检索结果-南通市图书馆

Preparation of FeCoNi medium entropy alloy from Fe^(3+)-Co^(2+)-Ni^(2+)solution system

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 92-101页

作者： Zongyou Cheng Qing zhao Mengjie Tao Jijun Du Xingxi Huang Chengjun liu Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-carbon Steelmaking(Ministry of Education) Shenyang 110819China

In recent years,medium entropy alloys have become a research hotspot due to their excellent physical and chemical *** controlling reasonable elemental composition and processing parameters,the medium entropy alloys can exhibit similar properties to high entropy alloys and have lower *** this paper,a FeCoNi medium entropy alloy precursor was prepared via sol-gel and coprecipitation methods,respectively,and FeCoNi medium entropy alloys were prepared by carbothermal and hydrogen *** phases and magnetic properties of FeCoNi medium entropy alloy were *** showed that FeCoNi medium entropy alloy was produced by carbothermal and hydrogen reduction at 1500℃.Some carbon was detected in the FeCoNi medium entropy alloy prepared by carbothermal *** alloy prepared by hydrogen reduction was uniform and showed a relatively high ***,the hydrogen reduction product exhibited better saturation magnetization and lower coercivity.

关键词： medium entropy alloy sol-gel co-precipitation carbothermal hydrogen reduction

Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan zhao Yidan Zhang Xin liu Jian Zhang Ya Gao Shuyue Li Cui Chang Xiang liu Guofeng Yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-Yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

Overexpression of low-density lipoprotein receptor prevents neurotoxic polarization of astrocytes via inhibiting NLRP3 inflammasome activation in experimental ischemic stroke

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 491-502页

作者： Shuai Feng Juanji Li Tingting liu Shiqi Huang Xiangliang Chen Shen liu Junshan Zhou Hongdong zhao Ye Hong Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina

Neurotoxic astrocytes are a promising therapeutic target for the attenuation of cerebral ischemia/reperfusion ***-density lipoprotein receptor,a classic cholesterol regulatory receptor,has been found to inhibit NLR family pyrin domain containing protein 3(NLRP3)inflammasome activation in neurons following ischemic stroke and to suppress the activation of microglia and astrocytes in individuals with Alzheimer’s ***,little is known about the effects of low-density lipoprotein receptor on astrocytic activation in ischemic *** address this issue in the present study,we examined the mechanisms by which low-density lipoprotein receptor regulates astrocytic polarization in ischemic stroke ***,we examined low-density lipoprotein receptor expression in astrocytes via immunofluorescence staining and western blotting *** observed significant downregulation of low-density lipoprotein receptor following middle cerebral artery occlusion reperfusion and oxygen-glucose deprivation/***,we induced the astrocyte-specific overexpression of low-density lipoprotein receptor using astrocyte-specific adeno-associated ***-density lipoprotein receptor overexpression in astrocytes improved neurological outcomes in middle cerebral artery occlusion mice and reversed neurotoxic astrocytes to create a neuroprotective ***,we found that the overexpression of low-density lipoprotein receptor inhibited NLRP3 inflammasome activation in oxygen-glucose deprivation/reoxygenation injured astrocytes and that the addition of nigericin,an NLRP3 agonist,restored the neurotoxic astrocyte *** findings suggest that low-density lipoprotein receptor could inhibit the NLRP3-meidiated neurotoxic polarization of astrocytes and that increasing low-density lipoprotein receptor in astrocytes might represent a novel strategy for treating cerebral ischemic stroke.

关键词： inflammation ischemia/reperfusion injury ischemic stroke low-density lipoprotein receptor neuroprotective astrocytes neurotoxic astrocytes NLRP3 inflammasome polarization

UHMWPE非织造材料防刺性能与拉伸、撕裂性能的相关性

在线全文

学校读者我要写书评

暂无评论

上海纺织科技 2017年第10期45卷 9-13页

作者：赵琴刘凡钱晓明邢京京成都市产品质量监督检验院四川成都610000 天津工业大学纺织学院天津300387

非织造材料的防刺性能与拉伸、撕裂性能相关,但是并没有学者对其具体相关性进行探究。为了解具体的相关性,将400 D超高分子量聚乙烯短纤和长丝加工成厚度和面密度不同的5种试样,测得各试样的纵横向拉伸强力、撕裂强力及准静态穿刺力。... 详细信息

非织造材料的防刺性能与拉伸、撕裂性能相关,但是并没有学者对其具体相关性进行探究。为了解具体的相关性,将400 D超高分子量聚乙烯短纤和长丝加工成厚度和面密度不同的5种试样,测得各试样的纵横向拉伸强力、撕裂强力及准静态穿刺力。结论为:防刺性能与抗拉伸性、抗撕裂性成线性相关,相关性系数分别是0.99和0.95。超高分子量聚乙烯纤维非织造材料具有优良的面密度和防刺性能,在一定范围内,材料静态穿刺力随面密度增加而增加,当面密度从100 g/m2增加到150 g/m2时,静态穿刺力提升了近3倍。静态穿刺力与拉伸强度、撕裂强度呈明显的线性关系,其回归方程分别为:y=3.2x-43.48、y=0.015x+5.45。静态穿刺力与拉伸强度的相关系数为:UHMWPE长丝横向为0.985,纵向为0.869;UHMWPE短纤横向为0.974,纵向为0.979。静态穿刺力与撕裂强度相关系数为:UHMWPE长丝横向为0.985,纵向为0.869;UHMWPE短纤横向为0.974,纵向为0.989。

关键词：非织造材料拉伸强度撕裂强度防刺性相关性

Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 821-835页

作者： Jing Wang Bing Zhang Lanfang Li Xiaomei Tang Jinyu Zeng Yige Song Chao Xu Kai zhao Guoqiang liu Youming Lu Xinyan Li Kai Shu Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Graduate Student Chongqing Medical UniversityChongqingChina Department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina Department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

Distributed fiber optic sensing system for vibration monitoring of 3D printed bridges

在线全文

学校读者我要写书评

暂无评论

Optoelectronics Letters 2025年第1期21卷 28-34页

作者： zhao Shuai ZHOU Ran LUO Mingming liu Jianfei liu Xiongfei ZHOU Tao School of Electronic Information Engineering Hebei University of Technology Tianjin Key Laboratory of Electronic Materials and Devices School of Civil Engineering and Transportation Hebei University of Technology Tianjin Jinhang Institute of Technical Physics

The fiber optic sensing technology provides data support in structural health monitoring of the macro facilities, including design, construction, and maintenance of bridges, tunnels, ports and other infrastructures. In this paper, a distributed vibration sensing system is proved to be responsive to a single touch over a 1.8-m-long equivalent fiber segment, covering a vibration frequency from 5 Hz to 25 kHz. The sensing fiber was arranged as an S type layout on the bridge to recognize the standing state, windblown disturbance, and walking vibration. Moreover, the knocking and climbing events are recognized fiber laying spinning lines and hanging on the fences, respectively. The demonstration shows an accurate positioning and sensitive vibration monitoring applied on the automated three-dimensional(3D) printed bridge, which is applicable to all kinds of 3D printed facilities as intelligent sensory neuro-networks.

关键词： Spinning (fibers)

Human neural stem cell-derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3245-3258页

作者： Jiayi Wang Mengke zhao Dong Fu Meina Wang Chao Han Zhongyue Lv Liang Wang Jing liu Stem Cell Clinical Research Center The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina Dalian Innovation Institute of Stem Cell and Precision Medicine DalianLiaoning ProvinceChina Institute(College)of Integrative Medicine Dalian Medical UniversityDalianLiaoning ProvinceChina

Human neural stem cell-derived extracellular vesicles exhibit analogous functions to their parental cells,and can thus be used as substitutes for stem cells in stem cell therapy,thereby mitigating the risks of stem cell therapy and advancing the frontiers of stem cell-derived *** lays a foundation for the development of potentially potent new treatment modalities for ischemic ***,the precise mechanisms underlying the efficacy and safety of human neural stem cell-derived extracellular vesicles remain unclear,presenting challenges for clinical *** promote the translation of therapy based on human neural stem cell-derived extracellular vesicles from the bench to the bedside,we conducted a comprehensive preclinical study to evaluate the efficacy and safety of human neural stem cell-derived extracellular vesicles in the treatment of ischemic *** found that administration of human neural stem cell-derived extracellular vesicles to an ischemic stroke rat model reduced the volume of cerebral infarction and promoted functional recovery by alleviating neuronal *** human neural stem cell-derived extracellular vesicles reduced neuronal apoptosis by enhancing phosphorylation of phosphoinositide 3-kinase,mammalian target of rapamycin,and protein kinase B,and these effects were reversed by treatment with a phosphoinositide 3-kinase *** findings suggest that human neural stem cell-derived extracellular vesicles play a neuroprotective role in ischemic stroke through activation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling ***,we showed that human neural stem cell-derived extracellular vesicles have a good in vivo safety ***,human neural stem cell-derived extracellular vesicles are a promising potential agent for the treatment of ischemic stroke.

关键词： behavior exosome extracellular vesicles ischemic stroke mammalian target of rapamycin(mTOR) middle cerebral artery occlusion neural stem cells neuronal apoptosis phosphoinositide 3-kinase(PI3K) protein kinase B(AKT)

持续气道正压通气对脑卒中合并阻塞性睡眠呼吸暂停低通气综合征患者的睡眠状况及神经心理特征的影响

在线全文

学校读者我要写书评

暂无评论

中华神经科杂志 2018年第4期51卷 256-262页

作者：万亚会赵凡刘蕾崔林阳裘志军薛蓉天津医科大学总医院神经内科 300052 天津市第五中心医院神经内科天津市武清区人民医院神经内科

目的探讨持续气道正压通气（CPAP）对脑卒中合并阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者的睡眠状况及神经心理特征的影响。方法收集2014年5月至2016年1月在天津医科大学总医院神经内科门诊就诊及住院的伴有打鼾的脑卒中且符合OSAH... 详细信息

目的探讨持续气道正压通气（CPAP）对脑卒中合并阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者的睡眠状况及神经心理特征的影响。方法收集2014年5月至2016年1月在天津医科大学总医院神经内科门诊就诊及住院的伴有打鼾的脑卒中且符合OSAHS诊断标准的患者54例，采用完全随机化分组方法随机分为CPAP联合药物治疗组（25例）和单纯药物治疗组（29例）。采用多导睡眠图（PSG）监测患者睡眠结构、呼吸参数；使用Epworth嗜睡量表（ESS）和匹茨堡睡眠质量指数（PsQI）评估主观睡眠状况，应用蒙特利尔认知评估量表（MoCA）、数字记忆广度测定（DST）、Hopkins词语学习测验（HVIJT）评估神经认知功能的变化；采用9条目患者健康问卷（PHQ9）评估抑郁情绪状态。分别比较CPAP联合药物治疗3个月后CPAP联合药物治疗组自身及其与单纯药物治疗组两组间的睡眠状况、认知功能及情绪的变化。结果CPAP联合药物治疗组脱落5例，2组有效例数分别为CPAP联合药物治疗组20例和单纯药物治疗组29例。CPAP联合药物连续治疗3个月后自身比较：治疗后睡眠呼吸暂停低通气指数（AHI；29．32±16．57）较治疗前（41．66±21．84）显著下降（t=3．926，P=0．001）、最低血氧饱和度（LSa02；82．11％±5．66％）较治疗前（76．11％±8．90％）明显升高（t=-5．054，P=0．000），治疗后的睡眠结构参数较治疗前差异无统计学意义；治疗后的ESS、PSQI、PHQ9评分[分；4．53±3．86、3．00±2．45、0．00（0．00，2．00）]较治疗前[10．58±7．82、7．53±2．87、3．00（1．00，9．00）l降低（t=-3．883，P=0．001；t=-6．522，P：0．000；Z=-3．549，P=0．000），治疗后MoCA、HVLT（总分、延迟）、DSTl、DST2评分（分；23．37±4．75、22．32±6．90、7．47±3．82、7．84±2．59、5．32±2．81）较治疗前（22．16±4．94、19．16±7．66、6．68±3．74、7．32±2．67、5．00±3．00）显著增高（t=-2．773，P=0．013；t=-6．857，P=0．000；t=-2．704，P=0．015；t=-2．249，P=0．037；t=-2．882，P：0．010）。CPAP联合药物连续治疗3个月CPAP联合药物治疗组与单纯药物治疗组比较：CPAP联合药物治疗组ESS、PSQI、PHQ9评分（分）较单纯药物治疗组[8．76±6．92、7．59±5．49、5．00（2．50，9．50）]显著降低（t=-2．711，P=0．009；t=-3．941，P=0．000；Z=-4．555，P=0．000），DSTl评分（分）较单纯药物治疗组（6．45±1．43）升高（t=2．144，P=0．042）。结论CPAP联合药物连续治疗3个月显著改善脑卒中合并OSAHS患者的日间嗜睡及抑郁情绪，认知功能以注意力方面改善明显，低通气、缺氧程度得到缓解，而睡眠结构紊乱无明显改善。

关键词：卒中睡眠呼吸暂停阻塞性认知抑郁

Enhanced autophagic clearance of amyloid-βvia histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2633-2644页

作者： Zhimin Long Chuanhua Ge Yueyang zhao Yuanjie liu Qinghua Zeng Qing Tang Zhifang Dong Guiqiong He Institute of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Physiology Chongqing Medical UniversityChongqingChina Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqingChina Ministry of Education Key Laboratory of Child Development and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina National Clinical Research Center for Child Health and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque ***,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's *** acetylation/deacetylation plays a central role in lysosomal ***,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's *** rthermore,we found that treatment with valproic acid markedly enhanced *** clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's *** findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.

关键词： Alzheimer's disease amyloid-β APP/PS1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPase