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Detection of Ultra Trace Amount Gossypol with Chemiluminescence Using Capillary Electrophoresis as Injection Techniques

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Chinese Chemical Letters 2005年第12期16卷 1649-1651页

作者： Er Bao liu Min ZHANG Bing Chun XUE Peng xiang zhao Yin liu School of Chemistry and Life Sciences Tianjin Normal University Tianjin 300074

Detection of ultra trace amount gossypol is reported. It is based on luminolhexacyanoferrate（Ⅲ） chemiluminescence reaction with gossypol as a sensitizer. The detection limit （3 σ ）of gossypol reaches 5.21 × 10^... 详细信息

关键词： Capillary electrophoresis chemiluminescence gossypol

Analysis of Process Control Model of Plate MAS Rolling

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Journal of Iron and Steel Research International 2010年第4期17卷 31-33页

作者： ZHU Fu-wen HU Xian-lei zhao Zhong liu xiang-hua State Key Laboratory of Rolling Technology and Automation Northeastern University Shenyang 110004 Liaoning China

Using the identification quantity to identify the long ear disfigurement was brought up, and by calculation, it can be found that identification quantity should be set as the quantity of long ear disfigurement of the position which is about 0. 2 times of plate width to the plate border. Conception of plate head tiny cell was brought up, and the long ear disfigurement was uncoupled into the product of elongation percentage and length of tiny cell. On the basis of prediction of long ear disfigurement, process control model of MAS rolling was built up, and application indicates that it can fit the on-line production and eliminate the long ear disfigurement commendably.

关键词： plate plane shape plan view pattern MAS rolling long ear disfigurement head disfigurement

Optimization of Holding Temperature and Holding Thickness for Controlled Rolling on Plate Mill

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Journal of Iron and Steel Research International 2006年第3期13卷 21-25页

作者： HU Xian-lei zhao Zhong WANG Jun WANG zhao-dong liu xiang-hua WANG Guo-dong State Key Laboratory of Rolling and Automation Northeastern University Shenyang 110004 Liaoning China

Holding temperature and holding thickness are main parameters for two-phase controlled rolling on plate mill. The optimization of holding temperature and holding thickness for pass schedule calculation of two-phase controlled rolling on plate mill was presented and its feature is as follows：（1） Determination of holding thickness can be automatically obtained based on the influence of mill safety limits, tracking zone length and holding time on holding thickness; （2） Determination of holding temperature can be automatically obtained and the holding time can be reduced as much as possible; （3） Algorithm can modify the holding temperature and thickness depending on slab size and product size.

关键词： plate two-phase controlled rolling pass schedule holding temperature holding thickness

Calculation of Taper Rolling Time in Plan View Pattern Control Process

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Journal of Iron and Steel Research International 2006年第5期13卷 1-3页

作者： JIAO Zhi-jie HU Xian-lei zhao Zhong liu xiang-hua WANG Guo-dong State Key Laboratory of Rolling and Automation Northeastern University Shenyang 110004 Liaoning China

The forward slip model with adhesion was used to derive the formula of calculating taper rolling time. The relation between the rolling time and the taper length and the relation between the rolling time and the taper thickness can be obtained. The numerical solution for this formula was used on site. According to the simulation result, the roll gap value should be changed linearly with rolling time.

关键词： plan view pattern control forward slip model taper time calculation

Derivation of Simplified Models of Plan View Pattern Control Function for Plate Mill

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Journal of Iron and Steel Research International 2007年第4期14卷 20-23页

作者： JIAO Zhi-jie HU Xian-lei zhao Zhong liu xiang-hua WANG Guo-dong State Key Laboratory of Rolling and Automation Northeastern University Shenyang 110004 Liaoning China

The plan view pattern control theoretical models were simplified. Under the condition of constant volume for the plan view pattern compensation, the relation between the thickness and the length can be simplified to the linearity in the segment for the plan view pattern control function. The compensation volume can be dispersed for easy calculation. By comparing the model calculation result with the actual result, it was concluded that the simplified model can be used for the online control process.

关键词： plan view pattern control theoretical model simplified model

Prevalence of gene mutations in a Chinese 46,XY disorders of sex development cohort detected by targeted next-generation sequencing

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Asian Journal of Andrology 2021年第1期23卷 69-73页

作者： Bing-Qing Yu zhao-xiang liu Yin-Jie Gao Xi Wang Jiang-Feng Mao Min Nie Xue-Yan Wu NHC Key Laboratory of Endocrinology Department of EndocrinologyPeking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100730China

46,XY disorders of sex development(DSD)is characterized by incomplete masculinization genitalia,with gonadal dysplasia and with/without the presence of Mullerian *** least 30 genes related to 46,XY DSD have been ***,the clinical phenotypes of patients with different gene mutations overlap,and accurate diagnosis relies on gene sequencing ***,this study aims to determine the prevalence of pathogenic mutations in a Chinese cohort with 46,XY DSD by the targeted nextgeneration sequencing(NGS)***-seven 46,XY DSD patients were enrolled from the Peking Union Medical College Hospital(Beijing,China).A total of fifty-four rare variants were identified in 60 patients with 46,XY *** incidence of these rare variants was approximately 69.0%(60/87).Twenty-five novel variants and 29 reported variants were *** on the American College of Medical Genetics and Genomics(ACMG)guidelines,thirty-three variants were classified as pathogenic or likely pathogenic variants and 21 variants were assessed as variants of uncertain *** overall diagnostic rate was about 42.5%based on the pathogenic and likely pathogenic *** receptor{AR),steroid 5-alpha-reductase 2(SRD5A2)and nuclear receptor subfamily 5 Group A member 1(NR5A1)gene variants were identified in 21,13 and 13 patients,*** incidence of these three gene variants was about 78.3%(47/60)in patients with rare *** is concluded that targeted NGS is an effective method to detect pathogenic mutations in 46,XY DSD patients and AR,SRD5A2,and NR5A1 genes were the most common pathogenic genes in our cohort.

关键词： 46,XY disorders of sex development mutations targeted next-generation sequencing

Two-state energy model and experimental study of coal adsorb methane

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Journal of Coal Science & Engineering(China) 2013年第4期19卷 488-492页

作者： Zeng-Chao FENG Dong zhao Zhi-xiang liu Yan-Qi WANG Hong-Qiang GOU Mining Technology Institute Taiyuan University of Technology Taiyuan 030024 China

There are two states of methane existing in coal, free methane and adsorptive methane. The two states of methane exchanged with each other which need the energy exchange with outside. It is released heat when methane adsorption on coal, instead of absorbed heat. According to the gas molecules Boltzmann energy distribution, is obtained the equilibrium equations of the two states of methane in coal, as well as the heat of adsorption equation when exchanged into each other. At the same time, high temperature experiments of methane adsorption on coal have been certificated to the theoretical model. At last the experimental results presented that： the two-state energy model could be accurately described the distribution of the two states of methane in the coal; the adsorption heat is related to the initial equilibrium state of methane adsorption; the adsorption heats are different with different coal ranks.

关键词： two-state energy model adsorption heat chemical potential experimental study

Predictive factors for pituitary response to pulsatile GnRH therapy in patients with congenital hypogonadotropic hypogonadism

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Asian Journal of Andrology 2018年第4期20卷 319-323页

作者： Jiang-Feng Mao Xi Wang Jun-Jie Zheng zhao-xiang liu Hong-Li Xu Bing-Kun Huang Min Nie Xue-Yan Wu Department of Endocrinology Peking Union Medical College Hospital Key Laboratory of Endocrinology Ministry of Health Beijing 100730 China

Pulsatile gonadotropin-releasing hormone （GnRH） may induce spermatogenesis in most patients with congenital hypogonadotropic hypogonadism （CHH） by stimulating gonadotropin production, while the predictors for a pituitary response to pulsatile GnRH therapy were rarely investigated. Therefore, the aim of our study is to investigate predictors of the pituitary response to pulsatile GnRH therapy. This retrospective cohort study included 82 CHH patients who received subcutaneous pulsatile GnRH therapy for at least 1 month. Patients were categorized into poor or normal luteinizing hormone （LH） response subgroups according to their LH level （LH 〈2 IU 1-1 or LH P_2 IU 1-1） 1 month into pulsatile GnRH therapy. Gonadotropin and testosterone levels, testicular size, and sperm count were compared between the two subgroups before and after GnRH therapy. Among all patients, LH increased from 0.4±0.5 IUI^-1 to 7.5±4.4 IUI^-1 and follicle-stimulating hormone （FSH） increased from 1.1±0.9 IUI^-1 to 8.8±5.3 IU 1-1. A Cox regression analysis showed that basal testosterone level （6 = 0.252, P = 0.029） and triptorelin-stimulated FSH60min（13 = 0.518, P = 0.01） were two favorable predictors for pituitary response to GnRH therapy. Nine patients （9/82, 11.0%） with low LH response to GnRH therapy were classified into the poor LH response subgroup. After pulsatile GnRH therapy, total serum testosterone level was 39± 28 ng dl^-1 versus 248±158 ng d1^-1 （P=0.001）, and testicular size was 4.0±3.1 ml versus 7.9±4.5 ml （P= 0.005） in the poor and normal LH response subgroups, respectively. It is concluded that higher levels of triptorelin-stimulated FSH60min. and basal total serum testosterone are favorable predictors of pituitary LH response to GnRH therapy.

关键词： congenital hypogonadotropic hypogonadism pulsatile GnRH therapy treatment

Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan zhao Yidan Zhang Xin liu Jian Zhang Ya Gao Shuyue Li Cui Chang xiang liu Guofeng Yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-Yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein