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Superhydrophobic and corrosion-resistant siloxane-modified MgAl-LDHs coatings on magnesium alloy prepared under mild conditions

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 450-463页

作者： Wenxi Zhang Zhangzelong Zhuo Dan Xu liang Wu Zhihui Xie Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province College of Chemistry and Chemical EngineeringChina West Normal UniversityNanchong 637002China College of Materials Science and Engineering/National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China

We have developed a superhydrophobic and corrosion-resistant LDH-W/PFDTMS composite coating on the surface of Mg *** composite comprised a tungstate-intercalated(LDH-W)underlayer that was grown at low temperature(relative to hydrothermal reaction conditions)under atmospheric pressure and an outer polysiloxane layer created from a solution containing perfluorodecyltrimethoxysilane(PFDTMS)using a simple immersion *** successful intercalation of tungstate into the LDH phase and the following formation of the polysiloxane layer were confirmed through X-ray diffraction(XRD),Fourier transform infrared(FTIR)spectroscopy,and X-ray photoelectron spectroscopy(XPS).The corrosion resistance of the LDH-W film,both before and after the PFDTMS modification,was evaluated using electrochemical impedance spectroscopy(EIS),Tafel curves,and immersion *** results showed that Mg coated with LDH-W/PFDTMS exhibited significantly enhanced corrosion protection compared to the unmodified LDHW film,with no apparent signs of corrosion after exposure to 3.5wt%NaCl solution for 15 ***,the LDH-W/PFDTMS coating demonstrated superior superhydrophobicity and self-cleaning properties against water and several common beverages,as confirmed by static contact angle and water-repellency *** results offer valuable insights into preparing superhydrophobic and corrosion-resistant LDH-based composite coatings on Mg alloy surfaces under relatively mild reaction conditions.

关键词： Mg alloy corrosion coating layered double hydroxide

微电流电解产H_(2)O_(2)抑制铜绿微囊藻生长研究

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长江科学院院报 2023年第9期40卷 24-31页

作者：张雨婷林莉贾迪董磊潘雄刘敏赵良元长江科学院流域水环境研究所武汉430010 长江科学院流域水资源与生态环境科学湖北省重点实验室武汉430010

为了探究微电流电解过程对铜绿微囊藻生长的影响,以铂钛作为阳极,碳黑聚四氟乙烯(C/PTFE)气体扩散电极为阴极,在微电流电解体系中可产生对铜绿微囊藻生长具有选择性抑制作用的活性物质H_(2)O_(2)。探究不同电解时间、电流密度和气体流... 详细信息

为了探究微电流电解过程对铜绿微囊藻生长的影响,以铂钛作为阳极,碳黑聚四氟乙烯(C/PTFE)气体扩散电极为阴极,在微电流电解体系中可产生对铜绿微囊藻生长具有选择性抑制作用的活性物质H_(2)O_(2)。探究不同电解时间、电流密度和气体流量对藻细胞生长的影响,结果表明:微电流电解的最佳条件为100 mL细胞密度为5×10^(5)个/mL的藻液在10 mA/cm^(2)的电流密度下以0.4 L/min的气体流量电解60 min。藻细胞光密度OD680从0.035降至0.003,表明藻细胞的生长完全受到抑制。测定电解处理前后藻细胞的叶绿素荧光参数Fv/Fm、Y(Ⅱ)、Y(NO)等可知,电解处理后藻细胞的光合作用机制已遭到完全破坏。测定电解过程中产生H_(2)O_(2)的质量浓度为79 mg/L,并且经过6次循环实验后,C/PTFE气体扩散电极产生H_(2)O_(2)质量浓度仍为首次使用产生H_(2)O_(2)质量浓度的66%(52 mg/L),说明C/PTFE气体扩散电极的稳定性良好,具有较大的应用前景。该研究可为微电流电解抑制蓝藻水华提供新手段。

关键词：气体扩散电极微电流过氧化氢铜绿微囊藻抑制作用

Role of the globus pallidus in motor and non-motor symptoms of Parkinson's disease

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Neural Regeneration Research 2025年第6期20卷 1628-1643页

作者： Yimiao Jiang Zengxin Qi Huixian Zhu Kangli Shen Ruiqi Liu Chenxin Fang Weiwei Lou Yifan Jiang Wangrui yuan Xin Cao liang Chen Qianxing Zhuang Department of Physiology School of MedicineNantong UniversityNantongJiangsu ProvinceChina Department of Neurosurgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghaiChina National Center for Neurological Disorders ShanghaiChina Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration ShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institute of Brain ScienceFudan UniversityShanghaiChina

The globus pallidus plays a pivotal role in the basal ganglia circuit. Parkinson's disease is characterized by degeneration of dopamine-producing cells in the substantia nigra, which leads to dopamine deficiency in the brain that subsequently manifests as various motor and non-motor symptoms. This review aims to summarize the involvement of the globus pallidus in both motor and non-motor manifestations of Parkinson's disease. The firing activities of parvalbumin neurons in the medial globus pallidus, including both the firing rate and pattern, exhibit strong correlations with the bradykinesia and rigidity associated with Parkinson's disease. Increased beta oscillations, which are highly correlated with bradykinesia and rigidity, are regulated by the lateral globus pallidus. Furthermore,bradykinesia and rigidity are strongly linked to the loss of dopaminergic projections within the cortical-basal ganglia-thalamocortical loop. Resting tremors are attributed to the transmission of pathological signals from the basal ganglia through the motor cortex to the cerebellum-ventral intermediate nucleus circuit. The cortico–striato–pallidal loop is responsible for mediating pallidi-associated sleep disorders. Medication and deep brain stimulation are the primary therapeutic strategies addressing the globus pallidus in Parkinson's disease. Medication is the primary treatment for motor symptoms in the early stages of Parkinson's disease, while deep brain stimulation has been clinically proven to be effective in alleviating symptoms in patients with advanced Parkinson's disease,particularly for the movement disorders caused by levodopa. Deep brain stimulation targeting the globus pallidus internus can improve motor function in patients with tremordominant and non-tremor-dominant Parkinson's disease, while deep brain stimulation targeting the globus pallidus externus can alter the temporal pattern of neural activity throughout the basal ganglia–thalamus network. Therefore, the comp

关键词： anxiety basal ganglia bradykinesia deep brain stimulation depression globus pallidus externus globus pallidus internus lateral globus pallidus medial globus pallidus neural circuit Parkinson's disease

丹江口水库消落带总氮和总磷变化特征及通量研究

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长江科学院院报 2023年第5期40卷 58-62页

作者：金海洋王立赵良元秦赫陶晶祥长江科学院流域水环境研究所武汉430010 南水北调中线水源有限责任公司湖北丹江口442700

开展丹江口水库消落带土壤总氮(TN)和总磷(TP)变化特征与通量研究,对明晰消落带污染输出特征、保护水库水质安全有着重要的实践作用。将丹江口水库划分为汉库和丹库两个区域,以不同区域内典型消落带为研究对象,监测分析了2020年9月-2021... 详细信息

开展丹江口水库消落带土壤总氮(TN)和总磷(TP)变化特征与通量研究,对明晰消落带污染输出特征、保护水库水质安全有着重要的实践作用。将丹江口水库划分为汉库和丹库两个区域,以不同区域内典型消落带为研究对象,监测分析了2020年9月-2021年9月不同时期不同区域消落带土壤TN和TP的变化特征,并通过收支平衡法构建模型,估算了丹江口水库消落带在不同时期的TN和TP通量。结果表明,2020年9-12月淹水期内,丹江口水库不同区域消落带TN、TP含量变化显著,汉库耕地和园地的TN、TP含量显著上升,其余区域消落带土壤均存在TN、TP流失现象。2021年3-6月落干期内,丹江口水库不同区域消落带TN、TP含量总体上呈现上升积累趋势。2020年9月-2021年9月,丹江口水库不同区域消落带TN、TP含量整体呈下降趋势。丹江口水库消落带在淹水期表现为氮和磷的释放源,TN通量834.66 t, TP通量10 422.12 t;在落干期表现为氮和磷的吸收汇,TN通量-8 623.69 t, TP通量-10 032.94 t。2020年9月—2021年9月,丹江口水库消落带总体上表现为氮和磷的释放源,TN通量20 122.22 t, TP通量1 509.52 t。丹江口水库消落带污染物释放对水库水质安全的风险不容忽视。

关键词：消落带 TN TP 通量丹江口水库

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探井井下流体温度异常在工程找漏上的应用

测井技术 2007年第4期31卷 390-392页

作者：王朝辉赵元良张向东中国石油塔里木油田分公司勘探事业部新疆库尔勒841000

能否在短时间内准确判断出漏点位置是成功堵漏的关键。利用井下温度变化引起热变电阻阻值变化的原理测量井内流体温度的井温测井的方法,移植到探井中,利用井下流体温度异常变化在温度曲线上的反映判断井漏的漏点位置。在已知钻井深度以... 详细信息

能否在短时间内准确判断出漏点位置是成功堵漏的关键。利用井下温度变化引起热变电阻阻值变化的原理测量井内流体温度的井温测井的方法,移植到探井中,利用井下流体温度异常变化在温度曲线上的反映判断井漏的漏点位置。在已知钻井深度以上地层漏失泥浆的地区,可以用温度测井确定循环失灵的深度。通常温度测井曲线将显示井漏位置出现温度降低的异常,紧挨漏失点以下温度急剧增加。漏失量越大,变化越明显。井下流体的温度异常并不都是由于井漏造成的,要结合围岩性质等条件综合考虑。在安全条件允许的情况下,利用井下流体温度判断井涌深度位置的准确率会更高。该方法具有快速、经济、实用的特点,经过在塔里木油田多次使用,取得了非常理想的应用效果。

关键词：生产测井井内流体井温异常井漏位置

Percutaneous nephrolithotomy (PCNL) with the patient in supine-slope position to treat the upper urinary tact urolithiasis(52 cases)

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Percutaneous nephrolithotomy (PCNL) with the patient in supi...

Percutaneous nephrolithotomy (PCNL) to treat the upper urinary tract urolithiasis(226 cases)

第十五届全国泌尿外科学术会议

作者： MING LIU,ZHONG-YAO HAO,CHAO-zhao liang,yuan-PING YE,XIAN-SHENG ZHANG,JUN ZHOU,YUN-XIAN JIANG,KE-XIAO WANG (Department of urology, the first affiliated hospital of Anhui Medical University, Hefei, China 230022)

Objectives: This study was intended to discuss the effectiveness and advantage of pecrutaneous nephrolithotomy (PCNL) with the patient in the supine-slope position to treat the upper urinary tact urolithiasis. Materials and methods: A total of 52 subjects underwent the supine-slope position percutaneous nephrolithotomy (PCNL) from October 2007 to May 2008. Among of them aged from 22

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Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

第十五届全国泌尿外科学术会议

Objectives: This study was intended to discuss the effectiveness and advantage of pecrutaneous nephrolithotomy (PCNL) treating the upper urinary tract urolithiasis. Materials and methods: A total of 226 subjects underwent the percutaneous nephrolithotomy (PCNL) from October 2004 to May 2008. Among of them aged from 13 to 72 years male and female, were 109 and 117, respectively.

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Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： Jie Jin Huajing Zhang Qianying Lu Linqiang Tian Sanqiao Yao Feng Lai Yangfan liang Chuanchuan Liu Yujia Lu Sijia Tian Yanmei zhao Wenjie Ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

槲皮素改善高糖损伤大鼠冠脉肌原性反应的机制研究

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中国病理生理杂志 2017年第10期33卷 1801-1805页

作者：侯晓敏张明升赵良渊齐鼎铭秦小江山西医科大学基础医学院山西太原030001 山西医科大学公共卫生学院山西太原030001

目的:通过大鼠冠状动脉(coronary artery,CA)张力测定和全细胞膜片钳记录CA血管平滑肌细胞(vascular smooth muscle cells,VSMC)的电压门控性钾通道(voltage-gated K^+channel,Kv)电流,研究槲皮素改善高糖损伤大鼠CA肌原性反应的机制。... 详细信息

目的:通过大鼠冠状动脉(coronary artery,CA)张力测定和全细胞膜片钳记录CA血管平滑肌细胞(vascular smooth muscle cells,VSMC)的电压门控性钾通道(voltage-gated K^+channel,Kv)电流,研究槲皮素改善高糖损伤大鼠CA肌原性反应的机制。方法:从正常SD大鼠急性分离得到CA环,然后分成6组:(1)正常对照组;(2)高糖组;(3)高糖+低剂量(3μmol/L)槲皮素组;(4)高糖+中剂量(10μmol/L)槲皮素组;(5)高糖+高剂量(30μmol/L)槲皮素组;(6)高糖+蛋白激酶C(protein kinase C,PKC)抑制剂C6303+高剂量槲皮素组。利用血管张力测定,检测CA环对血管收缩剂(60 mmol/L KCl和0.1 mmol/L U46619)的反应,并将CA环用60 mmol/L KCl预收缩后,用乙酰胆碱(acetylcholine,ACh;10^(-9)~10^(-5)mol/L)进行舒张,计算ACh引起CA环张力下降幅度与预先收缩的百分比。急性分离得到大鼠CA的VSMC,然后记录Kv电流。结果:与正常対照组相比,高糖组CA环对60mmol/L KCl和0.1 mmol/L U46619的反应明显升高;中、高剂量槲皮素的干预可以使高糖所致CA环对血管收缩剂的反应降低,孵育PKC特异性抑制剂C6303可减弱槲皮素的作用。与正常对照组相比,高糖组大鼠离体CA环对ACh的舒张幅度明显减弱。槲皮素的干预可以改善高糖孵育的大鼠离体CA环对ACh的舒张反应,C6303可以减弱槲皮素的作用。高糖孵育明显抑制CA VSMC的Kv电流,槲皮素干预可以减弱高糖对CA VSMC Kv电流的影响,孵育C6303可减弱槲皮素的作用。结论:槲皮素对高糖损伤大鼠CA肌原性反应具有保护作用,该作用与增大VSMC的Kv电流和激活PKC有关。

关键词：槲皮素冠状动脉高糖电压门控性钾通道蛋白激酶C