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CD146,from a melanoma cell adhesion molecule to a signaling receptor

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1161-1175页

作者： zhaoqing wang Qingji Xu Nengwei Zhang Xuemei Du Guangzhong Xu Xiyun Yan Key Laboratory of Protein and Peptide Pharmaceuticals Institute of BiophysicsChinese Academy of Sciences100101 BeijingChina College of Life Science University of Chinese Academy of Sciences100049 BeijingChina Department of Gastrointestinal Hepatobiliary Tumor Surgery Beijing Shijitan HospitalCapital Medical University100038 BeijingChina Departments of Pathology Beijing Shijitan HospitalCapital Medical University100038 BeijingChina Nanozyme Medical Center School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001China

CD146 was originally identified as a melanoma cell adhesion molecule(MCAM)and highly expressed in many tumors and endothelial ***,the evidence that CD146 acts as an adhesion molecule to mediate a homophilic adhesion through the direct interactions between CD146 and itself is still *** evidence revealed that CD146 is not merely an adhesion molecule,but also a cellular surface receptor of miscellaneous ligands,including some growth factors and extracellular *** the bidirectional interactions with its ligands,CD146 is actively involved in numerous physiological and pathological processes of *** of CD146 can be observed in most of malignancies and is implicated in nearly every step of the development and progression of cancers,especially vascular and lymphatic ***,immunotherapy against CD146 would provide a promising strategy to inhibit metastasis,which accounts for the majority of cancer-associated ***,to deepen the understanding of CD146,we review the reports describing the newly identified ligands of CD146 and discuss the implications of these findings in establishing novel strategies for cancer therapy.

关键词： CD146 melanoma metastasis

Occurrence of microplastics in natural and farmland soil in the Qilian Mountains of the Northern Tibetan Plateau

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Journal of Mountain Science 2024年第7期21卷 2159-2172页

作者： KANG Qiangqiang ZHANG Yulan KANG Shichang ZHANG Shengyin LUO Xi LI Longrui wang zhaoqing ZHANG Shuncun Key Laboratory of Petroleum Resources Exploration and Evaluation Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Cryospheric Science and Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China College of Earth and Environmental Sciences Lanzhou UniversityLanzhou 730000China

Microplastics(MPs)become ubiquitous in soil and are an environmental and public health concern ***,the status of MPs in natural and farmland soils in remote areas remains poorly *** this study,we investigated the characteristics of MPs in natural and farmland soils along two transects in the Qilian Mountains of the northern Tibetan *** average abundance of MPs in natural and farmland soils was 29,778 and 56,123 items kg^(-1),respectively,with a detection size range of 10-1000μ*** in the size range of 10-100μm accounted for 84.1%of particles *** the 21 polymers detected,polyethylene dominated in both farmland and natural *** shape of MPs was dominated by fragments(95.8%),followed by fibers(3.8%)and beads(0.4%).The abundance of MPs was positively correlated with increasing altitude in natural *** was no significant correlation between the abundance of MPs and soil physicochemical properties due to the narrow range of values of soil physicochemical *** the growing concern regarding MPs pollution,research on the status of MPs in high altitude and remote areas is critical to understanding their global cycle.

关键词： Microplastics pollution Soil Remote areas Tibetan Plateau

FXYD6： a novel therapeutic target toward hepatocellular carcinoma

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Protein & Cell 2014年第7期5卷 532-543页

作者： Qian Gao Xiongfei Chen Hongxia Duan zhaoqing wang Jing Feng Dongling Yang Lina Song Ningxin Zhou Xiyun Yan Key Laboratory of Protein and Peptide Pharmaceuticals CAS-University of Tokyo Joint Laboratory of Structural Virology and Immunology Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China Medical College of Soochow University Industrial Park Suzhou 215123 China Institute of Hepatobiliary Gastrointestinal Disease General Hospital of PLA Second Artillery Beijing 100088 China

FXYD6, FXYD domain containing ion transport regulator 6, has been reported to affect the activity of Na＋/K＋-ATP- ase and be associated with mental diseases. Here, we demonstrate that FXYD6 is up-regulated in hepatocellular carcinoma （HCC） and enhances the migration and prolif- eration of HCC cells. Up-regulation of FXYD6 not only positively correlates with the increase of Na＋IK＋-ATPase but also coordinates with the activation of its downstream Src-ERK signaling pathway. More importantly, blocking FXYD6 by its functional antibody significantly inhibits the growth potential of the xenografted HCC tumors in mice, indicating that FXYD6 represents a potential therapeutic target toward HCC. Altogether, our results establish a critical role of FXYD6 in HCC progression and suggest that the therapy targeting FXYD6 can benefit the clinical treatment toward HCC patients.

关键词： FXYD6 hepatocellular carcinoma (HCC)tumor progression therapeutic target Na+/K+-ATPase,Src-ERK signaling pathway

Cryosphere as a temporal sink and source of microplastics in the Arcticregion

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Geoscience Frontiers 2023年第4期14卷 187-199页

作者： Yulan Zhang Tanguang Gao Shichang Kang Deonie Allen zhaoqing wang Xi Luo Ling Yang Jinlei Chen Zhaofu Hu Pengfei Chen Wentao Du Steve Allen State Key Laboratory of Cryospheric Science Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China College of Earth and Environmental Sciences Lanzhou UniversityLanzhou 730000China School of Geography Earth and Environmental SciencesUniversity of BirminghamEdgbastonBirminghamB152TTUK School for Resource and Environmental Studies Dalhousie UniversityHalifaxNova Scotia B3H 4R2Canada University of Chinese Academy of Sciences Beijing 100049China

Microplastics(MPs)pollution has become a serious environmental issue of growing global concern due to the increasing plastic production and *** climate warming,the cryosphere,defined as the part of Earth’s layer characterized by the low temperatures and the presence of frozen water,has been experiencing significant *** Arctic cryosphere(e.g.,sea ice,snow cover,Greenland ice sheet,permafrost)can store and release pollutants into environments,making Arctic an important temporal sink and source of ***,we summarized the distributions of MPs in Arctic snow,sea ice,seawater,rivers,and sediments,to illustrate their potential sources,transport pathways,storage and release,and possible effects in this sentinel *** concentrations of MPs in snow and ice varied about 1-6 orders of magnitude in different regions,which were mostly attributed to the different sampling and measurement methods,and potential sources of *** concentrations from Arctic seawater,river/lake water,and sediments also fluctuated largely,ranging from several items of per unit to>40,000 items m^(-3),100 items m^(-3),and 10,000 items kg^(-1) dw,*** land snow cover can be a temporal storage of MPs,with MPs deposition flux of about(4.9-14.26)×10^(8) items km^(-2) yr^(-1).MPs transported by rivers to Arctic ocean was estimated to be approximately 8-48 ton/yr,with discharge flux of MPs at about(1.65-9.35)×10^(8) items/*** storage of MPs in sea ice was estimated to be about 6.1×10^(18) items,with annual release of about 5.1×10^(18) *** transport of MPs from long-distance terrestrial sources contributed significantly to MPs deposition in Arctic land snow cover,sea ice and oceanic surface *** Great Rivers can flow MPs into the Arctic *** ice can temporally store,transport and then release MPs in the surrounded *** currents from the Atlantic brought high concentrations of MPs into the ***,there existed large u

关键词： Microplastics Arctic Sea ice Snow Seawater Sediments

Numerical Optimization of Tunnel-recombination Junction and Optical Absorption Properties of a-Si:H/a-SiGe:H Double-junction Solar Cell

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Journal of the Chinese Ceramic Society 2015年第1期 1-11页

作者： KE Shaoying wang Chong PAN Tao wang zhaoqing YANG Jie YANG Yu Institute of Optoelectronic Information Materials Yunnan University National Laboratory for Infrared Physics Shanghai Institute of Technical Physics Chinese Academy of Science

The tunnel-recombination junction(TRJ) and optical absorption properties of a-Si:H/a-Si Ge:H double-junction solar cell were calculated by means of one dimensional simulator named AMPS-1D at the radiation of AM1.5G with a power density of 100 m W/cm2. Since the TRJ is the core component of the tandem solar cell, the optical absorption of the sub-cells and the electronic transport properties at the interface of the sub-cells are affected by the thickness and doping concentration of the TRJ. As a result, the TRJ parameters were optimized. The numerical results indicate that the maximum conversion efficiency(Eff) of 9.862% can be obtained when the thickness and doping concentration of the TRJ are 10 nm and 5*1019 cm–3, respectively. Based on the analysis of the contour map of short circuit current density, the optimal current matching can be achieved for 130 nm-thick top i-layer and 250 nm-thick bottom i-layer. In addition, four kinds of TRJ structures were also simulated for the comparison purpose. According to the calculated resistivity and band structures of the four TRJs, the efficiency of the solar cell with n-type μc-Si:H layer and p-type a-Si:H layer in TRJ structure is greater than that with other TRJ structures. It is assumed that the effect of the band offset that results in the formation of triangular barrier and backscattering behavior at the edge of the TRJ could be responsible to this phenomenon.

关键词： a-Si:H/a-Si Ge:H tandem solar cell tunnel-recombination junction current matching band offset

Effects of Cu<sup>2+</sup>on Wheat Seedlings Exposed to Enhanced Ultraviolet-B Radiation

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American Journal of Plant Sciences 2014年第20期5卷 3060-3065页

作者： Liyan Yang zhaoqing wang Yuqi Hou Rong Han Yi Sun Shanxi Normal University Linfen China Biotechnology Research Centre Shanxi Academy of Agricultural Sciences Taiyuan China Key Laboratory of Crop Gene Resources and Germplasm Enhancement on Loess Plateau Ministry of Agriculture Taiyuan China

To explore the wheat seedling development and physiological responses under copper contamination and enhanced ultraviolet-B (UV-B) irradiation, 10 mg·L-1 CuCl2 solution was irrigated to Triticum aestivum L. cv. Linyuan 2069 one day after germination with or without ultraviolet-B (10.08 kJ m-2·d-1) light exposure, respectively. The results showed that Cu2+ and UV-B caused various adverse effects on wheat seedling development. Cu2+ hindered root development by significantly reducing root number, while UV-B dwarfed seedling height and decreased the leaf length. Chlorophyll content and activity of ATPase in thylakoid membrane of wheat leaves dropped significantly under enhanced UV-B while the activity of ATPase in plasma membrane of seedling root was significantly decreased in Cu2+ group. Relative electric conductivity of leaves significantly increased in both Cu2+ and UV-B groups, so did the biomass. We also observed that combined Cu2+ and UV-B showed more adverse effects on wheat seedlings than either of them alone except for root growth.

关键词： Cu2+ Seedling Development UV-B Radiation Wheat

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多边形有限元研究进展

力学进展 2006年第3期36卷 344-353页

作者：王兆清山东建筑大学工程力学研究所济南250101

有限元法是数值求解偏微分方程边值问题的重要方法,采用不规则多边形单元网格,可以方便有效地模拟材料的力学性能,又使得区域网格剖分变得灵活方便．特别是对于复杂的几何形状,多边形单元网格具有更大的优势．本文对国内外有关多边形有... 详细信息

有限元法是数值求解偏微分方程边值问题的重要方法,采用不规则多边形单元网格,可以方便有效地模拟材料的力学性能,又使得区域网格剖分变得灵活方便．特别是对于复杂的几何形状,多边形单元网格具有更大的优势．本文对国内外有关多边形有限元法的最新进展作了初步的总结和评述,主要以基于位移法的多边形有限元为主．论述了多边形有限元的发展历史,给出了多边形单元上的Wachspress插值、Laplace插值和重心坐标的一些最新研究成果．与经典有限元法形函数为多项式形式不同,多边形单元的形函数为有理函数或者无理函数形式．多边形单元插值形函数满足线性完备性,可以再现线性位移场,像经典有限元法一样直接施加本质边界条件;插值函数在多边形的边界上是线性的,确保不同单元间的自动协调．不同单元的插值形函数表达公式形式统一,方便混合单元网格计算的程序编写．提出了多边形有限元法今后需要研究的问题．

关键词：有限元法多边形单元 Wachspress插值多边形Laplace插值多边形重心坐标

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多边形有限单元形函数的比较研究

应用力学学报 2007年第4期24卷 604-608页

作者：王兆清李淑萍山东建筑大学济南250101 山东警察学院济南250101

多边形有限单元形函数有Wachspress插值、Laplace插值和平均值插值三种类型。本文对三种多边形有限单元形函数的性质作了比较研究,给出了三种形函数各自的优点和局限性。Wachspress和Laplace形函数是有理函数形式,而平均值形函数是无理... 详细信息

多边形有限单元形函数有Wachspress插值、Laplace插值和平均值插值三种类型。本文对三种多边形有限单元形函数的性质作了比较研究,给出了三种形函数各自的优点和局限性。Wachspress和Laplace形函数是有理函数形式,而平均值形函数是无理函数形式。三种形函数均满足单位分解性、线性完备性,且在单元边界上呈线性。在三角形单元上,它们都等价于三角形面积坐标插值。在矩形单元上,Wachspress和Laplace形函数等价于双线性多项式插值形函数。Wachspress和平均值形函数适用于任意凸多边形单元,Laplace形函数更适用于圆内接多边形单元。Wachspress形函数不能推广到含有边节点的单元,平均值形函数可以直接推广到含有边节点的单元。数值试验,验证了本文理论分析的结论。

关键词：多边形单元形函数 Wachspress插值 Laplace插值平均值插值

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板料成形反向模拟精度修正法

机械工程学报 2009年第10期45卷 300-305页

作者：唐炳涛赵震王兆清山东建筑大学工程力学研究所济南250101 上海交通大学模具CAD国家工程研究中心上海200030

传统的板料成形反向模拟法(Traditional inverse analysis method,TIAM)没有考虑变形历史对成形过程的影响,使得反向模拟法计算的应力值与实际情况有较大偏差。金属在流经凹模圆角时受到强烈的弯曲—反弯曲作用,并且凹模圆角处往往是应... 详细信息

传统的板料成形反向模拟法(Traditional inverse analysis method,TIAM)没有考虑变形历史对成形过程的影响,使得反向模拟法计算的应力值与实际情况有较大偏差。金属在流经凹模圆角时受到强烈的弯曲—反弯曲作用,并且凹模圆角处往往是应力集中的区域,能否较为准确地描述该区域变形历史,关系到反向模拟法应力/应变计算精度。针对反向模拟法无法准确预测成形零件应力分布的缺点,提出一种快速搜索流经凹模圆角区域单元的方法,对该部分单元进行应力修正。采用一种高效的多步加载应力应变本构关系模型,避免了增量有限元法应力应变更新算法的复杂性,同时充分考虑了凹模圆角对金属变形历史的影响。NUMISHEET’93U形件弯曲的标准考题中,通过与增量有限元分析软件ABAQUS/Standard计算结果的比较,验证了采用所提出的多步加载本构关系模型可以有效地反映变形历史的影响,获得更为接近真实情况的应力分布。

关键词：板料成形反向模拟法应力修正模具圆角