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Cyr61 Alleviates Cholangitis by Inhibiting Cytotoxic Effects of CD8^(+) T Cells on Biliary Epithelial Cells

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Current Medical Science 2021年第6期41卷 1205-1213页

作者： Tiao-chun CHENG Han LI Xi LUO Lin-ling JU Lin CHEN Jian-guo SHAO Yong-jun SHE Min LI zhao-lian bian Medical School of Nantong University Nantong 226006China Nantong Institute of Liver Disease Nantong Third People’s Hospital Nantong UniversityNantong 226006China Department of Gastroenterology and Hepatology Nantong Third People’s HospitalNantong UniversityNantong 226006China Department of Anesthesiology Nantong Third People’s HospitalNantong UniversityNantong 226006China

Objective:Primary biliary cholangitis(PBC)is a chronic progressive cholestatic liver *** recent years,researchers have found that cysteine-rich angiogenic inducer 61(Cyr61,also known as CCN1)has a potential role in reducing portal inflammation in patients with *** study aimed to explore the relationship between Cyr61 and PBC to provide new ideas and an experimental basis for the clinical treatment of ***:After induction of the overexpression of Cyr61 in a mouse model of PBC using recombinant adenovirus,hematoxylin and eosin staining and pathological scores were used to indicate intrahepatic inflammation and bile duct ***-time PCR was used to detect changes in inflammation-related cytokines in the *** further study the mechanism,we assessed whether Cyr61 protects bile duct epithelial cells from cytotoxic ***:Serum and hepatic Cyr61 levels were increased in the murine model of *** of Cyr61 alleviated hepatic inflammation and bile duct injury in ***61 inhibited the cytotoxic effects of CD8^(+)T cells by acting on biliary epithelial cells(BECs)in ***:Our results provide novel insight into the pathogenesis of PBC and suggest that Cyr61 plays a dominant role in the cytotoxic effects on BECs in ***,therapeutic strategies targeting Cyr61 could be a potent therapy for PBC.

关键词： cysteine-rich angiogenic inducer 61 primary biliary cholangitis inflammation bile duct damage cytotoxicity

Mucosal-associated invariant T cells in hepatitis B virus-related liver failure

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World Journal of Gastroenterology 2020年第31期26卷 4703-4717页

作者： Hong Xue Han Li Lin-Ling Ju Xu-Dong Han Tiao-Chun Cheng Xi Luo Lin Chen Jian-Guo Shao Yong-Jun She zhao-lian bian Department of Liver Diseases Nantong Third People’s HospitalNantong UniversityNantong 226006Jiangsu ProvinceChina Medical School of Nantong University Nantong 226006Jiangsu ProvinceChina Nantong Institute of Liver Diseases Nantong Third People’s HospitalNantong UniversityNantong 226006Jiangsu ProvinceChina Department of Critical Care Medicine Nantong Third People’s HospitalNantong UniversityNantong 226006Jiangsu ProvinceChina Department of Gastroenterology and Hepatology Nantong Third People’s HospitalNantong UniversityNantong 226006Jiangsu ProvinceChina Department of Anesthesiology Nantong Third People’s HospitalNantong UniversityNantong 226006Jiangsu ProvinceChina

BACKGROUND Liver failure has high mortality and poor prognosis,and establishing new reliable markers for predicting its prognosis is ***-associated invariant T(MAIT)cells are a novel population of innate-like lymphocytes involved in inflammatory liver disease,and their potential role in liver failure remains *** To investigate alteration of circulating MAIT cells and assess its prognostic value in patients with hepatitis B virus(HBV)-related liver *** We recruited 55 patients with HBV-related liver failure,48 patients with chronic hepatitis B and 40 healthy controls(HCs)from Nantong Third People’s Hospital Affiliated to Nantong *** blood mononuclear cells were isolated,and the percentage and number of circulating MAIT cells were detected by flow *** levels of interleukin(IL)-7,IL-12p70,IL-18 and interferon-αwere measured by Luminex *** Circulating MAIT cells were significantly decreased in HBV-related liver failure patients(percentage:2.00±1.22 vs 5.19±1.27%,P<0.0001;number:5.47±4.93 vs 84.43±19.59,P<0.0001)compared with *** importantly,there was a significant reduction of MAIT cells in patients with middle/late-stage compared with early-stage liver *** MAIT cells partially recovered after disease improvement,both in percentage(4.01±1.21 vs 2.04±0.95%,P<0.0001)and in cell count(17.24±8.56 vs 7.41±4.99,P<0.0001).The proportion(2.29±1.01 vs 1.58±1.38%,P<0.05)and number(7.30±5.70 vs 2.94±1.47,P<0.001)of circulating MAIT cells were significantly higher in the survival group than in the dead/liver transplantation group,and the Kaplan–Meier curve showed that lower expression of circulating MAIT cells(both percentage and cell count)predicted poor overall survival(P<0.01).Also,the levels of IL-12(20.26±5.42 pg/mL vs 17.76±2.79 pg/mL,P=0.01)and IL-18(1470.05±1525.38 pg/mL vs 362.99±109.64 pg/mL,P<0.0001)were dramatically increased in HBV-related liver failure patients compared wit

关键词： Mucosal-associated invariant T cells Chronic hepatitis B Liver failure Prognosis Hepatitis B virus

Interleukin-34 deficiency aggravates development of colitis and colitis-associated cancer in mice

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World Journal of Gastroenterology 2022年第47期28卷 6752-6768页

作者： zhao-Xiu Liu Wei-Jie Chen Yang Wang Bing-Qian Chen Yi-Cun Liu Tiao-Chun Cheng Lei-Lei Luo Lin Chen Lin-Ling Ju Yuan Liu Ming Li Nan Feng Jian-Guo Shao zhao-lian bian Department of Gastroenterology and Hepatology Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Medical School Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Gastroenterology and Hepatology Nantong Third People’s HospitalAffiliated Nantong Hospital 3 of Nantong UniversityNantong 226006Jiangsu ProvinceChina Nantong Institute of Liver Diseases Nantong Third People’s HospitalAffiliated Nantong Hospital 3 of Nantong UniversityNantong 226006Jiangsu ProvinceChina Department of Gastroenterology and Hepatology The Sixth People’s Hospital Affiliated to Shanghai Jiaotong UniversityShanghai 200233China Department of Traditional Chinese Medicine Nantong Third People’s HospitalAffiliated Nantong Hospital 3 of Nantong UniversityNantong 226006Jiangsu ProvinceChina Division of Emergency Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200120China

BACKGROUND Although expression of interleukin(IL)-34 is upregulated in active ulcerative colitis(UC),the molecular function and underlying mechanism are largely *** To investigate the function of IL-34 in acute colitis,in a wound healing model and in colitis-associated cancer in IL-34-deficient *** Colitis was induced by administration of dextran sodium sulfate(DSS),and carcinogenesis was induced by azoxymethane(AOM).Whether the impact of IL-34 on colitis was dependent on macrophages was validated by depletion of macrophages in a murine *** association between IL-34 expression and epithelial proliferation was studied in patients with active *** IL-34 deficiency aggravated murine colitis in acute colitis and in wound healing *** effect of IL-34 on experimental colitis was not dependent on macrophage differentiation and ***-34-deficient mice developed more tumors than wild-type mice following administration of AOM and *** significant difference was shown in degree of cellular differentiation in tumors between wild-type and IL-34-deficient ***-34 was dramatically increased in the active UC patients as previously *** importantly,expression of IL-34 was positively correlated with epithelial cell proliferation in patients with *** IL-34 deficiency exacerbates colonic inflammation and accelerates colitis-associated carcinogenesis in *** might be served as a potential therapeutic target in UC.

关键词： Interleukin-34 Ulcerative colitis Mucosal healing Colitis-associated cancer Macrophage Murine model

From the perspective of experimental practice: High-throughput computational screening in photocatalysis

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Green Energy & Environment 2024年第1期9卷 1-6页

作者： Yunxuan zhao Junyu Gao Xuanang bian Han Tang Tierui Zhang Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing100190China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China Institute for AI Industry Research(AIR) Tsinghua UniversityBeijing100084China

Photocatalysis,a critical strategy for harvesting sunlight to address energy demand and environmental concerns,is underpinned by the discovery of high-performance photocatalysts,thereby how to design photocatalysts is now generating widespread interest in boosting the conversion efﬁ-ciency of solar *** the past decade,computational technologies and theoretical simulations have led to a major leap in the development of high-throughput computational screening strategies for novel high-efﬁciency *** this viewpoint,we started with introducing the challenges of photocatalysis from the view of experimental practice,especially the inefﬁciency of the traditional“trial and error”***-sequently,a cross-sectional comparison between experimental and high-throughput computational screening for photocatalysis is presented and discussed in *** the basis of the current experimental progress in photocatalysis,we also exempliﬁed the various challenges associated with high-throughput computational screening ***,we offered a preferred high-throughput computational screening procedure for pho-tocatalysts from an experimental practice perspective(model construction and screening,standardized experiments,assessment and revision),with the aim of a better correlation of high-throughput simulations and experimental practices,motivating to search for better descriptors.

关键词： Photocatalysis High-throughput computational screening Photocatalyst Theoretical simulations Experiments

Persistent radical anion of perylene dianhydride:an emerging metal-free photocatalyst for near-infrared photocontrolled RAFT polymerization

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Science China Chemistry 2024年第2期67卷 677-686页

作者： Haitao zhao Guoqing bian Xiang Xu Weiwei He Lifen Zhang Zhenping Cheng State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials Jiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationSuzhou Key Laboratory of Macromolecular Design and Precision SynthesisCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou215123China

Developing a new type of photocatalyst(PC) and catalytic mechanism for near-infrared(NIR) photocontrolled reversibledeactivation radical polymerization(RDRP) system is charming but ***,a novel PC of the persistent radical anion(PRA)(possessing the properties of both radical and anion) was developed for NIR photocontrolled reversible additionfragmentation chain transfer(RAFT) polymerization,enabling successful polymerization while gaining a deep insight into the mechanism of photo-induced electron transfer RAFT(PET-RAFT) *** from the conventional and wellaccepted reductive quenching(RQ) pathway,in which the radical anion intermediates of PCs(PCs^(·-)) must be generated in an excited state(ES),here,the PRA(3,4,9,10-perylenetetracarboxylic dianhydride radical anion(PTCDA^(·-))) could generate conveniently in situ in the ground state(GS) and subsequently serve as highly efficient PC in the NIR region(740–850 nm).The successful implementation of this strategy elucidates the peculiar role played by light and the real way of electron transfer *** fact,the transfer of a single electron from PRA to chain transfer agent(CTA) and cleavage of the C–S bonds is a process from ES to GS,rather than always from GS(PCs^(·-)) to GS(CTA) in the RQ pathway as is well known to *** addition,the excellent spatial-temporal control and powerful penetration ability of the NIR light were also confirmed by this PRAcatalyzed polymerization system.

关键词： photocatalyst persistent radical anion(PRA) near-infrared(NIR)light reversible-deactivation radical polymerization(RDRP) photo-induced electron transfer RAFT(PET-RAFT)polymerization

Trajectory of COVID-19 response and management strategy in China:scientific rationale driven strategy adjustments

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Frontiers of Medicine 2024年第1期18卷 19-30页

作者： Zeyu Zhang Yue Yan Lina zhao Yizhou bian Ning zhao You Wu Dahai zhao Zongjiu Zhang Institute for Hospital Management Tsinghua UniversityBeijing100084China School of Medicine Tsinghua UniversityBeijing100084China School of International and Public Affairs Shanghai Jiao Tong UniversityShanghai200030China Yale University-Shanghai Jiao Tong University Joint Center for Health Policy Shanghai Jiao Tong UniversityShanghai200030China

The pneumonia caused by novel coronavirus SARS-CoV-2 infection in early December 2019,which was later named coronavirus disease 2019(COVID-19)by the World Health Organization(WHO),rapidly spread across the *** has made extraordinary efforts to this unprecedented pandemic,put its response and control at a very high level of infectious disease management(Category B but with measures for Category A),given top priority to the people and their lives,and balanced the pandemic control and socio-economic *** more than three years’fighting against this disease,China downgraded the management of COVID-19 to Category B infectious disease on January 8,2023 and the WHO declared the end of public health emergency on May 5,***,the ending of pandemic does not mean that the disease is no longer a health *** against COVID-19 from China and the whole world should be learned to prepare well for the future public health *** article gives a systematic review of the trajectory of COVID-19 development in China,summarizes the critical policy arrangements and provides evidence for the adjustment during policy making process,so as to share experiences with international community and contribute to the global health for all humanity.

关键词： COVID-19 public health response and control strategy science-based policy making

Supersonic expansion and condensation characteristics of hydrogen gas under different temperature conditions

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Chinese Journal of Chemical Engineering 2024年第5期69卷 220-226页

作者： Xinyue Duan Zeyu Zhang Ziyuan zhao Yang Liu liang Gong Xuewen Cao Jiang bian College of New Energy China University of Petroleum(East China)Qingdao 266580China College of Pipeline and Civil Engineering China University of Petroleum(East China)Qingdao 266580China

This paper introduced supersonic expansion liquefaction technology into the field of hydrogen *** mathematical model for supersonic condensation of hydrogen gas in a Laval nozzle model was *** supersonic expansion and condensation characteristics of hydrogen gas under different temperature conditions were *** simulation results show that the droplet number rises rapidly from 0 at the nozzle throat as the inlet temperature increases,and the maximum droplet number generated is 1.339×10^(18)kg^(-1)at inlet temperature of 36.0 *** hydrogen nucleation occurs,the droplet radius increases significantly and shows a positive correlation with the increase in the inlet temperature,and the maximum droplet radii are 6.667×10^(-8)m,1.043×10^(-7)m,and 1.099×10^(-7)m when the inlet temperature is 36.0 K,36.5 K,and 37.0 K,*** maximum nucleation rate decreases with increasing inlet temperature,and the nucleation region of the Laval nozzle becomes *** liquefaction efficiency can be effectively improved by lowering the inlet *** is because a lower inlet temperature provides more subcooling,which allows the hydrogen to reach the thermodynamic conditions required for large-scale condensation more quickly.

关键词： Hydrogen Liquefaction Supersonic Condensation Laval nozzle Computational fluid dynamics

Recent Enhanced Deep Troposphere-to-Stratosphere Air Mass Transport Accompanying the Weakening Asian Monsoon

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Journal of Meteorological Research 2024年第4期38卷 708-719页

作者： Bin CHEN Jianzhong MA Wei ZHANG Jianchun bian Tianliang zhao Xiangde XU State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesChina Meteorological AdministrationBeijing100081China Department of Plants Soils and ClimateUtah State UniversityUT84322USA Key Laboratory of Middle Atmosphere and Global Environment Observation Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Key Laboratory for Aerosol-Cloud-Precipitation of China Meteorological AdministrationNanjing University of Information Science&TechnologyNanjing 210044China

The Asian monsoon(AM) region is a well-known region with prevailing stratosphere–troposphere exchange(STE).However,how the STE across this region changes with the weakening AM remains ***,we particularly diagnose the air mass transport between the planetary boundary layer(PBL) and the stratosphere over the AM region during 1992–2017 using the Lagrangian particle dispersion model FLEXPART based on the ERA-Interim reanalysis *** results show that both the downward and upward deep STEs exhibit a detectable increasing trend,while the latter,namely,the deep troposphere-to-stratosphere transport(DTST),is relatively more *** analysis reveals that the long-term trend of DTST over the AM region could be partly attributed to changes in the Pacific Walker circulation and the air temperature(especially at upper levels).Additionally,it is found that DTST increases markedly over the tropical oceanic regions,while the increasing DTST into the stratosphere can be attributed to the enhanced air masses originated from the PBL over the terrestrial regions,where large amounts of pollutant emissions *** results imply that the influence of the DTST on the chemical composition and the climate of the stratosphere over the AM region is expected to become increasingly important,and is thereby of relevance to climate projection in an evolving climate.

关键词： stratosphere–troposphere exchange(STE) air mass transport deep troposphere-to-stratosphere transport(DTST) Asian monsoon(AM) pollution

Influence of Recycled Concrete Fine Powder on Durability of Cement Mortar

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Fluid Dynamics & Materials Processing 2024年第1期20卷 45-58页

作者： Yadong bian Xuan Qiu Jihui zhao Zhong Li Jiana Ouyang School of Architectural and Civil Engineering Zhongyuan University of TechnologyZhengzhou450007China School of Civil Engineering Sun Yat-Sen University&Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai519082China

In this paper,the durability of cement mortar prepared with a recycled-concrete fine powder(RFP)was examined;including the analysis of a variety of aspects,such as the carbonization,sulfate attack and chloride ion erosion *** results indicate that the influence of RFP on these three aspects is *** carbonization depth after 30 days and the chloride diffusion coefficient of mortar containing 10%RFP decreased by 13.3%and 28.19%.With a further increase in the RFP content,interconnected pores formed between the RFP particles,leading to an acceleration of the penetration rate of CO_(2)and Cl^(−).When the RFP content was less than 50%,the corrosion resistance coefficient of the compressive strength of the mortar was 0.84-1.05 after 90 days of sulfate *** the expansion and cracking of the mortar was effectively alleviated due to decrease of the gypsum *** electron microscope(SEM)analysis has confirmed that 10%RFP contributes to the formation of a dense microstructure in the cement mortar.

关键词： Recycled concrete fine powder cement mortar carbonization sulfate chloride ion durability