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移动通信基站布点规划技术方法研究

数字技术与应用 2018年第5期36卷 62-63页

作者：赵尧松广东省电信规划设计院有限公司广东广州510630

基站是移动通信系统重要组成,在系统运行中有着不可忽视的作用。本文将以移动通信基站布点规划要求和建设形式为切入点,通过布点规划技术以及规划保障措施进行研究分析,旨在保证基站布点规划水平,保障移动通信基站效能发挥质量。

关键词：建设形式移动通信基站布点规划技术

多发性脑梗死与单发性脑梗死危险因素对比分析

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中国循证医学杂志 2008年第2期8卷 75-78页

作者：赵松耀刘鸣刘志勤四川大学华西医院神经内科成都610041

目的比较多发性脑梗死(MCI)与单发性脑梗死(SCI)的危险因素,以利于对其进行针对性的防治。方法前瞻性连续登记神经内科缺血性脑卒中患者,根据临床和影像学资料分为MCI和SCI组,对可能影响多发性脑梗死发病的24项因素先进行单因素分析,比... 详细信息

目的比较多发性脑梗死(MCI)与单发性脑梗死(SCI)的危险因素,以利于对其进行针对性的防治。方法前瞻性连续登记神经内科缺血性脑卒中患者,根据临床和影像学资料分为MCI和SCI组,对可能影响多发性脑梗死发病的24项因素先进行单因素分析,比较可能的危险因素在MCI与SCI组间有无差异,然后进行非条件logistic多元回归分析,校正混杂因素的影响。结果年龄、性别、高血压、糖尿病、心瓣膜病、吸烟、脑梗死史、入院首次收缩压等危险因素在MCI与SCI组间有显著差异,logistic多元回归分析显示,年龄[OR=1.014,95%CI(1.003,1.026)]、高血压[OR=1.566,95%CI(1.185,2.068)]、吸烟[OR=1.473,95%CI(1.052,2.061)]、脑梗死史[OR=1.948,95%CI(1.326,2.864)]为MCI的独立危险因素。结论与SCI相比,年龄、高血压、吸烟、脑梗死史为MCI的独立危险因素。

关键词：多发性脑梗死单发性脑梗死危险因素

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交流电失真度测量方法研究与实现

电测与仪表 2014年第19期51卷 70-74页

作者：赵耀松霍凯陈志鸿北京交通大学机械与电子控制工程学院北京100044

曲线拟合法从原理上能够实现正弦信号失真度计算,但正弦曲线拟合是一个四参数优化问题,传统算法在求取全局最优解时对初值敏感并容易陷入局部极值,这限制了曲线拟合法在失真度测量中的应用。针对正弦曲线拟合困难的问题,提出了一种三参... 详细信息

曲线拟合法从原理上能够实现正弦信号失真度计算,但正弦曲线拟合是一个四参数优化问题,传统算法在求取全局最优解时对初值敏感并容易陷入局部极值,这限制了曲线拟合法在失真度测量中的应用。针对正弦曲线拟合困难的问题,提出了一种三参数曲线拟合算法,设计并实现了一款基于ARM的交流电失真度测量仪,并对其硬件和软件设计中的关键技术进行了说明。测试表明,该方法能够完成交流电失真度的测量,设备运行稳定,满足应用要求。

关键词：交流电失真度三参数曲线拟合嵌入式系统 ARM

Rapid and scalable preparation of highly quaternized polymer networks to achieve efficient simultaneous adsorption of iodide and pertechnetate

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Science China Chemistry 2025年第01期 337-349页

作者： Meiyun Xu song Gu Fulong Chen Zhe zhao Peng Liu Daoben Hua State Key Laboratory of Radiation Medicine and Protection School of Radiological and Interdisciplinary Sciences (RAD-X) Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions Soochow University

The efficient separation of fission products,such as TcO4-and I-,holds strategic significance for the management of radioactive wastes and environmental *** this study,we propose an ultrafast strategy for scalable preparation of a highly quaternized organic network to facilitate efficient and synchronous separation of iodide and *** network can be prepared within a few minutes at room temperature,using polyethylenimine and 1,2,4,5-tetrakis（bromomethyl）benzene as building *** chlorine replacement,the network,abundantly decorated with quaternary ammonium groups （Cl@QPN）,exhibits an ultrahigh positive charge density of 7.6 mmol/*** enables the rapid and efficient enrichment of target anions through strong electrostatic Coulomb *** a result,Cl@QPN exhibits significantly higher adsorption rate constants of 0.830 g/（mg min） for ReO4-（a nonradioactive surrogate of TcO4-） and 0.677 g/（mg min） for I-compared to other ***,it possesses high adsorption capacities,reaching 1,681 mg/g for ReO4-and 917.4 mg/g for I-.Cl@QPN also demonstrates good selectivity towards target ions and shows efficient adsorption for99TcO4-.Additionally,Cl@QPN exhibits high dynamic processing capacities,handling up to 3,100 and 7,400 kg of simulated streams per kilogram of material for I-and ReO4-,respectively.

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FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

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Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： Jing yao Yuan Li Xi Liu Wenping Liang Yu Li Liyong Wu Zhe Wang Weihong song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor

Precise gradient separation of nanoparticles using reduced graphene oxide-polyoxomolybdate membranes

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Science China Chemistry 2025年第01期 209-216页

作者： Yixin Yang Wanlei zhao Ruoxuan Zheng Hongqiang Li Wei Chen Yu-Fei song State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Quzhou Institute for Innovation in Resource Chemical Engineering

The purification and size sieving of nanoparticles （NPs） represents a significant scientific ***,the r GO-polyoxometalates (POMs=PMo12,Mo132and Mo368) membranes were fabricated successfully via a simple and scalable POMsassisted in-situ photoreduction *** the mass ratio of r GO to PMo12was 1:30,the resultant r GO-PMo12membranes with highly ordered and uniform nanochannels of 1.0 nm can be obtained,which showed an accurate carbon quantum dots（CQDs） separation with a cut-off size approximately 1.0 *** increase of the size of the interlayered POMs from PMo12（1.0 nm）,{Mo132}（2.9 nm） to{Mo368}（3.8 nm）,the resultant r GO-PMo12,r GO-Mo132and r GO-Mo368exhibited precise gradient separation of CQDs and Au nanoparticles by size exclusion *** results pave a promising way to construct new twodimensional （2D） membranes for highly efficient size-selective separation.

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Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

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Neural Regeneration Research 2025年第3期20卷 821-835页

作者： Jing Wang Bing Zhang Lanfang Li Xiaomei Tang Jinyu Zeng Yige song Chao Xu Kai zhao Guoqiang Liu Youming Lu Xinyan Li Kai Shu Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Graduate Student Chongqing Medical UniversityChongqingChina Department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina Department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding Chun Chen Heng zhao Bin Dai Lei Ye Tao song Shuai Huang Jia Wang Tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

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罕见神经型白塞病治疗2例并文献复习

华西医学 2007年第2期22卷 370-371页

作者：赵松耀赖晓晖四川大学华西医院神经内科四川成都610041

目的检索有关神经白塞病治疗的文献,提供治疗方案。方法检索cochrane图书馆、medline数据库、中国生物医学文献数据库(CBM)及中国知识资源总库(CNKI)。结果共检索到符合要求的系统评价1篇,前瞻性队列研究1篇,系列病例分析和病例报道81... 详细信息

目的检索有关神经白塞病治疗的文献,提供治疗方案。方法检索cochrane图书馆、medline数据库、中国生物医学文献数据库(CBM)及中国知识资源总库(CNKI)。结果共检索到符合要求的系统评价1篇,前瞻性队列研究1篇,系列病例分析和病例报道81篇。结论通过证据的检索和评价,对两例罕见神经白塞病患者给予激素和免疫抑制剂治疗后获得了较好效果,还需要更多随机对照临床试验进一步评价药物疗效和安全性。

关键词：神经白塞病治疗文献分析