检索结果-南通市图书馆

Passive convergence-permeable reactive barrier (PC-PRB): An effective configuration to enhance hydraulic performance

引用

Frontiers of Environmental Science & Engineering 2022年第12期16卷 79-88页

作者： Kaixuan Zheng Xingshen Luo Yiqi Tan Zhonglei li Hongtao Wang Tan Chen li zhao liangtong Zhan School of Environment Tsinghua UniversityBeijing100084China College of life and Environmental Sciences Minzu University of ChinaBeijing100081China Institute of Geotechnical Engineering College of Civil Engineering and ArchitectureZhejiang UniversityHangzhou310058China

A novel permeable reactive barrier(PRB)configuration,the so-called passive convergence-permeable reactive barrier(PC-PRB),is proposed to overcome several shortcomings of traditional PRB configurations,such as high dependency to site hydrogeological characteristics and plume *** PC-PRB is designed to make the plume converge towards the PRB due to the passive hydraulic decompression-convergent flow *** corresponding passive groundwater convergence(PC)system is deployed upstream of the PRB system,which consists of passive wells,water pipes,and a buffer layer.A two-dimensional(2D)finite-difference hydrodynamic code,entitled PRB-Flow,is developed to examine the hydraulic performance parameters(i.e.,capture width(W)and residence time(t))of *** is proved that the horizontal 2D capture width(Wh)and vertical 2D capture depth(Wv)of the PC-PRB remarkably increase compared to that of the continuous reactive barrier(C-PRB).The aforementioned relative growth values in order are greater than 50%and 25%in this case ***,the PRB geometric dimensions as well as the materials cost required for the same plume treatment *** sensitivity analysis reveals that the dominant factors influencing the hydraulic performance of the PC-PRB are the water pipe length(Lp),PRB length(LPRB),passive well height(Hw),and PRB height(HPRB).The discrepancy between the Wh of PC-PRB and that of the C-PRB(i.e.,∆Wh)has a low correlation with PRB parameters and mainly depends on Lp,which could dramatically simplify the PC-PRB design ***,the proposed PC-PRB exhibits an effective PRB configuration to enhance hydraulic performance.

关键词： Passive convergence-permeable reactive barrier(PC-PRB) Permeable reactive barrier configuration Numerical simulation Hydraulic performance evaluation Sensitivity analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

CDs assembled metal-organic framework:Exogenous coreactant-free biosensing platform with pore confinement-enhanced electrochemiluminescence

引用

Chinese Chemical Letters 2022年第11期33卷 4803-4807页

作者： Xiu-li Tao Mei-Chen Pan xia Yang Ruo Yuan Ying Zhuo Key Laboratory of Luminescence Analysis and Molecular Sensing(Southwest University) Ministry of EducationCollege of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China

Despite the various synthesis approachs to obtain luminous carbon dots(CDs),it is still quite challenging to construct the efficient electrochemiluminescence(ECL)owing to their low ECL reactivity and easy ***,an efficient and concise ECL system was skillfully constructed by taking advantage of the nitrogen and sulfur co-doped CDs(N,S-CDs)with surfaces rich in hydrazide groups as luminophors to emit intense ECL,and metal-organic framework(MOF)as the matrix to confine CDs in its ***,the proposed CDs assembled MOF(CDs/ZIF-8)enhanced anodic ECL signal up to 250%of pure CDs under the exogenous coreactant-free *** a proof of concept,the highly sensitive detection of uric acid(UA)was realized by the constructed ECL platform with a low detection limit of 3.52 nmol/L ranging from 10 nmol/L to 50μmol/*** work expanded ideas for the application of pore confinement effect,and provided references for the detection of disease biomarkers of gout and hyperuricemia.

关键词： Carbon dots Zeolitic imidazolate framework-8 Pore confinement-enhanced ECL Exogenous coreactant-free Uric acid

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synthesis and cytotoxic evaluation of new colchicine derivatives bearing 1,3,4-thiadiazole moieties

引用

Chinese Chemical Letters 2013年第4期24卷 299-302页

作者： li-Hong Shen Hong-Yu li Hui-xia Shang Shu-Ting Tian Yi-Sheng Lai li-Jie liu Handan Key Laboratory of Organic Small Molecule Materials Handan College Center of Drug Discovery China Pharmaceutical University Hebei Yiling Medicine Corporation Ltd.

In search of novel anticancer agents, a series of N-methyl colchiceinamide derivatives （7a-7i） containing 1,3,4-thiadiazole moieties were synthesized, and their structures were confirmed by spectral analysis. Cytotoxicity of these compounds was evaluated by MTT assay in vitro against four human tumor cell lines, i.e. A2780, A549, BEL7402, and MCF-7. The results indicated that most of the derivatives showed significant anticancer activities, particularly, compounds 7h and 7i showed more potent cytotoxic activities of all screened cancer cells than colchicine.

关键词： ColchicineN-Methyl colchiceinamide1 3 4-ThiadiazoleCytotoxicity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Triamcinolone as an adjunct to the combination of anti-VEGF for the management of diabetic macular edema

引用

International Journal of Ophthalmology(English edition) 2021年第6期14卷 869-874页

作者： Ying-Ying Yu Yong Cheng li-Bin Chang Hui-Ka xia xiao-Xin li Department of Ophthalmology Peking University People’s HospitalEye diseases and Optometry InstituteBeijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid DiseasesCollege of OptometryPeking University Health Science CenterBeijing 100044China Department of Ophthalmology Beijing Jingmei Group General HospitalBeijing 102300China Department of Ophthalmology Hebei General HospitalShijiazhuang 050051Hebei ProvinceChina xiamen Eye Center of xiamen University Xiamen 361003Fujian ProvinceChina

AIM:To assess the efficacy of intravitreal triamcinolone(IVTA)as an adjunct to the combination of anti-vascular endothelial growth factor(VEGF)for the management of diabetic macular edema(DME).METHODS:A total of 51 patients with visual disabilities causing by DME from two sites were retrospectively collected and assigned to two groups according to the therapeutic method:intravitreal conbercept(IVC)combined with focal laser(24 eyes)and IVC combined with focal laser and IVTA(27 eyes).Best-corrected visual acuity(BCVA),the required number of IVCs,central retinal thickness(CRT),the mean costs of treatment burden and safety were compared over 12 ***:From baseline to month 1 through month 12,IVC combined with focal laser and IVTA improved the mean average change in BCVA superior to IVC combined with focal laser(+5.20 vs+2.71 letters).At month 12,20.83%of the IVC combined with focal laser and 37.04%of IVC combined with focal laser and IVTA arms gained more than 10 BCVA *** the period,the mean CRT decreased significantly in the IVC combined with focal laser and IVTA arm(-245.9μm)compared to the IVC combined with focal laser arm(-98.45μm).The average of 6.45 and 1.25 conbercept injections performed in the IVC combined with focal laser and IVC combined with focal laser and IVTA arms,*** mean cost of treatment burden for 12 mo was$6247.44±4069.18 in the IVC combined with focal laser arm and$1679.19±542.73 in the IVC combined with focal laser and IVTA arm,with a statistically significant *** from occasional minor subconjunctival hemorrhage,no other significant ocular adverse events(AEs)were observed in either group during the 12-month ***:It is effective and cost-effective to treat DME by utilizing triamcinolone as an adjunct to the combination of anti-VEGF.

关键词： diabetic macular edema intravitreal triamcinolone anti-vascular endothelial growth factor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Creation of cytochrome P450 catalysis depending on a non-natural cofactor for fatty acid hydroxylation

引用

Journal of Energy Chemistry 2023年第4期79卷 31-36页

作者： Qing li xiaojia Guo Xueying Wang Junting Wang li Wan Haizhao Xue Zongbao K.zhao Laboratory of Biotechnology Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina Dalian Key Laboratory of Energy Biotechnology Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina

Cytochrome P450 enzymes catalyze diverse oxidative transformations at the expense of reduced nicotinamide adenine dinucleotide phosphate(NADPH),however,their applications remain limited largely because NADPH is cost-prohibitive for biocatalysis at scale yet tightly regulated in host cells.A highly challenging task for P450 catalysis has been to develop an alternative and biocompatible electrondonating *** we engineered P450 BM3 to favor reduced nicotinamide cytosine dinucleotide(NCDH)and created non-natural cofactor-dependent P450 *** outstanding mutants were identified with over 640-fold NCDH preference improvement and good catalytic efficiencies of over15,000 M^(-1)s^(-1)for the oxidation of the fatty acid probe 12-(para-nitrophenoxy)-*** docking analysis indicated that these mutants bear a compacted cofactor *** fusing with an NCD-dependent formate dehydrogenase,fused proteins functioned as NCDH-specific P450catalysts by using formate as the electron ***,these mutants and fusions catalyzed NCDH-dependent hydroxylation of fatty acids with similar chain length preference to those by natural P450 BM3 in the presence of NADPH and also similar regioselectivity for subterminal hydroxylation of lauric *** P450 BM3 and its variants are catalytically powerful to take diverse substrates and convey different reaction paths,our results offer an exciting opportunity to devise advanced cell factories that convey oxidative biocatalysis with an orthogonal reducing power supply system.

关键词： Biocatalysis Cytochrome P450 Directed evolution Fatty acid hydroxylation Non-natural cofactor Synthetic biology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

GAS AND OIL POWER DISTRIBUTION RATIO OF A NEW HYDRAUliC BREAKER

引用

Chinese Journal of Mechanical Engineering 2007年第5期20卷 54-58页

作者： zhao Hongqiang li Meixiang GAO Bin HE Qinghua College of Mechanical and Electrical Engineering Central South University Changsha 410083 China

The working principle of a new hydraulic breaker operated jointly by gas and hydraulic flow which has a reasonable structure, high efficiency and long piston life-span, is analyzed, and the optimal power distribution ratio of the sealed nitrogen gas to the high-pressure oil in the process of piston impacting is studied. Through theoretical analysis, optimization simulation and detailed calculation, it is determined that the impact system has optimal mechanical performance and highest efficiency when the distribution ratio φ is between 0.3 and 0.5. The theoretical result is also verified by repeated tests.

关键词： Hydraulic breaker Power Distribution ratio Efficiency

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Design and synthesis of novel chiral molecular tweezers based on deoxycholic acid

引用

Chinese Chemical Letters 2008年第9期19卷 1051-1054页

作者： Zhi Gang zhao Xing li liu Yi Zhong College of Chemistry and Environmental Protection Engineering Southwest University for Nationalities Chengdu 610041 China

A novel type of chiral molecular tweezers has been designed and synthesized by using deoxycholic acid as backbone and ethanoyl and the chiral unsymmetrical urea unit as arms. Their structures were characterized by 1H NMR, IR, MS spectra and elemental analysis. These molecular tweezers showed good binding ability for neutral molecules and chiral molecules.

关键词： Molecular tweezer Deoxycholic acid Synthesis Molecular recognition

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Targeted Synthesis of Anthranilic Diamides Insecticides Containing Trifluoroethoxyl Phenylpyrazole

引用

Chemical Research in Chinese Universities 2021年第3期37卷 655-661页

作者： li Huangong zhao Yangyang SUN Pengwei GAO li XIONG lixia YANG Na ZHOU Sha li Yuxin li Zhengming State Key Laboratory of Elemento-Organic Chemistry Research Institute of Elemento-Organic ChemistryCollege of ChemistryNankai UniversityTianjin300071P.R.China

A series of novel anthranilic diamides analogues(9a-9t)containing trifluoroethoxyl pyrazole moiety was designed and synthesized and their insecticidal bioactivities against Mythimna separata(Walker,***)and Plutellaxylostella(***)were *** structures of the title compounds were confirmed by^(1)H NMR,^(13)C NMR and *** insecticidal activities showed that some of the title compounds possessed good to excellent bioactivities towards *** and *** 9c and 9t exhibited 100%mortality rate against *** at 0.2 mg/*** the ***,the synthesized compounds(9c-9e,9i and 9o)showed 70%,80%,75%,65%and 60%insecticidal activities at 1×10^(−6)mg/L,respectively,higher than that of chlorantraniliprole(0).Based on excellent insecticidal activities,the mode of the action was tested by the calcium-imaging technique,the results of which demonstrated that the novel compounds shared the same target with *** binding pose of the most active compound 9t in RyRs of *** was predicted by molecular docking,which showed that compound 9t interacted with the residues Glu140(A)and His147(A)via hydrogen bond.

关键词： Trifluoroethoxylphenylpyrazole Anthranilic diamide derivative Insecticidal bioactivity Mode of the action Molecular docking

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A NEW MODEL FOR ESTIMATION OF DIFFUSION COEFFICIENT OF PHENOL DESORPTION WITHIN POLYMERIC RESIN UNDER ULTRASOUND

引用

Chinese Journal of Reactive Polymers 2002年第1期11卷 1-10页

作者： li xiangbin zhao Yuechun xia Qibin XI Hongxia li Zhong Research Institute ofChemical Engineering South China University of Technology Guangzhou 510640P.R.China College of Science South China Agricultural UniversityGuangzhou 510642China

A new model, phase equilibrium-kinetics model (PEKM), for estimation of diffusion coefficient was proposed in this paper. Kinetic experiments of phenol desorption on NKAII resin in the presence and the absence of ultrasound were separately conducted, and diffusion coefficients of phenol within an adsorbent particle were estimated by means of proposed PEKM and classic simplified model. Results show that the use of ultrasound not only changes the phase equilibrium state of NKA II resin/phenol/water system which had been equilibrium at normal condition, but also enhances diffusion of phenol within the resin. The diffusion coefficient of phenol in the resin in the field of ultrasound increases in an order of magnitude in comparison with the diffusion coefficient determined under no ultrasound. Experimental results also indicated that the diffusion coefficients estimated by PEKM were more accurate than that estimated by the classic simplified model.

关键词： Ultrasound Diffusion coefficient PEKM Classic simplified model Phenol Desorption NKAII resin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Mid-Pleistocene Climate Transition Recorded in a 1.6 Myr-Period Lacustrine Sediment Sequence from Mazatage, Tarim Basin

引用

Acta Geologica Sinica(English Edition) 2015年第1期89卷 312-313页

作者： liU Jian WU li WANG Rujian zhao Yue Institute of Geomechanics CAGS School of Ocean and Earth Science Tongji University

The mid-Pleistocene climate transition （MPT） has been widely reported in worldwide geological events. As a key issue of the Quaternary geology, it has attracted much attention from the paleoclimate community. MPT refers to a period lasting for several hundreds of thousand years, during which the dominant climate periodicity gradually extended from 41 kyr to 100 kyr （Ruddiman et al., 1989）,

关键词： Wang Tarim Basin The Mid-Pleistocene Climate Transition Recorded in a 1.6 Myr-Period Lacustrine Sediment Sequence from Mazatage

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：