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Ruxolitinib add-on in corticosteroid-refractory graft-vs-host disease after allogeneic stem cell transplantation:Results from a retrospective study on 38 Chinese patients

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World Journal of Clinical Cases 2020年第6期8卷 1065-1073页

作者： Si-Hua Dang Qin Liu Rong Xie Na Shen Shu Zhou Wei Shi Wen Liu Ping Zou Yong You zhao-dong zhong Department of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Department of Oncology Luohe Central HospitalLuohe 462300Henan ProvinceChina Department of Gynecology and Obstetrics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina

BACKGROUND Graft-vs-host disease (GVHD) is a major cause of mortality after allogeneic hematopoietic stem cell *** patients have steroid-refractory(SR) *** To evaluate the effect and safety of ruxolitinib add-on in the treatment of patients with SR acute (a) and chronic (c) *** We retrospectively analyzed 38 patients administered ruxolitinib add-on to standard immunosuppressive therapy for SR-aGVHD or SR-cGVHD following allogeneic hematopoietic stem cell *** was administered5-10 mg/d depending on disease severity,patient status,and the use of antifungal *** response rate,time to best response,malignancy relapse rate,infection rate,and treatment-related adverse events were *** The analysis included 10 patients with SR-aGVHD (gradeⅢ/Ⅳ,n=9) and 28patients with SR-cGVHD (moderate/severe,n=24).For the SR-aGVHD and SRcGVHD groups,respectively:Median number of previous GVHD therapies was 2(range:1-3) and 2 (1-4);median follow-up was 2.5 (1.5-4) and 5 (1.5-10) mo;median time to best response was 1 (0.5-2.5) and 3 (1-9.5) mo;and overall response rate was 100%(complete response:80%) and 82.1%(complete response:10.7%) with a response observed in all GVHD-affected *** malignancy relapse rates for the SR-aGVHD and SR-cGVHD groups were 10.0%and 10.7%,*** rates for cytomegalovirus,Epstein-Barr virus,and varicella-zoster virus,respectively,were 30.0%,10.0%,and 0%for the SR-aGVHD group and 0%,14.3%,and 7.1%for the SR-cGVHD *** Ruxolitinib add-on was effective and safe as salvage therapy for SR-GVHD.

关键词： Graft-vs-host disease Graft-vs-leukemia effect Allogeneic hematopoietic stem cell transplantation Ruxolitinib Treatment Antifungal drugs

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Monitoring and Analysis of Chinese Chronic Myeloid Leukemia Patients Who Have Stopped Tyrosine Kinase Inhibitor Therapy

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Current Medical Science 2019年第2期39卷 211-216页

作者： Na SHEN Yong YOU zhao-dong zhong Li MENG Jian-feng ZHOU Ping ZOU Xiao-jian ZHU Hong-xiang WANG Fan-jun CHENG Institute of Hematology Union HospitalTongji Medical CollegeHtiazhong University of Science and TechnologyWuhan 430022China Department of Hematology Tongji HospitalTongji Medical CollegeHuajrong University of Science and TechnologyWuhan 430030China Department of Hematology The Central Hospital of WuhanWuhan 430014China

Discontinuation of tyrosine kinase inhibitor(TKI)therapy after achieving a persistent deep molecular response(DMR)is an urgently needed treatment goal for chronic myeloid leukemia(CML)patients and has been included in the National Comprehensive Cancer Network(NCCN)guidelines(version 2.2017)for ***,various studies have confirmed the feasibility of discontinuing TKI *** this study,we analyzed data from 45 CML patients who had discontinued TKI *** analysis was performed to predict factors that were potentially related to treatment-free remission(TFR)and identify the differences between early relapse and late *** of the 45 patients,20 exhibited molecular relapse after a median follow-up of 18 months(range,1-54 months),and the estimated TFR at 24 months was 40%.The univariate analysis revealed that a high Sokal score and interruptions or dose reductions during TKI treatment were the only baseline factors associated with poor *** results indicate that TKI discontinuation could be successfully put into practice in China.

关键词： discontinuation treatment-free remission chronic myeloid leukemia relapse

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Efficacy and Safety of Generic Dasatinib as a Second-line Treatment for Patients with Chronic Myeloid Leukemia:a Multicenter Retrospective Study in Hubei Province,China

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Current Medical Science 2018年第6期38卷 1005-1011页

作者： Li-feng CHEN Guo-lin YUAN zhao-dong zhong Ping ZOU Deng-ju LI Yin BAO Hong-bo REN Li MENG Wei-ming LI Department of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Hematology Xiangyang Central HospitalXiangyang 441000China Department of Hematology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Hematology Xiangyang No.1 People's HospitalXiangyang 441000China Department of Hematology the First People's Hospital of JingzhouJingzhou 434000China

Dasatinib is a second-generation tyrosine kinase inhibitor (TKI)and it could be used as a second-line treatment for patients with chronic myeloid leukemia (CML).Yinishu,a generic dasatinib made in China,was approved by the China Food and Drug Administration in 2013 and it costs much less than the patented dasatinib *** present study aimed to examine the efficacy and safety of Yinishu as a second-line treatment for CML by comparing the baseline clinical characteristics,rates of adverse events and efficacy between Yinishu and SPRYCEL groups. The results showed that there were no significant differences in the rates of optimal response between Yinishu and SPRYCEL for patients who started second-line treatment because of treatment *** patients who started second-line treatment because of intolerance of first-line treatment, their levels of BCR-ABL1/ABL1 on the international scale (BCR-ABL^IS)was maintained very low throughout the course of Yinishu ***-related adverse events occurred with the same frequency in these two *** was confirmed that Yinishu was effective and safe as a second- line treatment for CML *** may be more suitable for patients who are economically unable to pay for the patented dasatinib SPRYCEL.

关键词： chronic myeloid leukemia generic dasatinib second-line treatment efficacy safety

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钢结构高精度大型预埋件安装技术

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施工技术 2005年第10期34卷 23-23,82页

作者：赵忠东秦皇岛海三建设工程发展股份有限公司河北秦皇岛066000

秦皇岛市体育场屋盖结构形式为预应力空间悬挑钢桁架结构,由24榀变截面箱形主桁架组成,主桁架后部以铰支形式坐落于大直径混凝土柱上,单榀质量最大为52t,最大悬挑长度为41.8m,悬挑部分利用预应力索拉起,索的拉力通过柱顶的双立柱传递到... 详细信息

秦皇岛市体育场屋盖结构形式为预应力空间悬挑钢桁架结构,由24榀变截面箱形主桁架组成,主桁架后部以铰支形式坐落于大直径混凝土柱上,单榀质量最大为52t,最大悬挑长度为41.8m,悬挑部分利用预应力索拉起,索的拉力通过柱顶的双立柱传递到后拉杆上,然后从下拉杆传递到下部结构(见图1、2).

关键词：安装技术预埋件高精度钢结构钢桁架结构应力空间秦皇岛市混凝土柱预应力索

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Recent Advances in Artificial Sensory Neurons:Biological Fundamentals,Devices,Applications,and Challenges

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Nano-Micro Letters 2025年第3期17卷 168-216页

作者： Shuai zhong Lirou Su Mingkun Xu Desmond Loke Bin Yu Yishu Zhang Rong zhao Guangdong Institute of Intelligence Science and Technology HengqinZhuhai 519031People’s Republic of China College of Integrated Circuits Zhejiang UniversityHangzhou 3112000People’s Republic of China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 310027People’s Republic of China Department of Science Mathematics and TechnologySingapore University of Technology and DesignSingapore 487372Singapore Department of Precision Instruments Tsinghua UniversityBeijing 100084People’s Republic of China Center for Brain‑Inspired Computing Research Tsinghua UniversityBeijing 100084People’s Republic of China IDG/McGovern Institute for Brain Research Tsinghua UniversityBeijing 100084People’s Republic of China

Spike-based neural networks,which use spikes or action potentialsto represent information,have gained a lot of attention because of their high energyefficiency and low power *** fully leverage its advantages,convertingthe external analog signals to spikes is an essential *** including analog-to-digital converters or ring oscillators,and sensorssuffer from high power and area *** efforts are devoted to constructingartificial sensory neurons based on emerging devices inspired by the biologicalsensory *** can simultaneously perform sensing and spike conversion,overcoming the deficiencies of traditional sensory *** review summarizesand benchmarks the recent progress of artificial sensory *** starts with thepresentation of various mechanisms of biological signal transduction,followed bythe systematic introduction of the emerging devices employed for artificial ***,the implementations with different perceptual capabilitiesare briefly outlined and the key metrics and potential applications are also ***,we highlight the challenges and perspectives for the future development of artificial sensory neurons.

关键词： Artificial intelligence Emerging devices Artificial sensory neurons Spiking neural networks Neuromorphic sensing

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Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO2 photoreduction

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Science China Chemistry 2025年第1期68卷 201-208页

作者： Hui-Feng Wang Wen-Jie Shi Yu-Xin Yang Bao-Xia dong Tong-Bu Lu Di-Chang zhong School of Chemistry and Chemical Engineering Yangzhou University Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,Ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

关键词： metal-organic frameworks dinuclear metal centers synergistic catalysis CO2 reduction photocatalysis

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Dual‑Donor‑Induced Crystallinity Modulation Enables 19.23% Efficiency Organic Solar Cells

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Nano-Micro Letters 2025年第3期17卷 376-388页

作者： Anhai Liang Yuqing Sun Sein Chung Jiyeong Shin Kangbo Sun Chaofeng Zhu Jingjing zhao Zhenmin zhao Yufei zhong Guangye Zhang Kilwon Cho Zhipeng Kan Center On Nanoenergy Research Institute of Science and Technology for Carbon Peak&NeutralitySchool of Physical Science&TechnologyGuangxi UniversityNanning 530004People’s Republic of China Department of Chemical Engineering Pohang University of Science and TechnologyPohang 37673South Korea College of New Materials and New Energies Shenzhen Technology UniversityShenzhen 518118People’s Republic of China Zhejiang Engineering Research Center for Fabrication and Application of Advanced Photovoltaic Materials School of Materials Science and EngineeringNingboTech UniversityNingbo 315100People’s Republic of China State Key Laboratory of Featured Metal Materials and Life-Cycle Safety for Composite Structures Nanning 530004People’s Republic of China

Trap-assisted charge recombination is one of the primary limitationsof restricting the performance of organic solar cells. However, effectivelyreducing the presence of traps in the photoactive layer remains ***, wide bandgap polymer donor PTzBI-dF is demonstrated as an effectivemodulator for enhancing the crystallinity of the bulk heterojunction active layerscomposed of D18 derivatives blended with Y6, leading to dense and orderedmolecular packings, and thus, improves photoluminescence quenching *** a result, the photovoltaic devices exhibit reduced trap-assisted charge recombinationlosses, achieving an optimized power conversion efficiency of over 19%.Besides the efficiency enhancement, the devices comprised of PTzBI-dF as athird component simultaneously attain decreased current leakage, improved chargecarrier mobilities, and suppressed bimolecular charge recombination, leading toreduced energy losses. The advanced crystalline structures induced by PTzBI-dFand its characteristics, such as well-aligned energy level, and complementaryabsorption spectra, are ascribed to the promising performance *** findings suggest that donor phase engineering is a feasible approach to tuning the molecular packings in the active layer, providingguidelines for designing effective morphology modulators for high-performance organic solar cells.

关键词： Trap-assisted charge recombination Photoluminescence Miscibility Current leakage Power conversion efficiency

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2D CaWO4 nanosheets derived from scheelite minerals for enhanced electrocatalysis in oxygen evolution reaction

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Science China Chemistry 2025年

作者： Qing Sun Yongxiang Sun Yan dong Hong zhong Hongbo Zeng National&Local United Engineering Laboratory for New Petrochemical Materials&Fine Utilization of Resources College of Chemistry and Chemical EngineeringHunan Normal University Department of Chemical and Materials Engineering University of Alberta College of Chemistry and Materials Engineering Hunan University of Arts and Science College of Chemistry and Chemical Engineering Central South University

Scheelite （CaWO4） mineral holds promise as a cost-effective and efficient catalyst for the oxygen evolution reaction （OER）crucial in renewable energy ***,challenges such as limited active site exposure and low electrocatalytic performance need *** this work,we have fabricated two-dimensional （2D） CaWO4nanosheets from scheelite minerals via a straightforward ultrasonic exfoliation method and evaluated their efficacy as OER *** to scheelite powders,these 2D nanosheets exhibited superior crystallinity and a 1.26-fold increase in electrochemical surface area,promoting active site *** 2D CaWO4nanosheet electrode demonstrated outstanding OER catalytic performance,achieving a current density of 20 mA/cm2at an overpotential of 290 m V in alkaline conditions,which was lower than that of bulk CaWO4electrodes （～340 mV）.Density functional theory calculations attributed this enhanced catalytic performance to moderate adsorption of oxygenated intermediates （*OH,*O,and*OOH） on the W sites of 2D *** situ electrochemical atomic force microscopy tests also confirmed the catalytic enhancement by 2D CaWO4nanosheets during *** findings demonstrate the potential of affordable and abundant mineral resources in advancing electrochemical catalysts for oxygen evolution,highlighting their broader application in sustainable energy technologies.

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东庞矿原煤准备车间结构加固

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河北煤炭 2007年第4期 48-49页

作者：赵忠东河北金能金牛股份公司东庞矿迁建办河北邢台054201

结合工程实例,阐述了东庞矿原煤准备车间不停产结构加固机理及设计方法,总结了加固的特点及施工前后保证质量的措施。

关键词：原煤准备车间不停产结构加固

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Potassium ions and cyano group modified g-C3N4 for effective generation of H2O2 through two-electron oxygen reduction

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Science China Chemistry 2025年第1期68卷 192-200页

作者： dongying Wang Shulan Pu Yongmin Chen Ke Lei Yujie Duan Linjiao Mao Xuhui Zeng Xi Luo Yuntao Zhang Yuqin dong Jin zhong Zhang Yan Sun School of Mechanical Engineering Chengdu University Department of Chemistry and Biochemistry University of California

Potassium ions （K+） doped graphitic carbon nitride （g-C3N4） was prepared by a thermal etching method using potassium hydroxide （KOH） as an ion *** transform infrared spectroscopy （FTIR） and X-ray photoelectron spectroscopy （XPS）results showed that the generation of the cyano group was detected while introducing K+.Under simulated sunlight irradiation,the sample with a K+doping amount of 10%showed the highest hydrogen peroxide （H2O2） generation rate of2,140.2μmol *** apparent quantum yield （AQY） at 400 nm and the solar-to-chemical conversion （SCC） are 4.35%and1.23%,respectively.K+acted as a bridge between g-C3N4layers,which enhanced charge transfer ***,the cyano group enhanced the adsorption capacity of protons （H+） and promoted the yield of *** catalyst exhibited excellent photocatalytic stability based on four-cycle *** addition,a mechanism study showed that superoxide radicals （·O2-）were the most important active species in the reaction *** production of H2O2was achieved through consecutive single-electron *** study deepens the understanding of the oxygen reduction reaction process and opens up a new venue for improving H2O2generation.

关键词： photocatalysis hydrogen peroxide oxygen reduction reaction potassium doping cyano group

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