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Mixture prepared with Chinese medicines in terms of releasing exterior cold and clearing interior heat: its efficacy and safety in patients with seasonal influenza-a randomized controlled trial

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Journal of Traditional Chinese Medicine 2018年第5期38卷 746-753页

作者： Wu Zhisong Li Guodong Wei Wan liu zhaoheng Wang Wei Ma Ruihong liu Wenhong Ma Jiaju Wang Yuguang Jiao Yang Department of Intensive care unit Dongfang Hospital Affiliated to Beijing University of Chinese Medicine Graduate School Beijing University of Chinese Medicine Department of Chinese Medicine Concord Hospital Affiliated to Fujian Medical University Department of Respiratory medicine Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University Department of Internal Medicine Dongfang Hospital Affiliated to Beijing University of Chinese Medicine

OBJECTIVE: To assess the efficacy and safety in 105 patients with seasonal Influenza in Beijing, the mixture prepared with Chinese medicines follows the treatment regimen of releasing exterior cold andclearing interior ***: Total 330 patients with seasonal influenza were enrolled and randomly and averagely divided into the Chinese herbal medicine, the western medicine and the Chinese patent medicine group. They were treated with Chinese medicine Oseltamivir Phosphate Capsules and the Scattering Wind and Resolving Toxins Capsules. The main efficacy indicators were the antifebrile onset time and recovery time of body temperature. The efficacy and safety of the mixture was scientifically evaluated. Comparisons of several variables were ***: Median antifebrile onset time of the Chinese herbal medicine group was significantly shorter than the western medicine group(P < 0.05) and the Chinese patent medicine group(P < 0.05). The median antifebrile recovery time of the Chinese herbal medicine group was significantly shorter than the Chinese patent medicine group(P <0.05). The groups evaluated by TCM symptom pattern effect, both the Chinese herbal medicine group and Western Medicine group were better than the Chinese patent medicine group(P <0.05). The disappearance rate of main symptoms and some minor symptom patterns of the Chinese herbal medicine group were higher than the other 2 ***: The mixture of releasing exterior cold and clearing interior heat could significantly shorten the fever time with safety.

关键词： Releasing exterior cold and clearing interior heat Influenza efficacy Mixture prepared with Chinese medicines

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Assessment of traditional Chinese medicine pattern in a bleomycininduced pulmonary fibrosis mouse model: A pilot study

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Journal of Traditional Chinese Medical Sciences 2022年第4期9卷 400-408页

作者： Xiaofeng Gu Wan Wei zhaoheng liu Fang Cao Zhisong Wu Jie Xie Tianfang Wang Yang Jiao Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou310003China Department of Geriatrics Dongfang Hospital Affiliated to Beijing University of Chinese MedicineBeijing100078China School of Life Sciences Beijing University of Chinese MedicineBeijing102488China Department of Intensive Cae Unit Dongfang Hospital Affiliated to Beijing University of Chinese MedicineBeijing100078China School of Postgraduate Beijing University of Chinese MedicineBeijing100029China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing102488China Department of Respiratory Dongfang Hospital Affiliated to Beijing University of Chinese MedicineBeijing100078China

Objective:To initially explore traditional Chinese medicine patterns in a bleomycin-induced pulmonary fibrosis mouse ***:Thirty-six C57BL/6 mice were divided by the random number table method(with 12 rats per group)into three groups:a blank group,a model group,and a number 2 Feibi recipe(FBR-2)*** pulmonary fibrosis mouse model was established by intratracheal instillation of *** FBR-2 group was treated with FBR-2 for 4 *** in the mice such as mental behavior,food/water intake,body weight,body temperature,respiratory rate,and tongue image were *** samples were collected on the 14th day and 28th day after modeling,and lung tissues were visually assessed and microscopically evaluated by staining with hematoxylin-eosin and *** expression levels of hydroxyproline,interleukin(IL)-33,IL-37,tissue plasminogen activator,and plasminogen activator inhibitor-1 were determined by enzyme-linked immunosorbent ***:Mice in the model group were poor in spirit,less active,slow in response,showed reduced food/water intake,body temperature,and body weight,increased respiratory rate,and their tongue color had changed from light red to dark ***,treatment with FBR-2 significantly improved these *** inflammatory cell infiltration and collagen fiber deposition were observed in the lung tissues of the model *** with the blank group,the levels of hydroxyproline,IL-33,and plasminogen activator inhibitor-1 in the model group significantly increased(all P<.05),whereas that of tissue plasminogen activator significantly decreased on the 14th day and 28th day(P=.036 and P=.005,respectively).Moreover,FBR-2 improved lung inflammation and fibrinolysis imbalance and reduced collagen fiber ***:To some extent,our bleomycin-induced pulmonary fibrosis mouse model exhibited traditional Chinese medicine patterns of qi deficiency,blood stasis,and heat retention.

关键词： Bleomycin Idiopathic pulmonary fibrosis Pattern characteristics Tongue image Fibrinolytic factor Inflammatory factor

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Activation of GSDME by Lithospermum erythrorhizon drives pyroptotic cell death

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Journal of Traditional Chinese Medical Sciences 2023年第3期10卷 280-288页

作者： Sanjiao Wang zhaoheng liu Jiajian Guo Yunqian Li Yue Zhang Mingrui Yang Guoqi Niu Wenfu Ma School of Life Science Beijing University of Chinese MedicineBeijing 102488China Structural Biology Program Memorial Sloan Kettering Cancer CenterNew York 10065USA

Objective:To reveal GSDME-executed pyroptosis in cancer cells induced by the Chinese traditional herbal medicine plant Lithospermum erythrorhizon(***,Zi Cao)and to investigate the potential ***:*** was extracted by ultrasonication in 95%ethanol,and determined using high-performance liquid chromatography(HPLC).He La,A549,SW620,HEK-293 T,THP-1,K562,Raw264.7 and MDA-MB-231 cell lines were used to investigate the morphology and mechanism of pyroptosis induced by *** lactate dehydrogenase(LDH)release,propidium iodide(PI)/Hoechst double-staining,and pyroptosis reconstitution experiments were performed to study ***-induced cell ***:Compared with the death inhibitor,PI/Hoechst and LDH release experiments,we found that *** induced *** and western blot experiments confired that *** induced GSDME cleavage,which drives *** phenomenon is conserved in several cancer cell lines that might be triggered by caspase family *** mechanism of *** inducing pyroptosis is widely found in tumor ***:Our findings not only explain how *** triggers cancer cell pyroptosis,but also provide mechanistic insights to guide its clinical application in the future.

关键词： Lithospermum erythrorhizon Pyroptosis GSDME Anti-tumor activity

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Exploring the mechanism of Yishen Daluo decoction in the treatment of multiple sclerosis based on network pharmacology and in vitro experiments

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Journal of Traditional Chinese Medical Sciences 2023年第2期10卷 186-195页

作者： Shuo Cheng Ce Zhang Qingyuan Cai Xinghua Wang zhaoheng liu Peng Wei Xu Wang Yan Tan Qian Hua School of Life Sciences&School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing102488China School of Biomedical Informatics University of Texas Health Science Center at HoustonHoustonTX77030USA

Objective:To explore the mechanism and related active components of Yishen Daluo decoction(YSDLD)in treating multiple sclerosis(MS).Methods:Targets of YSDLD were collected through the TCMSP,Chemistry,and TCMID *** MS targets were collected through OMIM,DrugBank,Gencards,TTD,and Pharmgkb *** built“componentetarget”network diagrams and proteineprotein interaction(PPI)diagrams and performed topological *** targets were subjected to GO and KEGG enrichment *** docking verification was conducted on selected targets and ***,in vitro experiments were ***2 cells were induced by lipopolysaccharide for model ***8 experiment was conducted to explore the effect of YSDLD and RT-qPCR technology was used to explore the expression of key ***:There were 184 active components in YSDLD and 898 targets of its *** were 940 MS targets,and 215 targets were shared by YSDLD and *** to the“componentetarget”diagram,the top five key components included quercetin,kaempferol,beta-sitosterol,stigmasterol,and ***-6,IL-1 b,TNF-α,AKT1,and VEGFA were the important targets identified by PPI network to-pology analysis.A total of 564 functions were identified by GO enrichment analysis(P<0.01),mainly involving inflammatory response,hypoxia response,plasma membrane,neuronal cell body,protein phosphatase binding,and cytokine *** enrichment analysis enriched 98 pathways(P<.01).YSDLD at the concentration of 20 m g/mL had no effect on BV2 ***-qPCR indicated that YSDLD at the concentrations of 15 m g/mL and 20 m g/mL alleviated LPS-induced inflammatory injury and lowered the content of inflammatory factors(P<0.05).Conclusion:In this paper,the network pharmacology and in vitro experiments were used to explore the potential mechanism of YSDLD in treating *** research provides a good basis for the development of YSDLD and drugs for MS in future.

关键词： Yishen Daluo decoction Multiple sclerosis Network pharmacology Molecular docking BV2 cell

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Multiple-Objective Optimization and Design of Series-Parallel Systems Using Novel Hybrid Genetic Algorithm Meta-Heuristic Approach

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World Journal of Engineering and Technology 2018年第3期6卷 532-555页

作者： Essa Abrahim Abdulgader Saleem Thien-My Dao zhaoheng liu Department of Mechanical/Manufacturing Engineering école de Technologie Supérieure Montreal Canada

In this study, we develop a new meta-heuristic-based approach to solve a multi-objective optimization problem, namely the reliability-redundancy allocation problem (RRAP). Further, we develop a new simulation process to generate practical tools for designing reliable series-parallel systems. Because the?RRAP is an NP-hard problem, conventional techniques or heuristics cannot be used to find the optimal solution. We propose a genetic algorithm (GA)-based hybrid meta-heuristic algorithm, namely the hybrid genetic algorithm (HGA), to find the optimal solution. A simulation process based on the HGA is developed to obtain different alternative solutions that are required to generate application tools for optimal design of reliable series-parallel systems. Finally, a practical case study regarding security control of a gas turbine in the overspeed state is presented to validate the proposed algorithm.

关键词： Multi-Objective Optimization Reliability-Redundancy Allocation Overspeed Gas Turbine Hybrid Genetic Algorithm

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后灌浆桩复合地基在高层建筑中的应用

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水利水运工程学报 2001年第2期 60-62页

作者：庞春龙刘兆衡南京市城市建设开发集团总公司江苏南京210005 南京水利科学研究院院长办公室江苏南京210029

介绍了后灌浆桩复合地基的加固机理及施工工序 ,利用后灌浆桩加固南京某高层建筑物的地基 ,达到了工期短、安全可靠和造价低的效果 .

关键词：灌浆后灌浆桩地基加固高层建筑物

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新型反应装甲主装药射流感度研究

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火炮发射与控制学报 2022年第4期43卷 27-32页

作者：刘卓郁红陶刘兆恒西安工业大学机电工程学院陕西西安710021

研究爆炸反应装甲夹层装药的射流感度,能更全面地了解反应装甲的性能,同时研究结果又有助于反坦克武器的进一步发展。采用非线性有限元分析软件,参照国家军用标准,建立了射流冲击入射反应装甲主装药的有限元模型,进行了新型反应装甲主... 详细信息

研究爆炸反应装甲夹层装药的射流感度,能更全面地了解反应装甲的性能,同时研究结果又有助于反坦克武器的进一步发展。采用非线性有限元分析软件,参照国家军用标准,建立了射流冲击入射反应装甲主装药的有限元模型,进行了新型反应装甲主装药射流感度的数值模拟研究。通过调整隔板厚度分析射流入射反应装甲主装药的响应机制,得到了反应装甲主装药的射流感度值。结果表明:随着隔板厚度的增加,射流作用在反应装甲主装药上的刺激强度降低,起爆深入距离与延时时间增大,得到射流起爆新型反应装甲主装药的临界隔板厚度为58~60 mm,临界起爆阈值为50.39 mm^(3)·μs^(-2)。

关键词：反应装甲金属射流隔板试验起爆

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落锤撞击下丁羟推进剂点火反应的数值模拟

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弹箭与制导学报 2022年第2期42卷 89-93页

作者：刘兆恒郁红陶刘卓西安工业大学机电工程学院陕西西安710021

为研究典型丁羟推进剂在低压冲击作用下的点火机理,基于热点理论,建立了该型推进剂落锤试验的三维仿真模型,采用有限元计算方法和三项式点火增长反应速率模型对丁羟推进剂的落锤试验进行数值模拟,分析整个撞击过程中推进剂的点火反应和... 详细信息

为研究典型丁羟推进剂在低压冲击作用下的点火机理,基于热点理论,建立了该型推进剂落锤试验的三维仿真模型,采用有限元计算方法和三项式点火增长反应速率模型对丁羟推进剂的落锤试验进行数值模拟,分析整个撞击过程中推进剂的点火反应和动态力学响应。研究结果表明,在整个撞击过程中,由于受冲击后推进剂径向变形,剪切应力集中分布在推进剂上、下表面边缘区域,摩擦应力产生局部热量集中形成热点,引起推进剂发生点火及爆炸。计算得到了,在落高为75 cm时,10 kg落锤撞击丁羟推进剂的起爆阈值为540.2 MPa^(2)·s。

关键词：低压冲击丁羟推进剂落锤试验点火增长反应速率模型数值模拟

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先进的停车信息系统研究

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山西科技 2005年第2期20卷 74-75,82页

作者：刘照恒王波北京交通大学吉林大学

随着我国汽车数量的迅速增加 ,解决停车问题已成当务之急。为此我们需要一个先进的停车信息系统 (APIS) ,帮助解决我国交通问题和停车问题。文章结合智能运输系统(ITS) ,讨论先进停车信息系统的设计原则、结构、子系统功能及算法设计等 ... 详细信息

随着我国汽车数量的迅速增加 ,解决停车问题已成当务之急。为此我们需要一个先进的停车信息系统 (APIS) ,帮助解决我国交通问题和停车问题。文章结合智能运输系统(ITS) ,讨论先进停车信息系统的设计原则、结构、子系统功能及算法设计等 ,根据国内外发展的情况 ,提出了基于Internet的先进的停车信息服务网。最后指出一些有待进一步研究的问题。

关键词：系统研究智能运输系统(ITS) Internet 停车问题信息系统信息服务网交通问题设计原则算法设计系统功能国内外汽车

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针药并举辨治痉挛性斜颈

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实用中医内科杂志 2016年第5期30卷 114-115页

作者：刘肇恒张立德辽宁中医药大学第一临床学院沈阳110847 辽宁中医药大学机关办公室沈阳110847

痉挛性斜颈属"痉症"范畴,抗胆碱能药物、肉毒毒素、外科手术等手段副作用较大,不易被接受。中医药针灸与汤剂合用,可有效缓解肌肉紧张。针刺取百会、四神聪、上星,双侧神庭、通天、承光,顶旁2线,配双侧合谷、内关、神门、通里、心俞、... 详细信息

痉挛性斜颈属"痉症"范畴,抗胆碱能药物、肉毒毒素、外科手术等手段副作用较大,不易被接受。中医药针灸与汤剂合用,可有效缓解肌肉紧张。针刺取百会、四神聪、上星,双侧神庭、通天、承光,顶旁2线,配双侧合谷、内关、神门、通里、心俞、足三里,水沟,平补平泻法;局部延痉挛侧的斜方肌、胸锁乳突肌肌肉走行方向取穴,泻法;留针40min,每10min行针1次。药物治疗宜发汗解肌,祛除风寒,兼平肝潜阳,宁心定志,葛根汤(葛根30g,麻黄、桂枝、白芍各15g,生甘草10g,生姜、大枣、水牛角各15g,钩藤30g,桑叶20g,茯神、竹茹、栀子、龙胆草各15g)。附验案一则。

关键词：痉挛性斜颈痉症针刺葛根汤中医药治疗

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