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Ascorbic acid derived carbon dots promote circadian rhythm and contribute to attention deficit hyperactivity disorder

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Nano Research 2022年第9期15卷 8247-8254页

作者： Jian Huang Yun Wang zhaomin Zhong Yurong Ma Keru deng Changhong Liu Hui Huang Yang Liu Xin Ding Zhenhui Kang School of Biology&Basic Medical Science Soochow UniversitySuzhou 215123China Institute of Functional Nano and Soft Materials Laboratory(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou 215123China Division of Neonatology Children’s Hospital of Soochow UniversitySuzhou 215003China Macao Institute of Materials Science and Engineering(MIMSE) MUST-SUDA Joint Research Center for Advanced Functional MaterialsMacao University of Science and TechnologyTaipa 999078MacaoChina

Attention deficit hyperactivity disorder(ADHD)is one of the most prevalent psychiatric disorders in children,and ADHD patients always display circadian ***,the ADHD drugs currently used in clinic have strong side effects,such as psychosis,allergic reactions,and heart ***,we demonstrated carbon dots derived from the ascorbic acid(VCDs)could strongly rescue the hyperactive and impulsive behaviour of a zebrafish ADHD disease model caused by per1b *** prolonged the circadian period of zebrafish for more than half an *** addition,the amplitude and circadian phase were also *** dopamine level was specifically increased,which may be caused by stimulation of the dopaminergic neuron development in the ***,it was found that the serotonin level was not altered by VCDs ***,the gene transcriptome effects of VCDs were discussed in present *** results provided the dynamic interactions of carbon dots with circadian system and dopamine signaling pathway,which illustrates a potential application of degradable and bio-safe VCDs for the treatment of the attention deficient and hyperactive disorder through circadian intervention.

关键词： carbon dots circadian rhythm dopamine attention deficit hyperactivity disorder(ADHD) zebrafish

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The S190R mutation in the hemagglutinin protein of pandemic H1N1 2009 influenza virus increased its pathogenicity in mice

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Science China(Life Sciences) 2018年第7期61卷 836-843页

作者： Yongkun Chen Tian Bai Wenfei Zhu Rongbao Gao Zhihong deng Yi Shi Shumei Zou Yiwei Huang Xiyan Li Fangcai Li zhaomin Feng Tao Chen Jing Yang Dayan Wang Lidong Gao Yuelong Shu National Institute for Viral Disease Control and Prevention Collaboration Innovation Center for Diagnosis and Treatment of Infectious DiseasesChinese Center for Disease Control and PreventionKey Laboratory for Medical VirologyNational Health and Family Planning CommissionBeijing 102206China Hunan Provincial Center for Disease Control and Prevention Changsha 410005China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101 China School of Public Health(Shenzhen) Sun Yat-sen UniversityGuangzbou 510275China

Human influenza viruses preferentially bind to sialic acid-α2,6-galactose (SAα2,6Gal) receptors, which are predominant in human upper respiratory epithelia, whereas avian influenza viruses preferentially bind to SAα2,3Gal receptors. However, variants with amino acid substitutions around the receptor-binding sites of the hemagglutinin (HA) protein can be selected after several passages of human influenza viruses from patients’ respiratory samples in the allantoic cavities of embryonated chicken eggs. In this study, we detected an egg-adapted HA S190R mutation in the pandemic H1N1 virus 2009 (pdmH1N1), and evaluated the effects of this mutation on receptor binding affinity and pathogenicity in mice. Our results revealed that residue 190 is located within the pocket structure of the receptor binding site. The single mutation to arginine at position 190 slightly increased the binding affinity of the virus to the avian receptor and decreased its binding to the long human α2,6-linked sialic acid receptor. Our study demonstrated that the S190R mutation resulted in earlier death and higher weight loss in mice compared with the wild-type virus. Higher viral titers at 1 dpi (days post infection) and diffuse damage at 4 dpi were observed in the lung tissues of mice infected with the mutant virus.

关键词： pandemic HIN1 2009 influenza virus egg adaptation HA mutation receptor binding domain pathogenicity mice

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Independent and Interactive Effects of Environmental Conditions on Aerosolized Surrogate SARS-CoV-2-Beijing,China,June to September 2020

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China CDC weekly 2022年第26期4卷 565-569,I0004,I0005页

作者： Yixin Mao Yueyun Luo Wenda Zhang Pei Ding Xia Li Fuchang deng Kaiqiang Xu Min Hou Cheng Ding Youbin Wang zhaomin Dong Raina MacIntyre Xiaoyuan Yao Song Tang Dongqun Xu China CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijingChina Chinese Center for Disease Control and Prevention BeijingChina University of South Carolina ColumbiaSCUSA School of Space and Environment Beihang UniversityBeijingChina Beijing Advanced Innovation Center for Big Data-Based Precision Medicine Beihang UniversityBeijingChina The Kirby Institute Faculty of MedicineThe University of New South WalesSydneyNSWAustralia Center for Global Health School of Public HealthNanjing Medical UniversityNanjingJiangsu ProvinceChina

Summary What is already known about this topic?Environmental factors such as temperature and humidity play important roles in the transmission of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)via droplets/*** is added by this report?Higher relative humidity(61%–80%),longer spreading time(120 min),and greater dispersal distance(1 m)significantly reduced SARS-CoV-2 pseudovirus *** was an interaction effect between relative humidity and spreading *** are the implications for public health practice?The findings contribute to our understanding of the impact of environmental factors on the transmission of SARS-CoV-2 via airborne droplets/aerosols.

关键词： humidity finding interaction

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输电铁塔结构系统极限承载力及可靠性研究

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电力建设 2000年第2期21卷 12-14页

作者：邓洪洲王肇民同济大学上海市200092

用弹－塑性和半弹－塑性单元失效形式模拟结构系统中的拉杆和压杆，用增量载荷法结合有限元重分析技术计算结构系统的失效模式和极限承载力，并提出了一种有效的工程优化准则用于枚举结构系统的主要失效模式。该算法是一种对输电铁塔结... 详细信息

用弹－塑性和半弹－塑性单元失效形式模拟结构系统中的拉杆和压杆，用增量载荷法结合有限元重分析技术计算结构系统的失效模式和极限承载力，并提出了一种有效的工程优化准则用于枚举结构系统的主要失效模式。该算法是一种对输电铁塔结构系统进行极限承载力和可靠性分析的较方便的方法。

关键词：输电铁塔结构系统极限承载力可靠性

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油酸对轮古常压渣油胶体流变性的影响

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石油学报（石油加工） 2010年第3期26卷 425-430页

作者：李传王继乾邓文安李兆敏阙国和中国石油大学重质油国家重点实验室山东青岛266555 中国石油大学石油工程学院山东青岛266555

在轮古常压渣油(简称轮古常渣)中加入一定量的油酸,采用Rheostress300型流变仪测定油酸对轮古常渣流变特性曲线、黏-温曲线以及触变曲线等流变性质的影响,并采用柱色谱法、饱和蒸气压渗透法(简称VPO法)、流变性参数法、Zeta电位法和小角... 详细信息

在轮古常压渣油(简称轮古常渣)中加入一定量的油酸,采用Rheostress300型流变仪测定油酸对轮古常渣流变特性曲线、黏-温曲线以及触变曲线等流变性质的影响,并采用柱色谱法、饱和蒸气压渗透法(简称VPO法)、流变性参数法、Zeta电位法和小角X光散射法(SAXS法)分析了油酸对轮古常渣沥青质的含量、数均相对分子质量、缔合度和胶粒大小的影响,从而揭示油酸对轮古常渣胶体流变性影响的机理。结果表明,油酸能使轮古常渣沥青质的含量和数均相对分子质量降低,并使沥青质缔合度和胶粒平均半径减小,从而有效地改善轮古常渣的流动性能,使其黏度减小,触变程度降低,并在较低温度下呈牛顿流体状态流动。

关键词：油酸渣油流变性沥青质胶体

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结构系统疲劳可靠性分析方法及其应用

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同济大学学报（自然科学版） 1997年第1期25卷 17-22页

作者：邓洪洲王肇民同济大学建筑工程系上海200092

研究了结构系统疲劳可靠性分析方法，建立了结构系统疲劳可靠性分析模型，提出了求取结构系统疲劳主要失效模式的方法．最后，以一海上平台为工程实际算的验证了文中算法的可行性及有效性．

关键词：疲劳可靠性海上平台结构系统疲劳寿命

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桅杆结构风洞试验研究

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建筑结构学报 2000年第6期21卷 55-61页

作者：王肇民何艳丽马星邓洪洲颜明忠同济大学上海200092

本文介绍了国内首次桅杆结构风洞试验，记录了格构式和单筒式桅杆模型的自振特性和风振响应测试结果。试验结果表明：①桅杆结构的非线性程度随风速的增大而增强；②桅杆结构在风振计算中应考虑多阶振型的影响，随着风速的加大，高振型... 详细信息

本文介绍了国内首次桅杆结构风洞试验，记录了格构式和单筒式桅杆模型的自振特性和风振响应测试结果。试验结果表明：①桅杆结构的非线性程度随风速的增大而增强；②桅杆结构在风振计算中应考虑多阶振型的影响，随着风速的加大，高振型的贡献增加；③在顺风荷载作用下，桅杆结构可能出现横风共振和混沌现象。

关键词：桅杆结构风洞试验非线性动力特性

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一种具有稳定发射光谱的高效率白色有机电致发光器件

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化学学报 2012年第18期70卷 1904-1908页

作者：周亮邓瑞平郝召民宋明星张洪杰中国科学院长春应用化学研究所、稀土资源利用国家重点实验室长春130022

报道一种具有稳定发射光谱的新型白色有机电致发光器件.选择DCJTB作为红光染料将其掺入空穴传输材料NPB中作为空穴传输层和第一发光层,提供蓝光和红光;选择AlQ作为电子注入敏化剂,将其掺入NPB中作为第二发光层,提供蓝光和绿光.DCJTB和Al... 详细信息

报道一种具有稳定发射光谱的新型白色有机电致发光器件.选择DCJTB作为红光染料将其掺入空穴传输材料NPB中作为空穴传输层和第一发光层,提供蓝光和红光;选择AlQ作为电子注入敏化剂,将其掺入NPB中作为第二发光层,提供蓝光和绿光.DCJTB和AlQ的掺杂浓度分别被优化为0.4%和1.4%,第二发光层的厚度被优化为3 nm.最终,得到了纯白色发射的有机电致发光器件;该器件启亮电压仅3.1 V,最大亮度高达32749 cd/m2,器件的最大电流效率为8.67 cd/A,器件的最大功率效率为8.78 lm/W.而且,空穴型主体材料的选择导致该器件的色稳定性非常理想.随着电流密度的提高,该器件的色坐标始终稳定在(0.343,0.342)到(0.328,0.336)的范围内.

关键词：电致发光荧光材料电子注入载流子复合发光效率

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