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慢性鼻窦炎伴鼻息肉中MZB1的表达及其对局部免疫球蛋白表达的影响

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中山大学学报（医学科学版） 2024年第3期45卷 383-392页

作者：闫妍许兆丰黄嫣然中山大学附属第一医院耳鼻咽喉科医院广东广州510080

【目的】局部免疫球蛋白高表达是慢性鼻窦炎伴鼻息肉(CRSwNP)重要病理特征,本研究主要探讨亚洲CRSwNP中边缘区B和B-1(MZB1)与局部免疫球蛋白表达的关系。【方法】通过聚合酶链式反应(PCR)、lu-minex、免疫组化染色对40例CRSwNP患者的鼻... 详细信息

【目的】局部免疫球蛋白高表达是慢性鼻窦炎伴鼻息肉(CRSwNP)重要病理特征,本研究主要探讨亚洲CRSwNP中边缘区B和B-1(MZB1)与局部免疫球蛋白表达的关系。【方法】通过聚合酶链式反应(PCR)、lu-minex、免疫组化染色对40例CRSwNP患者的鼻息肉组织和6名健康对照者的下鼻甲分别进行mRNA水平和蛋白质水平的检测,通过单因素方差分析、独立样本t检验和Pearson相关性分析进行统计检验。【结果】与健康对照组相比,2型CRSwNP中MZB1(P<0.01)和HSP90B1(P<0.01)的mRNA表达水平显著升高,免疫组织化学染色显示MZB1蛋白表达在2型CRSwNP中表达显著增加。此外,MZB1与鼻息肉组织中的免疫球蛋白E(IgE)的表达呈线性相关(P<0.01,r=0.52)。MZB1与2型CRSwNP鼻息肉组织中的白细胞介素-5(IL-5)(P<0.05,r=0.4)、白细胞介素-13,(IL-13)(P<0.05,r=0.44)的表达也呈线性相关。MZB1与鼻息肉组织嗜酸性粒细胞数线性相关有统计学意义(P<0.05,r=0.72)。【结论】与对照组相比,MZB1在亚洲CRSwNP中表达显著增加,尤其是2型CRSwNP,并且与鼻息肉组织中IgE的高表达和CRSwNP疾病严重程度相关。

关键词：慢性鼻窦炎慢性鼻窦炎伴鼻息肉免疫球蛋白边缘区B和B-1基因 IgE

Heat and power load dispatching considering energy storage of district heating system and electric boilers

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Journal of Modern Power Systems and Clean Energy 2018年第5期6卷 992-1003页

作者： Xianzheng HUANG zhaofeng xu Yong SUN Yali xuE Zhe WANG Zhijun LIU Zhenyuan LI Weidou NI Department of Energy and Power Engineering State Key Lab of Power SystemsTsinghua University State Grid Jilin Electric Power Co. Ltd

As one of promising clean and low-emission energy, wind power is being rapidly developed in China.However, it faces serious problem of wind curtailment,particularly in northeast China, where combined heat and power(CHP) units cover a large proportion of the district heat supply. Due to the inherent strong coupling between the power and the heat load, the operational flexibility of CHP units is severely restricted in winter to meet the heat supply demand, which imparts considerable stress on the wind power connection to the grid. To promote the integration of wind power and enhance the flexibility of CHP units, this paper presented a method of heat and power load dispatching by exploring the energy storage ability of electric heating boilers and district heating systems. The optimization results indicate that the proposed method can integrate additional wind power into the grid and reduce the coal consumption of CHP units over the optimized period. Furthermore, the thermal inertia of a district heating system is found to contribute more to the reduction of coal consumption, whereas the electric heating boilers contribute to lower wind curtailment.

关键词： Wind power integration Combined heat and power Electric heating boiler Thermal inertia

Characteristic analysis and forecast of electricity supply and demand in APEC

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Global Energy Interconnection 2019年第5期2卷 414-423页

作者： Yong Sun Li Zhu zhaofeng xu Lingjuan Xiao Jianyun Zhang Jiqiang Zhang School of Architecture Tianjin UniversityTianjin 300072P.R.China APEC Sustainable Energy Center Tianjin 300072P.R.China Department of Energy and Power Engineering Tsinghua UniversityBeijing 100084P.R.China China Energy Technoloy&Economics Research Institute China Energy Investment Corporation LimitedBeijing 102211P.R.China

The Asia Pacific Economic Cooperation(APEC)comprises of the world’s largest producers and consumers of energy,accounting for 60.3%of primary energy supply,50.0%of final energy consumption,and 63.0%of electricity generation worldwide in 2016.This study discusses the primary energy supply and final energy consumption situation of the APEC and analyzes the characteristics of electricity in terms of its generation structure based on fuel,consumption by the end-use sector,access to electricity,and so on.The renewable energy and electricity generation projections up to 2030 based on trends in the APEC are also assessed.It is seen that electricity in final energy consumption has been on an upward trend,with an average annual growth rate of about 4.8%during 2006–2016,in 2016,its share reached 24.3%.The industry sector consumes the largest share of electricity,accounting for about 45.5%in 2016.Coal supply and consumption peaked in 2011 and then began to decline,while renewable energy has been on an upward trend,with its primary energy supply share increasing from 4.80%in 2010 to 6.29%in 2016.Solar photovoltaic and onshore wind power are on the verge of costing less than the operating cost of existing coal-fired plants in 2018.In the APEC’s target scenario in which renewable energy is doubled,the predicted net growth from 2017 to 2030 of solar,wind,and hydro power is about 963,497,and 157 GW,respectively,and to reach this target,the APEC economies need to accelerate renewable energy development.

关键词： APEC Electricity supply and demand Characteristics an alysis Renewable en ergy.

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兴隆洼文化头盖骨牌饰研究

辽宁师范大学学报（社会科学版） 2024年第2期47卷 1-14页

作者：徐昭峰逄馥璐辽宁师范大学历史文化学院辽宁大连116081

头盖骨牌饰在兴隆洼文化中出土数量较少,但其往往出土于墓主人贴身的位置,以及所用材质的特殊性,表明头盖骨牌饰与祖先崇拜有着密切关系,是原始宗教活动中不可缺少的器物之一。三件头盖骨牌饰分别代表了人面饰、臂饰、祭祀法器三个系统... 详细信息

头盖骨牌饰在兴隆洼文化中出土数量较少,但其往往出土于墓主人贴身的位置,以及所用材质的特殊性,表明头盖骨牌饰与祖先崇拜有着密切关系,是原始宗教活动中不可缺少的器物之一。三件头盖骨牌饰分别代表了人面饰、臂饰、祭祀法器三个系统。祭祀法器随着红山文化的消亡,也渐渐失去其原本的作用而消失。人面饰和臂饰则在文化交流中进入中原地区,并发展为青铜人面像和青铜兽面牌饰。青铜人面像在商周时期进一步影响到四川、陕西等地,使当地出现了一批具有地方特色的人面像;在汉代其作为百戏中的面具和仪式面舆继续流传,并衍生出了丧葬面具这一功能,而这一功能在辽代墓葬中亦有发现。臂饰与人面饰的发展脉络基本一致,商周时期其功能也一直被保留,被用于作为彰显身份地位的礼仪性用具且与宗教祭祀活动有着一定关系;秦汉时期,臂饰发展为臂鞲,更注重实用功能,并得到广泛流传;但是其最初的作用并未消失,至辽代仍可见用于彰显身份地位的礼仪性臂饰。

关键词：头盖骨牌饰祖先崇拜青铜人面像青铜兽面牌饰臂鞲

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具有劳动异质性的订单分批优化研究

重庆理工大学学报（自然科学） 2024年第2期38卷 257-266页

作者：徐兆峰姜雪松李春伟王婧东北林业大学机电工程学院哈尔滨150040

合理的订单分批和快速的拣选商品对于配送的时效性具有重要的意义。针对O2O超市仓储配送中心的订单分批问题展开研究,为了使具有劳动异质性的拣选员工更快地拣选订单商品和保证高效,同时使拣选员工工作更加均衡,构建了一个双目标混合整... 详细信息

合理的订单分批和快速的拣选商品对于配送的时效性具有重要的意义。针对O2O超市仓储配送中心的订单分批问题展开研究,为了使具有劳动异质性的拣选员工更快地拣选订单商品和保证高效,同时使拣选员工工作更加均衡,构建了一个双目标混合整数规划模型,其目标是拣选员工行走的最小距离和拣选员工的工作量最平衡。应用了一种动态自适应步长萤火虫算法,证明了所提模型和目标之间的相关性。通过数据实验验证模型和算法的有效性,结果表明该模型对订单分批和具有劳动异质性的员工具有较强的影响,为提高超市配送的时效性提供了科学依据。

关键词：订单分批改进萤火虫算法劳动异质性超市

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半球向全发射率测量实验教学系统设计与开发

实验技术与管理 2024年第1期41卷 165-170页

作者：吴宇颂田博宇李辉许兆峰霍雨佳符泰然清华大学能源与动力工程系北京100084 清华大学热科学与动力工程教育部重点实验室北京100084

针对传统半球向全发射率测量教学实验装置测试精度不高、温度量程低的问题,该文基于稳态量热方法设计了高温半球向全发射率测量实验教学系统,进行了样品测试区域热量损失的校准,该系统具有方法原理简单、测试精度高等特点。通过测量获... 详细信息

针对传统半球向全发射率测量教学实验装置测试精度不高、温度量程低的问题,该文基于稳态量热方法设计了高温半球向全发射率测量实验教学系统,进行了样品测试区域热量损失的校准,该系统具有方法原理简单、测试精度高等特点。通过测量获得不同温度下的材料半球向全发射率,便于同学们理解半球向全发射率与材料热辐射能力的相关性、光谱发射率与不同温度下的半球向全发射率的关联关系,实验测试结果可靠,满足热工系列课程研究型实验教学的需求。

关键词：半球向全发射率稳态热量法实验教学

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路网级桥梁集群监测系统建设关键技术及实践

广东公路交通 2024年第1期50卷 62-65,71页

作者：魏斌许肇峰吴益林王迎军广东交科检测有限公司广东广州510550 广东华路交通科技有限公司广东广州510420 东南大学江苏南京211189 广东省交通集团有限公司广东广州510623

桥梁健康监测是防范结构运行风险、提升养护管理和应急处置水平的重要举措之一,国家和行业政策对于桥梁结构健康监测系统建设提出了明确的要求。以广东交通集团路网节点桥梁集群监测系统为例,介绍了路网级桥梁监测系统的技术路线、总体... 详细信息

桥梁健康监测是防范结构运行风险、提升养护管理和应急处置水平的重要举措之一,国家和行业政策对于桥梁结构健康监测系统建设提出了明确的要求。以广东交通集团路网节点桥梁集群监测系统为例,介绍了路网级桥梁监测系统的技术路线、总体架构、关键技术和建设实践,可为地市级、路网级桥梁健康监测系统的构建提供参考。

关键词：桥梁健康监测路网级集群监测船撞监测预警车辆荷载时空分布

Effect of resistant starch supplementation on the diversity and composition of human gut microbiota: A systematic review and meta-analysis

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Food Science and Human Wellness 2024年

作者： Jiaxin xu Haocun Kong Caiming Li Xiaofeng Ban zhaofeng Li Collaborative Innovation Center of Food Safety and Quality Control Jiangnan University School of Food Science and Technology Jiangnan University State Key Laboratory of Food Science and Technology Jiangnan University

Resistant starch (RS) has attracted much researchers’ attention because of its health-beneficial effects. Gut microbiota obviously shapes human health， but the effects of RS supplementation on the changes of human gut microbiota remain unclear. This observational meta-analysis aimed to reveal the effects of RS intake on alpha diversity and composition of gut microbiota through meta-analysis. Two independent authors systematically searched articles from inception until February 2023 on four electronic databases. Twenty-four highly relevant trials were included conforming to Preferred Reporting Items for Systematic reviews and Meta-Analysis protocol， and a total of 816 individuals were included. Significant heterogeneity analyses revealed that RS intake notably decreased Shannon index (WMD: –0.11; 95% CI: –0.21， –0.01)， and stimulated the composition of health promoting bacteria genera， including Bifidobacterium (WMD: 1.75; 95% CI: 0.39， 3.11; WMD: 0.36; 95% CI: 0.04， 0.69)， Faecalibacterium (WMD: 0.70; 95% CI: 0.20， 1.20; ES: 0.91; 95% CI: 0.60， 1.23)， and Prevotella (WMD: 0.35; 95% CI: 0.01， 0.69). Taken together， the present study revealed that changes in the gut microbiota diversity and genera were correlated with RS supplementation， which may contribute to benefits in human health.

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Riverine sulfate sources and behaviors in arid environment,Northwest China:Constraints from sulfur and oxygen isotopes

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Journal of Environmental Sciences 2024年第3期137卷 716-731页

作者： Yifu xu Wenjing Liu Bing xu Zhifang xu Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Innovation Academy for Earth Science Chinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China

The fate of riverine sulfate ion (SO_(4)^(2-)) and its environmental effects in arid environment are difficult to evaluate due to its complicated sources and strongly coupled behaviors with water cycle which is significantly modified by humans.To understand the sulfur cycle in aquatic systems in arid environment,the chemical and sulfur and oxygen isotopic compositions (δ^(34)S_(SO4)and δ^(18)O_(SO4)) of major rivers around the Badain Jaran Desert,northwestern China,were investigated.These rivers had averaged SO_(4)^(2-)content at 1336μmol/L,over 10times higher than the global average.The δ^(34)S_(SO4)and δ^(18)O_(SO4)values ranged from-5.3‰to+11.8‰and+1.6‰to+12.8‰,respectively.The end-member analysis and the inverse model showed that riverine sulfate was mainly derived from evaporites dissolution (0-87%),sulfide oxidation (13%-100%) and precipitation (0-33%),indicating heterogeneity in sulfur sources and behaviors along the river drainage with the lithology variations and climate gradients.Multiple isotopic tools combining with hydro-chemistry compositions could be applied to reveal sulfur cycle in arid environment.Based on the calculation,sulfide oxidation plays the primary role in the headwater and upstream in the Qilian-Mountains area,where sulfide is widely exposed.While the proportion of evaporites dissolution contributing to riverine sulfate is much higher in downstream in a drier environment.Besides,less precipitation and higher temperature can lead to more intensive evaporation,affecting the process of sulfide oxidation and enhancing the rates of evaporites dissolution and sulfate precipitation in the basin.

关键词： Sulfur and oxygen isotopes Source apportionment Inverse model Arid environment Inland rivers Northwestern China