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Science China Life Sciences 2025年第1期68卷 297-299页

作者： Junbin Zhou Rongli wei Guanghan Fan Zhengxing lian Xuanyu Zhang Linsong Tang Zhetuo Qi Haiyang Xie Shusen Zheng Qiang wei Xiao Xu Department of Hepatobiliary and Pancreatic Surgery People's Hospital of LishuiAffiliated Lishui Hospital of Wenzhou Medical UniversityThe First Affiliated Hospital of Lishui University NHFPC Key Laboratory of Combined Multi-Organ Transplantation Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Department of Hepatobiliary and Pancreatic SurgeryHangzhou First People's Hospital Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of Medicine Department of Urology The Second Affiliated HospitalZhejiang University School of Medicine Department of Hepatobiliary and Pancreatic Surgery Department of Liver TransplantationShulan (Hangzhou) Hospital Hangzhou Medical College Zhejiang University School of Medicine

Dear Editor, Liver transplantation(LT) is the only curative therapy for patients with endstage liver disease(He et al., 2023; Ling et al., 2022). Post-transplant hypertriglyceridemia(PTHT), which has an incidence of up to 32.8% in 6 months after LT, is one of the major post-transplant complications(Toshima et al., 2020).

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SAS6.11版岭回归分析程序设计及其实例分析

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数理统计与管理 2001年第1期20卷 41-44,64页

作者：郭秀花赵连伟中国人民解放军北京军医学院北京100071

应用岭回归分析可以解决自变量之间存在复共线性时的回归问题。本文给出了在SAS6.1 1及以上版本中实现岭回归分析的程序。

关键词：岭回归分析 SAS程序实例分析多元线性回归程序设计

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中国东北区域盛夏雨季的客观识别

物理学报 2014年第20期63卷 418-429页

作者：房一禾龚志强赵连伟赵春雨李清泉沈阳区域气候中心沈阳110166 中国气象局国家气候中心开放实验室和监测室北京100081

鉴于我国东北三省雨季客观识别方法不尽相同,且无东北区域统一的雨季监测指标.为了更好地开展区域关键天气过程的客观化识别和监测,本文从区域角度出发,采用东北三省102站逐日降水量资料,通过对东北区域多年平均5点平滑处理的4月1日—10... 详细信息

鉴于我国东北三省雨季客观识别方法不尽相同,且无东北区域统一的雨季监测指标.为了更好地开展区域关键天气过程的客观化识别和监测,本文从区域角度出发,采用东北三省102站逐日降水量资料,通过对东北区域多年平均5点平滑处理的4月1日—10月31日逐日降水量序列的综合分析,及对历年逐日滑动平均雨量的对比试验,确定了东北盛夏雨季判别的阈值参数及通过阈值后的持续时间参数,进而研发了适合东北区域盛夏雨季开始和结束日期的客观识别方法.并采用美国环境预报中心和国家大气研究中心逐日再分析的风场、位势高度场资料,通过对盛夏雨季前、中、后期不同高度层大气环流场的对比分析,验证了该客观识别方法的合理性.结果表明,东北区域1981—2010年气候态平均的盛夏雨季的起止日期分别为每年的6月26日和8月30日.

关键词：东北地区盛夏雨季起止日期客观识别

Potential role and therapeutic implications of glutathione peroxidase 4 in the treatment of Alzheimer's disease

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Neural Regeneration Research 2025年第3期20卷 613-631页

作者： Yanxin Shen Guimei Zhang Chunxiao wei Panpan zhao Yongchun Wang Mingxi Li Li Sun Department of Neurology and Neuroscience Center The First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina Cognitive Impairment Center Department of NeurologyThe First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina

Alzheimer's disease is an age-related neurodegenerative disorder with a complex and incompletely understood pathogenesis. Despite extensive research, a cure for Alzheimer's disease has not yet been found. Oxidative stress mediates excessive oxidative responses, and its involvement in Alzheimer's disease pathogenesis as a primary or secondary pathological event is widely accepted. As a member of the selenium-containing antioxidant enzyme family, glutathione peroxidase 4 reduces esterified phospholipid hydroperoxides to maintain cellular redox homeostasis. With the discovery of ferroptosis, the central role of glutathione peroxidase 4 in anti-lipid peroxidation in several diseases, including Alzheimer's disease, has received widespread attention. Increasing evidence suggests that glutathione peroxidase 4 expression is inhibited in the Alzheimer's disease brain, resulting in oxidative stress, inflammation, ferroptosis, and apoptosis, which are closely associated with pathological damage in Alzheimer's disease. Several therapeutic approaches, such as small molecule drugs, natural plant products, and non-pharmacological treatments, ameliorate pathological damage and cognitive function in Alzheimer's disease by promoting glutathione peroxidase 4 expression and enhancing glutathione peroxidase 4 activity. Therefore, glutathione peroxidase 4 upregulation may be a promising strategy for the treatment of Alzheimer's disease. This review provides an overview of the gene structure, biological functions, and regulatory mechanisms of glutathione peroxidase 4, a discussion on the important role of glutathione peroxidase 4 in pathological events closely related to Alzheimer's disease, and a summary of the advances in small-molecule drugs, natural plant products, and non-pharmacological therapies targeting glutathione peroxidase 4 for the treatment of Alzheimer's disease. Most prior studies on this subject used animal models, and relevant clinical studies are lacking. Future clinica

关键词： apoptosis ferroptosis inflammation lipid peroxidation natural plant products neurodegenerative disorder neuroprotection oxidative stress small-molecule drugs

The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li wei Zhang Jian Wu Hui Hong wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao weijiang zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

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二噁英在子宫内膜异位症发病中的作用

生殖与避孕 2015年第11期35卷 806-810页

作者：黄苗苗魏兆莲安徽医科大学第一附属医院生殖中心合肥230022

尽管子宫内膜异位症(EMs)的病因不明确,其普遍可接受的病理生理学理论是经血逆流。但经血逆流只发生于部分EMs患者中,这提示EMs的发生还有其他因素。二噁英是指那些能与芳香烃受体结合、结构和性质相似的同类物或异构体的两大类有机化... 详细信息

尽管子宫内膜异位症(EMs)的病因不明确,其普遍可接受的病理生理学理论是经血逆流。但经血逆流只发生于部分EMs患者中,这提示EMs的发生还有其他因素。二噁英是指那些能与芳香烃受体结合、结构和性质相似的同类物或异构体的两大类有机化合物。二噁英能够增强雌激素作用,降低孕激素抑制子宫内膜异位的作用,促进T细胞表达、分泌CCL趋化因子(regulated on activation,normal T-cell expressed and secreted,Rantes)、子宫基质细胞金属蛋白酶(matrix metalloproteinase,MMP)、MMP-2、肿瘤坏死因子-α(TNF-α)。许多实验室和基于人群的研究表明,暴露于环境毒物也许是子宫内膜异位的诱因之一。

关键词：二噁英多氯二苯-对-二噁英(TCDD) 子宫内膜异位症(EMs) 血清

High-performance poly(aromatic pyridine) copolymers with crown ether moieties for high temperature polymer electrolyte membrane fuel cells

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Science China Chemistry 2025年

作者： Qian Wang Songhao zhao Yunpeng Guo wei wei Lele Wang Jingshuai Yang Department of Chemistry College of Sciences Northeastern University Institute of Metal Research Chinese Academy of Sciences

This study concentrates on the development of high temperature polymer electrolyte membranes（HT-PEMs）, which are essential components for HT-PEM fuel cells（HT-PEMFCs）. Although the phosphoric acid（PA）-doped polybenzimidazole（PBI） has been regarded as the successful HT-PEM, this system still suffers from several challenges, including the use of carcinogenic monomers, complex synthesis procedures, and poor solubility in organic solvents. To develop more cost-effective, readily synthesized and high-performance alternatives, this study employs a simply superacid-catalyzed Friedel-Crafts reaction to synthesize a series of poly（triphenyl-co-dibenzo-18-crown-6 pyridine） copolymers, denoted as P(TPx%-co-CEy%), using ptriphenyl, dibenzo-18-crown-6 and 4-acetylpyridine as monomers. The copolymerized hydrophilic and bulky crown ether unites introduce large free volumes and multiple interaction sites with PA molecules, as elucidated by theoretical *** microphase separation structures are formed as confirmed by atomic force microscope（AFM）, transmission electron microscopy（TEM） and small-angle X-ray scattering（SAXS）. Thus P(TPx%-co-CEy%) membranes exhibit excellent PA absorption and proton conduction abilities. For example, after immersing in 85 wt% PA at 30 °C, the P(TP91%-co-CE9%) membrane achieves a PA doping content of 205% and a high conductivity of 0.138 S cm-1at 180 °C, while maintaining a tensile strength of 7.5 MPa at room temperature. Without humidification and backpressure, the peak power density of an H2-O2cell equipped with P(TP91%-co-CE9%)/205%PA reaches nearly 1200 mW cm-2, representing one of the highest performances reported for PA-doped HT-PEMs to date. This work demonstrates the enormous potential of poly（triphenyl-co-crown ether pyridine） membranes in the HT-PEMFC applications.

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基于小波变换的阈值语音信号去噪

重庆科技学院学报（自然科学版） 2005年第4期7卷 73-75页

作者：赵未莲江西财经大学电子学院南昌330013

介绍了小波变换在语音去噪方面的应用概况。详细阐述了阈值法中的软阈值和硬阈值方法及它们的不足之处,并针对其缺点提出了软硬阈值折衷法去噪算法。最后,通过实验证明了该算法的优越性。

关键词：小波变换语音去噪软阈值法硬阈值法软硬阈值折衷法

CoTCPP integrates with BiOBr microspheres for improved solar-driven CO_(2)reduction performance

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Green Energy & Environment 2025年第1期10卷 193-202页

作者： Lina Li Yi Zhang Gaopeng Liu Tiange wei Junze zhao Bin Wang Mengxia Ji Yuanbin She Jiexiang Xia Huaming Li School of Chemistry and Chemical Engineering Institute for Energy ResearchJiangsu University301 Xuefu RoadZhenjiang212013China State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology College of Chemical EngineeringZhejiang University of TechnologyHangzhou310014China

CO_(2) photoreduction into carbon-based chemicals has been considered as an appropriate way to alleviate the energy issue and greenhouse ***,the 5,10,15,20-tetra(4-carboxyphenyl)porphyrin cobalt(II)(CoTCPP)has been integrated with BiOBr microspheres and formed the CoTCPP/BiOBr *** as-prepared CoTCPP/BiOBr-2 composite shows optimized photocatalytic performance for CO_(2) conversion into CO and CH_(4) upon irradiation with 300 W Xe lamp,which is 2.03 and 2.58 times compared to that of BiOBr,*** introduced CoTCPP significantly enhanced light absorption properties,promoted rapid separation of photogenerated carriers and boosted the chemisorption of CO_(2) *** metal Co^(2+) at the center of the porphyrin molecules also acts as adsorption center for CO_(2) molecules,accelerating the CO_(2) conversion into CO and *** possible mechanism of CO_(2) photoreduction was explored by in-situ FT-IR *** work offers a new possibility for the preparation of advanced photocatalysts.

关键词： BiOBr CoTCPP CO_(2)photoreduction Carriers transfer CO_(2)adsorption-activation

二甲双胍在多囊卵巢综合征患者IVF-ET治疗中疗效分析

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生殖与避孕 2009年第8期29卷 543-546页

作者：李慧蓉魏兆莲曹云霞安徽医科大学第一附属医院生殖中心合肥230022

目的:探讨应用二甲双胍(Met)对多囊卵巢综合征(PCOS)患者行IVF-ET治疗结局的影响。方法:回顾性分析120例行IVF-ET长方案治疗的PCOS患者,按是否预先服用Met分为Met组(M组)66个周期和对照组(NM组)58个周期。结果:①M组与NM组间获卵数(19.9... 详细信息

目的:探讨应用二甲双胍(Met)对多囊卵巢综合征(PCOS)患者行IVF-ET治疗结局的影响。方法:回顾性分析120例行IVF-ET长方案治疗的PCOS患者,按是否预先服用Met分为Met组(M组)66个周期和对照组(NM组)58个周期。结果:①M组与NM组间获卵数(19.9±10.7vs17.8±10.1)、卵裂率(93.43±16.48%vs92.18±15.73%)、移植胚胎数(2.1±0.9vs2.3±0.6)均无统计学差异(P>0.05);②组间hCG注射日E2值(9358.65±1551.10nmol/Lvs14777.44±1799.63nmol/L)、优质胚胎率(40.07%vs30.61%)、临床妊娠率(39.40%vs20.69%)、卵巢过度刺激综合征(OHSS)发生率(9.09%vs22.41%)间有显著差异(P<0.05)。结论:Met在PCOS患者IVF-ET治疗中,可改善患者的临床妊娠结局,降低OHSS发生率。

关键词：二甲双胍(Met) 多囊卵巢综合征(PCOS) 体外受精-胚胎移植(IVF-ET)