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Epigenetic regulation of the inflammatory response in stroke

Neural Regeneration Research 2025年第11期20卷 3045-3062页

作者： Jingyi liang fei Yang Zixiao Li Qian Li School of Basic Medical Sciences Capital Medical UniversityBeijingChina Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Laboratory for Clinical Medicine Beijing Key Laboratory of Neural Regeneration and RepairCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina Department of Biochemistry and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Beijing Key Laboratory of Cancer Invasion and Metastasis Research Capital Medical UniversityBeijingChina

Stroke is classified as ischemic or hemorrhagic,and there are few effective treatments for either *** mechanisms play a critical role in secondary brain injury following a stroke,which manifests as cytokine release,blood–brain barrier disruption,neuronal cell death,and ultimately behavioral *** the inflammatory response has been shown to mitigate this cascade of events in experimental stroke ***,in clinical trials of anti-inflammatory agents,longterm immunosuppression has not demonstrated significant clinical benefits for *** may be attributable to the dichotomous roles of inflammation in both tissue injury and repair,as well as the complex pathophysiologic inflammatory processes in *** acute harmful inflammatory responses or inducing a phenotypic shift from a pro-inflammatory to an anti-inflammatory state at specific time points after a stroke are alternative and promising therapeutic *** agents that can modulate inflammation requires a detailed understanding of the inflammatory processes of ***,epigenetic reprogramming plays a crucial role in modulating post-stroke inflammation and can potentially be exploited for stroke *** this review,we summarize current findings on the epigenetic regulation of the inflammatory response in stroke,focusing on key signaling pathways including nuclear factor-kappa B,Janus kinase/signal transducer and activator of transcription,and mitogen-activated protein kinase as well as inflammasome *** also discuss promising molecular targets for stroke *** evidence to date indicates that therapeutic targeting of the epigenetic regulation of inflammation can shift the balance from inflammation-induced tissue injury to repair following stroke,leading to improved post-stroke outcomes.

关键词： DNA methylation histone modification intracerebral hemorrhage ischemic stroke neuroinflammation neuroprotection non-coding RNA RNA methylation subarachnoid hemorrhage treatment

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Precise gradient separation of nanoparticles using reduced graphene oxide-polyoxomolybdate membranes

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Science China Chemistry 2025年第1期68卷 209-216页

作者： Yixin Yang Wanlei zhao Ruoxuan Zheng Hongqiang Li Wei Chen Yu-fei Song State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China Quzhou Institute for Innovation in Resource Chemical Engineering Quzhou 324000China

The purification and size sieving of nanoparticles(NPs)represents a significant scientific ***,the rGO-polyoxometalates(POMs=PMo_(12),Mo_(132)and Mo_(368))membranes were fabricated successfully via a simple and scalable POMsassisted in-situ photoreduction *** the mass ratio of rGO to PMo_(12)was 1:30,the resultant rGO-PMo_(12)membranes with highly ordered and uniform nanochannels of 1.0 nm can be obtained,which showed an accurate carbon quantum dots(CQDs)separation with a cut-off size approximately 1.0 *** increase of the size of the interlayered POMs from PMo_(12)(1.0 nm),{Mo132}(2.9 nm)to{Mo_(368)}(3.8 nm),the resultant rGO-PMo_(12),rGO-Mo_(132)and rGO-Mo_(368)exhibited precise gradient separation of CQDs and Au nanoparticles by size exclusion *** results pave a promising way to construct new twodimensional(2D)membranes for highly efficient size-selective separation.

关键词： reduced graphene oxide polyoxometalates membranes gradient separation nanoparticles

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New perspectives on DNA methylation modifications in ocular diseases

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International Journal of Ophthalmology(English edition) 2025年第2期18卷 340-350页

作者： fei-fei Zong Da-Dong Jia Guang-Kun Huang Meng Pan Hao Hu Shi-Yi Song liang Xiao Ru-Weng Wang liang liang The First College of Clinical Medical Science China Three Gorges UniversityDepartment of PathologyYichang Central People’s HospitalYichang 443003Hubei ProvinceChina The Second People’s Hospital of China Three Gorges University the Second People’s Hospital of YichangYichang 443000Hubei ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina Shaanxi University of Chinese Medicine Basic Medical CollegeXianyang 712046Shaanxi ProvinceChina

The methylation of DNA is a prevalent epigenetic modification that plays a crucial role in the pathological progression of ocular *** methylation can regulate gene expression,thereby affecting cell function and signal *** diseases are a kind of complex diseases,and their pathogenesis involves many factors such as genetic,environmental and individual *** addition,inflammation,oxidative stress and lipid metabolism,which abnormal DNA methylation is closely related to,are also considered to be major factors in eye *** current understanding of DNA methylation in eye diseases is becoming more complex and *** addition to the simple suppression of gene expression by hypermethylation,factors such as hypomethylation or demethylation,DNA methylation in non-promoter regions,interactions with other epigenetic modifications,and dynamic changes in DNA methylation must also be ***,although some genes are at abnormal methylation levels,their expression is not significantly changed,which indirectly reflects the complexity of gene *** review aims to summarize and compare some relevant studies,and provide with new ideas and methods for the prevention and treatment of different eye diseases,such as glaucoma,retinoblastoma,and diabetic retinopathy.

关键词： DNA methylation modification epigenetic glaucoma retinoblastoma diabetic retinopathy methylase inhibitors

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Strong absorption in ultra-wide band by surface nano engineering of metallic glass

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Fundamental Research 2025年第1期5卷 307-314页

作者： Fu, Jianan Li, Xin Li, Zhen Sun, fei Wen, Wenxin zhao, Jinlai Ruan, Wenqing Ren, Shuai Zhang, Zhenxuan liang, Xiong Ma, Jiang Shenzhen Key Laboratory of High Performance Nontraditional Manufacturing College of Mechatronics and Control Engineering Shenzhen University Shenzhen 518060 China College of Materials Science and Engineering Shenzhen Key Laboratory of Polymer Science and Technology Guangdong Research Center for Interfacial Engineering of Functional Materials Shenzhen 518060 China

Broadband light absorption is important for applications such as infrared detectors, solar energy collectors, and photothermal conversion. We propose a facile and common strategy to fabricate light absorbers with strong ultra-wideband absorption. Due to their excellent thermoplastic forming ability, metallic glasses could be patterned into finely arranged nanowire arrays, which show extremely low reflectivity (∼0.6%) in the visible and near-infrared regimes, and a low reflectivity (∼15%) in the mid-infrared regime as caused by multiscale nano spacing, multiple reflections, and plasmonic behavior. The strong absorption at surfaces with nanowires provides excellent photothermal conversion properties. The photothermal properties show that a surface with nanowires can be rapidly heated up to ∼160 °C at a rate of 28.75 °C/s, which is 30 times higher than smooth surfaces. Meanwhile, a surface with nanowires shows a high photothermal conversion efficiency (ηPT = 56.36%). The fabricated metallic glass absorbers exhibit adaptability as they can be easily formed into various complex shapes and meet the requirements under harsh conditions. The outcomes of our research open the door to manufacturing high-performance absorbers for applications in photothermal electric power generation, desalination, and photodetectors. © 2022

关键词： Metallic glass Nanoforming Photothermal properties Thermoplastic forming Ultra-wideband absorption

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Sunlight-induced Permanent Hair Dyeing

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Chinese Journal of Polymer Science 2025年第2期43卷 261-270页

作者： Ting Zhang Bo liang Jian-Hua Zhang Lei Yang Jun-fei Hua Yi-Wen Li College of Polymer Science and Engineering State Key Laboratoryof Polymer Materials EngineeringSichuan UniversityChengdu 60065China Schoolof Materials Science and Engineering Hubei University of Automotive TechnologyShiyan 442002China School of Emergent Soft Matter South China University of TechnologyGuangzhou 510640China

Hair coloring has emerged as an integral part of the cosmetic industry,particularly in response to the increasing global aging *** natural melanin analog,polydopamine(PDA),has garnered considerable attention as an eco-friendly hair dye,and several kinds of polymerization ways of dopamine(DA)have been proposed including alkali catalysis,metal ion catalysis,strong oxidants,and enzyme-mediated oxidation reactions and *** the controllability of polymerization and potential toxicity of involved metal ions are still in *** by the photoprotective mechanism in human skin,we have developed the melanin-inspired hair dyeing strategy that allowed for the in situ oxidative polymerization of DA under ultraviolet(UV)*** polymerization was triggered by photobase generators(PBGs),a class of compounds that produced organic bases upon UV and sunlight *** resulting hair showed an adjustable color from light brown to black by tuning the ratio of DA and PBG(DA@PBG),the concentration of DA,and light exposure *** dyed hairs showed excellent washing resistance and superior anti-static ***,Hair Color Spray DA@PBG also demonstrated a desirable hair dyeing effect and excellent biosecurity by simply spraying it on the hair under *** novel sunlight-induced method provided a new direction towards the preparation of natural hair dyes and could promote the development of green and safe hair dyes in colorful and brilliant artistic-grade hair coloring.

关键词： Polydopamine Melanin Polymerization Hair dye Photo-initiation

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Revealing the difference of Stark tuning rate between interface and bulk by surface-enhanced infrared absorption spectroscopy

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Chinese Chemical Letters 2025年第2期36卷 461-464页

作者： Manyu Zhu fei liang Lie Wu Zihao Li Chen Wang Shule Liu Xiue Jiang State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of Sciences School of Applied Chemistry and Engineering University of Science and Technology of China School of Materials Science and Engineering Sun Yat-sen University Research Center for Analytical Science College of ChemistryNankai University

Revealing the factors that affect the vibrational frequency of Stark probe at interface is a pre-requirement for evaluating the absolute interfacial electric *** using surface-enhanced infrared absorption(SEIRA) spectroscopy,attenuated total reflection (ATR) spectroscopy and molecular dynamics (MD),we reveal the assembled C≡N at gold nanofilm exhibits a reduced Stark tuning rate (STR) referring to the vibrational frequency shift in response to electric field comparing with the bulk which was regulated by the electron transfer between S and *** findings lead to a deeper understanding of the vibrational Stark effect at the interface and provide guidance for improving the interface electric field theory.

关键词： Attenuated total reflection spectroscopy Cyano group Stark tuning rate Surface-enhanced infrared spectroscopy Vibrational stark effect

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Dual-selective silver recovery strategy by simultaneous adsorption-reduction boosted by in-situ magnetic field

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Green Energy & Environment 2025年第2期10卷 433-440页

作者： Jianran Ren Zhiliang Zhu Yanling Qiu fei Yu Tao Zhou Jie Ma Jianfu zhao Research Center for Environmental Functional Materials State Key Laboratory of Pollution Control and Resource ReuseCollege of Environmental Science and EngineeringTongji UniversityShanghai200092China School of Civil Engineering Kashi UniversityKashi844000China College of Marine Ecology and Environment Shanghai Ocean UniversityShanghai201306China

The mainstream silver recovery has problems such as resource waste,weak silver selectivity,and complicated ***,self-propelled magnetic enhanced capture hydrogel(magnetic NbFeB/MXene/GO,MNMGH)was prepared by self-crosslinking encapsulation *** achieved high selectivity(K_(d)=23.31 mL/g)in the acidic range,and exhibited ultrahigh silver recovery capacity(1604.8 mg/g),which greatly improved by 66%with the assistance of in-situ magnetic *** recovered silver crystals could be directly physically exfoliated,without acid/base *** selective sieving effect of adsorption,MNMGH preferentially adsorbed Ag(I),and then selectively reduced to Ag(0),realizing dual-selective *** in-situ magnetic field enhanced selective adsorption by enhancing mass transfer,reactivity of oxygen-containing functional ***,density function theory simulations demonstrated that the in-situ magnetic field could lower the silver reduction reaction energy barrier to enhance the selective ***-drive synergy system(reduction drive,adsorption drive and magnetic drive)achieved ultrahigh silver recovery *** study pioneered an in-situ magnetic field assisted enhancement strategy for dual-selective(adsorption/reduction)recovery of precious metal silver,which provided new idea for low-carbon recovery of noble metal from industrial waste liquids.

关键词： In-situ magnetic field Silver recovery Adsorption-reduction Selectivity Physical separation

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Effects of Chlorine-Based Fertilizers on Tomato Growth under Soilless Culture

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Phyton-International Journal of Experimental Botany 2025年第1期94卷 243-250页

作者： fei Li Meili Ding Hui Yuan Siping Wang Bin liang College of Agriculture and Forestry Technology Weifang Vocational CollegeWeifang262737China College of Resources and Environment Qingdao Agricultural UniversityQingdao266109China

This study investigated the effects of chlorine-based fertilizers under varying nitrogen solution concentrations in a soilless culture system. The experiment included four nitrogen solution concentration levels, with nitrogen concentrations of 6 mmol/L (C1), 12 mmol/L (C2), 18 mmol/L (C3), and 24 mmol/L (C4). Each nutrient concentration level was further divided into four chloride ion treatments (R1, R2, R3, and R4), where 100%, 60%, 33%, and 0% of the NH4+ and K+ ions were derived from NH4Cl and KCl, respectively. The length, surface area and volume of root were significantly higher by 25.3%~136.9%, 40.1%~173.1%, 27.9%~178.0%, respectively, in the R4 treatment than in the R1 and R2 treatments at flowering stage. The aboveground biomass and yield in the R4 treatment were significantly higher, by approximately 15.6%~43.5% and 16.6%~28.6%, respectively, than in the R1, R2, and R3 treatments at the picking stage. The C3 and C4 treatments significantly decreased biomass and yield by 31.9%~50.2% and 20.7%~50.5%, respectively, compared to the C1 and C2 treatments at the picking stage. Besides, the higher nutrient solution increased the incidence of blossom-end rot. In conclusion, high concentrations of chloride ions in nutrient solutions, especially when the Cl− concentration exceeded 10 mmol/L, have been shown to inhibit tomato growth in soilless culture systems. Therefore, replacing sulfur-based fertilizers by chlorine-based fertilizers is not recommended for tomato production under the studied conditions.

关键词： Sand culture chloride ion nitrogen solution concentration tomato yield blossom-end rot

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Expression significance of biomarker MORC4 in colorectal cancer patients and its relationship with pathological features and prognosis

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 291-298页

作者： Li Wei liang Wang Ya-Gang Liu Li-fei Gao Department of General Surgery Cangzhou Central HospitalCangzhou 061000Hebei ProvinceChina Department of Hepatobiliary and Pancreatic Surgery Cangzhou Central HospitalCangzhou 061000Hebei ProvinceChina

BACKGROUND Colorectal cancer(CRC)is one of the most common malignant gastrointestinal tumors worldwide,with high incidence and mortality *** To investigate the expression significance of the chromatin-remodeling protein MORC family CW-type zinc finger 4(MORC4)as a biomarker in CRC patients,and to explore its relationship with pathological features and *** A total of 143 CRC specimens and 57 adjacent tissue specimens,surgically removed from our hospital between January 2020 and January 2021,were ***4 protein expression was assessed using immunohistochemistry after paraffin *** relationship between MORC4 protein expression and clinicopathological characteristics of patients was ***-Meier survival curves were plotted to analyze the relationship between MORC4 protein expression and prognosis in CRC *** Compared with adjacent tissues,the expression rate of MORC4 protein in CRC tissues was significantly higher(P0.05).However,significant differences were found in the high expression rate of MORC4 protein in patients with different degrees of differentiation,lymph node metastasis,distant metastasis,tumor-lymph node-metastasis stage,and serum carcinoembryonic antigen levels(P<0.05).Compared with patients with low MORC4 expression,patients with high MORC4 expression had a worse prognosis(P<0.05).CONCLUSION The upregulation of MORC4 expression in CRC patients is closely related to disease severity and prognosis,suggesting its potential as an evaluation biomarker,which warrants further investigation.

关键词： Colorectal cancer Biomarker MORC family CW-type zinc finger 4 Expression significance Pathological features Prognosis Relationship

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Topology Data Analysis-Based Error Detection for Semantic Image Transmission with Incremental Knowledge-Based HARQ

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China Communications 2025年第1期22卷 235-255页

作者： Ni fei Li Rongpeng zhao Zhifeng Zhang Honggang College of Information Science and Electronic Engineering Zhejiang UniversityHangzhou 310027China Zhejiang Lab Hangzhou 311121China Faculty of Data Science City University of MacaoMacaoChina

Semantic communication(SemCom)aims to achieve high-fidelity information delivery under low communication consumption by only guaranteeing semantic ***,semantic communication still suffers from unexpected channel volatility and thus developing a re-transmission mechanism(e.g.,hybrid automatic repeat request[HARQ])becomes *** that regard,instead of discarding previously transmitted information,the incremental knowledge-based HARQ(IK-HARQ)is deemed as a more effective mechanism that could sufficiently utilize the information ***,considering the possible existence of semantic ambiguity in image transmission,a simple bit-level cyclic redundancy check(CRC)might compromise the performance of ***,there emerges a strong incentive to revolutionize the CRC mechanism,thus more effectively reaping the benefits of both SemCom and *** this paper,built on top of swin transformer-based joint source-channel coding(JSCC)and IK-HARQ,we propose a semantic image transmission framework *** particular,different from the conventional CRC,we introduce a topological data analysis(TDA)-based error detection method,which capably digs out the inner topological and geometric information of images,to capture semantic information and determine the necessity for *** numerical results validate the effectiveness and efficiency of the proposed SC-TDA-HARQ framework,especially under the limited bandwidth condition,and manifest the superiority of TDA-based error detection method in image transmission.

关键词： error detection incremental knowledgebased HARQ joint source-channel coding semantic communication swin transformer topological data analysis

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