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Evaluation of the combined influence of geological layer property and in-situ stresses on fracture height growth for layered formations

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Petroleum Science 2024年第5期21卷 3222-3236页

作者： Peng Tan zhao-wei chen Liu-Ke Huang Qing zhao Sha-Rui Shao CNPC Engineering Technology R&D Company Limited National Engineering Research Center for Oil&Gas Drilling and Completion Technology School of Civil Engineering and Geomatics Southwest Petroleum University Shale Gas Research Institute Southwest Oil&Gas Field Company

Fracture geometry is important when stimulating low-permeability reservoirs for natural gas or oil production. The geological layer(GL) properties and contrasts in in-situ stress are the two most important parameters for determination of the vertical fracture growth extent and containment in layered rocks. However, the method for assessing the cumulative impact on growth in height remains ambiguous. In this research, a 3D model based on the cohesive zone method is used to simulate the evolution of hydraulic fracture(HF) height in layered reservoirs. The model incorporates fluid flow and elastic deformation, considering the friction between the contacting fracture surfaces and the interaction between fracture components. First, an analytical solution that was readily available was used to validate the model. Afterwards, a quantitative analysis was performed on the combined impacts of the layer interface strength, coefficient of interlayer stress difference, and coefficient of vertical stress *** results indicate that the observed fracture height geometries can be categorized into three distinct regions within the parametric space: blunted fracture, crossed fracture, and T-shaped ***, the results explained the formation mechanism of the low fracture height in the deep shale reservoir of the Sichuan Basin, China, as well as the distinction between fracture network patterns in mid-depth and deep shale reservoirs.

关键词： Deep shale Hydraulic fracturing HF propagation Fracture interaction Cohesive zone method

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Item Ownership Relationship Semantic Learning Strategy for Personalized Service Robot

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International Journal of Automation and computing 2020年第3期17卷 390-402页

作者： Hao Wu zhao-wei chen Guo-Hui Tian Qing Ma Meng-Lin Jiao School of Control Science and Engineering Shandong UniversityJinan 250061China

In order to satisfy the robotic personalized service requirements that can select exclusive items to perform inference and planning according to different service individuals,the service robots need to have the ability to independently obtain the ownership relationship between humans and their carrying *** this work,we present a novel semantic learning strategy for item ***,a human-carrying-items detection network based on human posture estimation and object detection model is ***,the transferred convolutional neural network is used to extract the characteristics of the objects and the back-end classifier to recognize the object *** the same time,the face detection and recognition model are used to identify the service ***,on the basis of the former two,the active learning of ownership items is *** experimental results show that the proposed ownership semantic learning strategy can determine the ownership relationship of private goods accurately and *** solution of this problem can improve the intelligence level of robot life service.

关键词： Service robot ownership relationship convolutional neural network human-object spatial relationship personalized service

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SIGMA-COORDINATE NUMERICAL MODEL FOR SIDE-DISCHARGE INTO NATURAL RIVERS

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Journal of Hydrodynamics 2009年第3期21卷 333-340页

作者： LIU zhao-wei chen Yong-can LI Ling ZHENG Jing-yun State Key Laboratory of Hydroscience and Engineering Tsinghua University Beijing 100084 China Wenzhou Oujiangkou Development and Construction Headquarters Wenzhou 325027 China

Due to large topography slopes in natural rivers, pollutant concentration embodies a property of three-dimensional distribution when wastewater is discharged from effluents along the bank. With the sigma coordinate along the vertical dimension fitted to both the moving free surface and the bed topography, a three-dimensional numerical model was developed in the present work to address pollutant transport processes in the above-mentioned cases. To avoid the reduction in accuracy caused by spurious diffusion in the case of steep bottom slopes, a formula for horizontal diffusion in the sigma coordinate system was derived. A case study for the side discharge into a straight open-channel flow shows that numerical results are verified well by experimental data. Furthermore, the present model is also verified by the simulation of discharging wastewater from Fuling Phosphorus Factory effluent into the Three Gorges Reservoir and the agreement between the numerical simulation results and field observation data is satisfactory. The change of the mixing zone scope in the water surface versus the layers along the vertical dimension was also discussed in detail. The study shows that a more realistic calculation for pollutant discharge has been provided by the present model than by the depth-average model which predicts an unrealistically smaller mixing zone.

关键词： sigma-coordinate three-dimensional model side-discharge natural rivers

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Application of ablative therapy for intrahepatic recurrent hepatocellular carcinoma following hepatectomy

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World Journal of Gastrointestinal Surgery 2023年第1期15卷 9-18页

作者： Rong Cong Xiao-Hong Ma Shuang Wang Bing Feng wei Cai zhao-wei chen Xin-Ming zhao Department of Diagnostic Radiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

The post-hepatectomy recurrence rate of hepatocellular carcinoma(HCC)is persistently high,affecting the prognosis of *** effective therapeutic option is crucial for achieving long-term survival in patients with postoperative *** ablative therapy has been established as a treatment option for resectable and unresectable HCCs,and it is also a feasible approach for recurrent HCC(RHCC)due to less trauma,shorter operation times,fewer complications,and faster *** review focused on ablation techniques,description of potential candidates,and therapeutic and prognostic implications of ablation for guiding its application in treating intrahepatic RHCC.

关键词： Hepatocellular carcinoma Recurrence Ablation techniques Radiofrequency ablation Combined therapy Therapeutic index

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All roads lead to Rome-a review of the potential mechanisms by which exerkines exhibit neuroprotective effects in Alzheimer’s disease

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Neural Regeneration Research 2022年第6期17卷 1210-1227页

作者： Yi-Yao Liang Li-Dan Zhang Xi Luo Li-Li Wu zhao-wei chen Guang-Hao wei Kai-Qing Zhang Ze-An Du Ren-Zhi Li Kwok-Fai So Ang Li Guangdong-Hong Kong-Macao Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Jinan University) Ministry of EducationGuangzhouGuangdong ProvinceChina Department of Medical Ultrasonics Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Key Laboratory of Liver Disease Research Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Clinical Medicine School of MedicineJinan UniversityGuangzhouGuangdong ProvinceChina Department of Clinical Medicine International SchoolJinan UniversityGuangzhouGuangdong ProvinceChina International Department of the Affiliated High School of South China Normal University GuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

Age-related neurodegenerative disorders such as Alzheimer’s disease(AD)have become a critical public health issue due to the significantly extended human lifespan,leading to considerable economic and social *** therapies for AD such as medicine and surgery remain ineffective,impractical,and *** studies have shown that a variety of bioactive substances released by physical exercise(called“exerkines”)help to maintain and improve the normal functions of the brain in terms of cognition,emotion,and psychomotor *** evidence suggests that exerkines may exert beneficial effects in AD as *** review summarizes the neuroprotective effects of exerkines in AD,focusing on the underlying molecular mechanism and the dynamic expression of exerkines after physical *** findings described in this review will help direct research into novel targets for the treatment of AD and develop customized exercise therapy for individuals of different ages,genders,and health conditions.

关键词： Alzheimer’s disease amyloid beta central nervous system exerkine neurodegeneration neuroinflammation neuroprotection oxidative stress physical exercise Tau protein

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Outcomes of laparoscopic bile duct exploration for choledocholithiasis with small common bile duct

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World Journal of Clinical Cases 2021年第8期9卷 1803-1813页

作者： Xiao-Xiao Huang Jia-Yi Wu Yan-Nan Bai Jun-Yi Wu Jia-Hui Lv wei-zhao chen Li-Ming Huang Rong-Fa Huang Mao-Lin Yan Department of Hepatobiliary and Pancreatic Surgery Shengli Clinical Medical College of Fujian Medical UniversityFujian Provincial HospitalFuzhou 350001Fujian ProvinceChina

BACKGROUND Laparoscopic cholecystectomy(LC)combined with laparoscopic common bile duct(CBD)exploration(LCBDE)is one of the main treatments for choledocholithiasis with CBD diameter of larger than 10 ***,for patients with small CBD(CBD diameter≤8 mm),endoscopic sphincterotomy remains the preferred treatment at present,but it also has some drawbacks associated with a series of complications,such as pancreatitis,hemorrhage,cholangitis,and duodenal *** date,few studies have been reported that support the feasibility and safety of LCBDE for choledocholithiasis with small *** To investigate the feasibility and safety of LCBDE for choledocholithiasis with small *** A total of 257 patients without acute cholangitis who underwent LC+LCBDE for cholecystolithiasis from January 2013 to December 2018 in one institution were *** clinical data were retrospectively collected and *** to whether the diameter of CBD was larger than 8 mm,257 patients were divided into large CBD group(n=146)and small CBD group(n=111).Propensity score matching(1:1)was performed to adjust for clinical *** demographics,intraoperative data,short-term outcomes,and long-term follow-up outcomes for the patients were recorded and *** In total,257 patients who underwent successful LC+LCBDE were enrolled in the study,146 had large CBD and 111 had small *** median follow-up period was 39(14-86)*** small CBD patients,the median CBD diameter was 0.6 cm(0.2-2.0 cm),the mean operating time was 107.2±28.3 min,and the postoperative bile leak rate,rate of residual CBD stones(CBDS),CBDS recurrence rate,and CBD stenosis rate were 5.41%(6/111),3.60%(4/111),1.80%(2/111),and 0%(0/111),respectively;the mean postoperative hospital stay was 7.4±3.6 *** large CBD patients,the median common bile duct diameter was 1.0 cm(0.3-3.0 cm),the mean operating time was 115.7±32.0 min,and the postoperative bile leak rate,rate of residual CBDS,CBDS recurre

关键词： Common bile duct stones Laparoscopic common bile duct exploration Endoscopic sphincterotomy Bile leak Choledochal stenosis Recurrence

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Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang Zeng wei Tan Xingxing chen Shuyuan Bai Qiong Wu Yushan chen Zhen wei Yufei Mei Yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

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阳和汤干预兔骨关节炎软骨细胞中血管内皮生长因子变化

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中西医结合学报 2008年第4期6卷 372-375页

作者：陈朝蔚陈永强上海市中医医院骨伤科上海200071

目的:观察阳和汤对兔骨关节炎软骨细胞中血管内皮生长因子(vascular endothelial growth factor,VEGF)表达的影响。方法:新西兰大白兔15只随机分为正常组、模型组和阳和汤组。按照Hulth法建立膝骨关节炎模型,术后第5周起至第7周末,阳和... 详细信息

目的:观察阳和汤对兔骨关节炎软骨细胞中血管内皮生长因子(vascular endothelial growth factor,VEGF)表达的影响。方法:新西兰大白兔15只随机分为正常组、模型组和阳和汤组。按照Hulth法建立膝骨关节炎模型,术后第5周起至第7周末,阳和汤组予混有阳和汤的颗粒饲料,正常组及模型组均给予普通饲料;术后第8周分别取各组胫骨平台关节软骨,采用番红O染色,进行Mankin评分;免疫组织化学染色测定关节软骨中VEGF表达的阳性指数。结果:正常对照组番红O染色的Mankin评分与模型组比较,差异有统计学意义(P<0.01)。阳和汤组番红O染色减少或缺失程度较模型组轻,差异有统计学意义(P<0.01)。各组关节软骨切片VEGF免疫组化染色分析,模型组VEGF的阳性指数明显高于正常组,差异有统计学意义(P<0.01),阳和汤组VEGF阳性指数明显低于模型组,差异有统计学意义(P<0.05)。结论:VEGF在骨关节炎形成早期起重要作用;阳和汤可延缓关节软骨退行性改变,其作用可能是通过调控VEGF而达到抑制血管增生的作用。

关键词：骨关节炎阳和汤软骨血管内皮生长因子血管生成病理性

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山水情致,现代物语——一次建构的传统园林文化意匠尝试

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装饰 2009年第5期 143-144页

作者：赵衡宇陈炜浙江工业大学艺术学院

传统园林文化在当下人居环境设计中如何阐释和建构始终是绕不开的课题。通过对杭州"庭院深深"居住小区景观设计的若干实例分析,就山水的生态建构、山水空间的整合融入及环境文化意匠营造等方面进行探讨,以图在建构良好生活环境的同时延... 详细信息

传统园林文化在当下人居环境设计中如何阐释和建构始终是绕不开的课题。通过对杭州"庭院深深"居住小区景观设计的若干实例分析,就山水的生态建构、山水空间的整合融入及环境文化意匠营造等方面进行探讨,以图在建构良好生活环境的同时延续居住文化。

关键词：传统园林居住文化山水

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高考试题难度预估研究

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数学教育学报 2018年第5期27卷 13-16页

作者：任子朝佟威赵轩陈昂教育部考试中心北京100084

高考由于其高利害性和敏感性,不能通过考前试测预先掌握试题难度,只能在命题过程中依靠命题人员主观预估确定试题的难度.在命题人员对每个试题进行难度预估后,可以采用各种统计方法对预估值进行数据处理,例如求预估难度与实测难度的相... 详细信息

高考由于其高利害性和敏感性,不能通过考前试测预先掌握试题难度,只能在命题过程中依靠命题人员主观预估确定试题的难度.在命题人员对每个试题进行难度预估后,可以采用各种统计方法对预估值进行数据处理,例如求预估难度与实测难度的相关系数,计算每人预估的平均差异,计算预估值的标准差等.根据数据处理的结果,确定对预估值与实测值的拟合程度和每个命题人员的预估精度,从而在以后的年份科学地利用预估数据预测高考试题的实测难度.

关键词：高考预估难度实测难度统计分析

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