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Prognostic model for prostate cancer based on glycolysis-related genes and non-negative matrix factorization analysis

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BIOCELL 2023年第2期47卷 339-350页

作者： ZECHAO LU FUcai TANG HAOBIN ZHOU ZEGUANG LU WANYAN cai JIAHAO ZHANG ZHICHENG TANG YONGCHANG LAI zhaohui HE Department of Urology The Eighth Affiliated HospitalSun Yat-Sen UniversityShenzhen518033China The First Clinical College of Guangzhou Medical University Guangzhou511436China The Second Clinical College of Guangzhou Medical University Guangzhou511436China Department of Social and Behavioural Sciences City University of Hong KongHong Kong999077China The Sixth Clinical College of Guangzhou Medical University Guangzhou511436China The Third Clinical College of Guangzhou Medical University Guangzhou511436China

Background:Establishing an appropriate prognostic model for PCa is essential for its effective *** is a vital energy-harvesting mechanism for *** a prognostic model for PCa based on glycolysis-related genes is novel and has great ***:First,gene expression and clinical data of PCa patients were downloaded from The Cancer Genome Atlas(TCGA)and Gene Expression Omnibus(GEO),and glycolysis-related genes were obtained from the Molecular Signatures Database(MSigDB).Gene enrichment analysis was performed to verify that glycolysis functions were enriched in the genes we obtained,which were used in nonnegative matrix factorization(NMF)to identify *** correlation between clusters and clinical features was discussed,and the differentially expressed genes(DEGs)between the two clusters were *** on the DEGs,we investigated the biological differences between clusters,including immune cell infiltration,mutation,tumor immune dysfunction and exclusion,immune function,and checkpoint *** establish the prognostic model,the genes were filtered based on univariable Cox regression,LASSO,and multivariable Cox ***–Meier analysis and receiver operating characteristic analysis validated the prognostic value of the model.A nomogram of the risk score calculated by the prognostic model and clinical characteristics was constructed to quantitatively estimate the survival probability for PCa patients in the clinical ***:The genes obtained from MSigDB were enriched in glycolysis *** clusters were identified by NMF analysis based on 272 glycolysis-related genes,and a prognostic model based on DEGs between the two clusters was finally *** prognostic model consisted of LAMPS,SPRN,ATOH1,TANC1,ETV1,TDRD1,KLK14,MESP2,POSTN,CRIP2,NAT1,AKR7A3,PODXL,CARTPT,and *** sample,training,and test cohorts from The Cancer Genome Atlas(TCGA)and the external validation cohort from GEO showed sig

关键词： Glycolysis Prostate cancer Tumor immune Non-negative matrix factorization Prognostic model

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A NOVEL SIMULTANEOUS NOISE AND INPUT VSWR MATCHING TECHNIQUE FOR BROADBAND LNA

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Journal of Electronics(China) 2010年第4期27卷 446-452页

作者： Nie zhaohui Bao Jingfu Lin Ping cai Fajuan University of Electronic Science and Technology of China Chengdu 611731 China China South Industries Group Corporation （Chengdu） Fire Control Technology Center Chengdu 611731 China

The Simultaneous Noise and Input Voltage Standing Wave Ratio (VSWR) Matching (SNIM) condition for Low Noise Amplifier (LNA), in principle, can only be satisfied at a single fre-quency. In this paper, by analyzing the fundamental limitations of the narrowband SNIM technique for the broadband application, the authors present a broadband SNIM LNA systematic design technique. The designed LNA guided by the proposed methodology achieves 10 dB power gain with a low Noise Figure of 0.53 dB. Meanwhile, it provides wonderful input matching of 27 dB across the fre-quency range of 3～5 GHz. Therefore, broadband SNIM is realized.

关键词： Low Noise Amplifier (LNA) Minimum Noise Figure Minimum input VSWR Simultaneous Noise and Input VSWR Matching (SNIM)

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Experimental demonstration of phase-sensitive multimode continuous variable quantum key distribution with improved secure key rate

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Photonics Research 2023年第11期11卷 1861-1869页

作者： ZIKANG SU JINTAO WANG DAJIAN cai XIAOJIE GUO DAWEI WANG zhaohui LI Guangdong Provincial Key Laboratory of Optoelectronic Information Processing Chips and Systems School of Electronics and Information TechnologySun Yat-sen UniversityGuangzhou 510006China Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications Institute of Photonics TechnologyJinan UniversityGuangzhou 510632China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519000China

We develop and experimentally demonstrate a phase-sensitive continuous variable quantum key distribution system with improved secure key *** is achieved using multimode coherent states with phase-conjugated subcarrier modulation and phase-sensitive *** local oscillator for phase-sensitive detection is regenerated from a polarization-multiplexed carrier wave via optical injection *** proposed scheme has a higher classical information capacity at a given number of received photons and exhibits a higher secure key rate when applying the security analysis of the GG02 *** results confirm the higher secret key rate and better excess noise tolerance of the new scheme compared to the typical implementation of GG02.

关键词： phase distribution quantum

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High-performance polarization management devices based on thin-film lithium niobate

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Light(Science & Applications) 2022年第5期11卷 868-876页

作者： Zhongjin Lin Yanmei Lin Hao Li Mengyue Xu Mingbo He Wei Ke Heyun Tan Ya Han zhaohui Li Dawei Wang X.Steve Yao Songnian Fu Siyuan Yu Xinlun cai State Key Laboratory of Optoelectronic Materials and Technologies School of Electronics and Information TechnologySun Yat-sen University510275 GuangzhouChina Department of Electrical and Computer Engineering The University of British ColumbiaVancouverBC V6T 1Z4Canada Photonics Information Innovation Center and Hebei Provincial Center for Optical Sensing Innovations College of Physics Science and TechnologyHebei University071002 BaodingChina Institute of Advanced Photonics Technology School of Information EngineeringGuangdong University of Technology510006 GuangzhouChina

High-speed polarization management is highly desirable for many applications,such as remote sensing,telecommunication,and medical ***,most of the approaches for polarization management rely on bulky optical components that are slow to respond,cumbersome to use,and sometimes with high drive ***,we overcome these limitations by harnessing photonic integrated circuits based on thin-film lithium niobate *** successfully realize a portfolio of thin-film lithium niobate devices for essential polarization management functionalities,including arbitrary polarization generation,fast polarization measurement,polarization scrambling,and automatic polarization *** present devices feature ultra-fast control speeds,low drive voltages,low optical losses and compact *** these devices,we achieve high fidelity polarization generation with a polarization extinction ratio up to 41.9 dB and fast polarization scrambling with a scrambling rate up to 65 Mrad s−1,both of which are best results in integrated *** also demonstrate the endless polarization state tracking operation in our *** demonstrated devices unlock a drastically new level of performance and scales in polarization management devices,leading to a paradigm shift in polarization management.

关键词： polarization lithium film

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后2020时期临界贫困群体的识别及影响机理研究——基于重庆市3117份农户样本的实证

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西南大学学报（自然科学版） 2025年第1期47卷 134-146页

作者：蔡进冯朝晖张宇禹洋春廖和平李斌重庆工商大学公共管理学院重庆400067 重庆工商大学工商管理学院重庆400067 西南大学地理科学学院重庆400715

临界贫困群体作为巩固脱贫攻坚时期及乡村振兴中农户返贫的潜在增量,研究其内涵、识别方法和影响机理对构建农村贫困长效治理机制具有重要意义。在阐释临界贫困内涵的基础上,构建了临界贫困群体的识别指标体系,运用全排列多边形综合图... 详细信息

临界贫困群体作为巩固脱贫攻坚时期及乡村振兴中农户返贫的潜在增量,研究其内涵、识别方法和影响机理对构建农村贫困长效治理机制具有重要意义。在阐释临界贫困内涵的基础上,构建了临界贫困群体的识别指标体系,运用全排列多边形综合图示法、中位数比例法和Dagum基尼系数,基于重庆市3117份农户样本,对临界贫困群体的识别及影响机理进行了实证研究。研究结果表明:样本农户的多维临界贫困指数整体较低,且呈现正态分布特征,介于0.257和0.839之间;从3117份一般户样本中识别出330户临界贫困户,临界贫困发生率为10.59%;在15个探测指标因素中,海拔、耕地流转情况、文化程度、劳动力数量、医疗教育负担、到场镇距离、疫情灾情影响、政策满意度、政策期望值9个指标因素与样本农户临界贫困群体在不同水平下具有统计学意义。外部环境因素中区域资源禀赋匮乏、外部机会获取偏少和地方政策支撑薄弱,内部个体因素中农户个体能力较弱、内生动力不足和家庭个体水平较差是造成临界贫困的主要因素。地方政府应规范相对贫困人口识别标准和程序,构建防止返贫致贫的动态监测预警以及农村低收入人口的帮扶机制,建立分类管理、分类帮扶、分类施策机制。

关键词：后2020时期临界贫困影响机理重庆市

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Endovascular treatment for left innominate vein aneurysm: Case report and literature review

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Journal of Interventional Medicine 2019年第1期2卷 35-37页

作者： Gaopo cai zhaohui Hua Peng Xu Zhouyang Jiao Hui Cao Shirui Liu Jing Yuan Zhengyu Peng Zhen Li Department of Endovascular Surgery First Affiliated Hospital of Zhengzhou University

Innominate vein aneurysms originating from the mediastinum are very rare. Previous treatments for this condition often required thoracotomy. We report a case of a 43-year-old male who presented a mediastinal mass by chest radiography. Contrast-enhanced CT and venography confirmed the diagnosis of left innominate vein aneurysm. The patient underwent endovascular treatment with stent placement and coil embolization of the left innominate vein. The patient remains well 18 months after surgery. The objective of this report is to discuss the diagnosis and endovascular treatment results of innominate vein aneurysm and to review the relevant literature to enhance and expand the pool of knowledge for this abnormality.

关键词： Innominate vein aneurysm Endovascular treatment Literature review

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LUT:A Lunar-based Ultraviolet Telescope

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Science China(Physics,Mechanics & Astronomy) 2011年第3期54卷 558-562页

作者： CAO Li RUAN Ping cai HongBo DENG JinSong HU JingYao JIANG XiaoJun LIU zhaohui QIU YuLei WANG Jing WANG Shen YANG JianFeng ZHAO Fei WEI JianYan National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China Xi' an Institute of Optics and Precision Mechanics Chinese Academy of Sciences Xi' an 710119 China

The Lunar-based Ultraviolet Telescope （LUT） is a funded lunar-based ultraviolet telescope dedicated to continuously monitor- ing variable stars for as long as dozens of days and performing low Galactic latitude sky surveys. The slow and smooth spin of the Moon makes its step by step pointing strategy possible. A flat mirror mounted on a gimbal mount is configured to enlarge the sky coverage of the LUT. A Ritehey-Chretien telescope with a Nasmyth focus configuration is adopted to reduce the total length of the system. A UV enhanced back illuminated AIMO CCD 47-20 chip together with the low noise electric design will minimize the instrumental influence on the system. The preliminary proposal for astrometric calibration and photometric cali- bration are also presented.

关键词： ultraviolet space-based ultraviolet telescope photometric instrumentation lunar probe

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Oxidative damage of primary cultured hippocampal neurons Does androgen have an antagonistic effect?

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Neural Regeneration Research 2010年第5期5卷 358-363页

作者： zhaohui Li Zhiping cai Huixian Cui Jinsong Zhu Sha Li Guosheng Xie Lei Xue Department of Neurosurgery Second Affiliated Hospital of Hebei Medical University Shijiazhuang 050000 Hebei Province China Department of Human Anatomy Hebei Medical University Shijiazhuang 050017 Hebei Province China Department of Anatomy Hebei University Basic Medical College Baoding 071000 Hebei Province China

BACKGROUND： Evidence illustrates that androgen has a neuroprotective role. However, whether androgen also has the protective effect on hippocampal neurons during free radical mediated injury remains unclear. OBJECTIVE： To investigate the neuroprotective effect of androgen on hippocampal neurons during free radical damage. DESIGN, TIME AND SETTING： A controlled in vitro experiment was performed at the Department of Human Anatomy, Cell Culture Lab, and Neuroendocrinology Lab, Basic Medical School, Hebei Medical University from February to June 2009. MATERIALS： Testosterone was provided by Tianjin Jinyao Amino Acid Company, China. METHODS： Primary cultured neurons from 24 Sprague Dawley rats were randomly assigned into four groups： control, H202, testosterone, and testosterone （pre-added） plus H2O2 groups. MAIN OUTCOME MEASURES： The positive cell ratio of microtubule associated protein-Ⅱ and neuron specific enolase was determined by immunocytochemistry. Neuronal morphology was observed by hematoxylin-eosin staining and Nissl staining. Cell vitality and viability were determined using an inverted phase contrast microscope. The content of nitric oxide synthase, malondialdehyde, and superoxide dismutase were measured with a spectrophotometer. RESULTS： As compared with the control group, cell vitality and viability, and superoxide dismutase level were significantly decreased in the H202 group （P 〈 0.05）, while nitric oxide synthase and malondialdehyde levels were significantly increased （P 〈 0.05）. Neuronal vitality and viability as well as superoxide dismutase level in the testosterone plus H2O2 group were significantly greater than in the H2O2 group （P 〈 0.05）, and nitric oxide synthase and malondialdehyde levels were significantly less than in the H2O2 group （P〈 0.05）. CONCLUSION： Androgen partially reversed H2O2-induced neuronal damage and protected neurons.

关键词： androgen primary cultured hippocampal neuron free radical nitric oxide synthase superoxide dismutase malondialdehyde oxidative damage

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1-Pbps orbital angular momentum fibre-optic transmission

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Light(Science & Applications) 2022年第8期11卷 1823-1833页

作者： Junyi Liu Jingxing Zhang Jie Liu Zhenrui Lin Zhenhua Li Zhongzheng Lin Junwei Zhang Cong Huang Shuqi Mo Lei Shen Shuqing Lin Yujie Chen Ran Gao Lei Zhang Xiaobo Lan Xinlun cai zhaohui Li Siyuan Yu State Key Laboratory of Optoelectronic Materials and Technologies School of Electronics and Information TechnologySun Yat-Sen UniversityGuangzhou510006China Yangtze Optical Fibre and Cable Joint Stock Limited Company State Key Laboratory of Optical Fibre and Cable Manufacture TechnologyNo.9 Guanggu AvenueWuhanHubeiChina School of Information and Electronics Beijing Institute of TechnologyBeijing100081China

Space-division multiplexing(SDM),as a main candidate for future ultra-high capacity fibre-optic communications,needs to address limitations to its scalability imposed by computation-intensive multi-input multi-output(MIMO)digital signal processing(DSP)required to eliminate the crosstalk caused by optical coupling between multiplexed spatial *** exploiting the unique propagation characteristics of orbital angular momentum(OAM)modes in ring core fibres(RCFs),a system that combines SDM and C+L band dense wavelength-division multiplexing(DWDM)in a 34 km 7-core RCF is demonstrated to transport a total of 24960 channels with a raw(net)capacity of 1.223(1.02)Peta-bit s−1(Pbps)and a spectral efficiency of 156.8(130.7)bit s−1 Hz−*** for such a high channel count,the system only uses fixed-size 4×4 MIMO DSP modules with no more than 25 time-domain *** ultra-low MIMO complexity is enabled by the simultaneous weak coupling among fibre cores and amongst non-degenerate OAM mode groups within each core that have a fixed number of 4 *** results take the capacity of OAM-based fibre-optic communications links over the 1 Pbps milestone for the first *** also simultaneously represent the lowest MIMO complexity and the 2nd smallest fibre cladding diameter amongst reported few-mode multicore-fibre(FM-MCF)SDM systems of>1 Pbps *** believe these results represent a major step forward in SDM transmission,as they manifest the significant potentials for further up-scaling the capacity per optical fibre whilst keeping MIMO processing to an ultra-low complexity level and in a modularly expandable fashion.

关键词： fibre momentum coupling

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Values of the Farmland Ecosystem Services of Qingdao City, China, and their Changes

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Journal of Resources and Ecology 2020年第5期11卷 443-453页

作者： cai Shizhen ZHANG Xuliang CAO Yinghui ZHANG zhaohui WANG Wei School of Tourism and Geography Science Qingdao UniversityQingdao 266071ShandongChina The First Institute of Oceanography Ministry of Natural ResourcesQingdao 266061ShandongChina

The values of farmland ecosystem services are composed of several components: provisioning service value, regulating service value, supporting service value and cultural service value, so it is important to make a full assessment of the values of farmland ecosystem services for agriculture and farmland protection. Here, we assessed the values of farmland ecosystem services in Qingdao City in 1997, 2002, 2007, 2012 and 2017 by using various methods(market value method, carbon tax method, afforestation cost method, substitute cost method, equivalent factor method, etc.) based on establishing an assessment index system for the farmland ecosystem services value. The results show that the total yearly value of farmland ecosystem services increased from 499.74× 10~8 Yuan to 681.74× 10~8 Yuan in the period of 1997-2017, and the yearly value of farmland ecosystem services per hectare increased from 6.57× 10~4 Yuan to 9.73× 10~4 Yuan. The product provisioning service, carbon fixation service and oxygen release service, as well as the soil conservation service, are the main farmland ecosystem services, and the proportions of these four ecosystem service values to the total value of farmland ecosystem services in Qingdao City were large and kept increasing. Some countermeasures are put forward to adequately use the indirect service value of the farmland ecosystem and provide improved well-being for humans, such as protecting and wisely using farmland, developing agriculture that is rooted in local conditions, promoting agricultural production efficiency, speeding up construction of modern agriculture gardens, deepening the supply-side structural reform of agriculture, developing agricultural eco-tourism, etc.

关键词： Qingdao City farmland ecosystem services value assessment

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