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Fabrication of flexible reduced graphene oxide/Fe2O3 hollow nanospheres based on-chip micro-supercapacitors for integrated photodetecting applications

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Nano Research 2016年第2期9卷 424-434页

作者： Shaosong Gu Zheng Lou Ludong Li zhaojun chen Xiangdong Ma Guozhen Shen Department of Material Science and Engineering China University of Mining & Technology (Beijing) Beijing 100083 China State Key Laboratory for Superlattices and Microstructures Institute of Semiconductors Chinese Academy of Sciences Beijing 100083China College of Chemical Science and Engineering Qingdao University Qingdao 266071 China

Micro-supercapacitors （MSCs） as important on-chip micropower sources have attracted considerable attention because of their unique and advantageous design for optimized maximum functionality within a minimized sized chip and excellent mechanical flexibility/stability in miniaturized portable electronic device applications. In this work, we report a novel, high-performance flexible integrated on-chip MSC based on hybrid nanostructures of reduced graphene oxide/Fe2O3 hollow nanospheres using a microelectronic photo-lithography technology combined with plasma etching technique. The unique structural design for on-chip MSCs enables high-performance enhancements compared with graphene-only devices, exhibiting high specific capacitances of 11.57 F·cm^-3 at a scan rate of 200 mV·s^-1 and excellent rate capability and robust cycling stability with capacitance retention of 92.08% after 32,000 charge/discharge cycles. Moreover, the on-chip MSCs exhibit superior flexibility and outstanding stability even after repetition of charge/discharge cycles under different bending states. As-fabricated highly flexible on-chip MSCs can be easily integrated with CdS nanowire-based photodetectors to form a highly compacted photodetecting system, exhibiting comparable performance to devices driven by conventional external energy storage units.

关键词： Fe2O3 microsupercapacitor photodetector flexible

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超高压等灭菌方式对刺梨汁营养及风味的影响研究

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食品科技 2024年第2期49卷 82-89页

作者：张欣王辉罗婧文刘嘉龙明秀王梅陈朝军贵州大学酿酒与食品工程学院贵州贵阳550025 贵州省农科院食品加工研究所贵州贵阳550006 贵州省现代农业发展研究所贵州贵阳550025

刺梨汁含有丰富的抗坏血酸和多酚类等热敏性物质,超高压灭菌能有效降低刺梨汁中功能性成分的损失。该实验研究了超高压对刺梨汁中色泽、抗坏血酸、总酚、总可溶性固形物、总酸等营养成分和超氧化物歧化酶(Superoxide dismutase,SOD)、... 详细信息

刺梨汁含有丰富的抗坏血酸和多酚类等热敏性物质,超高压灭菌能有效降低刺梨汁中功能性成分的损失。该实验研究了超高压对刺梨汁中色泽、抗坏血酸、总酚、总可溶性固形物、总酸等营养成分和超氧化物歧化酶(Superoxide dismutase,SOD)、多酚氧化酶(Polyphenol oxidase,PPO)酶活力的影响。利用气相色谱串联质谱法测定灭菌前后风味的变化,并与其他4种杀菌方式进行了对比,包括高温瞬时杀菌、辐照杀菌、微波杀菌、超声杀菌。结果表明,高温瞬时杀菌处理后刺梨汁褐变度显著高于超高压处理和超声处理。超高压、微波及超声处理可显著提高刺梨浊汁的总糖含量(P0.05),提高刺梨浊汁中的营养物质留存率。仅超高压处理可使刺梨浊汁SOD酶活性提升11.44%(P<0.05)。5种杀菌方式均能对PPO酶活性起到较好地抑制作用,辐照杀菌对PPO钝化效果最佳。挥发性化合物未处理组总含量为5959.55μg/L,除超高压组含量增加了3.66%外,其他组分别下降31.0%、53.77%、23.41%、42.03%。酸类物质对刺梨浊汁风味具有较大贡献。超高压处理与其他杀菌方式相比,在保持刺梨汁营养品质及风味上有显著优势。研究结果可为刺梨饮品深加工提供一定的理论依据。

关键词：刺梨汁超高压杀菌技术营养品质风味

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基于中医辨证分型应用中药外用制剂促进糖尿病足溃疡愈合的临床研究

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中国中医骨伤科杂志 2024年第1期32卷 36-41页

作者：潘旭月陈兆军祁印泽魏芳远北京中医药大学第三附属医院手足外科北京100029

目的:探讨基于中医辨证分型应用中药外用制剂促进糖尿病足溃疡愈合的疗效。方法:选取2019年7月至2022年7月住院的糖尿病足患者,随机分为治疗组和对照组。治疗组根据中医三期辨证分型,采用清创换药+相应中药外用制剂,对照组采用单纯清创... 详细信息

目的:探讨基于中医辨证分型应用中药外用制剂促进糖尿病足溃疡愈合的疗效。方法:选取2019年7月至2022年7月住院的糖尿病足患者,随机分为治疗组和对照组。治疗组根据中医三期辨证分型,采用清创换药+相应中药外用制剂,对照组采用单纯清创换药的方法。对比观察两组患者在临床综合疗效、患肢疼痛视觉模拟量表(VAS)评分、创面愈合时间等结果的差异。结果:纳入符合标准的病例90例,其中治疗组及对照组各45例,两组病例基本资料及病情差异无统计学意义(P>0.05)。临床综合疗效方面:治疗组治愈13例,显效25例,有效3例,无效4例,总有效率为91%;对照组治愈5例,显效20例,有效2例,无效18例,总有效率为60%,两组疗效比较差异有统计学意义(P0.05)。结论:根据中医三期辨证分型来合理应用中药外用制剂可促进糖尿病足溃疡愈合。

关键词：中药外用糖尿病足辨证分型

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Nanopores/Nanochannels Based on Electrical and Optical Dual Signal Response for Application in Biological Detection

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Chinese Journal of Chemistry 2023年第11期41卷 1374-1384页

作者： Guangwen Lu Niya Lin zhaojun chen Wenlian Jiang Jing-Jing Hu Fan Xia Xiaoding Lou State Key Laboratory of Biogeology and Environmental Geology Faculty of Materials Science and ChemistryChina University of GeosciencesWuhanHubei430078 China

Cancers and chronic diseases have always been global health problems. The occurrence and development of such diseases are closely related to the abnormalities of proteins, nucleic acids, ions or small molecules in the body. Nowadays, nanopores/nanochannels have emerged as a powerful platform for detecting these biomolecules based on the electrical signal variation caused by biomolecules passing. However, detection relied on the electrical signal easily suffered from the clogging defects, low throughput, and strong background signals. Fortunately, the emergence of designing nanopores/nanochannels based on electrical and optical dual signal response has brought innovative impetus to biological detection, which can also identify the chemical compositions and conformations of the biomolecules. In this review, we summarize the reasonable preparation of nanopores/nanochannels with electrical and optical dual signal response and their application in biological detection. According to different biomolecules, we divide the targets into four types, including nucleic acids, small molecules, ions and proteins. In each section, the design of representative examples and the principle of dual signal generation are introduced and discussed. Finally, the prospects and challenges of nanopores/nanochannels based on electrical and optical dual signal response are also discussed.

关键词： Biomolecules Nanopores nanochannels Electrical and optical Fluorescence lon current

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猪肌内脂肪沉积的影响因素及非编码RNA对其调控的研究进展

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黑龙江畜牧兽医 2024年第14期 18-22页

作者：李莉娜吴仙陈朝军张洁向清华王清峰谭露霖冯宇隆贵州省农业科学院畜牧兽医研究所贵阳550005 贵州省农业科学院生物技术研究所贵阳550025

肌内脂肪(intramuscular fat,IMF)俗称“大理石纹”,是猪肉脂肪组织的重要组成部分,可以改善肉的嫩度、多汁性,提升肉的风味,是评价猪肉品质的重要指标。IMF主要分布在肌纤维或肌纤维束间,由三酰甘油、磷脂和胆固醇组成,受遗传、营养、... 详细信息

肌内脂肪(intramuscular fat,IMF)俗称“大理石纹”,是猪肉脂肪组织的重要组成部分,可以改善肉的嫩度、多汁性,提升肉的风味,是评价猪肉品质的重要指标。IMF主要分布在肌纤维或肌纤维束间,由三酰甘油、磷脂和胆固醇组成,受遗传、营养、环境等因素的影响。文章对影响猪IMF沉积的主要因素及非编码RNA(non-coding RNA,ncRNA),包括微小RNA(microRNA,miRNA)、长链非编码RNA(long non-coding RNA,lncRNA)和环状RNA(circular RNA,circRNA)]在猪IMF沉积中的作用进行综述,旨在为深入研究猪脂肪沉积的分子机制提供理论基础。

关键词：猪肉品质肌内脂肪(IMF) 影响因素非编码RNA(ncRNA)

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HIV阳性和HIV阴性梅毒合并脑梗死的临床特征分析

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皮肤病与性病 2024年第1期46卷 5-9页

作者：郭凯张永喜熊勇邓莉平陈昭君柯亨宁武汉大学中南医院感染科湖北省艾滋病临床指导培训中心湖北武汉430071 泰康同济(武汉)医院消化内科湖北武汉430071

目的对比分析HIV阳性和HIV阴性梅毒合并脑梗死患者的临床特征,为提高诊断水平提供依据。方法回顾性分析2017年1月~2022年5月在武汉大学中南医院诊治的梅毒合并脑梗死的患者资料,根据是否合并HIV感染分为HIV阳性组和HIV阴性组,分析其... 详细信息

目的对比分析HIV阳性和HIV阴性梅毒合并脑梗死患者的临床特征,为提高诊断水平提供依据。方法回顾性分析2017年1月~2022年5月在武汉大学中南医院诊治的梅毒合并脑梗死的患者资料,根据是否合并HIV感染分为HIV阳性组和HIV阴性组,分析其临床特征和预后。结果 HIV阳性组的中位年龄低于HIV阴性组(Z=3.653,P 0.05)。两组在影像学病灶数量和累及的血管方面的差异均无统计学意义。结论梅毒合并脑梗死时,均需排除神经梅毒;HIV阳性梅毒合并脑梗死时,应首先考虑神经梅毒,尽快驱梅治疗可有效避免后遗症。

关键词：人类免疫缺陷病毒梅毒脑梗死临床特征

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Monolithic integrated optoelectronic chip for vector force detection

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Microsystems & Nanoengineering 2024年第3期10卷 245-257页

作者： Jiansong Feng Zhongqi Wang Mengyuan Zhanghu Xu Zhang Yong Shen Jing Yang Zhibin Li Bin chen Taihong Wang Xiaolong chen zhaojun Liu Department of Electrical and Electronic Engineering Southern University of Science and TechnologyShenzhen 518055China Department of Electrical and Electronic Engineering The University of Hong KongHong KongChina

Sensors with a small footprint and real-time detection capabilities are crucial in robotic surgery and smart wearable *** device footprint while maintaining its high performance is a major challenge and a significant limitation to their ***,we proposed a monolithic integrated micro-scale sensor,which can be used for vector force *** sensor combines an optical source,four photodetectors,and a hemispherical silicone elastomer component on the same sapphire-based AlGaInP *** chip-scale optical coupling is achieved by employing the laser lift-off techniques and the flip-chip bonding to a processed sapphire *** hemispherical structure device can detect normal and shear forces as low as 1mN within a measurement range of 0–220 mN for normal force and 0–15 mN for shear *** packaging,the sensor is capable of detecting forces over a broader range,with measurement capabilities extending up to 10 N for normal forces and 0.2 N for shear *** has an accuracy of detecting a minimum normal force of 25 mN and a minimum shear force of 20 ***,this sensor has been validated to have a compact footprint of approximately 1.5 mm^(2),while maintaining high real-time *** also demonstrate its promising potential by combining this sensor with fine surface texture perception in the fields of compact medical robot interaction and wearable devices.

关键词： robot force smart

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Dynamic gut microbiome-metabolome in cationic bovine serum albumin induced experimental immune-complex glomerulonephritis and effect of losartan and mycophenolate mofetil on microbiota modulation

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Journal of Pharmaceutical Analysis 2024年第4期14卷 562-577页

作者： Wenying Shi zhaojun Li Weida Wang Xikun Liu Haijie Wu Xiaoguang chen Xunrong Zhou Sen Zhang State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100050China State Key Laboratory of Functions and Applications of Medicinal Plants College of PharmacyGuizhou Provincial Engineering Technology Research Center for Chemical Drug R&DGuizhou Medical UniversityGuiyang550004China Department of Medicine Solna Center for Molecular MedicineKarolinska University Hospital and Karolinska InstituteStockholm17176Sweden Department of Pharmacy The Second Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550001China

Dynamic changes in gut dysbiosis and metabolomic dysregulation are associated with immune-complex glomerulonephritis(ICGN).However,an in-depth study on this topic is currently ***,we report an ICGN model to address this *** was induced via the intravenous injection of cationized bovine serum albumin(c-BSA)into Sprague-Dawley(SD)rats for two weeks,after which mycophenolate mofetil(MMF)and losartan were administered *** and six weeks after ICGN establishment,fecal samples were collected and 16S ribosomal DNA(rDNA)sequencing and untargeted metabolomic were *** microbiota transplantation(FMT)was conducted to determine whether gut normali-zation caused by MMF and losartan contributed to their renal protective effects.A gradual decline in microbial diversity and richness was accompanied by a loss of renal *** 18 genera were found to have significantly different relative abundances between the early and later stages,and Marvinbryantia and Allobaculum were markedly upregulated in both *** metabolomics indicated that the tryptophan metabolism was enhanced in ICGN,characterized by the overproduction of indole and kynurenic acid,while the serotonin pathway was *** of losartan and MMF ameliorated microbial dysbiosis and reduced the accumulation of indoxyl conjugates in *** using feces from animals administered MMF and losartan improved gut dysbiosis by decreasing the Firmicutes/Bacteroidetes(F/B)ratio but did not improve renal *** findings indicate that ICGN induces serous gut dysbiosis,wherein an altered tryptophan metabolism may contribute to its *** and losartan significantly reversed the gut microbial and metabolomic dysbiosis,which partially contributed to their renoprotective effects.

关键词： Immune-complex glomerulonephritis Gut microbiome Metabolomics Fecal microbiota transplant Tryptophan metabolism

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血清胃蛋白酶原和胃泌素-17结合幽门螺杆菌检测在胃部病变鉴别诊断中的应用价值

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浙江医学 2024年第8期46卷 826-830,839页

作者：孟宪梅陈兆军刘晓婷徐锦许宁沁姚心怡张腊红杭州师范大学临床医学院 310015 杭州市第三人民医院院办杭州师范大学附属医院检验科

目的探讨血清胃蛋白酶原(PG)Ⅰ、PGⅡ、PGⅠ/PGⅡ(PGR)、胃泌素-17和幽门螺杆菌(Hp)检测在胃部病变鉴别诊断中的临床应用价值。方法选取2021年6月至2023年6月杭州师范大学附属医院就诊的321例胃部病变患者,根据胃镜和病理学检查结果将... 详细信息

目的探讨血清胃蛋白酶原(PG)Ⅰ、PGⅡ、PGⅠ/PGⅡ(PGR)、胃泌素-17和幽门螺杆菌(Hp)检测在胃部病变鉴别诊断中的临床应用价值。方法选取2021年6月至2023年6月杭州师范大学附属医院就诊的321例胃部病变患者,根据胃镜和病理学检查结果将患者分为慢性浅表性胃炎组148例、慢性萎缩性胃炎组80例、胃溃疡组57例和胃癌组36例。4组患者均行胃镜检查并取胃黏膜组织进行病理检查来确定Hp感染情况(不确定时以14C呼气试验证实);同时采集所有患者空腹外周静脉血5 mL检测并分析PGⅠ、PGⅡ、PGR和胃泌素-17的差异;比较慢性浅表性胃炎组患者Hp阳性率及血清PGⅠ、PGⅡ、PGR和胃泌素-17差异;通过ROC曲线分析血清标志物、Hp感染单独以及联合对胃癌与慢性萎缩性胃炎鉴别诊断的效能。结果胃溃疡组Hp阳性率最高;胃癌组PGⅠ、PGⅡ和胃泌素-17水平均高于慢性浅表性胃炎组和慢性萎缩性胃炎组,差异均有统计学意义(均P<0.05);胃癌组PGR低于慢性浅表性胃炎组,差异有统计学意义(P<0.05)。PGⅠ+PGⅡ+PGR+胃泌素-17+Hp+性别+年龄的联检法(7MP)在胃癌和慢性萎缩性胃炎鉴别诊断中的AUC为0.875,灵敏度和特异度分别为0.778和0.875。结论慢性浅表性胃炎、慢性萎缩性胃炎、胃溃疡和胃癌患者的血清PGⅠ、PGⅡ、PGR和胃泌素-17水平及Hp检查结果存在差异性,7MP对胃癌和慢性萎缩性胃炎的鉴别诊断具有较好的效能。

关键词：胃部病变胃蛋白酶原胃泌素-17 鉴别诊断

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Multi-granularity Rough Set and Measure Based on Weighted Granularity on the Dual Universes

Multi-granularity Rough Set and Measure Based on Weighted Gr...

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第30届中国控制与决策会议

作者： Peng Liangui Yan Ruixia chen zhaojun School of Management Shanghai University of Engineering Science

Considering attribute weight and universe expansion, lower and upper approximation operators on dual universes are presented. And multi-granularity rough set model on the dual universes is proposed. Some properties of the multi-granularity rough set model on the dual universes is discussed considering different weighted granularity. Then, roughness and precision factor for multi-granularity rough set model on the dual universes are introduced to measure the uncertainty of the information system. Also, properties about the relation between information granular and subset in information system are researched.

关键词： Multi-granularity rough set Dual universes Weighted granularity Uncertainty measure

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