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Nano-Micro Letters 2025年第1期17卷 135-159页

作者： Zhengqing Fan Ruimin li Xin Zhang Wanyu zhao Zhenghui Pan xiaowei Yang School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China School of Chemistry and Chemical Engineering Taiyuan University of TechnologyTaiyuan 030024People’s Republic of China School of Materials Science and Engineering Tongji UniversityShanghai 201804People’s Republic of China

Rechargeable magnesium batteries(RMBs)have been considered a promising“post lithium-ion battery”system to meet the rapidly increasing demand of the emerging electric vehicle and grid energy storage ***,the sluggish diffusion kinetics of bivalent Mg^(2+)in the host material,related to the strong Coulomb effect between Mg^(2+)and host anion lattices,hinders their further development toward practical *** engineering,regarded as an effective strategy to break through the slow migration puzzle,has been validated in various cathode materials for *** this review,we first thoroughly understand the intrinsic mechanism of Mg^(2+)diffusion in cathode materials,from which the key factors affecting ion diffusion are further ***,the positive effects of purposely introduced defects,including vacancy and doping,and the corresponding strategies for introducing various defects are *** applications of defect engineering in cathode materials for RMBs with advanced electrochemical properties are also ***,the existing challenges and future perspectives of defect engineering in cathode materials for the overall high-performance RMBs are described.

关键词： Rechargeable magnesium battery Sluggish diffusion kinetic Defect engineering Cathode materials Ion migration

Potential role and therapeutic implications of glutathione peroxidase 4 in the treatment of Alzheimer's disease

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Neural Regeneration Research 2025年第3期20卷 613-631页

作者： Yanxin Shen Guimei Zhang Chunxiao Wei Panpan zhao Yongchun Wang Mingxi li li Sun Department of Neurology and Neuroscience Center The First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina Cognitive Impairment Center Department of NeurologyThe First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina

Alzheimer's disease is an age-related neurodegenerative disorder with a complex and incompletely understood pathogenesis. Despite extensive research, a cure for Alzheimer's disease has not yet been found. Oxidative stress mediates excessive oxidative responses, and its involvement in Alzheimer's disease pathogenesis as a primary or secondary pathological event is widely accepted. As a member of the selenium-containing antioxidant enzyme family, glutathione peroxidase 4 reduces esterified phospholipid hydroperoxides to maintain cellular redox homeostasis. With the discovery of ferroptosis, the central role of glutathione peroxidase 4 in anti-lipid peroxidation in several diseases, including Alzheimer's disease, has received widespread attention. Increasing evidence suggests that glutathione peroxidase 4 expression is inhibited in the Alzheimer's disease brain, resulting in oxidative stress, inflammation, ferroptosis, and apoptosis, which are closely associated with pathological damage in Alzheimer's disease. Several therapeutic approaches, such as small molecule drugs, natural plant products, and non-pharmacological treatments, ameliorate pathological damage and cognitive function in Alzheimer's disease by promoting glutathione peroxidase 4 expression and enhancing glutathione peroxidase 4 activity. Therefore, glutathione peroxidase 4 upregulation may be a promising strategy for the treatment of Alzheimer's disease. This review provides an overview of the gene structure, biological functions, and regulatory mechanisms of glutathione peroxidase 4, a discussion on the important role of glutathione peroxidase 4 in pathological events closely related to Alzheimer's disease, and a summary of the advances in small-molecule drugs, natural plant products, and non-pharmacological therapies targeting glutathione peroxidase 4 for the treatment of Alzheimer's disease. Most prior studies on this subject used animal models, and relevant clinical studies are lacking. Future clinica

关键词： apoptosis ferroptosis inflammation lipid peroxidation natural plant products neurodegenerative disorder neuroprotection oxidative stress small-molecule drugs

日粮中添加酵母培养物对育肥猪生长性能、养分表观消化率、血清生化指标及经济效益的影响

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饲料研究 2023年第15期46卷 23-28页

作者：赵丽霞曹源漯河食品职业学院河南漯河462300

试验旨在研究酵母培养物对育肥猪生长性能、养分表观消化率、血清生化指标及经济效益的影响。选取320头“杜×长×大”三元商品猪随机分为4组,每组5个重复,每个重复16头猪。对照组育肥猪饲喂基础日粮,试验A组、B组、C组分别在基础日粮... 详细信息

试验旨在研究酵母培养物对育肥猪生长性能、养分表观消化率、血清生化指标及经济效益的影响。选取320头“杜×长×大”三元商品猪随机分为4组,每组5个重复,每个重复16头猪。对照组育肥猪饲喂基础日粮,试验A组、B组、C组分别在基础日粮中添加3、6、9 g/kg酵母培养物,等量替代基础日粮中的麸皮。试验期30 d。结果显示,试验B组和试验C组育肥猪平均日增重分别比对照组提高11.64%和17.45%(P<0.05)。试验C组育肥猪平均日采食量比对照组提高11.33%(P<0.05)。试验A组、B组、C组育肥猪料重比分别比对照组降低1.35%、3.07%、5.21%(P<0.05)。与对照组相比,试验C组育肥猪胴体重、屠宰率均显著提高(P<0.05),平均背膘厚显著降低(P<0.05),眼肌面积显著提高(P<0.05)。试验C组育肥猪血清总蛋白(TP)含量显著高于对照组(P<0.05)。试验A组、B组、C组育肥猪血清球蛋白(GLB)和高密度脂蛋白胆固醇(HDL-C)含量显著高于对照组(P<0.05)。试验B组、C组育肥猪血清尿素氮(BUN)含量显著低于对照组(P<0.05);对粗蛋白表观消化率高于对照组(P<0.05)。试验A组、B组、C组每头育肥猪试验阶段养殖利润分别比对照组高6.0929、15.7292、25.7611元/头。研究表明,日粮中添加酵母培养物可以提高育肥猪生长性能,改善胴体性状和血清生化指标,提高粗蛋白表观消化率和养殖经济效益,建议在育肥猪日粮中添加9 g/kg的酵母培养物。

关键词：酵母培养物育肥猪生长性能血清生化指标养分表观消化率经济效益

哺乳动物印记域DLK1-DIO3的研究进展

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遗传 2010年第8期32卷 769-778页

作者：赵丽霞赵高平周欢敏内蒙古农业大学生物工程学院呼和浩特010018 内蒙古农业大学动物科学与医学学院呼和浩特010018

DLK1-DIO3印记域定位于人14号染色体、小鼠12号染色体及绵羊18号染色体远端,在真哺乳亚纲动物中印记保守。该印记域包含3个编码蛋白的父系表达基因Dlk1、Rtl1和Dio3以及若干大小不同的母系表达印记非编码RNA,如miRNAs、snoRNAs和大型非... 详细信息

DLK1-DIO3印记域定位于人14号染色体、小鼠12号染色体及绵羊18号染色体远端,在真哺乳亚纲动物中印记保守。该印记域包含3个编码蛋白的父系表达基因Dlk1、Rtl1和Dio3以及若干大小不同的母系表达印记非编码RNA,如miRNAs、snoRNAs和大型非编码RNA Gtl2等。人和小鼠该印记域内印记基因剂量的改变将导致严重的表型异常甚至胚胎致死,暗示正常的发育需要域内印记基因的正常表达。文章重点论述了哺乳动物DLK1-DIO3印记域的印记调控机制和域内印记基因及其功能的研究进展。

关键词： DLK1-DIO3 印记印记调控区(ICR) DNA甲基化非编码RNA

Performance Analysis of a Coupled System based on Organic Rankine Cycle and Double Effect Absorption Refrigeration for Waste Heat Recovery in Data Center

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Journal of Thermal Science 2025年第1期34卷 188-205页

作者： li Peng XU Jiaqi WANG Binbin liU Jianyang zhao Wensheng HAN Zhonghe School of Energy Power and Mechanical Engineering North China Electric Power University Hebei Key Laboratory of Low Carbon and High Efficiency Power Generation Technology North China Electric Power University

During data center operation,it generates a significant volume of low-grade waste *** recover waste heat,a coupled system including solar collector,double effect absorption refrigeration and organic Rankine cycle is *** system performance is analyzed in *** the organic Rankine cycle,five organic working fluids(R245fa,R245ca,R123,R11,and R113) are selected.R245fa,R113 and R245ca obtain the maximum net power output,thermal efficiency and exergy efficiency,*** the double effect absorption refrigeration system,the evaporation temperature,condensation temperature,and generation pressure affect the COP and exergy *** the generator pressure is unchanged,the COP increases with increasing evaporation temperature and decreasing condensation *** the COP reaches 1.3,the COP slightly decreases as the evaporation temperature or condensation temperature ***,the exergy efficiency of refrigeration systems exhibits the same trend as the COP,and the exergy efficiency maximum value appears at approximately 0.32.A new performance indicator,rPUE,was defined to evaluate the data center power utilization *** flow distribution ratio and heat source temperature were optimized with multi-objective *** the mass flow distribution rate is 0.6 and the heat source temperature is 441.5 K,rPUE and the total unit production costs of the system obtain the optimal solution.

关键词： Exergy

Wave effect of gravitational waves intersected with a microlens field Ⅱ:An adaptive hierarchical tree algorithm and population study

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 241-254页

作者： Xikai Shan Guoliang li Xuechun Chen Wen zhao Bin Hu Shude Mao Department of Astronomy Tsinghua University Purple Mountain Observatory Chinese Academy of Sciences Institute for Frontier in Astronomy and Astrophysics Beijing Normal University School of Physics and Astronomy Beijing Normal University School of Astronomy and Space Science University of Science and Technology of China CAS Key Laboratory for Researches in Galaxies and Cosmology Department of Astronomy University of Science and Technology of ChinaChinese Academy of Sciences

The gravitational lensing wave effect generated by a microlensing field embedded in a lens galaxy is an inevitable phenomenon in strong lensed gravitational waves （SLGWs）.This effect presents both challenges and opportunities for the detection and application of ***,investigating this wave effect requires computing a complete diffraction integral over each microlens in the *** is extremely time-consuming due to the large number of microlenses （10～3-10～6）.Therefore,simply adding all the microlenses is ***,the complexity of the time delay surface makes the lens plane resolution a crucial factor in controlling numerical *** this paper,we propose a trapezoid approximation-based adaptive hierarchical tree algorithm to meet the challenges of calculation speed and *** find that this algorithm accelerates the calculation by four orders of magnitude compared to the simple adding method and is one order of magnitude faster than the fixed hierarchical tree algorithm proposed for electromagnetic *** importantly,our algorithm ensures controllable numerical errors,increasing confidence in the *** with our previous work （***.66,239511,2023）,this paper addresses all numerical issues,including integral convergence,precision,and computational time1).Finally,we conducted a population study on the microlensing wave effect of SLGWs using this algorithm and found that the microlensing wave effect cannot be ignored,especially for Type II SLGWs （from saddle position of the time delay surface） due to their intrinsic geometric structures and their typical intersection with a denser microlensing ***,more than 33%（11%） of SLGWs have a mismatch larger than 1%（3%） compared to the unlensed ***,we found that the mismatch between signal pairs in a doubly imaged GW is generally larger than 10-3,and 61%（25%） of signal pairs have a mismatch larger than 1%（3%）.Therefo

关键词： gravitational lensing diffractional integral algorithm gravitational wave

Correlation of Primary Hepatocellular Carcinoma with HBV Genotypes, Subgenotypes and Gene Mutations in Gansu Province

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国际感染病学（电子版） 2014年第2期3卷 92-96页

作者： Wen-jie Zhang zhao-xia li Deng-hai Mi Jing li Jian-jun Yang Wei-wu Mao Yan-xuan Gong Yan Qu The Second Hospital of Gansu Province The First Clinical Medicine College of Lanzhou University

Objective To investigate the occurrence of basal core promoter(BCP) and pre-C mutations in patients with hepatitis B virus(HBV) infection in Gansu Province, China, and to analyze the correlation of HBV mutation and HBV genotype with primary hepatocellular carcinoma(HCC). Methods PCR-RFLP was applied to detect HBV subgenotypes, and the presence of the pre-C and BCP mutations in 62 patients with HCC, 70 patients with hepatitis B induced liver cirrhosis(LC) and 90 patients with chronic hepatitis B(CHB). Results In HCC patients, genotype C was the major genotype(70.97%). The pre-C mutation was found in 59.68%, 31.43% and 16.67% patients with HCC, LC and CHB, respectively. The frequency of BCP mutations was significantly different between patients with HCC, LC and CHB(74.19%, 51.43% and 37.78%, respectively; χ2=30.727, 19.540, respectively, P < 0.01). Patients in HCC group had a higher incidence of pre-C as well as BCP mutations compared to the other groups. The prevalence of pre-C and BCP mutations was significantly higher in patients with genotype C1(44.32% and 69.32%, respectively) compared to patients with other subgenotypes(P < 0.05). Conclusions The incidence of pre-C and BCP mutations increases with disease progression. Pre-C and BCP mutations frequently occur in patients with genotype C1. HBV genotype C, pre-C mutations and BCP mutations are closely related to the occurrence of HCC.

关键词： Hepatitis B virus Hepatocellular carcinoma Genotype Subgenotype Mutation

“强政府、强社会”模式:我国竞技体育改革的路径与策略探讨

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南京体育学院学报（社会科学版） 2017年第1期31卷 53-58页

作者：赵立霞吴贻刚上海体育学院体育教育训练学院上海200438 徐州工程学院体育学院江苏徐州221008

对我国竞技体育的发展进行了思考,长期以来竞技体育发展"单一中心"的制度设计已经出现了各种弊端,引发了各方的讨论。政府在竞技体育管理中"大而不强"——管理低效导致竞技体育失衡发展,管理短视导致竞技后备人才不足,管理手段单一导致... 详细信息

对我国竞技体育的发展进行了思考,长期以来竞技体育发展"单一中心"的制度设计已经出现了各种弊端,引发了各方的讨论。政府在竞技体育管理中"大而不强"——管理低效导致竞技体育失衡发展,管理短视导致竞技后备人才不足,管理手段单一导致利益格局固化;社会在竞技体育发展中"作用不足"——学校竞技体育发展动力不足,职业竞技体育发展机制不畅,社会组织竞技体育参与排斥,个人竞技体育投入动力匮乏。介于此,基于国情结合国际经验,提出了竞技体育发展的"强政府、强社会"模式,"强政府"是保持政府主导地位和确保改革顺畅与稳定的需要(政府起到宏观把控和社会失灵领域的保底作用);"强社会"能够缓解政府行政负担、财政负担,提高竞技体育的发展效率。并提出了优化国家竞技体育发展的顶层设计,正视与优化竞技体育既得利益格局,培育扶持多元主体竞争、协同的竞技体育发展体系,完善社会参与竞技体育的激励机制等发展策略。

关键词：竞技体育强政府强社会学校体育职业体育

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西藏乡村经济转型的目标与基本路径

西藏研究 2007年第4期 108-115页

作者：李爱琴赵丽霞西藏民族学院财经学院陕西咸阳712082 厦门大学经济学院福建厦门361005

西藏自治区是一个以农牧业为主的地区,乡村人口占总人口的80%以上。西藏乡村经济在西藏国民经济中占有十分重要的地位,是西藏经济发展和社会稳定的基础。推动西藏乡村经济发展、增加农牧民收入、全面建设西藏新农村,不仅仅是经济问题,... 详细信息

西藏自治区是一个以农牧业为主的地区,乡村人口占总人口的80%以上。西藏乡村经济在西藏国民经济中占有十分重要的地位,是西藏经济发展和社会稳定的基础。推动西藏乡村经济发展、增加农牧民收入、全面建设西藏新农村,不仅仅是经济问题,也是社会问题和政治问题。文章以当前西藏乡村经济的环境和现状为立足点,着重研究西藏乡村经济结构转型的目标与基本路径,提出构建适应社会主义市场经济的西藏乡村经济发展模式的建议。

关键词：西藏乡村经济转型目标基本路径

Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 2015-2028页

作者： Jian Yang Jiang Wu Xueshun Xie Pengfei xia Jinxin Lu Jiale liu Lei Bai xiang li Zhengquan Yu Haiying li Department of Neurosurgery&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Stroke Research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to *** of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve *** is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic ***,there are few studies on oligodendrocyte progenitor cell *** analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral *** analysis suggested that perilipin-2(PliN2)was involved in oligodendrocyte progenitor cell ***2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet *** further investigation,we established a mouse model of cerebral ischemia/*** found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin *** also found increased PliN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor ***2 knockdown rescued demyelination and improved neurological *** findings suggest that targeting PliN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing