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Journal of Environmental Sciences 2012年第5期24卷 834-839页

作者： Changwei zhao Yong Yan Deyin hou zhaokun Luan Zhiping Jia Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China

A method of direct contact membrane distillation （DCMD） with a self-made hollow polyvinylidene fluoride membrane was applied to prepare high concentration polyaluminum chloride （PACl） with high Alb content based on chemical synthesis. The permeate flux and Al species distribution were investigated. The experimental results showed that the permeate flux decreased from 14 to 6 kg/（m2·hr） at the end of the DCMD process, which can be mainly attributed to the formation of NaCl deposits on the membrane surface. The Alb content decreased slightly, only from 86.3% to 84.4%, when the DCMD experiment finished, correspondingly the Alc content increased slightly from 7.2% to 8.5%, and the Ala content remained at 7% during the whole DCMD process. A PACl with Alb content of 84% at total aluminum concentration 2.2 mol/L was successfully prepared by the chemical synthesis-DCMD method.

关键词： polyaluminum chloride membrane distillation high concentration high Alb content PVDF hollow fiber membrane

Biomimetic melatonin-loaded silk fibroin/GelMA scaffold strengthens cartilage repair through retrieval of mitochondrial functions

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Journal of Materials Science & Technology 2023年第15期146卷 102-112页

作者： Mingzhuang hou Yijian Zhang Yang Liu Xiaoyang Ge Xiayu Hu Zhijian zhao xin Tian Tao Liu Huilin Yang Xi Chen Fan He Xuesong Zhu Department of Orthopaedics The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Orthopaedic Institute Medical CollegeSoochow UniversitySuzhou 215007China Department of Pathology The Third Affiliated Hospital of Soochow UniversityChangzhou 213003China

Articular cartilage injury induced by collision or trauma is a common sports-related condition that may progress to pain,dysfunction,and secondary osteoarthritis(OA).Limited by self-renewal potential,cartilage regeneration faces a quandary while bio-inspired novel strategies are urgently *** this study,by a soft freezing method and surface modification technique,a multi-functional silk fibroin(SF)plus gelatin methacrylate(GelMA)scaffold laden with melatonin(MT)was ***-GelMA@MT scaffold demonstrated enhanced biomechanical characteristics and long-acting melatonin *** vitro treatment with SF-GelMA@MT induced the synthesis of cartilage extracellular matrix(ECM)***,sustained release of melatonin yielded robust chondroprotective effects via improving mitochondrial polarization and antioxidant ***-GelMA@MT implantation boosted cartilage renascence in a full-thickness cartilage defect model via mitochondria-associated sirtuins 1(SIRT1)-superoxide dismutase 2(SOD2)signaling pathway in *** summary,this research proposed a welldesigned bionic composite scaffold that promotes cartilage regeneration via mitochondrial function enhancement,which is of tremendous potential for cartilage tissue engineering.

关键词： Cartilage injury Silk fibroin Gelatin methacrylate Melatonin Mitochondri

Finite element modeling of macrosegregation coupled with shrinkage cavity in steel ingots using arbitrary Lagrangian-Eulerian model

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China Foundry 2019年第5期16卷 291-299页

作者： Kang-xin Chen Hao Shi hou-fa Shen Key Laboratory for Advanced Materials Processing Technology Ministry of EducationSchool of Materials Science and Engineering Tsinghua University

Shrinkage cavity has significant influence on macrosegregation in steel ingots. An arbitrary Lagrangian-Eulerian (ALE) model based on volume averaging method is developed to predict the coupled formation progress of macrosegregation and shrinkage cavity during solidification of steel ingots. The combined effect of thermal-solutal convection and solidification shrinkage on macrosegregation is considered in the model. A specially designed mesh update algorithm is proposed to consider the formation of shrinkage cavity. The streamline-upwind/Petrov–Galerkin (SUPG) stabilized finite element algorithm is adopted to solve the conservation equations. Two solution methods for the energy conservation equation are proposed, i.e. the temperature-based solver and enthalpy-based solver. A Pb-48wt.%Sn solidification benchmark is used for validation. Then, the ALE model is applied to a Fe-3.6wt.%C industrial steel ingot. The formation progress of macrosegregation coupled with shrinkage cavity is predicted. By comparison with the predictions of the finite element model and finite volume model, the effect of shrinkage cavity formation on macrosegregation is investigated. Results show that the formation of shrinkage cavity can significantly change the segregation region and segregation degree at the hot top. It is demonstrated that the ALE model can predict the coupled formation of macrosegregation and shrinkage cavity in steel ingots.

关键词： steel ingot macrosegregation shrinkage cavity ALE model finite element modeling

Associations of genome-wide structural variations with phenotypic differences in cross-bred Eurasian pigs

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Journal of Animal Science and Biotechnology 2024年第1期15卷 68-87页

作者： Wencheng Zong Jinbu Wang Runze zhao Naiqi Niu Yanfang Su Ziping Hu xin Liu xinhua hou Ligang Wang Lixian Wang Longchao Zhang State Key Laboratory of Animal Biotech Breeding Institute of Animal SciencesChinese Academy of Agricultural SciencesBeijing 100193China College of Animal Science Shanxi Agricultural UniversityJinzhong 030801China College of Animal Science and Technology Qingdao Agricultural UniversityQingdao 266109China

Background During approximately 10,000 years of domestication and selection,a large number of structural variations(SVs)have emerged in the genome of pig breeds,profoundly influencing their phenotypes and the ability to adapt to the local ***(≥50 bp)are widely distributed in the genome,mainly in the form of insertion(INS),mobile element insertion(MEI),deletion(DEL),duplication(DUP),inversion(INV),and translocation(TRA).While studies have investigated the SVs in pig genomes,genome-wide association studies(GWAS)-based on SVs have been rarely *** Here,we obtained a high-quality SV map containing 123,151 SVs from 15 Large White and 15 Min pigs through integrating the power of several SV tools,with 53.95%of the SVs being reported for the first *** high-quality SVs were used to recover the population genetic structure,confirming the accuracy of *** functional SV loci were then identified based on positional effects and breed ***,GWAS were performed for 36 traits by genotyping the screened potential causal loci in the F2 population according to their corresponding genomic *** identified a large number of loci involved in 8 carcass traits and 6 skeletal traits on chromosome 7,with FKBP5 containing the most significant SV locus for almost all *** addition,we found several significant loci in intramuscular fat,abdominal circumference,heart weight,and liver weight,*** We constructed a high-quality SV map using high-coverage sequencing data and then analyzed them by performing GWAS for 25 carcass traits,7 skeletal traits,and 4 meat quality traits to determine that SVs may affect body size between European and Chinese pig breeds.

关键词： Body size GWAS Pig Skeleton Structural variations

Ethylene-induced nitric oxide production and stomatal closure in Arabidopsis thaliana depending on changes in cytosolic pH

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Chinese Science Bulletin 2010年第22期55卷 2403-2409页

作者： LIU Jing LIU GuoHua hou LiXia LIU xin Life Sciences College Qingdao Agricultural University Qingdao 266109 China

We investigated changes in cytosolic pH and nitric oxide (NO) during ethylene-induced stomatal closure in Arabidopsis thaliana using pharmacological, laser scanning confocal microscopy (LSCM), and spectrophotography techniques. Treatment with ethephon (a direct source of ethylene when applied to plants) and 1-aminocycloaminopropane-1-carboxylic acid (ACC, an ethylene precursor) resulted in a rapid accumulation of NO and cytosolic alkalinization in guard cells. Acetic acid (a weak acid) and sodium orthovanadate (NaVO3; a plasmalemma H+-ATPase inhibitor) reduced stomatal closure induced by ethylene and blocked ethylene-induced activity of nitrate reductase. However, 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (cPTIO), a NO scavenger, had no effect. These results suggest that NO production is downstream of the rise in cytosolic pH in A. thaliana.

关键词：气孔关闭一氧化氮乙烯利 pH值细胞内拟南芥诱导激光扫描共聚焦显微镜

Hydraulic Optimization of a Double-channel Pump's Impeller Based on Multi-objective Genetic Algorithm

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Chinese Journal of Mechanical Engineering 2015年第3期28卷 634-640页

作者： zhao Binjuan WANG Yu CHEN Huilong QIU Jing hou Duohua School of Energy and Power Engineering Jiangsu University Shanghai Kaiquan Pump (Goup) Co. Ltd

Computational fluid dynamics（CFD） can give a lot of potentially very useful information for hydraulic optimization design of pumps, however, it cannot directly state what kind of modification should be made to improve such hydrodynamic performance. In this paper, a more convenient and effective approach is proposed by combined using of CFD, multi-objective genetic algorithm（MOGA） and artificial neural networks（ANN） for a double-channel pump＇s impeller, with maximum head and efficiency set as optimization objectives, four key geometrical parameters including inlet diameter, outlet diameter, exit width and midline wrap angle chosen as optimization parameters. Firstly, a multi-fidelity fitness assignment system in which fitness of impellers serving as training and comparison samples for ANN is evaluated by CFD, meanwhile fitness of impellers generated by MOGA is evaluated by ANN, is established and dramatically reduces the computational expense. Then, a modified MOGA optimization process, in which selection is performed independently in two sub-populations according to two optimization objectives, crossover and mutation is performed afterword in the merged population, is developed to ensure the global optimal solution to be found. Finally, Pareto optimal frontier is found after 500 steps of iterations, and two optimal design schemes are chosen according to the design requirements. The preliminary and optimal design schemes are compared, and the comparing results show that hydraulic performances of both pumps 1 and 2 are improved, with the head and efficiency of pump 1 increased by 5.7% and 5.2%, respectively in the design working conditions, meanwhile shaft power decreased in all working conditions, the head and efficiency of pump 2 increased by 11.7% and 5.9%, respectively while shaft power increased by 5.5%. Inner flow field analyses also show that the backflow phenomenon significantly diminishes at the entrance of the optimal impellers 1 and 2, both the area of vort

关键词： double-channel pump's impeller multi-objective genetic algorithm artificial neural network computational fluid dynamics(CFD) uni

Adsorption of 2-mercaptobenzothiazole from aqueous solution by organo-bentonite

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Journal of Environmental Sciences 2013年第6期25卷 1139-1144页

作者： Ping Jing Meifang hou Ping zhao Xiaoyan Tang Hongfu Wan South China Botanical Garden Chinese Academy of Sciences Graduate School of Chinese Academy of Sciences School of Ecological Technology and Engineering Shanghai Institute of Technology Guangdong Key Laboratory of Agricultural Environment Pollution Integrated Control Guangdong Institute of Eco-environmental and Soil Sciences

The adsorption behavior of 2-mercaptobenzothiazole onto organo-bentonite was investigated. Natural bentonite from Gaozhou in Guangdong Province, China was collected. Organo-bentonite was prepared by intercalation of cetyltrimethyl ammonium bromide into the natural bentonite. The physicochemical properties of the prepared organo-bentonite were characterized by X-ray diffraction, N2 adsorption-desorption isotherm and Fourier transform infrared spectroscopy. The results showed that montmorillonite is the main component of the natural bentonite. The basal spacing of the natural bentonite is 1.47 nm, which increased to 1.98 nm on intercalation with cetyltrimethyl ammonium bromide. Moreover, both the surface area and pore volume increased with intercalation. Clear CH2 stretching （3000-2800 cm-1） and scissoring （1480-1450 cm-1） modes of the intercalated surfactants were observed for organo- bentonite. Compared with the pseudo first-order kinetic model, the pseudo second-order kinetic model is more suitable to describe the adsorption kinetics of 2-mercaptobenzothiazole onto organo-bentonite. The adsorption capacity of 2-mercaptobenzothiazole onto organo-bentonite increased with increasing initial concentration of 2-mercaptobenzothiazole, but decreased with increasing adsorbent dosage. The adsorption isotherm of 2-mercaptobenzothiazole onto organo-bentonite fits well with the Langmuir model. The maximum adsorption capacity of organo-bentonite for 2-mercaptobenzothiazole was 33.61 mg/g, indicating that organo-bentonite is a promising adsorbent for 2-mercaptobenzothiazole.

关键词： 2-mercaptobenzothiazole bentonite intercalation adsorption

Estimation of inbreeding and identification of regions under heavy selection based on runs of homozygosity in a Large White pig population

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Journal of Animal Science and Biotechnology 2020年第4期11卷 965-974页

作者： Liangyu Shi Ligang Wang Jiaxin Liu Tianyu Deng Hua Yan Longchao Zhang xin Liu Hongmei Gao xinhua hou Lixian Wang Fuping zhao Key Laboratory of Animal Genetics Breeding and Reproduction(poultry)of Ministry of AgricutureInstitute of Animal SciencesChinese Academy of Agricultural SciencesBeijing 100193China

Background: Runs of homozygosity(ROHs) are homozygous segments of the genome where the two haplotypes inherited from the parents are identical. The current availability of genotypes for a very large number of single nucleotide polymorphisms(SNPs) is leading to more accurate characterization of ROHs in the whole genome. Here,we investigated the occurrence and distribution of ROHs in 3,692 Large White pigs and compared estimates of inbreeding coefficients calculated based on ROHs(FROH), homozygosity(FHOM), genomic relationship matrix(FGRM)and pedigree(FPED). Furthermore, we identified genomic regions with high ROH frequencies and annotated their candidate ***: In total, 176,182 ROHs were identified from 3,569 animals, and all individuals displayed at least one ROH longer than 1 Mb. The ROHs identified were unevenly distributed on the autosomes. The highest and lowest coverages of Sus scrofa chromosomes(SSC) by ROH were on SSC14 and SSC13, respectively. The highest pairwise correlation among the different inbreeding coefficient estimates was 0.95 between FROH_totaland FHOM, while the lowest was-0.083 between FGRMand FPED. The correlations between FPEDand FROHusing four classes of ROH lengths ranged from 0.18 to 0.37 and increased with increasing ROH length, except for ROH > 10 Mb. Twelve ROH islands were located on four chromosomes(SSC1, 4, 6 and 14). These ROH islands harboured genes associated with reproduction, muscular development, fat deposition and adaptation, such as SIRT1, MYPN, SETDB1 and ***: FROHcan be used to accurately assess individual inbreeding levels compared to other inbreeding coefficient estimators. In the absence of pedigree records, FROHcan provide an alternative to inbreeding *** findings can be used not only to effectively increase the response to selection by appropriately managing the rate of inbreeding and minimizing the negative effects of inbreeding depression but also to help detect genomic regions with an

关键词： Candidate genes Inbreeding coefficients Runs of homozygosity Sus scrofa

Adaptive nonuniformity correction for IRFPA sensors based on neural network framework

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Journal of Systems Engineering and Electronics 2012年第4期23卷 618-624页

作者： Junqi Bai Hongyi hou Chunguang zhao Ning Sun Xianya Wang The 28th Institute of China Electronics Technology Group Corporation Nanjing 210007 R R. China Department of Mathematics Nanjing University Nanjing 210093 E R. China School of Electronic Engineering and Optoelectronic Technique Nanjing University of Science and Technology Nanjing 210094 P. R. China

For infrared focal plane graded during signal acquisition array sensors, imagery is departicularly nonuniformity. In this paper, an adaptive nonuniformity correction technique is proposed which simultaneously estimates detector-level and readout- channel-level correction parameters using neural network approaches. Firstly, an improved neural network framework is designed to compute the desired output. Secondly, an adaptive learning rate rule is used in the gain and offset parameter estimation process. Experimental results show the proposed algorithm can achieve a faster convergence speed and better stability, remove nonuniformity and track parameters drift effectively, and present a good adaptability to scene changes and nonuniformity conditions.

关键词： infrared focal plane array nonuniformity correction,neural network (NN) least mean square (LMS).

Longitudinal Compression Behavior of Functionally Graded Ti–6Al–4V Meshes

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Journal of Materials Science & Technology 2016年第11期32卷 1098-1104页

作者： Shangzhou Zhang Cong Li Wentao hou Shuo zhao Shujun Li School of Environmental and Materials Engineering Yantai University Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences

The compressive deformation behavior in the longitudinal direction of graded Ti–6Al–4V meshes fabricated by electron beam melting was investigated using experiments and finite element methods（FEM）.The results indicate that the overall strain along the longitudinal direction is the sum of the net strain carried by each uniform mesh constituent and the deformation behavior fits the Reuss model well. The layer thickness and the sectional area have no effect on the elastic modulus, whereas the strength increases with the sectional area due to the edge effect of each uniform mesh constituent. By optimizing3 D graded/gradient design, meshes with balanced superior properties, such as high strength, energy absorption and low elastic modulus, can be fabricated by electron beam melting.

关键词： Graded Ti–6Al–4V meshes Electron beam melting Reuss model Compressive deformation Edge effect