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Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2982-2997页

作者： Hongli li Jianhua Huang Di zhao Lemei Zhu Zheyu Zhang Min Yi Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Metabolic Diseases ChangshaHunan ProvinceChina Hunan Academy of Chinese Medicine ChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina

Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut *** aim of this study was to investigate systemic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease *** do this,we analyzed peripheral organ metabolism and the gut microbiota in amyloid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of ***-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with younger APP/PS1 ***,a strong correlation emerged between the gut microbiota and kidney metabolism in APP/PS1 *** findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.

关键词： Alzheimer’s disease APP/PS1 mice brain-kidney axis gut microbiota heart-brain axis liver-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metabolism spleen-brain axis

Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

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Neural Regeneration Research 2025年第8期20卷 2373-2381页

作者： lifang zhao Mingkai Zhang Qimeng li Xuemin Wang Jie Lu Ying Han Yanning Cai Department of Clinical Biobank Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Geriatric Medical Research Center BeijingChina Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Radiology and Nuclear Medicine Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics BeijingChina Key Laboratory of Neurodegenerative diseases Ministry of EducationBeijingChina School of Biomedical Engineering Hainan UniversityHaikouHainan ProvinceChina Center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijingChina National Clinical Research Center for Geriatric Diseases BeijingChina Institute of Biomedical Engineering Shenzhen Bay LaboratoryGaoke Innovation CenterShenzhenGuangdong ProvinceChina Department of Neurobiology Xuanwu HospitalCapital Medical UniversityBeijingChina

Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative ***,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°*** aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large *** samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline *** samples were stored at-80°C for up to 6 years before being used in this *** results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage ***,the level of total tau showed a negative correlation with sample storage ***,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage *** was not observed in individuals with cognitive ***,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage ***,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's ***,in cohort studies,it is important to consider the impact of storage time on the overall results.

关键词： Alzheimer’s disease amyloid-β diagnostic ability glial fibrillary acidic protein neurodegeneration neurofilament light chain plasma biomarkers single molecule array storage time tau

Amperometric Glucose Sensor Based on Batch CuO-Modified Screen-Printed Silver-Carbon Electrodes

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 35-41页

作者： xia Haiyan HUANG Yin YANG Hua WANG Xintian SHI Jianping liU lixia FU Yacheng QUAN Changyun li Suyuan Cofoe Medical Technology Company limited Changsha 410000China Institute of New Energy Hexi UniversityZhangye 734000China Chemistry and Chemical Engineering Central South UniversityChangsha 410000China

CuO nanoparticles were successfully synthesized via a two-jet electrospun method,and then screen-printed on silver-carbon electrodes,forming CuO-modified Ag-C(CuO/Ag-C)disposable strip *** natural environment condition for glucose detection,the obtained CuO/Ag-C electrodes show a high sensitivity of 540 nA·mM^(-1)·cm^(-2),and a low limit of detection(0.68 mM)in a wide linear response range of 0.68 mM and 3 mM(signal/noise=3),*** addition,the CuO/Ag-C electrodes also exhibit excellent anti-interference,air stability and *** a result,the fabrication of CuO nanoparticles via an electrospun process and the technique of screen-printed electrodes are of great significance for glucose detection.

关键词： electrochemical sensor CuO nanoparticles glucose detection screen-printing technique

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腹腔镜治疗食管裂孔疝术后吞咽困难的比较

世界华人消化杂志 2016年第5期24卷 744-748页

作者：赵凯李朝霞陈震孙向宇天津医科大学研究生院天津市300070 天津市西青医院普外科天津市300380 天津市西青医院耳鼻喉科天津市300380 天津市南开医院微创外科天津市300100

目的:探讨食管裂孔疝行腹腔镜裂孔修补术加Nissen360°胃底折叠术和Toupet270°胃底折叠术后吞咽困难的发生率.方法:回顾分析天津市南开医院2012-02/2014-02采用腹腔镜技术治疗的64例食管裂孔疝患者资料,其中行腹腔镜Nissen360°胃底折... 详细信息

目的:探讨食管裂孔疝行腹腔镜裂孔修补术加Nissen360°胃底折叠术和Toupet270°胃底折叠术后吞咽困难的发生率.方法:回顾分析天津市南开医院2012-02/2014-02采用腹腔镜技术治疗的64例食管裂孔疝患者资料,其中行腹腔镜Nissen360°胃底折叠术32例,行腹腔镜Toupet270°胃底折叠术32例.对两组术后吞咽困难的发生率、术后反酸发生率、手术时间、术中出血量、术后Demeester评分及术后住院时间进行观察,并进行统计学分析.结果:术后Nissen组有6例出现吞咽困难,这6例吞咽困难病例均未使用补片修补,予对症治疗3 mo后,4例吞咽困难仍不能缓解,行胃镜下扩张术后症状缓解;有1例术后出现轻度反酸,经抑酸治疗后症状缓解.术中Toupet组有1例巨大食管裂孔疝使用补片修补,术后Toupet组未出现吞咽困难病例,有2例患者出现轻度反酸,经抑酸、促进胃动力治疗后症状消失.术后吞咽困难的发生率Nissen组高于Toupet组,比较有统计学差异(P0.05).结论:食管裂孔疝患者行Nissen360°胃底折叠术术后吞咽困难的发生率高于行Toupet270°胃底折叠术.

关键词：食管裂孔疝腹腔镜 Nissen胃底折叠术 Toupet胃底折叠术

探讨长期服用麝香保心丸治疗冠心病的临床效果

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世界最新医学信息文摘 2019年第54期19卷 17-18页

作者：赵丽侠北京市西城区天桥社区卫生服务中心

目的研讨冠心病患者长期口服麝香保心丸的临床作用与安全性。方法选择148例冠心病患者为观察对象,并采用计算机对所选患者进行随机分组,将74例采取常规基础用药者纳入A组,将74例在基础用药下接受麝香保心丸长期口服者纳入B组,对比两组... 详细信息

目的研讨冠心病患者长期口服麝香保心丸的临床作用与安全性。方法选择148例冠心病患者为观察对象,并采用计算机对所选患者进行随机分组,将74例采取常规基础用药者纳入A组,将74例在基础用药下接受麝香保心丸长期口服者纳入B组,对比两组临床疗效。结果 B组用药后取得94.6%的总有效率,较A组的用药总有效率(83.8%)显著提高,P0.05,无统计学意义;用药后,B组的心绞痛症状较A组显著改善,硝酸甘油用量较A组显著减少,P<0.05,有统计学意义。结论冠心病患者长期采用麝香保心丸口服治疗有显著的用药效果,并且副反应较少,对缓解心绞痛症状、减少硝酸甘油用量有明显的助益,值得推荐。

关键词：冠心病麝香保心丸临床作用安全性

中医辨证治疗脾胃气虚型功能性消化不良的临床效果

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智慧健康 2019年第26期5卷 47-49页

作者：赵丽侠北京市西城区天桥社区卫生服务中心北京100050

目的对中医辨证治疗脾胃气虚型功能性消化不良的临床效果进行探讨。方法将研究纳入标准、排除标准作为筛选前提,从我社区中心2017年1月至2018年12月收治的患者人群中抽取43例脾胃气虚型功能性消化不良患者参与研究,临床上予以中医辨证治... 详细信息

目的对中医辨证治疗脾胃气虚型功能性消化不良的临床效果进行探讨。方法将研究纳入标准、排除标准作为筛选前提,从我社区中心2017年1月至2018年12月收治的患者人群中抽取43例脾胃气虚型功能性消化不良患者参与研究,临床上予以中医辨证治疗,并设为观察组。在相同的时间段抽取另外43例脾胃气虚型消化不良患者参与研究,临床上予以常规西药治疗,设为参照组。就两组患者的临床治疗情况以及预后情况展开分析和数据对比。结果观察组在治疗效果方面相对参照组更为出色,数值方面总有效率更高,与参照组差异较大,P<0.05,存在统计学意义;观察组在症状积分方面相对参照组更为出色,数值方面分值改善幅度更大,与参照组差异较大,P<0.05,存在统计学意义;观察组的不良反应发生率相对参照组更为出色,数值更低,与参照组差异较大,P<0.05,存在统计学意义;观察组在治疗后生活质量方面相对参照组更为出色,数值方面SF-36各项分值更高,与参照组差异较大,P<0.05,存在统计学意义。结论对脾胃气虚型功能性消化不良患者实施中医辨证治疗,可有效改善患者病情症状,提高生活质量、且疗效显著,安全性高。

关键词：中医辨证脾胃气虚功能性消化不良临床效果

稳心颗粒联合酒石酸美托洛尔片治疗高血压性心脏病合并室性期前收缩的疗效及安全性评价

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中外医学研究 2014年第36期12卷 125-126页

作者：赵立侠北京市大兴区礼贤中心卫生院北京102604

目的:探讨中药稳心颗粒联合西药酒石酸美托洛尔片治疗高血压性心脏病合并室性期前收缩的临床效果及不良反应的发生情况。方法:将2012年3月-2013年3月笔者所在医院收治的80例高血压性心脏病合并室性期前收缩的患者随机分为观察组和对照组... 详细信息

目的:探讨中药稳心颗粒联合西药酒石酸美托洛尔片治疗高血压性心脏病合并室性期前收缩的临床效果及不良反应的发生情况。方法:将2012年3月-2013年3月笔者所在医院收治的80例高血压性心脏病合并室性期前收缩的患者随机分为观察组和对照组,每组40例,对照组患者在原有治疗的基础上加酒石酸美托洛尔,观察组则实施稳心颗粒联合酒石酸美托洛尔片进行治疗,比较两组患者治疗后的临床效果和并发症的发生率。结果:观察组治疗后临床总有效率(97.50%)明显高于对照组(72.50%),差异有统计学意义(P0.05)。结论:采用稳心颗粒联合酒石酸美托洛尔片能明显提高高血压性心脏病合并室性期前收缩的治疗效果,临床使用安全可靠,建议推广。

关键词：稳心颗粒酒石酸美托洛尔片高血压性心脏病室性期前收缩