检索结果-南通市图书馆

Blood compatibility of zinc-calcium phosphate conversion coating on Mg-1.33Li-O.6Ca alloy

在线全文

学校读者我要写书评

暂无评论

Frontiers of Materials Science 2016年第3期10卷 281-289页

作者： Yu-Hong ZOU Rong-Chang ZENG qing-zhao wang Li-Jun LIU Qian-Qian XU Chuang wang Zhi-Wei LIU College of Chemical and Environmental Engineering Shandong University of Science and Technology Qingdao 266590 China College of Materials Science and Engineering Shandong University of Science and Technology Qingdao 266590 China Hospital of Shandong University of Science and Technology Qingdao 266590 China State Key Laboratory of Mining Disaster Prevention and Control Co-founded by Shandong Province and the Ministry of Science and Technology Shandong University of Science and Technology Qingdao 266590 China

Magnesium alloys as a new class of biomaterials possess biodegradability and biocompatibility in comparison with currently used metal implants. However, their rapid corrosion rates are necessary to be manipulated by appropriate coatings. In this paper, a new attempt was used to develop a zinc-calcium phosphate （Zn-Ca-P） conversion coating on Mg-1.33Li-0.6Ca alloys to increase the biocompatibility and improve the corrosion resistance. In vitro blood biocompatibility of the alloy with and without the Zn-Ca-P coating was investigated to determine its suitability as a degradable medical biomaterial. Blood biocompatibility was assessed from the hemolysis test, the dynamic cruor time test, blood cell count and SEM observation of the platelet adhesion to membrane surface. The results showed that the Zn-Ca-P coating on Mg-1.33Li-0.6Ca alloys had good blood compatibility, which is in accordance with the requirements for medical biomaterials.

关键词： magnesium alloy lithium biomaterial biocompatibility zinc-calciumphosphate coating

Protein Product Encoded by a Human Novel Gene E9730 Enhances AP-1 Activity through Interacting with Jab1

在线全文

学校读者我要写书评

暂无评论

Acta Biochimica et Biophysica Sinica 2004年第1期36卷 11-15页

作者： zhao-qing wang, Han-Dong WEI, and Fu-Chu HE(Department of System Biology, Beijing Institute of Radiation Medicine, Chinese Human National Center at Beijing, Beijing 100850, China) Department of System Biology Beijing Institute of Radiation Medicine Chinese Human National Center at Beijing Beijing 100850 China

A novel human gene, named E9730 (a clone number of fetal liver cDNA library), has been identified from more than 14,000 expressed sequence tags (ESTs) based on our large scale sequencing of human fetal liver cDNA libraries. Although sequencing of this novel human gene indicates that it is a leucine zipper protein, the function of E9730 and its homologous genes among species is unknown yet. To find out physiological functional clue of E9730, the yeast two-hybrid system was used to screen the E9730-interac-ting protein(s), and one clone containing a cDNA insert with almost the entire coding sequence (amino acids 39-335) of human Jabl (Jun-activating domain binding protein 1) that interacted specifically with E9730 was identified. A specific association between Jabl and E9730 was shown by co-immunoprecipitation and co-localization experiments. Furthermore, E9730 appeared to enhance Jab 1 -induced AP-1 activity in a concentration-dependent manner and Jabl may be involved in the intracellular signaling trans

关键词： human E9730 gene CSN5/Jabl protein-protein interaction signaling transduction

Effect of hepatocyte apoptosis induced by TNF-α on acute severe hepatitis in mouse models

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2000年第5期6卷 688-692页

作者： Guo qing Zang Xia Qiu Zhou Hong Yu qing Xie Guo Ming zhao Bin wang qing Guo Yue Qin Xiang Dan Liao Department of Infectious Diseases,Rujin Hospital,Shanghai Second Medical University,Shanghai 200025,China Guo qing Zang Xia Qiu Zhou Hong Yu Qing Xie Guo Ming Zhao Bin Wang Qing Guo Yue Qin Xiang Dan Liao Department of Infectious Diseases Rujin Hospital Shanghai Second Medical University Shanghai 200025 China Guo qing Zang graduated from Xian Medical University as a postgraduate in 1990 associate professor of lemology engaged in diagnosis and treatment of viral hepatitis and hemorrahgic fever with renal syndrome having 12 papers published.

AIM To study the effect of hepatocyteapoptosis and necrosis induced by TNF-α on thepathogenesis of acute severe hepatitis(ASH).METHODS The model of ASH was prepared inD-galactosamine(GAIN)sensitized BALB/c miceby injection of either endotoxin(ET)or tumornecrosis factor-α(TNF-α).Morphologicalchanges of apoptotic hepatocytes were studiedby both light and electron microscope and in siteend labeling method(ISEL).Molecular biologicalchanges of DNA ladder were observed byelectrophoresis of extract from liver *** changes were measured by alanineaminotransferase(ALT),asparticaminotransferase(AST)and TNF-α.The relationbetween apoptosis and necrosis was *** The sequence of hepatocyteapoptosis,necrosis,and final death from ASHwas observed both in GAIN/ET and GAIN/*** was prominent at 3.5 h and 5 hafter injection of inducer,while necrosis becamedominant at 9 h after *** appearanceof apoptosis was earlier in GAIN/TNF-α groupthan that in GAIN/ ET *** ofmice with antiTNF IgG1 may completely preventthe liver injury induced by GalN/*** TNF-α can cause liver damageby inducing hepatic apoptosis and necrosis inmice with endotoxemia.

关键词： tumor necrosis factor hepatitis apoptosis alanine transaminase aspartate transaminase endotoxins mice

Solution of Coal Char-steam Pressurized Kinetic Parameters Based on Atmospheric Thermo Gravimetric Analyzer

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国电机工程学报 2013年第32期33卷 I0004-I0004,10页

作者： zhao qing wang Xiaoliang TAO Shuchang Dongfang Electric Corporation

根据文献中气化速率对总压不敏感、对反应气体分压敏感的实验结论，探索利用常压热重实验得到加压动力学参数的便捷方法。采用NETZSCH STA449F3同步热分析仪进行4种煤焦与水蒸气反应的常压热重实验（水蒸气分压pH2O为0.016~0.053 MPa）... 详细信息

根据文献中气化速率对总压不敏感、对反应气体分压敏感的实验结论，探索利用常压热重实验得到加压动力学参数的便捷方法。采用NETZSCH STA449F3同步热分析仪进行4种煤焦与水蒸气反应的常压热重实验（水蒸气分压pH2O为0.016~0.053 MPa），通过实验数据处理，获得反应速率与温度、水蒸气分压的关系式，分别以 n 级速率方程和Langmuir-Hinshelwood （LH）速率方程表示，并对上述关系式在水蒸气分压为0.057~0.063 MPa 的工况下进行了实验验证。随着水蒸气分压增大，计算结果与实验数据的相对误差逐渐减小。LH速率方程比n级速率方程更适合描述水蒸气分压的作用。水蒸气分压对反应速率的影响程度随水蒸气分压升高而减小。温度对煤焦-水蒸气反应速率的影响程度大于水蒸气分压对反应速率的影响。温度范围较窄时，煤种本身引起的煤焦反应活性变化幅度会超过温度对煤焦反应活性的影响。在不同的温度和水蒸气分压下，煤种的化学反应活性强弱次序会发生变化，某一特定工况下的次序不能未加实验而随意扩展到其他工况。

关键词：动力学参数热重分析仪蒸汽加压大气煤焦气化速率分析实验反应

Association of Genetic Polymorphisms of Anti-Müllerian Hormone (AMH) and Its Type II Receptor with Ovarian Hyperstimulation Syndrome

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Reproduction and Contraception 2013年第1期24卷 30-37页

作者： Yi-qing zhao Han-wang ZHANG Medical Reproductive Center Department of Obstetrics and Gynecology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

Objective To explore the association of genetic polymorphisms in the genes encoding the anti-Miillerian hormone （AMH） and its type H receptor （AMHRII） with ovarian hyperstimulation syndrome （OHSS）. Methods Using polymerase chain reaction （PCR） and DNA sequencing techniques, the exons of AMH and AMHRII were analyzed in 27 OHSS patients （OHSS group） and 22 non-OHSS patients （control group） who were applied controlled ovarian hyper- stimulation （COH）. Single nucleotide polymorphisms （SNPs） were also analyzed. Results SNPs G〉 T at position 146 of AMH exon 1 and G〉 A at position 134 of AMH exon 2 showed significant differences between the OHSS group and control group （P〈0.05）. SNP G〉 T at position 303 of AMH exon 1 showed no significant difference between the OHSS group and control group （P〉0.05）. No SNP was detected from the AMHR H exons 1 to 11 in either groups. Conclusion Genetic polymorphisms in the AMH gene may be a cause of ovarian hypersensitivity to exogenous hormone stimulation and the development of OHSS.

关键词： ovarian hyperstimulation syndrome (OHSS) anti-Mtillerian hormone (AMH) anti-M/illerian hormone type II receptor (AMHRII) single nucleotidepolymorphisms (SNPs)

Virus load and virus shedding of SARS-CoV-2 and their impact onpatient outcomes

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2020年第24期8卷 6252-6263页

作者： Pei-Fen Chen Xia-Xia Yu Yi-Peng Liu Di Ren Min Shen Bing-Sheng Huang Jun-Ling Gao heng-Yang Huang Ming Wu Wei-Yan wang Li Chen Xia Shi zhao-qing wang Ying-Xia Liu Lei Liu Yong Liu Department of Respiratory Diseases Shenzhen Key Laboratory of Pathogen and ImmunityNational Clinical Research Center for Infectious DiseaseState Key Discipline of Infectious DiseasesShenzhen Third People’s HospitalThe Second Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518114Guangdong ProvinceChina School of Biomedical Engineering Health Science CenterShenzhen UniversityShenzhen 518060Guangdong ProvinceChina Expert Panel of Shenzhen 2019-nCoV Pneumonia The Second People’s Hospital of ShenzhenShenzhen 518035Guangdong ProvinceChina Shenzhen Key Laboratory of Pathogen and Immunity National Clinical Research Center for Infectious DiseaseState Key Discipline of Infectious DiseasesShenzhen Third People’s HospitalThe Second Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518114Guangdong ProvinceChina Medical AI Laboratory School of Biomedical EngineeringHealth Science CentreShenzhen UniversityShenzhen 518060Guangdong ProvinceChina Buddhism and Science Research Laboratory Centre of Buddhist StudiesThe University of Hong KongPokfulamHong Kong 999077China ICU The Second People's Hospital of ShenzhenShenzhen 518035Guangdong ProvinceChina Expert Panel of Shenzhen 2019-nCoV Pneumonia Shenzhen HospitalSouthern Medical UniversityShenzhen 518000Guangdong ProvinceChina

BACKGROUND Understanding a virus shedding patterns in body fluids/secretions is importantto determine the samples to be used for diagnosis and to formulate infectioncontrol *** To investigate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)shedding patterns and its risk *** All laboratory-confirmed coronavirus disease 2019 patients with completemedical records admitted to the Shenzhen Third People’s Hospital from January28, 2020 to March 8, 2020 were included. Among 145 patients (54.5% males;median age, 46.1 years), three (2.1%) died. The bronco-alveolar lavage fluid(BALF) had the highest virus load compared with the other samples. The viralload peaked at admission (3.3 × 108 copies) and sharply decreased 10 d *** The viral load was associated with prolonged intensive care unit (ICU) *** in the ICU had significantly longer shedding time compared to those inthe wards (P 60 years [hazard ratio (HR) = 0.6;95% confidenceinterval (CI): 0.4-0.9] was an independent risk factor for SARS-CoV-2 shedding,while chloroquine (HR = 22.8;95%CI: 2.3-224.6) was a protective *** BALF had the highest SARS-CoV-2 load. Elderly patients had higher virus loads,which was associated with a prolonged ICU stay. Chloroquine was associatedwith shorter shedding duration and increased the chance of viral negativity.

关键词： COVID-19 Virus shedding Viral load Patient outcome China Infectious disease

Preliminary PET/CT Study of ^(18)F-FDG Uptake in Cervical and Supraclavicular Brown Adipose Tissue

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Clinical Oncology 2008年第5期5卷 349-353页

作者： Na Fang Yanli wang Xinjian Cui Lei Zeng Lili Ma Xiumei zhao Wei zhao qing wang Shan Gao Wei Ding Department of PET/CT Municipal Central Hospital of Qingdao Qingdao 266042 Shandong Province China.

OBJECTIVE The clinical use of PET/CT in oncology has led to the realization that 18F-FDG uptake in brown adipose tissue(BAT) can be a common cause of potentially misleading false-positive PET *** goal of this study was to study 18F-FDG uptake in cervical and supraclavicular regions and its characteristics with PET/*** the PET/CT scans obtained at our institutionfrom July 2007 to January 2008 were retrospectively reviewed forincreased 18F-FDG uptake in *** cases in which increased18F-FDG in cervical and supraclavicular regions was not localizedto a so -tissue mass or lymph node or muscle on the CT images,were included in this *** following features were recorded:body weight,body mass index(BMI) and maximal standardizeduptake value(SUVmax).In these selected patients,the BAT uptake in other area of the body was also *** PET/CT scans were obtained in 457 patients(259 males and 198 females).In all of the scans,cervical and supraclavicular BAT uptake was observed in 12 patients(2 males and 10 females) and was typically bilateral,symmetric and *** range of the SUVmax was 3.6～12.82(mean 6.9 ± 2.6).BAT uptake was more common in females than in males,showing a significant difference(P = 0.004).Although 18F-FDG uptake in BAT occurred more o en in underweight patients with low BMI,there was no difference in the body weight(P = 0.607) or BMI(P = 0.491) of these patients with hypermetabolic BAT compared with *** Hypermetabolic BAT uptake can be localized in cervical and supraclavicular regions with it occurring more commonly in females compared to *** of this potential pitfall with PET/CT is important in improving diagnostic interpretation and accurate staging.

关键词： brown adipose tissue, ^18F-EDG PET/CT.

IL-7R在膝关节骨关节炎滑膜中的表达及意义

在线全文

学校读者我要写书评

暂无评论

中国现代医学杂志 2017年第2期27卷 52-55页

作者：赵清王婧王来芳河南大学淮河医院风湿免疫科河南开封475000

目的探讨白细胞介素7受体(IL-7R)基因在膝关节骨关节炎(KOA)疾病中的表达作用及意义,为其诊断和治疗以及进一步研究提供一定的科学依据。方法选取河南大学淮河医院骨科70例患者新鲜滑膜组织,采用Trizol法提取总RNA,采取Applied Biosyst... 详细信息

目的探讨白细胞介素7受体(IL-7R)基因在膝关节骨关节炎(KOA)疾病中的表达作用及意义,为其诊断和治疗以及进一步研究提供一定的科学依据。方法选取河南大学淮河医院骨科70例患者新鲜滑膜组织,采用Trizol法提取总RNA,采取Applied Biosystems逆转录试剂盒逆转录合成c DNA第一链,用实时逆转录聚合酶链反应(real time RT-PCR)检测膝关节髌上囊滑膜组织中IL-7R基因的表达。结果 IL-7R基因表达在KOA滑膜组织中降低(P<0.05)。结论 IL-7R在KOA滑膜中的表达下降,且与膝关节骨关节炎病变有密切的关联,为检测和治疗KOA疾病提供一定数据支撑和参考。

关键词：骨关节炎白细胞介素7受体基因滑膜组织

The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing Xue Yuejia Ma Ke Ye Xue zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong wang qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation