cycle reversibility.

关键词： O_(2)cathode materials at different calcination temperatures for lithium-ion batteries Structural doped LiNi electrochemical and cycling properties of Nb

阶梯思维护理对肝癌手术患者肝功能、术后恢复情况及生活质量的影响

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中外医学研究 2024年第9期22卷 95-98页

作者：林燕萍陈昭硕王燕福建医科大学肿瘤临床医学院(福建省肿瘤医院) 福建福州350000

目的:分析阶梯思维护理对肝癌手术患者肝功能、术后恢复情况及生活质量的影响。方法:选取2021年1月—2022年6月福建医科大学肿瘤临床医学院收治的80例肝癌手术患者。根据患者的意愿将其分为观察组(40例)和对照组(40例)。对照组给予常规... 详细信息

目的:分析阶梯思维护理对肝癌手术患者肝功能、术后恢复情况及生活质量的影响。方法:选取2021年1月—2022年6月福建医科大学肿瘤临床医学院收治的80例肝癌手术患者。根据患者的意愿将其分为观察组(40例)和对照组(40例)。对照组给予常规护理,观察组在对照组的基础上给予阶梯思维护理。比较两组护理前后肝功能、生活质量及术后恢复情况。结果:护理后,两组天冬氨酸氨基转移酶(aspartate transaminase,AST)、丙氨酸转氨酶(alanine transaminase,ALT)、总胆红素(total bilirubin,TBIL)水平均降低,观察组AST、ALT、TBIL水平均低于对照组,差异有统计学意义(P<0.05)。护理后,两组躯体功能、角色功能、情绪功能评分均升高,观察组躯体功能、角色功能、情绪功能评分均高于对照组,差异有统计学意义(P<0.05)。观察组肠鸣音恢复时间、排便时间、排气时间、下床活动时间均显著早于对照组,差异有统计学意义(P<0.05)。结论:阶梯思维护理能有效改善肝癌手术患者肝功能,提升术后恢复效果和患者的生活质量。

关键词：肝癌阶梯思维护理手术肝功能术后恢复生活质量

Effect of preheating and annealing temperature on the microstructure and optoelectronic properties of CZTS films prepared by sol-gel method

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光电子快报:英文版 2023年第7期19卷 410-415页

作者： HU zhaoshuo XUE Yuming DAI Hongli wang Luoxin ZHANG Jiuchao wang Jiangchao Institute of New Energy Intelligence Equipment School of Integrated Circuit Science and EngineeringTianjin Universityof TechnologyTianjin 300384China

The effects of different preheating and annealing temperatures on the surface morphology,microstructure,and optical properties of Cu_(2)ZnSnS_(4)(CZTS) thin films are investigated by controlling the preheating and annealing temperatures.The prepared thin films were characterized using X-ray diffraction(XRD),Raman spectroscopy,scanning electron microscopy(SEM),and ultra-violet-visible(UV-Vis) spectroscopy techniques.XRD and Raman spectroscopy showed that a Kesterite structure with a selective orientation along the(112) peak was generated,and the thin films produced at a preheating temperature of 300℃ and annealing temperature of 570℃ had fewer secondary phases,which was beneficial for improving the performance of the solar cells.SEM confirms that the crystallite size increases and then decreases as the temperature increases,and the largest and most uniform crystallite size with the smoothest surface is generated at the above preheating and annealing temperatures.UV-Vis measurements show that the thin films generated at the above temperature have the lowest transmittance and the lowest optical band gap value of 1.46 e V,which is close to the optimal band gap value for solar cells and is suitable as an absorber layer material.

关键词： annealing microstructure films

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国产T700级碳纤维及复合材料性能表征

化工新型材料 2020年第4期48卷 238-240页

作者：张海燕李根臣刘震宇王义师邵蒙王存铎郑素萍孟昭瑞王昭硕魏化震山东非金属材料研究所济南250031

研究了两种国产T700级碳纤维微观形貌以及相应的环氧树脂基复合材料的基本力学性能,并与日本东丽T700碳纤维进行比较。结果发现,与表面光滑的东丽T700碳纤维相比,国产碳纤维表面有颗粒附着,呈凹凸不平的形貌;国产Ⅰ型和东丽碳纤维较国... 详细信息

研究了两种国产T700级碳纤维微观形貌以及相应的环氧树脂基复合材料的基本力学性能,并与日本东丽T700碳纤维进行比较。结果发现,与表面光滑的东丽T700碳纤维相比,国产碳纤维表面有颗粒附着,呈凹凸不平的形貌;国产Ⅰ型和东丽碳纤维较国产Ⅱ型碳纤维的力学性能稳定性更好,国产Ⅰ型碳纤维与东丽纤维力学性能数据相近,其中国产Ⅰ型碳纤维复合材料拉伸强度为2323MPa、拉伸弹性模量为143GPa、弯曲强度为2327MPa、弯曲弹性模量为140GPa。

关键词：国产T700级碳纤维东丽T700碳纤维表面形貌碳纤维增强环氧树脂基复合材料力学性能