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Research trends in exercise therapy for the treatment of pain in postmenopausal osteoporosis over the past decade:A bibliometric analysis

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World Journal of Orthopedics 2024年第10期15卷 950-964页

作者： zhao-qiu dai Xiao-Yan Gong Rong Zhang Mei-Qin Jin Wei Lu Wen Wen Jie Chen Fang-Jie Lu Yi-Fan Yang Lei Wang Xiao-Jin He Changshu Hospital Affiliated with Nanjing University of Chinese Medicine Changshu 215500Jiangsu ProvinceChina Affiliated Hospital of Nanjing University of Chinese Medicine Jiangsu Province Hospital of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Nanjing University of Chinese Medicine Nanjing 210023Jiangsu ProvinceChina

BACKGROUND Postmenopausal osteoporosis(PMOP)is the most common form of primary osteoporosis among women,and the associated pain often drives patients to seek clinical *** studies have highlighted the unique clinical benefits of exercise therapy(ET)in alleviating PMOP-related ***,bibliometric analyses examining collaboration,development trends,and research frontiers in the field of ET for PMOP pain remain *** To explore the research trends in ET for pain treatment in PMOP patients over the past *** All scholarly works were meticulously sourced from the Science Citation Index-Expanded within the prominent Web of Science Core *** the capabilities of CiteSpace 6.2.R5,we conducted a thorough analysis of publications,authors,frequently cited scholars,contributing nations,institutions,journals of significant citation,comprehensive references,and pivotal ***,our examination explored keyword cooccurrences,detailed timelines,and periods of heightened citation *** comprehensive search,from 2014 through 2023,was completed within a single day,on October 11,*** In total,2914 articles were ultimately included in the *** was a rapid increase in annual publication output in 2015,followed by stable growth in subsequent ***,Michael L,is the most prolific author,whereas Ware JE has the most *** United States’global influence is significant,surpassing all other *** University of California System and Harvard University are the most influential academic institutions.J Bone Joint Surg Am is the most influential journal in this field.“Spinal cord injury”is the keyword that has garnered the most attention from *** developmental pattern in this field is characterized by interdisciplinary fusion,with different disciplines converging to drive *** The academic development of the field of ET for pain in PMOP has matured and stabili

关键词： Exercise therapy Pain Postmenopausal osteoporosis CiteSpace Bibliometric analysis Web of Science

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MET receptor tyrosine kinase promotes the generation of functional synapses in adult cortical circuits

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Neural Regeneration Research 2025年第5期20卷 1431-1444页

作者： Yuehua Cui Xiaokuang Ma Jing Wei Chang Chen Neha Shakir Hitesch Guirram Zhiyu dai Trent Anderson Deveroux Ferguson Shenfeng qiu Basic Medical Sciences University of Arizona College of Medicine-PhoenixPhoenixAZUSA Department of Medicine University of Arizona College of Medicine-PhoenixPhoenixAZUSA

Loss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration,however,few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse *** have previously shown that MET receptor tyrosine kinase in the developing cortical circuits promotes dendritic growth and dendritic spine *** investigate whether enhancing MET in adult cortex has synapse regenerating potential,we created a knockin mouse line,in which the human MET gene expression and signaling can be turned on in adult(10–12 months)cortical neurons through doxycycline-containing *** found that similar to the developing brain,turning on MET signaling in the adult cortex activates small GTPases and increases spine density in prefrontal projection *** findings are further corroborated by increased synaptic activity and transient generation of immature silent *** MET signaling resulted in an increasedα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/N-methyl-Daspartate(AMPA/NMDA)receptor current ratio,indicative of enhanced synaptic function and *** data reveal that enhancing MET signaling could be an interventional approach to promote synaptogenesis and preserve functional connectivity in the adult *** findings may have implications for regenerative therapy in aging and neurodegeneration conditions.

关键词： aging circuit connectivity cortical circuits molecular mechanisms neural regeneration neurodegeneration synapses

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Unlocking the stable interface in aqueous zinc-ion battery with multifunctional xylose-based electrolyte additives

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Journal of Energy Chemistry 2025年第1期100卷 770-778页

作者： Xiaoqin Li Jian Xiang Lu qiu Xiaohan Chen Yinkun zhao Yujue Wang Qu Yue Taotao Gao Wenlong Liu Dan Xiao zhaoyu Jin Panpan Li Institute for Advanced Study Chengdu University School of Mechanical Engineering Chengdu University College of Food and Biological Engineering Chengdu University Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China College of Materials Science and Engineering Sichuan University

The growth of dendrites and the side reactions occurring at the Zn anode pose significant challenges to the commercialization of aqueous Zn-ion batteries（AZIBs）. These challenges arise from the inherent conflict between mass transfer and electrochemical kinetics. In this study, we propose the use of a multifunctional electrolyte additive based on the xylose（Xylo） molecule to address these issues by modulating the solvation structure and electrode/electrolyte interface, thereby stabilizing the Zn anode. The introduction of the additive alters the solvation structure, creating steric hindrance that impedes charge transfer and then reduces electrochemical kinetics. Furthermore, in-situ analyses demonstrate that the reconstructed electrode/electrolyte interface facilitates stable and rapid Zn2+ion migration and suppresses corrosion and hydrogen evolution reactions. As a result, symmetric cells incorporating the Xylo additive exhibit significantly enhanced reversibility during the Zn plating/stripping process, with an impressively long lifespan of up to 1986 h, compared to cells using pure ZnSO4electrolyte. When combined with a polyaniline cathode, the full cells demonstrate improved capacity and long-term cyclic stability. This work offers an effective direction for improving the stability of Zn anode via electrolyte design, as well as highperformance AZIBs.

关键词： Solvation

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Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding Chun Chen Heng zhao Bin dai Lei Ye Tao Song Shuai Huang Jia Wang Tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

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应用碳氮稳定同位素比较养殖鲍鱼食性的空间差异

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福州大学学报（自然科学版） 2017年第3期45卷 454-458页

作者：徐军王沈黄红霞姚小燕赵康顺邱彬戴明中国科学院水生生物研究所湖北武汉430072 福建省产品质量检验研究院福建福州350002 福州大学化学学院福建福州350116

选择福建省黄岐半岛的皱纹盘鲍、南日岛的杂交鲍和古雷半岛的杂交皱纹盘鲍为研究对象,通过分析三个地点的鲍鱼和其可能的食物来源的稳定性碳和氮同位素比率,利用贝叶斯混合模型分别得出三个地点鲍鱼的食性.研究发现,三地鲍鱼的食性存在... 详细信息

选择福建省黄岐半岛的皱纹盘鲍、南日岛的杂交鲍和古雷半岛的杂交皱纹盘鲍为研究对象,通过分析三个地点的鲍鱼和其可能的食物来源的稳定性碳和氮同位素比率,利用贝叶斯混合模型分别得出三个地点鲍鱼的食性.研究发现,三地鲍鱼的食性存在差异,黄岐半岛、南日岛和古雷半岛的鲍鱼的食物来源分别有3,5和4种,通过比较鲍鱼的食性比例与投饵比例之间的差异,提出应减小龙须菜占比,增大海带占比的建议.

关键词：鲍鱼稳定性同位素食性分析养殖

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Self-nucleation Effect of Crystallization with Various Nucleating Agents

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Chinese Journal of Polymer Science 2023年第12期41卷 1912-1920,I0009页

作者： dai Zhang Rui-Jun zhao Gui-qiu Ma Zhe Ma Tianjin Key Laboratory of Composite and Functional Materials and School of Materials Science and EngineeringTianjin UniversityTianjin 300072China

In this work,the self-nucleation effect on crystallization was studied for polypropylene with various nucleating *** talc was employed to accelerate crystallization of monoclinic α-crystallites,while N,N′-dicyclohexyl-2,6-naphthalenedicarboxamide TMB-5 was used to accelerate the crystallization kinetics and also induce formation of trigonal β-*** induce self-nucleation effect,the occurrence criterion was assessed by the transition temperatures from various domains and the available temperature *** importantly,the resulting influences of self-nucleation effect were quantified by the change of crystallization kinetics and the potential polymorphism *** was found that the α-nucleating agents of talc broadened the temperature window for inducing Domain Ⅱ by elevating the transition temperature from Domain Ⅰ to Domain Ⅱ.Although β-nucleating agent(β-NA)of N,N′-dicyclohexyl-2,6-naphthalenedicarboxamide TMB-5 elevated cooling crystallization temperature obviously,the temperature window for Domain Ⅱ was *** should be emphasized that in presence of β-NA TMB-5,the self-nucleation effect enhances the crystallization of α-crystallite,which show the competition with β-NA *** last,the ternary PP/talc/TMB-5 blend was prepared with the same amounts of α-NA talc and β-NA TMB-5 and it exhibits a similar self-nucleation effect of crystallization,indicating the dominant role of β-NA TMB-5.

关键词： Crystallization Kinetic Polymorphism

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Interaction Between Cytochrome c and the Hapten 2,4-Dinitro- fluorobenzene by Electrospray Ionization Mass Spectrometry

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Chinese Journal of Chemical Physics 2008年第3期21卷 217-220页

作者： Bo Wu Yan-qiu Chu zhao-yun dai Chuan-fan Ding Physical Chemistry Institute Department of Chemistry Fudan University Shanghai 200433 China Infectious Disease Department Huadong Hospital Shanghai 200040 China

Allergic contact dermatitis is a delayed hypersensitivity reaction, which results from skin exposure to low molecular weight chemicals such as haptens. To clarify the pathogenic mechanism, electrospray ionization mass spectrometry （ESI-MS） and hydrogen/deuterium （H/D） exchange, as well as UV spectroscopy, were applied to determine the interaction between the model protein cytochrome c （cyt c） and the hapten 2,4- dinitro-fiuorobenzene （DNFB）. The ESI-MS results demonstrate that the conformation of cyt c can change from native folded state into partially unfolded state with the increase of DNFB. The equilibrium state H/D exchange followed by ESI-MS further confirms the above results. UV spectroscopy indicates that the strong- field coordination between iron of heme （prosthetic group） and His18 or Met80 of cyt c is not obviously affected by the hapten.

关键词： Interaction Cytochrome c 2 4-dinitro-fluorobenzene ESI-MS

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鄱阳湖地区湿地保护现状及其主要影响因素

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东北林业大学学报 2025年第2期53卷 122-126页

作者：邱万保赵英杰新疆政法学院图木舒克832003 东北林业大学

在鄱阳湖区域,选取鄱阳湖国家级自然保护区、鄱阳湖南矶湿地国家级自然保护区、都昌候鸟省级自然保护区、东鄱阳湖国家湿地公园、都昌北鄱阳湖湿省级地公园5个典型湿地保护地为研究地;采用问卷调查方法,选择研究地的管理人员、技术人员... 详细信息

在鄱阳湖区域,选取鄱阳湖国家级自然保护区、鄱阳湖南矶湿地国家级自然保护区、都昌候鸟省级自然保护区、东鄱阳湖国家湿地公园、都昌北鄱阳湖湿省级地公园5个典型湿地保护地为研究地;采用问卷调查方法,选择研究地的管理人员、技术人员、野外工作人员、其他工作人员,调查研究地的资源保护与破坏现状、湿地保护地存在的问题、保护地存在问题的成因、对现实问题的解决方式及建议,问卷有效率93.64%。依据调查数据,分析鄱阳湖地区湿地保护现状及其主要影响因素。调查结果表明:①鄱阳湖湿地保护现状较为理想,湿地资源得到了合理的保护和利用。在受访者中,83.50%工作人员认为湿地水鸟种类增加或维持不变、74.76%工作人员认为湿地水鸟数量增加或维持不变、73.78%工作人员认为湿地水鸟已经达到或基本达到最适数量、63.11%工作人员认为湿地水鸟繁殖能力增加或不变。②各保护地的湿地保护现状差异明显,在受访者中,62.38%工作人员认为鄱阳湖地区湿地保护过程中存在不利影响,主要集中在生态旅游、水量减少、湿地污染、湿地占用等方面。80.58%工作人员认为湿地生态旅游存在负面影响,其中63.10%工作人员认为生态旅游存在严重影响;33.01%工作人员认为湿地保护地的不利基础设施建设存在严重影响或一般影响;82.52%工作人员认为湿地水量减少是湿地保护面临的问题之一;53.40%工作人员认为湿地污染是湿地保护面临的问题之一。③鄱阳湖地区湿地破坏的成因包括鄱阳湖地区湿地保护法规不完善、湿地保护的政府间联动机制不健全、湿地工作人员构成不合理。④改进措施,完善地方湿地立法、政府间部门联动机制、地区人才培养机制及相关政策。

关键词：鄱阳湖湿地保护自然保护区

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Association between the infection probability of COVID-19 and ventilation rates:An update for SARS-CoV-2 variants

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Building Simulation 2023年第1期16卷 3-12页

作者： Hui dai Bin zhao Departmentof Building Science School of ArchitectureTsinghua UniversityBeijing 100084China Beijing Key Laboratory of Indoor Air Quality Evaluation and Control Tsinghua UniversityBeijing 100084China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the cause of the current coronavirus disease 2019(COVID-19)pandemic,is ***,the risk of airborne transmission in confined spaces may be higher,and corresponding precautions should be ***,we obtained the quantum generation rate(q)value of three SARS-CoV-2 variants(Alpha,Delta,and Omicron)for the Wells-Riley equation with a reproductive number-based fitted approach and estimated the association between the infection probability and ventilation *** q value was 89–165 h^(−1)for Alpha variant,312–935 h^(−1)for Delta variant,and 725–2,345 h^(−1)for Omicron *** ventilation rates increased to ensure an infection probability of less than 1%,and were 8,000–14,000 m^(3)h^(−1),26,000–80,000 m^(3)h^(−1),and 64,000–250,000 m^(3)h^(−1)per infector for the Alpha,Delta,and Omicron variants,*** the infector and susceptible person wore N95 masks,the required ventilation rates decreased to about 1/100 of the values required without masks,which can be achieved in most typical *** air purifier was ineffective for reducing transmission when used in scenarios without *** prolonged exposure time in confined spaces remains critical in reducing the risk of airborne transmission for highly contagious SARS-CoV-2 variants.

关键词： COVID-19 SARS-CoV-2variants mask ventilation air purifier

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Synthesis and Crystal Structure of Unprecedented Pentanuclear Cu_5~Ⅱ Complex Containing both Macrocyclic and Azido Ligands

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Chemical Research in Chinese Universities 2009年第3期25卷 265-268页

作者： SUN Ya-qiu FAN Lan-lan GAO Dong-zhao LIAO dai-zheng Tianjin Key Laboratory of Structure and Performance for Functional Molecule Tianjin Key Laboratory of Cyto-Genetical and Molecular Regulation College of Chemistry and Life Science Tianjin Normal University Tianjin 300387 P. R. China Department of Chemistry Nankai University Tianjin 300071 P. R. China

The organic-inorganic hybrid complex with formula [（CuL）2Cu3（μ-1,1-N3）4（ClO4）2], complex 1, {CuL, [5,6：14,l5-dibenzo-1,4,8,12-tetraazacyclopentadeca-7,3-diene-2,3-dione（2-）]copper（Ⅱ）}, has been synthesized and structurally determined. The crystals of complex 1 crystallize in the triclinic system with space group P1, a=0.92983（12） nm, b=1.09644（14） nm, c=1.27396（16） nm, α=70.782（2）°β=86.266（2）°,γ=78.284（2）°. In this complex, the five copper ions are bridged by macrocyclic oxamide groups and azido. Furthermore, C-H…O hydrogen bond interactions link the pentanuclear fragments to form a 2D supramolecular architecture.

关键词： Macrocyclic oxamide complex Azido complex Polynuclear complex

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