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冠心病患者自我认知与治疗依从性的关系探究

四川生理科学杂志 2024年第4期46卷 828-830,896页

作者：任猛赵方慧秦丽只赵根尚安阳道简医院内科河南安阳455000

目的:研究冠心病患者自我认知与治疗依从性之间的相关性。方法:选取2022年1月至12月期间于本院就诊的50例冠心病患者作为研究对象。收集患者基线资料,评估患者的治疗依从性、自我认知情况,分析患者自我认知与治疗依从性的相关性。结果:... 详细信息

目的:研究冠心病患者自我认知与治疗依从性之间的相关性。方法:选取2022年1月至12月期间于本院就诊的50例冠心病患者作为研究对象。收集患者基线资料,评估患者的治疗依从性、自我认知情况,分析患者自我认知与治疗依从性的相关性。结果:不同学历、病程的冠心病患者的自我认知、治疗依从性评分比较有差异(P<0.05)。不依从患者(31例)的自我认知评分明显低于依从患者(29例)(P<0.05)。经Pearson相关性检验,冠心病患者自我认知与治疗依从性之间呈正相关性(P<0.05)。结论:冠心病患者的自我认知与治疗依从性呈正相关,患者自我认知低下,依从性差,反之自我认知高,依从性好;此外,学历较好及病程较长患者的自我认知和治疗依从性较高。

关键词：冠心病自我认知治疗依从性

不同生育期施用牡蛎壳粉对小麦籽粒镉积累的影响

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江苏农业学报 2024年第2期40卷 243-250页

作者：陈星旺杨华蔡雄飞赵慧芳肖彩霞瞿朝正王胜利贵州师范大学地理与环境科学学院贵州贵阳550001 贵州省喀斯特山地生态环境国家重点实验室培育基地贵州贵阳550001

减少作物可食用部位镉(Cd)积累是降低人体Cd暴露风险的有效途径。牡蛎壳粉因能改善土壤酸化程度、促进作物增产和减少Cd在作物中的积累而备受关注。为明确不同生育期施用牡蛎壳粉对小麦籽粒Cd富集的影响,本研究设置不施用牡蛎壳粉(CK)... 详细信息

减少作物可食用部位镉(Cd)积累是降低人体Cd暴露风险的有效途径。牡蛎壳粉因能改善土壤酸化程度、促进作物增产和减少Cd在作物中的积累而备受关注。为明确不同生育期施用牡蛎壳粉对小麦籽粒Cd富集的影响,本研究设置不施用牡蛎壳粉(CK)、拔节期施用牡蛎壳粉和抽穗期施用牡蛎壳粉3个处理,分析不同生育期施用牡蛎壳粉对小麦各器官Cd积累和分配的影响。结果表明:拔节期施用牡蛎壳粉和抽穗期施用牡蛎壳粉都能显著增加小麦千粒质量及地上部干质量,小麦籽粒Cd含量分别降低24.9%和37.7%。2个时期施用牡蛎壳粉处理对籽粒总Cd吸收量影响不大,籽粒中Cd的分配比例略有增加。抽穗期施用牡蛎壳粉能更有效促进Cd在穗下节间的积累。总之,抽穗期是小麦籽粒中Cd积累的关键期,此时期施用牡蛎壳粉能增加Cd在穗下节间的滞留,减轻Cd对小麦植株生长的胁迫,小麦籽粒产量增加,从而导致小麦籽粒Cd含量的降低。

关键词：小麦牡蛎壳粉镉含量

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细胞学、组织P16~(INK4A)和HPV感染结果与年轻妇女CIN1进展情况的相关性研究

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中国妇幼卫生杂志 2024年第3期15卷 56-62页

作者：江慧贾鑫华胡尚英潘秦镜张询赵方辉乔友林中国医学科学院北京协和医学院群医学及公共卫生学院北京100730 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院肿瘤医院北京协和医学院肿瘤医院北京100021

目的探索在不同细胞学筛查结果、免疫组化染色法体现抑癌基因P16^(INK4A)表达情况和人乳头瘤病毒(human papilloma virus,HPV)感染状态下,轻度宫颈上皮内瘤样病变(cervical intraepithelial neoplasia grade Ⅰ,CIN1)人群的进展状况。... 详细信息

目的探索在不同细胞学筛查结果、免疫组化染色法体现抑癌基因P16^(INK4A)表达情况和人乳头瘤病毒(human papilloma virus,HPV)感染状态下,轻度宫颈上皮内瘤样病变(cervical intraepithelial neoplasia grade Ⅰ,CIN1)人群的进展状况。方法回顾性分析2008—2019年149例初次宫颈活检病理为CIN1的年轻妇女的长期随访资料,以中重度宫颈上皮内瘤样病变(CIN2+)为研究终点,使用Kaplan-Meier生存分析计算CIN2+的累积发生率和平均生存时间,使用Log Rank检验比较不同检测结果组间的生存时间差异性,使用Cox回归计算细胞学筛查结果、组织P16^(INK4A)表达情况和HPV感染状态对进展为CIN2+的风险比。结果 149例CIN1人群的中位随访时间为68个月,随访结束时共有16例进展为CIN2+,CIN2+的累积发生率为10.74%。细胞学不除外高级别鳞状上皮内病变/高度鳞状上皮内病变/非典型性腺细胞的妇女进展风险是细胞学阴性/意义不明确的非典型鳞状细胞/低度鳞状上皮内病变妇女的3.04倍(95%CI:1.06~8.76,P=0.04)。组织P16^(INK4A)弥漫性染色阳性妇女CIN2+的累积发生率为14.00%,进展风险是P16^(INK4A)弥漫性染色阴性者的1.70倍(95%CI:0.63~4.58,P=0.29)。HPV-16/18感染、HPV-31/33/45/52/58感染和其他HPV高危型别感染妇女CIN2+的累积发生率分别为34.78%、9.84%和2.63%,进展风险分别是高危HPV阴性者的12.70倍(95%CI:1.58~102.16,P=0.02)、2.96倍(95%CI:0.36~24.60,P=0.32)和0.82倍(95%CI:0.05~13.05,P=0.89)。联合分析HPV感染状态和组织P16^(INK4A)染色结果时发现,HPV-16/18感染且P16^(INK4A)弥漫性阳性人群进展为CIN2+的风险是高危HPV感染和P16^(INK4A)弥漫性染色同时阴性人群的14.43倍(95%CI:1.60~130.49,P=0.02)。结论细胞学筛查结果和HPV-16/18检测对CIN1的进展具有重要指示作用,而组织P16^(INK4A)染色作为CIN1进展参考指标的可行性还需进一步研究。

关键词：轻度宫颈上皮内瘤样病变细胞学 P16~(INK4A)免疫组化染色高危型人乳头瘤病毒

Dual-filler reinforced PVDF-HFP based polymer electrolyte enabling high-safety design of lithium metal batteries

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Nano Research 2024年第6期17卷 5251-5260页

作者： Chang fang Kangsheng Huang Jing zhao Shiqi Tian hui Dou Xiaogang Zhang Jiangsu Key Laboratory of Electrochemical Energy Storage Technologies College of Materials Science and TechnologyNanjing University of Aeronautics and AstronauticsNanjing 210016China

Despite the high energy density of lithium metal batteries(LMBs),their application in rechargeable batteries is still hampered due to insufficient ***,we present a novel flame-retardant solid-state electrolyte based on polyvinylidene fluoride-hexafluoropropylene(PVDF-HFP)with nano SiO_(2)aerogel as an inert filler but Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZTO)as an auxiliary component to enhance the ion *** introduction of SiO_(2)aerogels imparts the polymer electrolyte with exceptional thermal stability and flame ***,the interaction between hydroxyl groups of SiO_(2)particles and PVDF-HFP creates a strong cross-linking structure,enhancing the mechanical strength and stability of the ***,the presence of SiO_(2)aerogel and LLZTO facilitates the dissociation of lithium salts through Lewis acid-base interactions,resulting in a high ionic conductivity of 1.01×10^(−3)S·cm^(−1)and a wide electrochemical window of~5.0 V at room temperature for the prepared ***,the assembled Li|Li cell demonstrates the excellent resistance to lithium dendrite and runs stablly for over 1500 h at a current density of 0.25 mA·cm^(−2).Thus,we prepare a pouch cell with high safety,which can work normally after short-circuiting under the external folding and cutting.

关键词： polymer electrolyte SiO_(2)/Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZTO)dual-filler non-flammable long cycle life lithium metal battery

On the Structure of the Augmentation Quotient Group for Some Non-abelian p-groups

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Communications in Mathematical Research 2017年第4期33卷 289-303页

作者： zhao hui-fang NAN JI-ZHU Du Xian-kun Police Technology Department Railway Police College School of Mathematical Sciences Dalian University of Technology

In this paper, we study the basis of augmentation ideals and the quotient groups of finite non-abelian p-group which has a cyclic subgroup of index p, where p is an odd prime, and k is greater than or equal to 3. A concrete basis for the augmentation ideal is obtained and then the structure of its quotient groups can be determined.

关键词： integral group ring augmentation ideal quotient group p-group

Effects of traditional Chinese exercises on blood glucose and hemoglobin A1c levels in patients with prediabetes: A systematic review and meta-analysis

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Journal of Integrative Medicine 2020年第4期18卷 292-302页

作者： Dong-dong Yu Liang-zhen You Wan-qiu Huang hui Cao Fan-jing Wang Xiu-qin Tang zhao-hui fang Guo-ming Shen Yu-xiang Guan Graduate School Anhui University of Chinese MedicineHefei 230038Anhui ProvinceChina Endocrinology Department the First Affiliated HospitalAnhui University of Chinese MedicineHefei 230031Anhui ProvinceChina

Background:Traditional Chinese exercises(TCEs)have a positive effect on glycemic control and hemoglobin A1 c(HbA1 c),but there is no consensus on the benefits of TCEs for patients with ***:The objective of this study was to systematically investigate the effects of TCEs on blood glucose control in patients with *** strategy:Comprehensive retrieval of randomized controlled trials(RCTs)was carried out using PubMed,Cochrane Library,Embase,China National Knowledge Infrastructure,VIP Database for Chinese Technical Periodicals,Wanfang Data Knowledge Service Platform,China Biology Medicine disc,Google Scholar and Baidu academic *** retrieval window ranged from the establishment of the database to December 2018,and references related to the included trials were searched without language *** criteria:The study included RCTs with a clinical diagnosis of prediabetes that was also treated with *** extraction and analysis:Literature screening,data extraction and literature quality assessment were performed independently by two *** the case of disagreement,a third party was invited to negotiate and make a *** mean difference(SMD)was used to estimate the therapeutic ***-analysis was performed using Review Manager 5.3.5 and Stata *** was assessed using Q test and I2,and the source of heterogeneity was determined using Galbraith diagram and sensitivity analysis.A Q test resulting in P50%indicated significant difference and random effect model analysis was ***,a fixed effect model was ***’s and Egger’s tests were used to assess publication ***:Nine RCTs involving 485 participants were included in this *** results showed that TCEs could reduce fasting blood glucose(FBG),2 h blood glucose(2 hPBG)and HbA1 c in patients with *** treatment subgroup showed that an intervention of 6 months had better results,w

关键词： Traditional Chinese exercises Prediabetes Blood sugar Glycemic control Hemoglobin A1c Systematic review Meta-analysis

Dynamic interwell connectivity analysis of multi-layer waterflooding reservoirs based on an improved graph neural network

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Petroleum Science 2024年第2期21卷 1062-1080页

作者： zhao-Qin Huang zhao-Xu Wang hui-fang Hu Shi-Ming Zhang Yong-Xing Liang Qi Guo Jun Yao School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina Exploration and Development Research Institute Shengli OilfieldSINOPECDongying257015ShandongChina

The analysis of interwell connectivity plays an important role in the formulation of oilfield development plans and the description of residual oil distribution. In fact, sandstone reservoirs in China's onshore oilfields generally have the characteristics of thin and many layers, so multi-layer joint production is usually adopted. It remains a challenge to ensure the accuracy of splitting and dynamic connectivity in each layer of the injection-production wells with limited field data. The three-dimensional well pattern of multi-layer reservoir and the relationship between injection-production wells can be equivalent to a directional heterogeneous graph. In this paper, an improved graph neural network is proposed to construct an interacting process mimics the real interwell flow regularity. In detail, this method is used to split injection and production rates by combining permeability, porosity and effective thickness, and to invert the dynamic connectivity in each layer of the injection-production wells by attention *** on the material balance and physical information, the overall connectivity from the injection wells,through the water injection layers to the production layers and the output of final production wells is established. Meanwhile, the change of well pattern caused by perforation, plugging and switching of wells at different times is achieved by updated graph structure in spatial and temporal ways. The effectiveness of the method is verified by a combination of reservoir numerical simulation examples and field example. The method corresponds to the actual situation of the reservoir, has wide adaptability and low cost, has good practical value, and provides a reference for adjusting the injection-production relationship of the reservoir and the development of the remaining oil.

关键词： Graph neural network Dynamic interwell connectivity Production-injection splitting Attention mechanism Multi-layer reservoir

Enhancing personalized exercise recommendation with student and exercise portraits

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Journal of Electronic Science and Technology 2024年第2期22卷 91-109页

作者： Wei-Wei Gao hui-fang Ma Yan zhao Jing Wang Quan-Hong Tian College of Computer Science and Engineering Northwest Normal UniversityLanzhou730070China Computer Center of Gansu Province Lanzhou730070China

The exercise recommendation system is emerging as a promising application in online learning scenarios,providing personalized recommendations to assist students with explicit learning *** solutions generally follow a collaborative filtering paradigm,while the implicit connections between students(exercises)have been largely *** this study,we aim to propose an exercise recommendation paradigm that can reveal the latent connections between student-student(exercise-exercise).Specifically,a new framework was proposed,namely personalized exercise recommendation with student and exercise portraits(PERP).It consists of three sequential and interdependent modules:Collaborative student exercise graph(CSEG)construction,joint random walk,and recommendation list ***,CSEG is created as a unified heterogeneous graph with students’response behaviors and student(exercise)***,a joint random walk to take full advantage of the spectral properties of nearly uncoupled Markov chains is performed on CSEG,which allows for full exploration of both similar exercises that students have finished and connections between students(exercises)with similar ***,we propose to optimize the recommendation list to obtain different exercise *** analyses of two public datasets,the results demonstrated that PERP can satisfy novelty,accuracy,and diversity.

关键词： Educational data mining Exercise recommend Joint random walk Nearly uncoupled Markov chains Optimization Personalized learning

Characterization of gut microbial and metabolite alterations in faeces of Goto Kakizaki rats using metagenomic and untargeted metabolomic approach

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World Journal of Diabetes 2023年第3期14卷 255-270页

作者： Jin-Dong zhao Min Sun Yan Li Chan-Juan Yu Ruo-Dong Cheng Si-Hai Wang Xue Du zhao-hui fang Department of Endocrinology The First Affiliated Hospital of Anhui University of Chinese MedicineHefei 230031Anhui ProvinceChina Graduate School Anhui University of Chinese MedicineHefei 230012Anhui ProvinceChina School of Life Sciences Anhui UniversityHefei 230039Anhui ProvinceChina Department of Infectious Disease The First Affiliated Hospital of Anhui University of Chinese MedicineHefei 230031Anhui ProvinceChina

BACKGROUND In recent years,the incidence of type 2 diabetes(T2DM)has shown a rapid growth *** Kakizaki(GK)rats are a valuable model for the study of T2DM and share common glucose metabolism features with human T2DM patients.A series of studies have indicated that T2DM is associated with the gut microbiota composition and gut *** aimed to systematically characterize the faecal gut microbes and metabolites of GK rats and analyse the relationship between glucose and insulin *** To evaluate the gut microbial and metabolite alterations in GK rat faeces based on metagenomics and untargeted *** Ten GK rats(model group)and Wistar rats(control group)were observed for 10 wk,and various glucose-related indexes,mainly including weight,fasting blood glucose(FBG)and insulin levels,homeostasis model assessment of insulin resistance(HOMA-IR)and homeostasis model assessment ofβcell(HOMA-β)were *** faecal gut microbiota was sequenced by metagenomics,and faecal metabolites were analysed by untargeted *** metabolic pathways were evaluated based on the differential metabolites identified,and the correlations between blood glucose and the gut microbiota and metabolites were *** The model group displayed significant differences in weight,FBG and insulin levels,HOMA-IR and HOMA-βindexes(P<0.05,P<0.01)and a shift in the gut microbiota structure compared with the control *** results demonstrated significantly decreased abundances of Prevotella ***:604 and Lactobacillus murinus(P<0.05)and a significantly increased abundance of Allobaculum stercoricanis(P<0.01)in the model group.A correlation analysis indicated that FBG and HOMA-IR were positively correlated with Allobaculum stercoricanis and negatively correlated with Lactobacillus *** orthogonal partial least squares discriminant analysis suggested that the faecal metabolic profiles differed between the model and control *** pote

关键词： Type 2 diabetes mellitus Gut microbial Metabolites Goto-Kakizaki rats Metagenomics Untargeted metabolomics