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国外国防工业网络安全态势研究

工业信息安全 2024年第4期 12-17页

作者：黄锋樊伟张兆祺国家工业信息安全发展研究中心北京100040

国际战略竞争日益激化,正将博弈重心转移到网络安全、国防工业等领域。各国将国防工业网络安全视作决定战争胜负的关键,并强调国防工业供应链的网络安全,确保作战能力的生成和维持,随时为危机与冲突做好准备。西方国家认为国防工业供应... 详细信息

国际战略竞争日益激化,正将博弈重心转移到网络安全、国防工业等领域。各国将国防工业网络安全视作决定战争胜负的关键,并强调国防工业供应链的网络安全,确保作战能力的生成和维持,随时为危机与冲突做好准备。西方国家认为国防工业供应链末端承包商存在非密网络安全风险较高、安全认证成本高、缺乏技术保障与资金支持、缺乏网络威胁信息共享等方面的风险。为此,各国采取共享网络威胁信息、制定网络安全标准要求、报告网络安全事件、支持网络研发合作等诸多措施,持续加强国防工业网络弹性。此外,国外国防工业网络安全态势情况也值得高度关注与警惕。

关键词：国防工业网络安全发展态势风险分析

Optimised trajectory tracking control for quadrotors based on an improved beetle antennae search algorithm

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Journal of Control and Decision 2023年第3期10卷 382-392页

作者： Zhe Lin Ping Li zhaoqi zhang College of Information Science and Engineering Huaqiao UniversityXiamenPeople’s Republic of China

This paper focuses on the trajectory tracking of quadrotors under bounded external *** optimised robust controller is proposed to drive the position and attitude ofa quadrotor converge to their references quickly. At first, nonsingular fast terminal slidingmode control is developed, which can guarantee not only the stability but also finite-timeconvergence of the closed-loop system. As the parameters of the designed controllers playa vital role for control performance, an improved beetle antennae search algorithm is proposedto optimise them. By employing the historical information of the beetle’s antennaeand dynamically updating the step size as well as the range of its searching, the optimisingis accelerated considerably to ensure the efficiency of the quadrotor control. The superiorityof the proposed control scheme is demonstrated by simulation experiments, from whichone can see that both the error and the overshooting of the trajectory tracking are reducedeffectively.

关键词： Quadrotor control trajectory tracking nonsingular fast terminal sliding mode control optimisation improved beetle antennae search algorithm

Highly ordered graphene architectures by duplicating melamine sponges as a three-dimensional deformation- tolerant electrode

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Nano Research 2016年第10期9卷 2938-2949页

作者： Le Li Kai Wang zhaoqi Huang Chao zhang Tianxi Liu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials & College of Materials Science and Engineering Donghua University Shanghai 201620 China

In this study, macroscopic graphene-wrapped melamine foams （MF-G） were fabricated by an MF-templated layer-by-layer （LBL） assembly using graphene oxide as building blocks, followed by solution-processed reduction. By concisely duplicating sponge-like, highly ordered three-dimensional architectures from MF, the resulting MF-G with an interconnected graphene-based scaffold and tunable nanostructure was explored as compressible, robust electrodes for efficient energy storage. A thin layer of pseudocapacitive polypyrrole （PPy） was then attached and uniformly coated on MF-G, resulting in a well-defined core- double-shell configuration of the MF-G-PPy ternary composite sponges. The as-assembled devices exhibited enhancement of supercapacitor performance, with a high specific capacitance of 427 F·g-1 under a compressive strain of 75% and an excellent cycling stability with only 18% degradation after 5,000 charge- discharge cycles. Besides, the MF-G-PPy electrode maintained stable capacitance up to 100 compression-release cycles, with a compressive strain of 75%. These encouraging results thus provide a new route towards the low-cost, easily scalable fabrication of lightweight and deformation-tolerant electrodes.

关键词： graphene layer-by-layer self-assembly highly ordered architecture conducting polymer deformation-tolerant electrode

Spaceflight and simulated microgravity suppresses macrophage development via altered RAS/ERK/NFκB and metabolic pathways

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Cellular & Molecular Immunology 2021年第6期18卷 1489-1502页

作者： Lu Shi Hongling Tian Peng Wang Ling Li zhaoqi zhang Jiayu zhang Yong Zhao State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijingChina

Spaceflight-associated immune system weakening ultimately limits the ability of humans to expand their presence beyond the earth's orbit. A mechanistic study of microgravity-regulated immune cell function is necessary to overcome this challenge. Here, we demonstrate that both spaceflight (real) and simulated microgravity significantly reduce macrophage differentiation, decrease macrophage quantity and functional polarization, and lead to metabolic reprogramming, as demonstrated by changes in gene expression profiles. Moreover, we identified RAS/ERK/NFκB as a major microgravity-regulated pathway. Exogenous ERK and NFκB activators significantly counteracted the effect of microgravity on macrophage differentiation. In addition, microgravity also affects the p53 pathway, which we verified by RT-qPCR and Western blot. Collectively, our data reveal a new mechanism for the effects of microgravity on macrophage development and provide potential molecular targets for the prevention or treatment of macrophage differentiation deficiency in spaceflight.

关键词： Microgravity Hematopoietic progenitor cells Macrophage differentiation Macrophage polarization RAS/ERK/NFκB pathway

中医药调控线粒体自噬治疗急性肾损伤的研究进展

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生命的化学 2024年第4期44卷 719-727页

作者：赵幸如张寒吴宇清张钊奇高坤南京中医药大学附属医院南京210029 山东中医药大学济南250355

急性肾损伤(acute kidney injury,AKI)是短时间内肾功能急速下降的临床综合征,主要由缺血再灌注损伤、脓毒症、造影剂或顺铂等药物引起。肾脏作为人体的高耗能器官,内含丰富的线粒体,并发展出多种精细的质量调控机制以维持线粒体稳态。... 详细信息

急性肾损伤(acute kidney injury,AKI)是短时间内肾功能急速下降的临床综合征,主要由缺血再灌注损伤、脓毒症、造影剂或顺铂等药物引起。肾脏作为人体的高耗能器官,内含丰富的线粒体,并发展出多种精细的质量调控机制以维持线粒体稳态。线粒体自噬(mitophagy)便是其中一种热点机制,可以选择性清除受损的线粒体,维持细胞正常的结构与功能,亦可参与肾组织的炎症、氧化应激和细胞凋亡等过程。中医理论认为,肾失气化,浊毒瘀滞是AKI发生发展的内在机制。中医药调控线粒体自噬以达“阴阳平衡”作为AKI的治疗靶点具有潜在前景。本文综述了线粒体自噬在各种病因所致AKI中的调控机制,对中医药靶向线粒体自噬,防止其抑制或过度激活以治疗AKI的研究现状进行总结和展望,旨在为AKI治疗的提供新方向。

关键词：急性肾损伤线粒体自噬线粒体稳态中药

Experimental research on the influence of temperature on the discharge signal of void defects in GIS

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High Voltage 2022年第2期7卷 314-324页

作者： zhaoqi zhang Hui Song Xianglin Meng Gehao Sheng Xiuchen Jiang Department of Electrical Engineering Shanghai Jiao Tong UniversityShanghaiChina

Temperature is an important environmental factor during the operation of gas‐insulated switchgear(GIS),affecting the evaluation results of the GIS equipment to increase the risk of the power ***,the influence of temperature on the partial discharge detection signal of GIS is still *** at the common void defects in GIS,the law of change on the number of ultrahigh‐frequency(UHF)pulses,the UHF amplitude,the characteristic value of the UHF map,and the maximum apparent charge of a single pulse with temperature are obtained using the UHF method and IEC60270,and corresponding theoretical analysis is carried *** results show that an increase in temperature leads to a decrease in the void discharge delay time,causing an increase in UHF pulses and a decrease in the apparent charge of a single discharge pulse in the *** in-crease of temperature makes the void discharge current rise quickly so that the induced UHF amplitude *** the range of 40-70℃,the maximum pulse amplitude in-creases by approximately 30%for every 10℃ increase,and the average pulse amplitude increases by approximately 12%.The result of UHF signals affected by temperature obtained in this study has research significance for the realisation of a comprehensive evaluation of the insulation state of GIS equipment considering temperature.

关键词： signal apparent insulation

北京市属医院住院医嘱点评审核工作现状调查与分析

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中国药房 2024年第10期35卷 1266-1270页

作者：所伟王悦陈亮张兆琦古浩璁罗小军王文凤首都医科大学附属北京安贞医院药事部北京100029 北京市医院管理中心药事处北京100053 首都医科大学附属北京朝阳医院物资器械中心北京100043

目的调研北京市属医院住院医嘱点评审核工作现状,为进一步完善相关工作提出对策建议。方法通过问卷调查法调查北京22家市属医院的住院医嘱点评审核工作现状,对调查结果进行统计分析。结果共发放问卷22份,问卷回收率和有效率均为100%。2... 详细信息

目的调研北京市属医院住院医嘱点评审核工作现状,为进一步完善相关工作提出对策建议。方法通过问卷调查法调查北京22家市属医院的住院医嘱点评审核工作现状,对调查结果进行统计分析。结果共发放问卷22份,问卷回收率和有效率均为100%。22家医院均开展了住院医嘱点评工作,但各医院住院医嘱点评比例不尽相同(0.88%~98.54%);点评药品主要集中在抗菌药物、质子泵抑制剂、麻醉药品/第一类精神药品、辅助用药等品类;205名药师参加了住院医嘱点评工作,大部分具有中级及以上职称(89.27%);21家医院将住院医嘱点评结果向相关科室或责任人进行了反馈,但干预情况不尽相同。18家医院开展了住院医嘱审核工作,审核的药品品类与医嘱点评药品品类大致相同,审核内容包括给药途径、给药剂量等的适宜性,主要采取审核软件和药师人工配合的审核方式。结论北京市属医院住院医嘱点评和审核工作有序开展,取得了初步成效;但也需要进一步提升医嘱点评审核药师的工作能力、完善点评审核规范、优化审核软件,通过医药协同促进住院患者合理用药。

关键词：医嘱审核医嘱点评药师合理用药

Wip1 inhibits neutrophil extracellular traps to promote abscess formation in mice by directly dephosphorylating Coronin-1a

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Cellular & Molecular Immunology 2023年第8期20卷 941-954页

作者： Yifang Chen Chenxu Zhao Han Guo Weilong Zou zhaoqi zhang Dong Wei Hezhe Lu Lianfeng zhang Yong Zhao State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina Beijing Institute for Stem Cell and Regeneration BeijingChina Department of Hepatobiliary Surgery The Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhouChina Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhenChina Key Laboratory of Human Diseases Comparative Medicine Ministry of Health Institute of Laboratory Animal Science Chinese Academy of Medical SciencesBeijingChina

Neutrophil extracellular traps (NETs) participate in the rapid inhibition and clearance of pathogens during infection;however, the molecular regulation of NET formation remains poorly understood. In the current study, we found that inhibition of the wild-type p53-induced phosphatase 1 (Wip1) significantly suppressed the activity of Staphylococcus aureus (S. aureus) and accelerated abscess healing in S. aureus-induced abscess model mice by enhancing NET formation. A Wip1 inhibitor significantly enhanced NET formation in mouse and human neutrophils in vitro. High-resolution mass spectrometry and biochemical assays demonstrated that Coro1a is a substrate of Wip1. Further experiments also revealed that Wip1 preferentially and directly interacts with phosphorylated Coro1a than compared to unphosphorylated inactivated Coro1a. The phosphorylated Ser426 site of Coro1a and the 28–90 aa domain of Wip1 are essential for the direct interaction of Coro1a and Wip1 and for Wip1 dephosphorylation of p-Coro1a Ser426. Wip1 deletion or inhibition in neutrophils significantly upregulated the phosphorylation of Coro1a-Ser426, which activated phospholipase C and subsequently the calcium pathway, the latter of which promoted NET formation after infection or lipopolysaccharide stimulation. This study revealed Coro1a to be a novel substrate of Wip1 and showed that Wip1 is a negative regulator of NET formation during infection. These results support the potential application of Wip1 inhibitors to treat bacterial infections.

关键词： Wild-type p53-induced phosphatase 1(Wip1) Coro1a Calcium pathway Neutrophils Neutrophil extracellular trap(NET) Abscess

Coordinated Restoration Method for Electric Buses and Network Reconfigurations in Distribution Systems Under Extreme Events

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CSEE Journal of Power and Energy Systems 2024年第5期10卷 1994-2003页

作者： Bo zhang Lu zhang Wei Tang zhaoqi Wang Chen Wang China Agricultural University Beijing 100083China State Grid Energy Research Institute Co.Ltd Beijing 102209China State Grid Beijing Electric Power Research Institute Beijing 100075China

Distribution systems are facing challenges in serving lifeline loads after extreme *** reconfiguration is a traditional and practical method for power supply restoration,which has strong but inflexible power transfer capabilities influenced by network *** failures of utility power under extreme events will further limit the efficiency of network *** buses(EBs)can be utilized to achieve power supply considering their discharging capabilities as mobile storage ***,the mobility of EBs and the influences of transport systems must be carefully considered to enhance the resilience of distribution *** and EBs are complementary in terms of recovery capabilities and location flexibility,and more important loads can be recovered by the coordination between EBs and network *** paper proposes a coordinated restoration method for EBs and reconfigurations considering the influences of transport *** post-disaster restoration problem is formulated as a bi-level model,in which the network topology is optimized in the upperlevel aiming at maximizing restoration loads through the main grid and EBs,while the traffic paths of all EBs are optimized with the goal of maximizing the restoration loads by the EBs in the lower-level considering time consumption and energy consumption during *** PSO and a genetic algorithm are used to solve the proposed bi-level optimization *** studies are performed to verify the superiority of the proposed method.

关键词： Distribution system electric bus extreme event network reconfiguration restoration transport system