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安罗替尼胶囊联合替吉奥胶囊二线治疗晚期鼻咽癌的临床研究

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中国卫生标准管理 2022年第10期13卷 148-150页

作者：杨昌卫朱政陈永强陈钊锦彭寿洲茂名市中医院肿瘤二科广东茂名525000

目的探讨采用安罗替尼胶囊、替吉奥胶囊联合疗法对一线治疗失败的晚期鼻咽癌患者进行治疗的临床疗效。方法选取我院在2020年2月1日—2021年2月1日收治的一线放化疗失败的晚期鼻咽癌患者60例作为研究对象,根据随机数字表法进行分组。其... 详细信息

目的探讨采用安罗替尼胶囊、替吉奥胶囊联合疗法对一线治疗失败的晚期鼻咽癌患者进行治疗的临床疗效。方法选取我院在2020年2月1日—2021年2月1日收治的一线放化疗失败的晚期鼻咽癌患者60例作为研究对象,根据随机数字表法进行分组。其中对照组30例仅口服替吉奥胶囊,观察组30例给予安罗替尼胶囊联合替吉奥胶囊治疗,连续用药2周停1周为1疗程,共计化疗6个疗程。比较两组患者的临床疗效与不良反应的发生情况。结果观察组总有效率高达86.7%,对照组的总有效率为63.3%,相比对照组观察组总有效率明显更高,差异有统计学意义(χ^(2)=4.356,P=0.037)。60例患者的主要毒副反应包括恶心、呕吐、食欲减退、皮肤色素沉着及白细胞降低等,反应均比较轻,经对症治疗后均恢复正常。治疗过程中无患者由于不良反应而推迟治疗或减少用药剂量。结论安罗替尼胶囊、替吉奥胶囊联合疗法用于治疗一线治疗失败的晚期鼻咽癌患者,可获得确切疗效,不良反应轻微,建议进一步推广应用。

关键词：安罗替尼胶囊替吉奥胶囊二线治疗晚期鼻咽癌疗效不良反应

探讨无创持续气道正压通气(CPAP)联合布地奈德在新生儿呼吸窘迫综合征中的临床应用价值

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中外医疗 2021年第36期40卷 38-40,49页

作者：程芬陈召金麦瑞林程青王玉映广东省东莞市企石医院儿科广东东莞523500

目的探讨无创持续气道正压通气(CPAP)联合布地奈德雾化治疗新生儿呼吸窘迫综合征的临床效果。方法随机选取2020年1月—2021年6月该院收治的70例新生儿呼吸窘迫综合征患儿为研究对象,随机分为对照组和观察组,各35例。对照组给予CPAP治疗... 详细信息

目的探讨无创持续气道正压通气(CPAP)联合布地奈德雾化治疗新生儿呼吸窘迫综合征的临床效果。方法随机选取2020年1月—2021年6月该院收治的70例新生儿呼吸窘迫综合征患儿为研究对象,随机分为对照组和观察组,各35例。对照组给予CPAP治疗,观察组给予CPAP联合布地奈德雾化治疗。比较两组CPAP治疗时间、住院时间、并发症发生率、治疗24 h后NEWS评分、治疗2 h和24 h后动脉血气分析指标。结果观察组的CPAP治疗时间和住院时间均短于对照组,差异有统计学意义(P<0.05);观察组并发症总发生率(5.71%)低于对照组(22.86%),差异有统计学意义(χ^(2)=4.200,P<0.05);经治疗后,观察组NEWS评分低于对照组,差异有统计学意义(P<0.05),在动脉血气分析方面,治疗2 h和24 h后观察组的PaCO2低于对照组,而PaO2和pH值则高于对照组,差异有统计学意义(P<0.05)。结论CPAP联合布地奈德雾化治疗新生儿呼吸窘迫综合征可提高临床效果,同时缩短CPAP治疗时间和住院时间,减少并发症发生率,并明显改善NEWS评分和动脉血气分析指标,改善疾病预后,且具有较高安全性,值得临床推广应用。

关键词：新生儿呼吸窘迫综合征无创持续气道正压通气(CPAP) 布地奈德动脉血气分析

和解法中医辨证防治肝癌化疗栓塞综合征的疗效观察

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智慧健康 2022年第13期8卷 132-135页

作者：陈永强陈钊锦杨昌卫朱政彭寿洲劳明珠茂名市中医院肿瘤科广东茂名525000

目的探讨和解法中医辨证防治肝癌化疗栓塞综合征的疗效。方法选取茂名市中医院2019年1月-2021年9月收治的行肝动脉栓塞化疗(Transcatheter arterial chemoembolization,TACE)术的原发性肝癌患者72例作为研究对象,依据治疗方式将患者分... 详细信息

目的探讨和解法中医辨证防治肝癌化疗栓塞综合征的疗效。方法选取茂名市中医院2019年1月-2021年9月收治的行肝动脉栓塞化疗(Transcatheter arterial chemoembolization,TACE)术的原发性肝癌患者72例作为研究对象,依据治疗方式将患者分为观察组42例,对照组30例。对照组采用西医对症治疗,观察组采用西医对症联合和解法中医辨证治疗。对比两组患者的中医症状积分,KPS评分,化疗栓塞综合征症状积分及肝功能情况。结果术后7d、14d,两组患者中医症状积分对比(P<0.05)。观察组术后3d中医症状积分与术前对比(P<0.05);术后7d、14d分别与术后3d对比(P<0.05);术后7d与14d比较,差异有统计学意义(P<0.05)。对照组术后3d、7d、14d中医症状积分分别与术前对比,差异有统计学意义(P<0.05);术后14d分别与术后3d、7d对比,差异有统计学意义(P<0.05)。术后7d,两组患者KPS评分比较,差异有统计学意义(P<0.05)。术后3d,两组患者的恶心呕吐评分对比,差异有统计学意义(P<0.05);术后7d,两组患者的黄疸、发热、便干、脘腹胀满及纳呆食少症状积分比较,差异有统计学意义(P<0.05)。术后14d,两组患者的黄疸、发热及纳呆食少症状积分比较,差异有统计学意义(P<0.05)。术后7d,两组患者的TB、ALB、GGT、ALT、AST肝功能水平比较,差异有统计学意义(P<0.05)。结论和解法中医辨证防治肝癌化疗栓塞综合征临床疗效显著,可明显改善患者的生活质量及肝功能水平,意义重大。

关键词：和解法中医辨证防治肝癌化疗栓塞综合征疗效

益气养阴法治疗对气阴两虚型晚期肺癌患者生活质量的影响

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临床医学工程 2017年第10期24卷 1401-1402页

作者：杨昌卫彭寿洲朱政陈永强陈钊锦黄秋光茂名市中医院广东茂名525000

目的探讨益气养阴法治疗对气阴两虚型晚期肺癌患者生活质量的影响。方法选择我院2013年6月至2017年2月收治的气阴两虚型晚期肺癌患者共100例,随机分为对照组和治疗组各50例。两组均采用常规治疗(复方氨基酸注射液18AA-II,中/长链脂肪乳... 详细信息

目的探讨益气养阴法治疗对气阴两虚型晚期肺癌患者生活质量的影响。方法选择我院2013年6月至2017年2月收治的气阴两虚型晚期肺癌患者共100例,随机分为对照组和治疗组各50例。两组均采用常规治疗(复方氨基酸注射液18AA-II,中/长链脂肪乳注射液),治疗组在此基础上采用益气养阴法治疗(生脉注射液静滴和补中益气汤口服),比较两组患者治疗前后的生活质量(QOL-C30)。结果治疗前两组患者的QOL-C30各项评分及总分比较无统计学差异(P>0.05);治疗后两组患者的躯体功能、情绪功能、认知功能、角色功能和社会功能5个方面评分及总分均较治疗前显著提高,组内比较差异有统计学意义(P<0.05),且治疗组各项评分均显著高于对照组,差异具有统计学意义(P<0.05)。结论益气养阴法治疗对提高气阴两虚型晚期肺癌患者的生活质量具有重要作用。

关键词：益气养阴法气阴两虚型肺癌生活质量

环境因子对太白山锐齿槲栎林林下草本植物组成和多样性的影响

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西北农林科技大学学报（自然科学版） 2020年第3期48卷 64-74页

作者：任学敏崔志鹏朱雅陈兆进丁传雨阚德龙李玉英张乃群杨改河南阳师范学院农业工程学院河南南阳473061 河南省南水北调中线水源区生态安全重点实验室河南南阳473061 南水北调中线水源区水安全河南省协同创新中心河南南阳473061 西北农林科技大学农学院陕西杨凌712100

【目的】探索太白山锐齿槲栎林林下草本植物组成和多样性与环境因子的关系,为该区域森林保护、经营管理提供理论指导。【方法】基于太白山锐齿槲栎林林下草本植物野外调查及室内试验数据,采用CCA和偏CCA排序法分析环境因子对太白山锐齿... 详细信息

【目的】探索太白山锐齿槲栎林林下草本植物组成和多样性与环境因子的关系,为该区域森林保护、经营管理提供理论指导。【方法】基于太白山锐齿槲栎林林下草本植物野外调查及室内试验数据,采用CCA和偏CCA排序法分析环境因子对太白山锐齿槲栎林林下草本植物组成的影响,采用相关分析和多元逐步回归分析探索环境因子对其草本植物多样性的影响。【结果】环境因子能显著解释太白山锐齿槲栎林林下草本植物组成变异,海拔、坡向、坡度、pH、枯落物厚度和有机质、碱解N、有效P、有效K含量及郁闭度、灌木盖度11个环境因子共解释了物种组成变异的39.05%。其中,郁闭度、土壤有效P含量、pH值和海拔是影响林下草本植物组成的主要环境因子。海拔、郁闭度、有效P和有效K含量能够显著影响太白山锐齿槲栎林林下草本植物的多样性,海拔较高、郁闭度较大、土壤有效P和有效K含量较高的生境具有较好的草本植物多样性。【结论】在太白山锐齿槲栎林经营管理中,可通过适量施用P肥和K肥来促进林下草本植物发育,提高物种多样性。

关键词：草本植物锐齿槲栎林物种多样性环境因子太白山

Using big data to track marine oil transportation along the 21st-century Maritime Silk Road

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Science China(Technological Sciences) 2019年第4期62卷 677-686页

作者： chenG Liang YAN zhaojin XIAO YiJia chen YanMing ZHANG FangLi LI ManChun Jiangsu Provincial Key Laboratory of Geographic Information Science and Technology Nanjing University Collaborative Innovation Center for the South Sea Studies Nanjing University Collaborative Innovation Center of Novel Software Technology and Industrialization Nanjing University School of Geography and Ocean Science Nanjing University Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application

China's designation of the "21 st-century Maritime Silk Road"(MSR) region is of extraordinary significance to its maritime rights, transportation security, and socio-economic development. We developed a technical framework allowing the use of "big data" derived from the Automatic Identification System(AIS, an automatic ship-tracking network) for two purposes: the accurate mapping of oil tanker trajectories and the creation of heat maps showing the relative use of oil tanker routes and marine shipping chokepoints. We then applied these methods to 1.5 billion AIS records collected within the MSR in 2014 to statistically identify and analyze busy routes, areas, and chokepoints in this strategic region. Our results demonstrate that the proposed framework can provide an effective analysis of oil movements based on large-scale AIS datasets, helping researchers and policy makers better understand the footprint and strategic implications of maritime oil transportation in the MSR region.

关键词： 21st-century Maritime Silk Road(MSR) maritime oil transportation transportation chokepoints heat map automatic identification system(AIS)

Peptide-drug conjugates(PDCs):a novel trend of research and development on targeted therapy,hype or hope?

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Acta Pharmaceutica Sinica B 2023年第2期13卷 498-516页

作者： chen Fu Lifeng Yu Yuxi Miao Xinli Liu zhaojin Yu Minjie Wei Department of Pharmacology School of PharmacyChina Medical UniversityShenyang 110122China Liaoning Key Laboratory of Molecular Targeted Anti-Tumor Drug Development and Evaluation China Medical UniversityShenyang 110122China Liaoning Medical Diagnosis and Treatment Center Shenyang 110000China Department of Digestive Oncology Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital&InstituteShenyang 110042China

Peptide-drug conjugates(PDCs)are the next generation of targeted therapeutics drug after antibody-drug conjugates(ADCs),with the core benefits of enhanced cellular permeability and improved drug *** drugs are now approved for market by US Food and Drug Administration(FDA),and in the last two years,the pharmaceutical companies have been developing PDCs as targeted therapeutic candidates for cancer,coronavirus disease 2019(COVID-19),metabolic diseases,and so *** therapeutic benefits of PDCs are significant,but poor stability,low bioactivity,long research and development time,and slow clinical development process as therapeutic agents of PDC,how can we design PDCs more effectively and what is the future direction of PDCs?This review summarises the components and functions of PDCs for therapeutic,from drug target screening and PDC design improvement strategies to clinical applications to improve the permeability,targeting,and stability of the various components of *** holds great promise for the future of PDCs,such as bicyclic peptide-toxin coupling or supramolecular nanostructures for peptide-conjugated *** mode of drug delivery is determined according to the PDC design and current clinical trials are *** way is shown for future PDC development.

关键词： Peptide Drug Linker Targeted therapy Stability Permeability

Current status and trends in small nucleic acid drug development:Leading the future

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Acta Pharmaceutica Sinica B 2024年第9期14卷 3802-3817页

作者： Yuxi Miao chen Fu zhaojin Yu Lifeng Yu Yu Tang Minjie Wei Department of Pharmacology School of PharmacyChina Medical UniversityShenyang 110122China Liaoning Key Laboratory of Molecular Targeted Anti-Tumor Drug Development and Evaluation China Medical UniversityShenyang 110122China Liaoning Medical Diagnosis and Treatment Center Shenyang 110000China Department of Oncology Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital and InstituteShenyang 110042China

Small nucleic acid drugs,composed of nucleotides,represent a novel class of pharmaceuticals that differ significantly from conventional small molecule and antibody-based *** agents function by selectively targeting specific genes or their corresponding messenger RNAs(mRNAs),further modulating gene expression and regulating translation-related *** examples within this category include antisense oligonucleotides(ASO),small interfering RNAs(siRNAs),micro-RNAs(miRNAs),and *** emergence of small nucleic acid drugs as a focal point in contemporary biopharmaceutical research is attributed to their remarkable specificity,facile design,abbreviated development cycles,expansive target spectrum,and prolonged *** challenges such as poor stability,immunogenicity,and permeability issues have been addressed through the integration of chemical modifications and the development of drug delivery *** review provides an overview of the current status and prospective trends in small nucleic acid drug *** with a historical context,we introduce the primary classifications and mechanisms of small nucleic acid ***,we delve into the advantages of the *** and Drug Administration(FDA)approved drugs and mainly discuss the challenges encountered during their *** from researching chemical modification and delivery system that efficiently deliver and enrich small nucleic acid drugs to target tissues,promoting endosomal escape is a critical scientific question and important research direction in siRNA drug *** directions in this field will prioritize addressing these challenges to facilitate the clinical transformation of small nucleic acid drugs.

关键词： Small nucleic acid drugs Oligonucleotide drugs siRNA ASO miRNA Aptamer RNAi Drug development

A new inclination-based method to evaluate the global geomagnetic configuration and axial dipole moment

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Earth and Planetary Physics 2022年第4期6卷 359-365页

作者： KaiHua Xu Fei He Yong Wei Ross N.Mitchell Si chen YuQi Wang zhaojin Rong Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China School of Earth and Environment University of LeedsLeedsLS29JTUK

The strength and configuration of the geomagnetic field control the average shape of the *** pure dipole assumption and the virtual dipole moment(VDM),determined by individual records,have been widely adopted to evaluate the strength of the geomagnetic field in geological ***,such an assumption might not be valid during geomagnetic transitions,such as reversals and *** traditional spherical harmonic modeling of the geomagnetic field could be difficult to implement because accurate global records are ***,we report that an empirical relationship exists between the ratio of the VDM to the true axial dipole moment(VDM/ADM)and the ratio of the power of the axial dipole to that of the non-axial dipole(AD/NAD)based on a new method utilizing globally distributed inclination *** root mean square global deviation of inclination(RMSΔI)to the standard inclination distribution of the AD was fitted to the AD/NAD with a cubic polynomial by utilizing a large number of geodynamo *** with geomagnetic field models showed that the AD/NAD derived from the RMSΔI agreed well with that calculated by using the Gauss coefficients,and the estimated ADM was consistent with the true ***,the application of volcanic records during the Laschamp excursion showed the VDM might overestimate the ADM by a factor of *** new method will be useful in future studies that characterize the configuration of the geomagnetic field and the strength of the axial dipole.

关键词： axial dipole magnetic inclination virtual dipole moment